Research Progress of Fuzheng Jiedu Huayu Method in Reducing Toxicity and Enhancing Efficacy of Immunotherapy by Yufan CHEN, Sicong LI, Yiyuan CUI, Li FENG

“…Immune checkpoint inhibitors, which block programmed death receptor 1 or programmed death ligand 1, have been included in the first-line clinical treatment for advanced solid tumors, such as non-small cell lung cancer and malignant melanoma. …”
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An In silico Approach towards Finding the Cancer-Causing Mutations in Human MET Gene by Fayeza Sadia Laskar, Md. Nazmul Islam Bappy, Md. Sowrov Hossain, Zenifer Alam, Dilruba Afrin, Sudeb Saha, Kazi Md. Ali Zinnah

“…Moreover, these nsSNPs exhibited substantial effects on structure, binding affinity with ligand, phylogenetic conservation, secondary structure, and post-translational modification sites of MET, which were evaluated using MutPred2, RaptorX, ConSurf, PSIPRED, and MusiteDeep, respectively. …”
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Characterization of Cu(II)-ACC Complexes and Conversion of the Bound ACC into Ethylene in the Presence of Hydrogen Peroxide. Detection of a Brown Intermediate at Low Temperature by Wadih Ghattas, Michel Giorgi, Christian Gaudin, Antal Rockenbauer, Marius Réglier, A. Jalila Simaan

“…The presence of an exogenic ligand (bpy) is important for the reactivity and may stabilize a reaction intermediate. …”
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Slow Relaxation of the Magnetisation in a Two-Dimensional Metal–Organic Framework with a Layered Square Lattice by Samia Benmansour, Christian Cerezo-Navarrete, Carlos J. Gómez-García

“…Herein, we present the synthesis and structural characterisation of two layered MOFs with the asymmetric ligand 3-chloro,6-cyano-2,5-dihydroxy-1,4-benzoquinone dianion (C₆O₄(CN)Cl²⁻ = chlorocyananilato). …”
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Cell signaling communication within papillary craniopharyngioma revealed by an integrated analysis of single-cell RNA sequencing and bulk RNA sequencing by Xiaoyue Zhu, Yanfei Jia, Zicheng Zhao, Xiaoyu Zhang, Yunlong Zhao, Songbai Gui, Xiu-An Yang

“…Methods Five samples of PCP were utilized for single-cell RNA sequencing. The most relevant ligand and receptor interactions among different cells were calculated using the CellChat package in R software. …”
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Effect of Tumor Necrosis Factor Family Member LIGHT (TNFSF14) on the Activation of Basophils and Eosinophils Interacting with Bronchial Epithelial Cells by Huai Na Qiu, Chun Kwok Wong, Jie Dong, Christopher Wai-Kei Lam, Zhe Cai

“…Tumor necrosis factor (TNF) family ligand LIGHT (TNFSF14) is a cytokine that binds herpesvirus entry mediator (HVEM)/TNFRSF14 and lymphotoxin β receptor (LTβR). …”
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Structural basis for the interaction between the Drosophila RTK Sevenless (dROS1) and the GPCR BOSS by Jianan Zhang, Yuko Tsutsui, Hengyi Li, Tongqing Li, Yueyue Wang, Salma Laraki, Sofia Alarcon-Frias, Steven E. Stayrook, Daryl E. Klein

“…Here we provide a cryo-EM structure of dROS1’s extracellular region, which mediates ligand binding. We show that the extracellular region of dROS1 adopts a folded-over conformation stabilized by an N-terminal domain comprised of two disulfide stapled helical hairpins. …”
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Elevated Salivary Inflammatory Biomarkers are Associated with SARS-CoV-2 Infection Severity by Hanadi Abdullah Alwafi, Soad Shaker Ali, Sunil Babu Kotha, Layla Waleed Abuljadayel, Maha Ibrahim, Ibrahim Rashad Noor Elahi, Hebah Abdullah Alwafi, Mohammed S. Almuhayawi, Matthew D. Finkelman, Nagla A. El-Shitany

“…Saliva was collected from 142 controls and 158 SARS-CoV-2 patients (mild 72 and severe 86) to measure interleukin-6 (IL-6), C-reactive protein (CRP), and C-X-C motif chemokine ligand-10 (CXCL-10). IL-6 and CXCL-10 were significantly increased in patients with mild and severe SARS-CoV-2 infections. …”
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SYNTHESIS AND INFRARED STUDY OF SOME PHENYLPHOSPHONATE, DIPHENYLPHOSPHINATE AND ACETATOPHOSPHONATE NEW ORGANOTIN (IV) DERIVATIVES AND ADDUCTS by MODOU SARR, AMINATA DIASSE-SARR, LIBASSE DIOP

“…The suggested structures, while considering the anionic counterpart, are discrete, dimeric, double and triple metallic components or of infinite chain types, the anion behaving as a monochelating, a bichelating or a bidentate ligand. In OH containing structures, when extra hydrogen bonds are considered, supramolecular architectures may be obtained. …”
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Extraction, GC-MS analysis, cytotoxic, anti-inflammatory and anticancer potential of Cannabis sativa female flower; in vitro, in vivo and in silico by Waqas Safir, Arif Malik, Arif Malik, Haleema Saadia, Ayesha Zahid, Jinyao Li

“…The bioinformatics analysis of molecular docking proved significant ligand-protein interactions of CBD, THC, and humulene with cancer-associated proteins such as PD-1/PD-L1, TNF-α, and MMP-9. …”
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Gene Expression of CD70 and CD27 Is Increased in Alopecia Areata Lesions and Associated with Disease Severity and Activity by Radwa El- Sayed Mahmoud Marie, Noha M. Abd El-Fadeel, Yara El-Sayed Marei, Lina M. Atef

“…CD27-CD70 is a receptor-ligand complex which enhances T helper and cytotoxic T cell activation, survival, and proliferation. …”
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Evaluation of B cell related markers and autoantibodies in rheumatoid arthritis patients treated with abatacept by Ting Wang, Natalia V. Giltiay, Christian Lood, Ning Wang, Bobby Kwanghoon Han

“…Baseline levels and longitudinal changes of markers were assessed between responders and nonresponders.ResultsBaseline levels of anti-cyclic citrullinated peptide (anti-CCP) antibodies (p=0.01), IgM rheumatoid factor (RF) (p=0.02), CXC chemokine ligand 13 (CXCL13, p=0.02), sCD23 (p<0.05), as well as frequencies of CD19+CD11c+IgD-CD27- B cells (p=0.04), were higher in responders than nonresponders. …”
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KAI2-dependent signaling controls vegetative reproduction in Marchantia polymorpha through activation of LOG-mediated cytokinin synthesis (14) by Aino Komatsu, Mizuki Fujibayashi, Kazato Kumagai, Hidemasa Suzuki, Yuki Hata, Yumiko Takebayashi, Mikiko Kojima, Hitoshi Sakakibara, Junko Kyozuka

“…KAI2A perceives unidentified endogenous ligand(s), tentatively referred to as KAI2 ligands (KL). …”
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Integration of bulk and single-cell RNA-seq reveals prognostic gene signatures in patients with bladder cancer treated with immune checkpoint inhibitors by Mina Cho, Hyun Chang, Ju Han Kim

“…However, as the benefits of programmed death-1/ programmed death-ligand-1 blockade immunotherapy do not extend to all patients with BC, biomarkers are required to improve prognostic stratification. …”
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The Expansion of CD25highIL-10highFoxP3high B Regulatory Cells Is in Association with SLE Disease Activity by Zahava Vadasz, Regina Peri, Nasren Eiza, Gleb Slobodin, Alexandra Balbir-Gurman, Elias Toubi

“…While sharing similar regulatory mechanisms such as IL-10 dependency, they also defer in exhibiting their suppressive effects by expressing Fas-Ligand, TGF-beta, and PDL-1. In this study we show, for the first time, the expansion of CD25highFoxP3high Bregs in systemic lupus erythematosus (SLE) patients compared to healthy individuals (18.5 ± 3.052% versus 11.0 ± 1.654%, p<0.001, resp.). …”
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Improved Insulin Resistance and Lipid Metabolism by Cinnamon Extract through Activation of Peroxisome Proliferator-Activated Receptors by Xiaoyan Sheng, Yuebo Zhang, Zhenwei Gong, Cheng Huang, Ying Qin Zang

“…The transactivities of both full length and ligand-binding domain (LBD) of PPARγ and PPARα are activated by cinnamon as evidenced by reporter gene assays. …”
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The Missing Heritability in T1D and Potential New Targets for Prevention by Brian G. Pierce, Ryan Eberwine, Janelle A. Noble, Michael Habib, Hennady P. Shulha, Zhiping Weng, Elizabeth P. Blankenhorn, John P. Mordes

“…Here we review new data on the cognate ligand of MHC molecules, the T cell receptor (TCR). …”
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Urocortin in Second Trimester Amniotic Fluid: Its Role as Predictor of Preterm Labor by C. Iavazzo, K. Tassis, D. Gourgiotis, M. Boutsikou, S. Baka, D. Hassiakos, C. Vogiatzi, L. Florentin-Arar, A. Malamitsi-Puchner

“…Urocortin is a specific ligand for the corticotropin-releasing factor (CRF) receptor expressed by human trophoblast and fetal membranes. …”
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Gemistocytic tumor cells programmed for glial scarring characterize T cell confinement in IDH-mutant astrocytoma by Levi van Hijfte, Marjolein Geurts, Iris de Heer, Santoesha A. Ghisai, Hayri E. Balcioglu, Youri Hoogstrate, Wies R. Vallentgoed, Rania Head, Rosa Luning, Thierry van den Bosch, Bart Westerman, Pieter Wesseling, Johanna A. Joyce, Pim French, Reno Debets

“…Neighboring GTCs and TAMs express receptor-ligand pairs characteristic of reactive astrogliosis and glial scarring, such as SPP1/CD44 and IL-1β/IL1R1. …”
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The Dynamic Interplay between the Gut Microbiota and Autoimmune Diseases by Huihui Xu, Meijie Liu, Jinfeng Cao, Xiaoya Li, Danping Fan, Ya Xia, Xiangchen Lu, Jingtao Li, Dahong Ju, Hongyan Zhao

“…Aryl hydrocarbon receptor, a ligand-activated transcription factor, is a master moderator of host-microbiota interactions because it shapes the immune system and impacts host metabolism. …”
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