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361
TDP-43 nuclear retention is antagonized by hypo-phosphorylation of its C-terminus in the cytoplasm
Published 2025-01-01“…We show that C-terminus phosphorylation prevents the recruitment of TDP-43 in mRNA-rich stress granules only under acute stress conditions because of a low affinity for mRNA but not under mild stress conditions. …”
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362
Chronic Glucocorticoid-Rich Milieu and Liver Dysfunction
Published 2016-01-01“…MSG rats displayed degenerated optic nerves, hypophagia, low body and liver weights, and enlarged adipose tissue mass; higher peripheral levels of glucose, triglycerides, insulin, uric acid, leptin, corticosterone, transaminases and TBARS, and peripheral and liver insulin resistance; elevated liver OS, inflammation markers, and glucokinase (mRNA/activity) and fructokinase (mRNA). Additionally, MSG liver phosphofructokinase-2, glucose-6-phosphatase (mRNA and activity) and glucose-6-phosphate dehydrogenase, Chrebp, Srebp1c, fatty acid synthase, and glycerol-3-phosphate (mRNAs) were increased. …”
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363
A Novel Role of Globular Adiponectin in Treatment with HFD/STZ Induced T2DM Combined with NAFLD Rats
Published 2014-01-01“…But the protein and mRNA expressions of adipoR1 increased (P<0.05, resp.) in T2DM group and no change was found in the gAd-treated group. …”
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364
Macrophage Migration Inhibitory Factor Interacting with Th17 Cells May Be Involved in the Pathogenesis of Autoimmune Damage in Hashimoto’s Thyroiditis
Published 2015-01-01“…Results. MIF mRNA, IL-17A mRNA expressions and Th17 cells percentages, serum MIF, and IL-17A protein levels were all significantly higher in HT patients, even in euthyroid subgroup. …”
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365
Genetic Polymorphism and Expression of CXCR4 in Breast Cancer
Published 2015-01-01“…The present study aimed to investigate the influence of CXCR4 rs2228014 polymorphism on its mRNA and protein expression in breast cancer samples. …”
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366
Modulation of DAPK1 expression by its alternative splice variant DAPK1-215 in cancer
Published 2025-01-01“…Finally, clinical liver cancer specimens were analyzed to assess the prognostic relevance of DAPK1-215 and DAPK1 mRNA levels. Results DAPK1-215 downregulated DAPK1 expression in liver, kidney, and gastric cancer cells by reducing DAPK1 mRNA stability. …”
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367
Level of CYP4G19 Expression Is Associated with Pyrethroid Resistance in Blattella germanica
Published 2010-01-01“…Two to eight days after injection, the result showed that CYP4G19 mRNA expressions were significantly reduced in the groups injected with dsRNAs.…”
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368
Competing Endogenous RNA: The Key to Posttranscriptional Regulation
Published 2014-01-01“…It has recently been discovered that, apart from protein-coding ceRNAs, pseudogenes, long noncoding RNAs (lncRNAs), and circular RNAs act as miRNA “sponges” by sharing common MRE, inhibiting normal miRNA targeting activity on mRNA. These MRE sharing elements form the posttranscriptional ceRNA network to regulate mRNA expression. ceRNAs are widely implicated in many biological processes. …”
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369
Calculation of Free Energy Consumption in Gene Transcription with Complex Promoter Structure
Published 2020-01-01“…Then, we show that the numbers of the ON and OFF states of a promoter can reduce energy consumption of the gene system and the Fano factor of mRNA, and in contrast to other regulatory ways, the cooperative binding of transcription factors to DNA sites always reduces energy consumption but amplifies the mRNA noise. …”
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370
The effect of COVID-19 and COVID-19 vaccines on chronic spontaneous urticaria: single center experience
Published 2024-04-01“…As a result, omalizumab had to be started in 3/8 patients after mRNA vaccination due to CSU exacerbation or treatment failure. …”
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371
Enhanced Suppressive Activity of Regulatory T Cells in the Microenvironment of Malignant Pleural Effusions
Published 2018-01-01“…TGF-β and IL-10 concentrations were measured using human TGF-β1 and IL-10 ELISA kit. Relative mRNA expression of studied genes was analyzed by real-time PCR. …”
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372
Topological Characterization of Human and Mouse m5C Epitranscriptome Revealed by Bisulfite Sequencing
Published 2018-01-01“…Surprisingly, an inverse correlation between mRNA and DNA m5C methylation is observed at CpG sites. …”
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373
PPARα: A Master Regulator of Bilirubin Homeostasis
Published 2014-01-01“…Similar positive regulations were also observed with the 3 PPARα ligands in CASMCs where HO-1 mRNA and protein levels were increased. In HH and HepG2 cells, both UGT1A1 and MRP2 transcripts were also accumulating. …”
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374
Oxidized LDL Induces Alternative Macrophage Phenotype through Activation of CD36 and PAFR
Published 2013-01-01“…The mRNA expression of IL-12, RANTES and CXCL2 were not affected. …”
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375
Interleukin-12p70 Expression by Dendritic Cells of HIV-1-Infected Patients Fails to Stimulate gag-Specific Immune Responses
Published 2012-01-01“…To this end, mature DCs were (i) co-electroporated with mRNA encoding interleukin (IL)-12p70 mRNA, or (ii) activated with a cytokine cocktail consisting of R848 and interferon (IFN)-γ. …”
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376
Proinflammatory Effects of Diesel Exhaust Nanoparticles on Scleroderma Skin Cells
Published 2014-01-01“…Euro 5 particle exposure increased the mRNA expression of MMP-2, -7, and -9 in SSc fibroblasts in a dose dependent manner and only at the highest concentration in normal cells. …”
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377
Effects of coal mine dust on lung function in rats
Published 2025-01-01“…There were interactions between dust type and exposure duration on ROS and ATP levels, the relative mRNA and protein expressions of PGC-1α and TFAM (all P<0.05). …”
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378
Effects of Simvastatin on Glucose Metabolism in Mouse MIN6 Cells
Published 2014-01-01“…Compared with control group, the mRNA and protein expression of Kir6.2 increased with treatment of simvastatin (P<0.05), and mRNA and protein expression of Cav1.2 and GLUT2 decreased in response to simvastatin (P<0.05). …”
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379
The Role of CD40 in Allergic Rhinitis and Airway Remodelling
Published 2021-01-01“…After treated with CD40 siRNA, AR mice had significantly more Foxp3+ Tregs. (3) AR mice exhibited a significantly higher CD40 mRNA levels than control. Administration of CD40 siRNA significantly reduced the CD40 mRNA level. (4) The AR mice showed significantly greater collagen deposition than the control in MT staining. …”
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380
Overexpression of HIF-2α, TWIST, and CXCR4 Is Associated with Lymph Node Metastasis in Papillary Thyroid Carcinoma
Published 2013-01-01“…TWIST and CXCR4 mRNA expression levels were up-regulated in PTCs, and high mRNA expression of TWIST and CXCR4 was significantly correlated with LNM (P=0.005 and P=0.010, resp.). …”
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