Radioiodine Labeled Anti-MIF McAb: A Potential Agent for Inflammation Imaging by Chao Zhang, Gui-hua Hou, Jian-kui Han, Jing Song, Ting Liang

“…Macrophage migration inhibitory factor (MIF) is a proinflammatory cytokine that may play a role in the pathogenesis of inflammation. …”
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Inflammatory Serum Biomarkers in Colorectal Cancer in Kazakhstan Population by L. Akhmaltdinova, V. Sirota, V. Zhumaliyeva, D. Babenko, I. Kadyrova, Z. Tauesheva, D. Taizhanova, A. Ibraeva, M. Maratkyzy, A. Turmukhambetova

“…The following biomarkers were included in the study panel: stem cell factor (SCF), vascular endothelial growth factor (VEGF), fibroblast growth factor (FGF2), interleukin 6 (IL6), interleukin 8 (IL8), macrophage migration inhibitory factor (MIF), soluble Fas (SFAS), soluble Fas ligand (sFASL), transforming growth factor β (TGF), tumor necrosis factor (TNF), TNF-related apoptosis-inducing ligand (TRAIL), and programmed death ligand 1 (PD-L1). …”
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Transplanted Adult Neural Stem Cells Express Sonic Hedgehog In Vivo and Suppress White Matter Neuroinflammation after Experimental Traumatic Brain Injury by Genevieve M. Sullivan, Regina C. Armstrong

“…Importantly, NSC transplantation significantly reduced reactive astrogliosis and microglial/macrophage activation in the corpus callosum after TBI. …”
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Adipose Tissue Remodeling as Homeostatic Inflammation by Michiko Itoh, Takayoshi Suganami, Rumi Hachiya, Yoshihiro Ogawa

“…Notably, saturated fatty acids, which are released from hypertrophied adipocytes via the macrophage-induced lipolysis, serve as a naturally occurring ligand for Toll-like receptor 4 complex, thereby activating macrophages. …”
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First detection of recombinant variant of African swine fever virus in the Russian Federation (brief communication) by A. S. Igolkin, R. S. Chernyshev, N. G. Zinyakov, E. O. Morozova, A. R. Shotin, K. N. Gruzdev, I. A. Chvala, A. Mazloum

“…The characterized strain ASFV/Primorsky_2023/DP-4560.Recdemonstrates hemadsorption, active propagation in porcine primary macrophage cell culture, 99.9917% identity with the first recombinant isolates from the People’s Republic of China, recovered in 2021. …”
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Decreased Expression of CD14 in MSU-Mediated Inflammation May Be Associated with Spontaneous Remission of Acute Gout by Lihua Duan, Jiao Luo, Qiang Fu, Ke Shang, Yingying Wei, Youlian Wang, Yan Li, Jie Chen

“…The results showed that CD14 expression on macrophage and sCD14 levels in the culture supernatants were significantly decreased after MSU treatment. …”
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Hepatitis B e Antigen Seroconversion Is Related with the Function of Dendritic Cells in Chronic Hepatitis B Virus Infection by Chunjing Lin, Hai Zou, Shumin Wang

“…The peripheral blood mononuclear cells (PBMC) from 21 chronic HBV patients in immune tolerance state, 23 patients in inactive HBsAg carrier state, and 10 healthy HBV-naive blood donors were incubated and induced into DC in presence of granulocyte-macrophage colony stimulating factor (GM-CSF) and interleukin-4 (IL-4), respectively. …”
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The Diagnostic and Predictive Significance of Immune-Related Genes and Immune Characteristics in the Occurrence and Progression of IgA Nephropathy by Jian-Bo Qing, Wen-Zhu Song, Chang-Qun Li, Ya-Feng Li

“…A ceRNA network associated with IgAN progression which contained 8 miRNAs, 14 lncRNAs, and 3 mRNAs was established. A higher macrophage ratio and lower CD4+ T cell ratio in IgAN compared to controls were observed, and the correlation between macrophages and monocytes in the glomeruli of IgAN patients was inverse compared to controls. …”
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Dynamic interplay of autophagy and membrane repair during Mycobacterium tuberculosis Infection. by Jacques Augenstreich, Anna T Phan, Charles N S Allen, Anushka Poddar, Hanzhang Chen, Lalitha Srinivasan, Volker Briken

“…Our data does not support a role for autophagy in either cell-autonomous defense against Mtb or membrane repair of the MCV in human macrophages. In addition, the combined dynamics of LC3 recruitment and Lysoview staining emerged as promising markers for investigating the damage and repair processes of phagosomal membranes.…”
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Phase I Study of Anti-CD3 x Anti-Her2 Bispecific Antibody in Metastatic Castrate Resistant Prostate Cancer Patients by Ulka Vaishampayan, Archana Thakur, Ritesh Rathore, Nicola Kouttab, Lawrence G. Lum

“…The men received 2.5, 5 or 10 × 109 aATC per infusion with low dose interleukin-2 and granulocyte-macrophage colony stimulating factor. Results. There were no dose limiting toxicities, and there was 1 partial responder and 3 of 7 patients had significant decreases in their PSA levels and pain scores. …”
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Anti-Inflammatory Effect of By-Products from Haliotis discus hannai in RAW 264.7 Cells by Ho-Seok Rho, Hyang Kim, Jung-Ae Kim, Fatih Karadeniz, Byul-Nim Ahn, Ki-Ho Nam, Youngwan Seo, Chang-Suk Kong

“…In this study, anti-inflammatory potential of mucus-secreting glands from shell-shucking waste of H. discus hannai was evaluated using RAW 264.7 mouse macrophage cell model. Results indicated that presence of H. discus hannai mucosubstance by-products (AM) significantly lowered the nitric oxide (NO) production along the expressional suppression of inflammatory mediators such as cytokines TNF-α, IL-1β, and IL-6 and enzymes iNOS and COX-2. …”
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Wedelolactone Mitigates Alcoholic Steatohepatitis via Modulating the TLR4/MyD88/NF-κB Pathway by Tao Jiang, Bingde Hu, Yongxia Li, Shuihong Yu

“…Histopathological evaluations revealed that WEL mitigated liver injury, lipid accumulation, and macrophage infiltration provoked by alcohol consumption and a high-fat diet in mice. …”
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ATP-Binding Pocket-Targeted Suppression of Src and Syk by Luteolin Contributes to Its Anti-Inflammatory Action by Jeong-Oog Lee, Deok Jeong, Mi-Yeon Kim, Jae Youl Cho

“…In the present study, the anti-inflammatory mode of action in activated macrophages of luteolin from Artemisia asiatica was examined by employing immunoblotting analysis, a luciferase reporter gene assay, enzyme assays, and an overexpression strategy. …”
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P2X7 Receptor Activation Induces Reactive Oxygen Species Formation and Cell Death in Murine EOC13 Microglia by Rachael Bartlett, Justin J. Yerbury, Ronald Sluyter

“…This study aimed to determine if P2X7 activation induces the uptake of organic cations, reactive oxygen species (ROS) formation, and death in the murine microglial EOC13 cell line. Using the murine macrophage J774 cell line as a positive control, RT-PCR, immunoblotting, and immunolabelling established the presence of P2X7 in EOC13 cells. …”
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Differential pathological changes in colon microenvironments in acute and chronic mouse models of inflammatory bowel disease by NaYeon Ham, Minji Park, Young-An Bae, Eui-Ju Yeo, YunJae Jung

“…During the acute phase, activated innate inflammation marked by M1 macrophage infiltration was prominent. In contrast, the chronic phase was characterized by tissue remodeling, with a significant increase in M2 macrophages and lymphocytes. …”
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4-Aminoquinoline as a privileged scaffold for the design of leishmanicidal agents: structure–property relationships and key biological targets by Angel H. Romero, Francisco Delgado

“…., depolarization of potential mitochondrial, accumulation into macrophage lysosome, and immunostimulation of host cells). …”
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Neuroinflammation and Oxidative Stress in Diabetic Neuropathy: Futuristic Strategies Based on These Targets by Reddemma Sandireddy, Veera Ganesh Yerra, Aparna Areti, Prashanth Komirishetty, Ashutosh Kumar

“…The cross talk between oxidative stress and inflammation is due to the activation of NF-κB and AP-1 and inhibition of Nrf2, peroxynitrite mediate endothelial dysfunction, altered NO levels, and macrophage migration. These all culminate in the production of proinflammatory cytokines which are responsible for nerve tissue damage and debilitating neuropathies. …”
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The Effects of Dexmedetomidine on Secondary Acute Lung and Kidney Injuries in the Rat Model of Intra-Abdominal Sepsis by Uğur Koca, Çimen Gülben Olguner, Bekir Uğur Ergür, Emel Altekin, Aydın Taşdöğen, Seden Duru, Pelin Girgin, Kerim Gündüz, Serap Cilaker Mıcılı, Seda Güzeldağ, Muhammed Akkuş

“…In order to evaluate tissue injury we determined kidney tissue mononuclear cell infiltration score, alveolar macrophage count, histological kidney and lung injury scores and kidney and lung tissue immunoreactivity scores. …”
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Preliminary screening of new biomarkers for sepsis using bioinformatics and experimental validation. by Hao Wang, Wei Xiong, Wu Zhong, Yingchun Hu

“…S100A11 and QPCT were widely distributed in all immune cells, and QPCT was mainly localized in the macrophage cell lineage. In the sepsis group, the qPCR results showed that S100A11, QPCT, and IFITM2 expression levels were significantly higher in the sepsis group(P < 0.05).…”
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Understanding Delayed T-Cell Priming, Lung Recruitment, and Airway Luminal T-Cell Responses in Host Defense against Pulmonary Tuberculosis by Christopher R. Shaler, Carly Horvath, Rocky Lai, Zhou Xing

“…Customarily, the alveolar macrophage (AM) acts as a sentinel, detecting and alerting surrounding cells to the presence of an invader. …”
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