Peroxisome Proliferator-Activated Receptors in Lung Cancer by Venkateshwar G. Keshamouni, ShouWei Han, Jesse Roman

“…Peroxisome proliferator-activated receptors (PPARs) are ligand-activated transcription factors belonging to the nuclear hormone receptor superfamily. …”
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Molecular Basis of Inhibitory Activities of Berberine against Pathogenic Enzymes in Alzheimer's Disease by Hong-Fang Ji, Liang Shen

“…Further inspection to the binding modes found that hydrophobic interactions between the hydrophobic surface of berberine and neighboring hydrophobic residues are the principal forces contributing to the ligand-receptor interactions. Although berberine cation also has potential to form electrostatic interaction with neighboring residues, it is interesting to find that electrostatic force is excluded in the four cases unexpectedly. …”
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Supercritical Fluid Extraction of Metals Using Bis(2,4,4-trimethyl-pentyl)monothiophosphinic Acid as Chelating Agent for Subsequent ICP-MS Analyses of Mercury, Cadmium and Lead in... by E. C. Roa, M. Schultz, M. B. Capangpangan

“…This study investigated and validated the optimum conditions for a supercritical fluid extraction (SFE) method using bis(2,4,4-trimethylpentyl)-monothiophosphinic acid as a chelating ligand, for subsequent ICP-MS analyses of mercury, cadmium and lead in sediment. …”
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Structure and Physiological Actions of Ghrelin by Christine Delporte

“…Ghrelin is a gastric peptide hormone, discovered as being the endogenous ligand of growth hormone secretagogue receptor. Ghrelin is a 28 amino acid peptide presenting a unique n-octanoylation modification on its serine in position 3, catalyzed by ghrelin O-acyl transferase. …”
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2-Hydroxy-5-methylbenzophenone oxime(HMBO) as an Analytical Reagent for Gravimetric Determination of Cu(II) by S. K. Shingadia, K. K. Desai

“…Job’s method and mole ratio method revealed that the stoichiometry of the complex is 1:2 (metal: ligand). Beer’s law is obeyed up to 61.25 ppm of Cu(II). …”
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Hyperbaric oxygen potentiates platelet-rich plasma composition and accelerates bone healing by Wen-Shuo Chang, Chien-Cheng Huang, Tzu-Hao Chen, Ssu-Han Chao, Cheng-Hsien Lin, Ching-Ping Chang, Chi-Sheng Chien

“…Bone healing was assessed weekly by X-ray, while histological and immunofluorescence analyses evaluated inflammatory status, osteoprotegerin (OPG), receptor activator of nuclear factor kappa-B ligand (RANKL) expression, and the presence of osteoblasts, osteoclasts, and osteocytes during healing. …”
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An abundant ginger compound furanodienone alleviates gut inflammation via the xenobiotic nuclear receptor PXR in mice by Xiaojuan Wang, Guohui Zhang, Zhiwei Bian, Vimanda Chow, Marina Grimaldi, Coralie Carivenc, Savannah Sirounian, Hao Li, Lucia Sladekova, Stefano Mott, Yulia Luperi, Yufeng Gong, Cait Costello, Linhao Li, Matthew Jachimowicz, Miao Guo, Shian Hu, Derek Wilson, Patrick Balaguer, William Bourguet, Sridhar Mani, Laura Bonati, Hui Peng, John March, Hongbing Wang, Shengpeng Wang, Henry M. Krause, Jiabao Liu

“…In this study, we find that a major ginger component, furanodienone (FDN), is a selective pregnane X receptor (PXR) ligand with agonistic transcriptional outcomes. We show that FDN binds within a sub-pocket of the PXR ligand binding domain (LBD), with subsequent alterations in LBD structure. …”
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Cutting-edge Bioinformatics strategies for synthesizing Cyclotriazadisulfonamide (CADA) analogs in next-Generation HIV therapies by Jay Gabriel B. Larga, Wrynan T. Munabirul, Abu Tayab Moin, Md Maisum Sarwar Jyoti, Mst Sanjida Nasrin, Minhaz Abdullah Al Mueid, Abdul Ahad, Anwar Parvez, Mst Sabrina Yeasmin, Rupali M. Barhate, Rajesh B. Patil, Margel C. Bonifacio

“…Structure-binding energy analyses were done to the top-binding analogs to show favorable structural modifications. Enzyme-ligand interactions were analyzed to elucidate the forces contributing to these binding energies. …”
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Sweet Taste Receptor Signaling Network: Possible Implication for Cognitive Functioning by Menizibeya O. Welcome, Nikos E. Mastorakis, Vladimir A. Pereverzev

“…Due to their pleiotropic signaling properties and multisubstrate ligand affinity, sweet taste receptors are able to cooperatively bind multiple substances and mediate signaling by other receptors. …”
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Synthesis and Application of Phenyl Nitrone Derivatives as Acidic and Microbial Corrosion Inhibitors by Shijun Chen, Kang Zhao, Gang Chen

“…With the special structure, nitrone can also be used as ligand in inorganic chemistry. Based on the current research, the nitrones are anticipated to be effective inhibitors against acidic and microbial corrosion. …”
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Electrochemiluminescence Study of Europium (III) Complex with Coumarin3-Carboxylic Acid by Stefan Lis, Krzysztof Staninski, Tomasz Grzyb

“…The studies proved a predominate role of the ligand-to-metal energy transfer (LMET) in the generated ECL.…”
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The Mechanisms of Catalysis by Metallo 𝛽-Lactamases by Michael I. Page, Adriana Badarau

“…There are two metal-ion binding sites that have different zinc ligands but the exact roles of the metal-ion remain controversial, and distinguishing between their relative importance is complex. …”
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A Novel Type of Non-coding RNA, nc886, Implicated in Tumor Sensing and Suppression by Yong Sun Lee

“…Collectively, nc886 provides a novel example how epigenetic silencing of a ncRNA contributes to tumorigenesis by controlling the activity of its protein ligand.…”
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C-Reactive Protein (CRP) and Autoimmune Disease: Facts and Conjectures by Alexander J. Szalai

“…C-reactive protein (CRP) is a blood component comprised of five identical subunits with a combined molecular mass of 110 kDa; in the presence of Ca++ it binds phosphocholine (PC) with high affinity. Ligand-bound CRP activates complement and the protein reportedly binds various Fc receptors. …”
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Potentiometric and UV Spectral Studies of Binary and Ternary Complexes of Some Metal Ions with N-Acetylcysteine and Amino Acids by Shaesta Quyoom, Badr-Ud-Din Khan

“…The formation constants of the binary 1:1 and 1:2 complexes of Cu(II), Zn(II), Cd(II), Hg(II), and Pb(II) with N-acetylcysteine (NAC) and 1:1:1 ternary complexes of the said metal ions with NAC as a primary ligand and some biologically important amino acids as secondary ligands have been determined potentiometrically in aqueous medium. …”
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The Role of Peroxisome Proliferator-Activated Receptors in Colorectal Cancer by Joo-In Park, Jong-Young Kwak

“…Among these receptors, special attention has been focused on the role of peroxisome proliferator-activated receptors (PPARs) in colorectal cancer, because PPARs are involved in regulation of lipid and carbohydrate metabolism. PPARs are ligand-activated intracellular transcription factors. …”
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Peroxisome Proliferator-Activated Receptors in Diabetic Nephropathy by Shinji Kume, Takashi Uzu, Keiji Isshiki, Daisuke Koya

“…Peroxisome proliferator-activated receptors (PPARs) are ligand-activated nuclear transcription factors that play important roles in lipid and glucose homeostases. …”
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Denosumab as the Treatment of Recalcitrant Tuberculous Pleural Effusion-Associated Hypercalcemia by Afdhal Afiq Abd Jalil, Sharifah Faradila Wan Muhamad Hatta, Aimi Fadilah Mohamad, Mohammed Fauzi Abdul Rani

“…Denosumab is a human monoclonal antibody that binds to RANKL (receptor activator of nuclear factor-kappa B ligand). It has mainly been used in the treatment of osteoporosis for a variety of causes especially in situations refractory to bisphosphonates or when kidney function is impaired. …”
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The Role of Peroxisome Proliferator-Activated Receptors in Pulmonary Vascular Disease by Rachel E. Nisbet, Roy L. Sutliff, C. Michael Hart

“…Peroxisome proliferator-activated receptors (PPARs) are ligand-activated transcription factors belonging to the nuclear hormone receptor superfamily that regulate diverse physiological processes ranging from lipogenesis to inflammation. …”
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Synthesis, Characterization, Antibacterial and Anti-Inflammatory Activities of Enoxacin Metal Complexes by Saeed Arayne, Najma Sultana, Urooj Haroon, M. Ahmed Mesaik

“…Results suggest that enoxacin interacts with the metals as a monoanionic bidentate ligand. These complexes were also tested for their antibacterial activity against eleven (11) different microorganisms, and the results were compared with the parent drug. …”
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