In-Silico Evaluation of Binding Interaction and ADME Properties of Novel Pyrazoline and Pyrimidine Derivatives Targeting Cyclooxygenase-2 Enzyme by Sarmad Abbas Fadhil, Karima Fadhil Ali, Wesen Adel Mehde

“…Docking studies employing gold software facilitated the visualization of ligand-protein interactions, utilizing the crystal structure of the COX-2 protein (PDB ID: 4m11). …”
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Advanced anaplastic thyroid carcinoma with positive expression of PD-L1 response to immune checkpoint inhibitors: A case report by Shanmin Fan, Yang Yuan, Yanfang Su, Die Sang

“…Recent evidence has demonstrated promising efficacy of immune checkpoint inhibitors, particularly those targeting programmed death-1 (PD-1)/programmed death ligand 1 (PD-L1), in a variety of solid tumors. However, there have been no research of immune checkpoint inhibitors plus chemotherapy in ATC. …”
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Solid Phase Extraction of Inorganic Mercury Using 5-Phenylazo-8-hydroxyquinoline and Determination by Cold Vapor Atomic Fluorescence Spectroscopy in Natural Water Samples by Mirna Daye, Baghdad Ouddane, Jalal Halwani, Mariam Hamzeh

“…8-Hydroxyquinoline (8-HQ) was chosen as a powerful ligand for Hg solid phase extraction. Among several chelating resins based on 8-HQ, 5-phenylazo-8-hydroxyquinoline (5Ph8HQ) is used for mercury extraction in which the adsorption dynamics were fully studied. …”
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Coordinated Actions of FXR and LXR in Metabolism: From Pathogenesis to Pharmacological Targets for Type 2 Diabetes by Lin Ding, Shuguang Pang, Yongmei Sun, Yuling Tian, Li Yu, Ningning Dang

“…Nuclear receptors (NRs) are ligand-inducible transcription factors that mediate changes to metabolic pathways within the body. …”
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Pro-Inflammatory Cytokine-Mediated Anemia: Regarding Molecular Mechanisms of Erythropoiesis by F. Morceau, M. Dicato, M. Diederich

“…In this review we summarize the effect of tumor necrosis factor (TNF)α, TNF-related apoptosis-inducing ligand (TRAIL), and interferon (IFN)-γ on erythropoiesis with a particular interest for molecular feature.…”
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Synthesis, Spectroscopic Characterization, and Biological Activities of Metal Complexes of 4-((4-Chlorophenyl)diazenyl)-2-((p-tolylimino)methyl)phenol by C. Anitha, C. D. Sheela, P. Tharmaraj, V. V. Hema

“…Antimicrobial studies against several microorganisms indicate that the complexes are more potent bactericides and fungicides than the ligand. The electrochemical behavior of the copper(II) complex was studied by cyclic voltammetry. …”
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M2-like macrophage-derived exosomes inhibit osteoclastogenesis via releasing miR-1227-5p by Shan Chen, Jian Liu, Lilei Zhu

“…The results showed that exosomes from M2 macrophages inhibited receptor activator of nuclear factor κ-B ligand (RANKL)-induced osteoclast differentiation. …”
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Nicotine Impairs the Response of Lung Epithelial Cells to IL-22 by Hannah My-Hanh Nguyen, Jaclene Amber Torres, Sudhanshu Agrawal, Anshu Agrawal

“…Results indicate that nicotine inhibited the secretion of IL-22 from T cells in response to aryl hydrocarbon receptor (AHR) ligand, FICZ. Altogether, the data suggests that nicotine negatively influences the IL-22-IL-22R axis. …”
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Effects of D128N Mutation on OsSERK2 in Xa21-Mediated Immune Complex: An In Silico Study by Raghib Ishraq Alvy, M. H. M. Mubassir, Mohd Firdaus Abdul-Wahab, Salehhuddin Hamdan

“…The in silico results showed that the D128N mutation in OsSERK2 can significantly change the interaction pattern of the critical residues of the OsSERK2 and affects its receptor-ligand (Xa21-RaxX21-sY) interaction in the complex. …”
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Iron-catalysed stereoselective NH transfer enables dynamic kinetic resolution of sulfoxides by Fang-Xu Fan, Hui Xu, Shi-Xiong Tang, Yanfeng Dang, Fei Wang

“…Computational studies on the NH imidation reaction suggest the involvement of an iron-aminyl radical intermediate, and its reaction with sulfoxide proceeds through a synchronous nucleophilic addition of sulfoxide to nitrogen center and ligand-to-metal single electron transfer process to form the N–S bond. …”
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Peroxisome Proliferator-Activated Receptor Targets for the Treatment of Metabolic Diseases by Francisco A. Monsalve, Radha D. Pyarasani, Fernando Delgado-Lopez, Rodrigo Moore-Carrasco

“…The PPARs are transcriptional factors belonging to the ligand-activated nuclear receptor superfamily. So far, three isoforms of PPARs have been identified, namely, PPAR-α, PPAR-β/δ, and PPAR-γ. …”
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Identification of key regulators in pancreatic ductal adenocarcinoma using network theoretical approach. by Kankana Bhattacharjee, Aryya Ghosh

“…Our analysis revealed 33 key regulators were predominantly enriched in neuroactive ligand-receptor interaction, Cell adhesion molecules, Leukocyte transendothelial migration pathways; positive regulation of cell proliferation, positive regulation of protein kinase B signaling biological functions; G-protein beta-subunit binding, receptor binding molecular functions etc. …”
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Synthesis, Characterization, and Thermal Decomposition Kinetics of Manganese Complex of Methionine Hydroxy Analogue by Mei-Ling Wang, Zhi-Xian Wu, Qing Zang, Guo-Qing Zhong

“…The experimental results indicated that the manganese ion was, respectively, coordinated by the carboxylic and hydroxyl oxygen atoms from the methionine hydroxy analogue ligand. The crystal structure of the complex belonged to monoclinic system with the lattice parameters of a = 1.2775 nm, b = 1.5764 nm, c = 1.5764 nm, and β = 94.06°. …”
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Synthesis, Spectroscopic, and Thermal Investigations of Metal Complexes with Mefenamic Acid by Karolina Kafarska, Michał Gacki, Wojciech M. Wolf

“…The novel metal complexes with empirical formulae M(mef)2·nH2O (where M = Mn(II), Co(II), Ni(II), Cu(II), Zn(II), and Cd(II); mef is the mefenamic ligand) were synthesized and characterized by elemental analysis, molar conductance, FTIR-spectroscopy, and thermal decomposition techniques. …”
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Induction of xenobiotic-metabolizing enzymes in hepatocytes by beta-naphthoflavone: Time-dependent changes in activities, protein and mRNA levels by Lněničková Kateřina, Skálová Lenka, Stuchlíková Lucie, Szotáková Barbora, Matoušková Petra

“…To show the differences in responses of tested enzymes, the common aryl hydrocarbon receptor (AhR) ligand agonist, beta-naphthoflavone (BNF), was used. …”
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Heavy Metal Stress and Some Mechanisms of Plant Defense Response by Abolghassem Emamverdian, Yulong Ding, Farzad Mokhberdoran, Yinfeng Xie

“…The key elements of these are chelating metals by forming phytochelatins (PCs) or metallothioneins (MTs) metal complex at the intra- and intercellular level, which is followed by the removal of HM ions from sensitive sites or vacuolar sequestration of ligand-metal complex. Nonenzymatically synthesized compounds such as proline (Pro) are able to strengthen metal-detoxification capacity of intracellular antioxidant enzymes. …”
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The Molecular Mechanism of FABP4 Inhibition Effects of GAS and 4-HBA in Gastrodia elata Blume Was Discussed Based on NMR and Molecular Docking by Yuyu Yang, Shihan Liu, Wenfang Jin, Zengyi Qu, Baolei Fan

“…The FABP4 protein was added to GAS and 4-HBA, and the NMR experiment was performed to observe ligand binding. Finally, according to the spectral information of STD-NMR and molecular docking technology, the interaction between ligands and protein was studied. …”
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Synthesis and Structural Studies of Some Inorganic Polymers of Succinoyl Carboxymethyl Cellulose by H. D. Juneja, Manisha Joshi, N. T. KhatiI

“…On the basis of these studies, the composition of the polymeric unit was found to be [M(II)L]n, [Mʼ(II)L.2H2 O]n, {[Mˮ(II)L.2H2O]n H2O}, where M= Zn(II), Mʼ = Mn(II), Ni(II) and Cu(II) and Mˮ = Co(II), L = SCMC ligand. On the basis of instrumental techniques, it has been found that the [Zn(II)(SCMC)]n inorganic polymer has tetrahedral geometry, whereas {[Cu(II)(SCMC)].2H2O}n has square planar geometry and [Mn(II)(SCMC).2H2O]n, {[Co(II)(SCMC).2H2O)].H2O}n and [Ni(II) (SCMC).2H2O]n have octahedral geometry. …”
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Effect of Magnolol on the Function of Osteoblastic MC3T3-E1 Cells by Eun Jung Kwak, Young Soon Lee, Eun Mi Choi

“…Bone-resorbing cytokines, receptor activator of nuclear factor-κB ligand (RANKL), TNF-α, and IL-6 were measured with an enzyme immunoassay system. …”
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Coordination Polymer: Synthesis, Spectral Characterization and Thermal Behaviour of Starch-Urea Based Biodegradable Polymer and Its Polymer Metal Complexes by Ashraf Malik, Shadma Parveen, Tansir Ahamad, Saad M. Alshehri, Prabal Kumar Singh, Nahid Nishat

“…The thermogravimetric analysis revealed that all the polymeric metal complexes are more thermally stable than the parental ligand. In addition, biodegradable studies of all the polymeric compounds were also carried out through ASTM standards of biodegradable polymers by CO2 evolution method.…”
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