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Proteome‐Wide Mendelian Randomization Identifies Therapeutic Targets for Abdominal Aortic Aneurysm
Published 2025-02-01“…Several causal proteins are involved in pathways regulating lipid metabolism, immune responses, and extracellular matrix organization. …”
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2962
Low Citrate Synthase Activity Is Associated with Glucose Intolerance and Lipotoxicity
Published 2019-01-01“…This could be due to impaired lipid metabolism in muscle cells.…”
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2963
Poor Control of Plasma Triglycerides Is Associated with Early Decline of Estimated Glomerular Filtration Rates in New-Onset Type 2 Diabetes in China: Results from a 3-Year Follow-U...
Published 2020-01-01“…This study aims to explore the impact of long-term lipid control on renal outcome in new-onset type 2 diabetes mellitus (T2DM). …”
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2964
MicroRNA-147a Targets SLC40A1 to Induce Ferroptosis in Human Glioblastoma
Published 2022-01-01“…Mechanistically, we determined that miR-147a directly bound to the 3′-untranslated region of SLC40A1 and inhibited SLC40A1-mediated iron export, thereby facilitating iron overload, lipid peroxidation, and ferroptosis. Furthermore, miR-147a mimic-treated human glioblastoma cells exhibited higher sensitivity to TMZ chemotherapy than those treated with the mimic control in vitro. …”
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2965
Curcumin nanoparticles alleviate brain mitochondrial dysfunction and cellular senescence in γ-irradiated rats
Published 2025-01-01“…The data obtained demonstrated that oral administration of CNPs for eight weeks attenuated oxidative stress in γ-irradiated rats by lowering the brain’s lipid peroxidation level [malondialdehyde (MDA)] and enhancing antioxidant markers [superoxide dismutase (SOD), reduced glutathione (GSH), and total antioxidant capacity (TAC)] (P < 0.05). …”
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Dietary and plasma atherogenic and thrombogenic indices and cardiometabolic risk factors among overweight and individuals with obesity
Published 2025-02-01“…Additionally, biochemical parameters, including serum total cholesterol (TC), triglyceride (TG), high-density lipoprotein cholesterol (HDL-C), fasting serum glucose (FSG), and insulin levels, were measured using enzymatic methods. The lipid profile was quantified. Results For participants in higher tertiles of the AIP, the percentage of men was significantly higher than women (men: 48.1%, women: 51.7%, p < 0.001). …”
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2968
Pharmacological effects of fibroblast growth factor 21 are sex-specific in mice with the <em>lethal yellow</em> (A<sup>y</sup>) mutation
Published 2020-04-01“…In control Ay -mice, expression of genes involved in lipid and glucose metabolism (Ppargc1a, Cpt1, Pck1, G6p, Slc2a2) in the liver and genes involved in lipogenesis (Pparg, Lpl, Slc2a4) in visceral adipose tissue was higher in females than in males, and FGF21 administration inhibited the expression of these genes in females. …”
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2969
Comprehensive analysis of histophysiology, transcriptomics and metabolomics in goslings exposed to gossypol acetate: unraveling hepatotoxic mechanisms
Published 2025-01-01“…Overall, GA-induced hepatotoxicity involves impaired energy production, disrupted lipid metabolism, and abnormal liver focal adhesion, leading to liver cell dysfunction. …”
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Wheat flour as carbon source on water quality, growth performance, hemolymph biochemical and immune parameters of Pacific white shrimp (Penaeus vannamei) juveniles in biofloc techn...
Published 2025-03-01“…Adding wheat flour to the rearing system improved the biochemical composition of shrimp bodies, so that the control group had the lowest level of protein (75.31 % DW), lipid (6.81 % DW), and ash (11.48 % DW) (P < 0.05). …”
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Early effects of LT3 + LT4 combination therapy on quality of life in hypothyroid patients: a randomized, double-blind, parallel-group comparison trial
Published 2025-01-01“…While no significant differences emerged between the groups in terms of blood pressure, lipid profiles (except for low-density lipoprotein cholesterol), or body weight, there were notable improvements in physical functioning and bodily pain in the LT4 + LT3 group compared to the LT4 + placebo group. …”
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2973
2′-O-Methylperlatolic Acid Enhances Insulin-Regulated Blood Glucose-Lowering Effect through Insulin Receptor Signaling Pathway
Published 2022-01-01“…Next, qRT-PCR was performed to detect the mRNA expression of genes involved in lipid and glucose metabolism in the liver and muscle tissues. …”
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2974
Morphological, Physiological, and Transcriptional Changes in <i>Crocus sativus</i> L. Under In Vitro Polyethylene Glycol-Induced Water Stress
Published 2025-01-01“…PEG-induced drought led to decreased plant growth and biomass and lowered relative water content of leaves. Lipid peroxidation, membrane damage, and H<sub>2</sub>O<sub>2</sub> content increased, indicating heightened stress levels. …”
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2975
Impact of duration of treatments with metformin and sulfonylureas, individually or in combination, on diabetic retinopathy among newly diagnosed type 2 diabetic patients: a pooled...
Published 2025-01-01“…Methods The data of 4,068 newly diagnosed DM individuals(mean age, 60.2 ± 0.85 years) from three prospective cohorts of Tehran Sugar and Lipid Study (TLGS), Multi-Ethnic Study of Atherosclerosis (MESA), and Atherosclerosis Risk in Communities (ARIC) with a mean age of 59.6 ± 08 years were pooled. …”
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2976
Lipoprotein Particle Predictors of Arterial Stiffness after 17 Years of Follow Up: The Malmö Diet and Cancer Study
Published 2020-01-01“…Associations between c-fPWV and lipoprotein particles were determined with multiple linear regression, controlling for sex, presence of diabetes, waist-to-hip circumference, and smoking status at baseline, as well as heart rate (measured at the carotid artery), mean arterial pressure, antihypertensive and lipid-lowering medications, C-reactive protein (CRP), and age at the time of c-fPWV measurement. …”
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ZnO Nanoparticle-Assisted Synthesis of Thiazolo[3,2-α]Pyrimidine Analogs: Antibacterial and Antioxidant Activity, In Silico Molecular Docking, and ADMET Prediction Study
Published 2022-01-01“…Compound 19 displayed the highest percent inhibition of DPPH with an IC50 value of 9.48 g/mL using the DPPH free radical scavenging assay compared to ascorbic acid (3.21 g/mL) and promising inhibition of peroxide formation (76.28 ± 0.12%), demonstrating its potential in preventing the formation of lipid peroxides. Thus, according to our findings, both the biological activities and in silico computational results revealed that compounds 14, 16, and 18 are good antibacterial agents against P. aeruginosa and E. coli, whereas compound 19 was found to be a promising antibacterial agent against S. aureus and an antioxidant agent. …”
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Atherogenic Index in Type 2 Diabetes and Its Relationship with Chronic Microvascular Complications
Published 2018-01-01“…This study included 2523 patients with T2DM who had not been treated with lipid-lowering drugs and were admitted to the Department of Endocrinology at Zhongnan Hospital, Wuhan University, during the period from January 2015 to February 2018. …”
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Status of sleeping habits and its influence on growth and metabolism of children in Beijing: a population-based cross-sectional study
Published 2025-02-01“…Body composition, body mass index (BMI), blood pressure, fasting plasma glucose, and blood lipid levels were assessed. Results Girls had a greater rate of sleep anxiety, while boys had a greater rate of sleep-disordered breathing (SDB) across all age groups. …”
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Anticancer activity of Ilex khasiana, a rare and endemic species of holly in Northeast India, against murine lymphoma
Published 2025-01-01“…Reduction of body mass, lipid peroxidation, alanine transaminase, aspartate aminotransferase, and creatinine were seen in DLA-transplanted mice after treatment with the plant extract. …”
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