Coordination Behavior of 3-Ethoxycarbonyltetronic Acid towards Cu(II) and Co(II) Metal Ions by Giorgos Athanasellis, Georgia Zahariou, Stefanos Kikionis, Olga Igglessi-Markopoulou, John Markopoulos

“…From the obtained results, a preliminary complexation mode of the ligand is proposed.…”
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Cytokines and Angiogenesis in the Corpus Luteum by António M. Galvão, Graça Ferreira-Dias, Dariusz J. Skarzynski

“…Using the mare CL as a model, reports on locally produced cytokines, such as tumor necrosis factor α (TNF), interferon gamma (IFNG), or Fas ligand (FASL), pointed out their role on angiogenic activity modulation throughout the luteal phase. …”
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Caspase-10 Is the Key Initiator Caspase Involved in Tributyltin-Mediated Apoptosis in Human Immune Cells by Harald F. Krug

“…When compared to Fas-ligand control stimulation, the same sequence of events occurs: membrane blebbing, phosphatidylserine externalisation, the activation of the “death-inducing signalling complex,” and the following sequence of cleavage processes. …”
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HMBG1 as a Driver of Inflammatory and Immune Processes in the Pathogenesis of Ocular Diseases by Yi Liu, Guo-Bin Zhuang, Xue-Zhi Zhou

“…In this review, we summarize current knowledge on HMGB1 as a ligand that can evoke inflammation and immune responses in ocular diseases.…”
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The Discovery of Novel Experimental Therapies for Inflammatory Arthritis by Charles J. Malemud

“…Over the past few years, sphingosine-1-phosphate, interleukin-7 receptor, spleen tyrosine kinase, extracellular signal-regulated kinase, mitogen-activated protein kinase 5/p38 kinase regulated/activated protein kinase, micro-RNAs, tumor necrosis factor-related apoptosis inducing ligand and the polyubiquitin-proteasome pathway were identified as promising novel targets for potential antiarthritis drug development. …”
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Resolving the Two “Bony” Faces of PPAR-γ by Beata Lecka-Czernik, Larry J. Suva

“…Emerging evidence suggests that the pro-adipocytic and the anti-osteoblastic properties of PPAR-γ are ligand-selective, suggesting the existence of multiple mechanisms by which PPAR-γ controls bone mass and fat mass in bone.…”
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Hormone Receptors in Cervicovaginal Cells by Şayeste Demirezen, Funda Gerçeker, Sinan Beksaç

“…The steroid hormone receptors are made up of three functional domains: N-terminal domain (NTD), DNA binding domain (DBD) and ligand-binding domain (LBD). Initially, the steroid hormones diffuse into the cell and bind to its spesific receptor protein. …”
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Hepatocellular Carcinoma with Osteoclast-Like Giant Cells: Report of the Seventh Case in the Literature by Lorenzo Dioscoridi, Damiano Bisogni, Giancarlo Freschi

“…Immunohistochemistry was positive for CD10 and CD68 and in situ hybridization revealed the expression of receptor activator of nuclear factor-kappa B (RANK) in the giant cells and receptor activator of nuclear factor-kappa B ligand (RANKL) in the tumor cells.…”
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Structural and Optoelectronic Properties of CdSe Tetrapod Nanocrystals for Bulk Heterojunction Solar Cell Applications by Nguyen Tam Nguyen Truong, Thao Phuong Ngoc Nguyen, Chinho Park

“…The exchange of surface ligands changed the physical properties of the nanocrystals, which resulted in a slight decrease in the nanoparticles size. …”
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A Review on the Application of PD-1 Blockade in EBV-Associated Nasopharyngeal Carcinoma Immunotherapy by Jin Bian, Yan Niu, Yanli Ma, Fuhua Chen, Ning Ma

“…Immune checkpoint blockade therapy targeting the programmed cell death-1 (PD-1) and programmed cell death ligand-1 (PD-L 1) receptors have shown efficacy in early phase I clinical trials, with ongoing phase III clinical trials. …”
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Anti- and Protumorigenic Effects of PPARγ in Lung Cancer Progression: A Double-Edged Sword by Howard Li, Mary C. M. Weiser-Evans, Raphael Nemenoff

“…Ligands for PPARγ include naturally occurring fatty acids and the thiazolidinedione class of antidiabetic drugs. …”
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PPAR Could Contribute to the Pathogenesis of Hepatocellular Carcinoma by Osamu Kimura, Yasuteru Kondo, Tooru Shimosegawa

“…Peroxisome proliferator-activated receptor (PPAR) is known to have an important role in fatty liver, and the mechanism of carcinogenesis has been clarified. PPAR controls ligand-dependent transcription, and three subtypes (α, δ, and γ) in humans are known. …”
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Peroxisome Proliferator-Activated Receptor-γ-Mediated Polarization of Macrophages in Leishmania Infection by Marion M. Chan, Nagasuresh Adapala, Cui Chen

“…Activation of peroxisome proliferator-activated receptor (PPAR) is one of the tactics used. This ligand-activated nuclear factor curbs inflammation to protect the host from excessive injuries by setting a limit to its destructive force. …”
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The Synthesis of π,n-Complexes of 1-Thio-1,3-dienes with Chromium Group Metals. The Inner-Sphere Hydrophosphorylation of α-Enethiones by Kuramshin A.I., Kolpakova E.V., Kuramshina E.A., Cherkasov R.A., Galkin V.I.

“…New 1-thio-1,3-diene complexes of chromium(0), molybdenum(0), and tungsten(0) with the biden-tate bonding of unsaturated ligand to the metal’s core via the π-system of the C=C bond and sulfur lone electron pair of heterodiene are obtained. …”
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Synthesis and Characterization of a New N"-[(1Z,2E)-2- (Hydroxyimino)-1-phenylpropylidene]-N"'-[(1E)-phenylmethylene]thiocarbonohydrazide and its Complexes with Co(II), Ni(II) and... by Dilip C. Sawant, A. Venkatchallam, R. G. Deshmukh

“…Synthesis and characterization of a new N"-[(1Z,2E)-2- (Hydroxyimino)-1-phenylpropylidene]-N"'-[(1E)-phenylmethylene]thiocarbonohydrazide and its metal complexes with Co(II), Ni(II) and Cu(II) metal ions. The ligand synthesis and characterization is reported for first time. …”
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Deciphering the therapeutic effects of Xiyanping injection: insights into pulmonary and gut microbiome modulation, SerpinB2/PAI-2 targeting, and alleviation of influenza a virus-in... by Tengwen Liu, Shuping Li, Xuerui Wang, Mingjiang Liu, Yuchen Wang, Jie Ying, Shuwen Zhang, Yan Lin, Ning Wang, Yungjing Bai, Lan Xie, Tengfei Chen, Quansheng Feng, Xiaolong Xu

“…XYP injection down-regulated the activity of malondialdehyde, and the levels of interleukin (IL)-1β, IL-5, IL-6, tumor necrosis factor-α, IL-18, IL-15, granulocyte colony-stimulating factor, IL-9, chemokine (C-C motif) ligand-5, and C-X-C motif chemokine ligand 5, while up-regulated the activities of glutathione peroxidase reactive and superoxide dismutase, and the level of interferon-γ. …”
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From structure prediction to function: defining the domain on the African swine fever virus CD2v protein required for binding to erythrocytes by Ana Luisa Reis, Anusyah Rathakrishnan, Vlad Petrovan, Muneeb Islam, Lynnette Goatley, Katy Moffat, Mai Tuyet Vuong, Yuan Lui, Simon J. Davis, Shinji Ikemizu, Linda K. Dixon

“…This region differed from the putative CD58 ligand binding site of host CD2, suggesting that CD2v may bind to a ligand(s) other than CD58. …”
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Cigarette smoke compromises macrophage innate sensing in response to pneumococcal infection by Wei-Chih Liao, Chia-Huei Chou, Mao-Wang Ho, Jo-Tsen Chen, Shu-Ling Chou, Yu-Tsen Huang, Ngoc-Niem Bui, Hui-Yu Wu, Chi-Fan Lee, Wei-Chien Huang, Chih-Ho Lai

“…Results: The results from the cytokine array showed that the production of C-C Motif Chemokine Ligand 2 (CCL2), CCL4, CCL3, C-X-C Motif Chemokine Ligand 2 (CXCL2), and CXCL-10, in pneumococcus-infected cells was reduced upon 5 % CSE treatment. …”
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Molecular docking and dynamics studies to identify novel active compounds targeting potential breast cancer receptor proteins from an indigenous herb Euphorbia thymifolia Linn [ver... by ShamaPrasada K, Reshma Kumarchandra, Vasavi Kumblekar, K Sreedhara Ranganath Pai, Suman Manandhar, Sharada Rai, Rajeshwari Shastry

“…Compounds with good docking scores were further subjected to dynamic studies to understand the protein ligand binding stability, ligand pathway calculation, and molecular mechanics energies combined with Poisson-Boltzmann (MM/PBSA) calculations using the Schrodinger suite. …”
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Targeting aldose reductase using natural African compounds as promising agents for managing diabetic complications by Miriam E. L. Gakpey, Shadrack A. Aidoo, Toheeb A. Jumah, George Hanson, Siyabonga Msipa, Florence N. Mbaoji, Omonijo Bukola, Palesa C. Tjale, Mamadou Sangare, Hedia Tebourbi, Olaitan I. Awe

“…The ADMET and protein-ligand interaction results revealed that these compounds interacted with key inhibiting residues through hydrogen and hydrophobic interactions and demonstrated favorable pharmacological and low toxicity profiles. …”
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