Current Research Progress on Long Noncoding RNAs Associated with Hepatocellular Carcinoma by Haihong Shi, Yuxin Xu, Xin Yi, Dandan Fang, Xia Hou

“…It has been found that long noncoding RNAs (lncRNAs) are involved in many human cancers, including liver cancer. It has been identified that carcinogenic and tumor-suppressing lncRNAs are associated with complex processes in liver cancer. …”
Get full text

Stromal architecture and fibroblast subpopulations with opposing effects on outcomes in hepatocellular carcinoma by Yifei Cheng, Xiaofang Chen, Li Feng, Zhicheng Yang, Liyun Xiao, Bin Xiang, Xiaodong Wang, Dongbin Liu, Penghui Lin, Jieyi Shi, Guohe Song, Wulei Qian, Boan Zhang, Yanan Xu, Zheng Gao, Lv Chen, Yingcheng Wu, Jiaqiang Ma, Youpei Lin, Haichao Zhao, Lihua Peng, Xuebin Mao, Yang Liu, Hao Hou, Mingyu Yang, Yuan Ji, Xiaoying Wang, Jian Zhou, Xun Xu, Xiyang Liu, Wu Wei, Xiaoming Zhang, Qiang Gao, Hu Zhou, Yidi Sun, Kui Wu, Jia Fan

Get full text

Synthetic Retinoid Sulfarotene Selectively Inhibits Tumor‐Repopulating Cells of Intrahepatic Cholangiocarcinoma via Disrupting Cytoskeleton by P‐Selectin/PSGL1 N‐Glycosylation Bloc... by Xiaojing Du, Zhuoran Qi, Sinuo Chen, Jinlan Wu, Ye Xu, Sunkuan Hu, Zhijie Yu, Jiayun Hou, Yuan Fang, Jinglin Xia, Xin Cao

Get full text

Somatic Mutations from Whole Exome Sequencing Analysis of the Patients with Biliary Tract Cancer by Kyong-Ah Yoon, Sang Myung Woo, Yun-Hee Kim, Sun-Young Kong, Sung-Sik Han, Sang-Jae Park, Woo Jin Lee

Get full text

Protocol for reconstructing ancestral genomes from present-day samples by applying local ancestry inference by Xiaoxi Zhang, Baonan Wang, Jia Wen, Yang Gao, Yuwen Pan, Shuhua Xu

Get full text

Modules Identification in Gene Positive Networks of Hepatocellular Carcinoma Using Pearson Agglomerative Method and Pearson Cohesion Coupling Modularity by Jinyu Hu, Zhiwei Gao

“…Finally, the biological significance of the two types of modules is analyzed and explained, which shows that these modules are closely related to the proliferation and metastasis of liver cancer. This discovery of the new modules may provide new clues and ideas for liver cancer treatment.…”
Get full text

Single‐cell landscape of the intrahepatic ecosystem in alcohol‐related liver disease by Xiaofang Zhao, Senyan Wang, Qi Liu, Wenjuan Wei, Xiaoyan Sun, Hao Song, Jing Xu, Shuijun Zhang, Hongyang Wang, Jing Fu

“…Moreover, ALB+KRT7+ epithelium‐derived ALD organoids promote the tumour growth by activating Wnt/β‐catenin signalling of liver cancer cells. Most importantly, blocking the Wnt protein secretion or knockdown the Wnt receptor suppressed the tumour promoting effect of ALD organoids. …”
Get full text

Enhancing hepatocellular carcinoma therapy with DOX-loaded SiO2 nanoparticles via mTOR-TFEB pathway autophagic flux inhibition by Huanyu Chen, Jun Liu, Zhichao Cao, Jiajia Li, Hong Zhang, Qianqian Yang, Jian Cheng, Yuxian Shen, Kewu He

“…This novel diagnostic-integrated nanocarrier is expected to be a promising tool for targeted liver cancer treatment.…”
Get full text

Propensity Score Matching Analysis for Alcohol‐Related Liver Disease by Fangfang Duan, Shanshan Song, Hang Zhai, Yazhi Wang, Jun Cheng, Song Yang

“…ABSTRACT Objectives This study aims to investigate the impact of comorbidity with chronic hepatitis B (CHB) on the survival rates and incidence of liver cancer in patients with alcohol‐related liver disease (ARLD). …”
Get full text

Endoplasmic reticulum stress-related super enhancer promotes epithelial-mesenchymal transformation in hepatocellular carcinoma through CREB5 mediated activation of TNC by Anqi Wang, Sitong Yan, Jiatao Liu, Xiang Chen, Mengyao Hu, Xiao Du, Weijia Jiang, Zhipeng Pan, Lulu Fan, Guoping Sun

“…Mechanistically, CREB5 upregulates the transcription of tenascin-C (TNC) by directly binding to its promoter region, thereby promoting EMT in liver cancer cells. In summary, our findings suggest that ERS activation promotes EMT in liver cancer cells via SE-mediated upregulation of the CREB5/TNC pathway. …”
Get full text

Neoadjuvant atezolizumab plus bevacizumab prior liver transplantation for hepatocellular carcinoma by Parissa Tabrizian, Rebecca Marino, Sherrie Bhoori, Marcus Zeitlhoefler, Neil Mehta, Vanessa Banz, Salvatore Gruttadauria, Massimo Iavarone, Chiara Mazzarelli, Nicolò Simonotti, Francis Yao, Vincenzo Mazzaferro, Josep M. Llovet

Get full text

ACSL4 promotes the formation of the proliferative subtype in hepatoblastoma by Wei Dang, Qin Li, Xiaoying Wang

Get full text

Comprehensive profiling of serum microRNAs in normal and non-alcoholic fatty liver disease (NAFLD) patients by Jian-Wei Zhang, Kamran Ullah, Nauman Khan, Hai-Tao Pan

“…Abstract Pediatric non-alcoholic fatty liver disease (NAFLD) is emerging as a worldwide health concern with the potential to advance to cirrhosis and liver cancer. NAFLD can also directly contribute to heart problems through inflammation and insulin resistance, even in individuals without other risk factors. …”
Get full text

Prophylactic Role of Averrhoa carambola (Star Fruit) Extract against Chemically Induced Hepatocellular Carcinoma in Swiss Albino Mice by Ritu Singh, Jyoti Sharma, P. K. Goyal

“…Liver cancer remains one of the severe lethal malignancies worldwide and hepatocellular carcinoma (HCC) is the most common form. …”
Get full text

Immunotherapy for Hepatocellular Carcinoma: Current Advances and Future Expectations by Yingjun Xie, Yien Xiang, Jiyao Sheng, Dan Zhang, Xiaoxiao Yao, Yongsheng Yang, Xuewen Zhang

“…Primary liver cancer is a common kind of digestive cancers with high malignancy, causing 745,500 deaths each year. …”
Get full text

Immunotherapy of Liver Diseases by Dechun Feng, YinYing Lu, Xiaoni Kong, Feng Li

Get full text

Modulation of DAPK1 expression by its alternative splice variant DAPK1-215 in cancer by QingShui Wang, ShuYun Weng, WenTing Zhong, YouYu Lin, Yan Yu, YiMin Huang, LiLin Ge, XiuLi Zhang, FangQin Xue, Yehuda G. Assaraf, Yao Lin

“…Finally, clinical liver cancer specimens were analyzed to assess the prognostic relevance of DAPK1-215 and DAPK1 mRNA levels. …”
Get full text

Research progress of MRI-based radiomics in hepatocellular carcinoma by Xiao-Yun Xie, Rong Chen

“…BackgroundPrimary liver cancer (PLC), notably hepatocellular carcinoma (HCC), stands as a formidable global health challenge, ranking as the sixth most prevalent malignant tumor and the third leading cause of cancer-related deaths. …”
Get full text

Mortality among Alaska Native Adults with Confirmed Hepatitis C Virus Infection Compared with the General Population in Alaska, 1995–2016 by Sara S. Bressler, Dana Bruden, Leisha D. Nolen, Michael G. Bruce, Lisa Towshend-Bulson, Philip Spradling, Brian J. McMahon

“…The LRD death rate among the AK-HepC cohort was 18- and 11-fold higher than the non-AN and AN, respectively. The liver cancer rate among the AK-HepC cohort was 26-fold higher compared to the Alaska statewide population. …”
Get full text

Lnc-EST885 promotes hepatocellular carcinoma metastasis through PI3K / AKT pathway by interaction with TRAF4 by Shaoliang Zhu, Gang Wang, Yuxuan Zhang, Mengjie Zou, Zhi Li, Shenhong Qu, Xiaosu Zou, Wenqian Nong, Weiwei Miao, Qicong Chen, Juanmei Mo, Huibing Chen, Lequn Li, Xiaofeng Dong, Honglin Luo

“…Functional experiments have shown that lnc-EST885 significantly promotes the proliferation and migration of liver cancer cells, inhibits apoptosis, and induces EMT. …”
Get full text