Soluble CD14 Enhances the Response of Periodontal Ligament Stem Cells to Toll-Like Receptor 2 Agonists by Christian Behm, Alice Blufstein, Johannes Gahn, Nazanin Noroozkhan, Andreas Moritz, Xiaohui Rausch-Fan, Oleh Andrukhov

“…The resulting expression of interleukin- (IL-) 6, chemokine C-X-C motif ligand 8 (CXCL8), and chemokine C-C motif ligand 2 (CCL2) was measured by qPCR and ELISA. …”
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IFN-γ/TNF-α Synergism Induces Pro-Inflammatory Cytokine and Chemokine Production by In Vitro Canine Keratinocytes by Kyungsook Jung, Ji-Yeong Ku, Je-Seong Kwon, Gayeon Won, Hakyoung Yoon, Sang-Ik Oh, Mi Hye Kim, Chongchan Kim, Ji-Seon Yoon

“…Culture supernatants were analyzed for cytokine concentration, including chemokine ligand (CXCL) 8, IL-10, IL-6, IL-1ß, IL-12, and chemokine ligand 2 (CCL2) by enzyme-linked immunosorbent assay. …”
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Insights into the Intramolecular Properties of η6-Arene-Ru-Based Anticancer Complexes Using Quantum Calculations by Adebayo A. Adeniyi, Peter A. Ajibade

“…The hydrogen bonds strength was found to be related to the reported anticancer activities and the activation of the complexes by hydration. The metal–ligand bonds were found to be closed shell systems that are characterised by high positive Laplacian values of electron density. …”
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Peroxisome Proliferator-Activated Receptors (PPARs) as Potential Inducers of Antineoplastic Effects in CNS Tumors by Lars Tatenhorst, Eric Hahnen, Michael T. Heneka

“…The peroxisome proliferator-activated receptors (PPARs) are ligand-inducible transcription factors which belong to the superfamily of nuclear hormone receptors. …”
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PPAR𝛾, PTEN, and the Fight against Cancer by Rosemary E. Teresi, Kristin A. Waite

“…Peroxisome proliferator-activated receptor gamma (PPAR𝛾) is a ligand-activated transcription factor, which belongs to the family of nuclear hormone receptors. …”
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Microwave-assisted synthesis of palladium nanoparticles supported on copper oxide in aqueous medium as an efficient catalyst for Suzuki cross-coupling reaction by Hany A Elazab, M.A. Sadek, Tamer T El-Idreesy

“…The catalytic activity and recyclability of the prepared catalyst were experimentally explored in the ligand-free Suzuki cross-coupling reaction with a diverse series of functionalized substrates. …”
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The Role of Targeted Therapy in Metastatic Renal Cell Carcinoma by Jaya Unnithan, Brian I. Rini

“…The most clinically developed targeted therapies in advanced RCC are those that target the vascular endothelial growth factor (VEGF) ligand or receptor (VEGFR) and therapy directed against the mammalian target of rapamycin (mTOR). …”
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System-Wide Expression and Function of Olfactory Receptors in Mammals by S. June Oh

“…The OR is a G protein‒coupled receptor that binds the guanine nucleotide-binding Gαolf subunit and the Gβγ dimer to recognize a wide spectrum of organic compounds in accordance with its cognate ligand. Mammalian ORs were originally identified from the olfactory epithelium of rat. …”
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NEW SELENATO TRIPHENYLTIN (IV) AND TRIMETHYLTIN (IV) DERIVATIVES: SYNTHESIS, INFRARED AND NMR STUDIES by WALY DIALLO, LIBASSE DIOP

“…The suggested structures are infinite chains or oligomers, the environment around the tin centre being trans trigonal bipyramidal, the phenyl and methyl substituants occupying equatorial positions, the selenate anion behaving as a bridging bidentate ligand and occupying the apical positions. When cations are involved, supramolecular architectures may be obtained. …”
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NEW TETRANUCLEAR AND MONONUCLEAR OXALATO ORGANOTIN (IV) COMPLEXES WITH MONOCYCLOHEXYLAMMONIUM AS ADVERSE CATION: SYNTHESIS AND INFRARED STUDY by MODOU SARR, AMINATA DIASSE-SARR, LIBASSE DIOP

“…Discrete, layered or infinite chain structures are suggested with an oxalate behaving as a monodentate, bidentate, monochelating or bichelating ligand, the environment around the tin centres being tetrahedral, cis trigonal bipyramidal or octahedral. …”
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CXCR4 and Axillary Lymph Nodes: Review of a Potential Biomarker for Breast Cancer Metastasis by David Hiller, Quyen D. Chu

“…Research has shown CXCR4 to be implicated in the invasion and metastasis of several cancers, including carcinoma of the breast. CXCL12 is the ligand for CXCR4 and is highly expressed in areas common for breast cancer metastasis, including the axillary lymph nodes. …”
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Preparation, Characterization, and Antimicrobial Activities of Bimetallic Complexes of Sarcosine with Zn(II) and Sn(IV) by Yasir Arafat, Saqib Ali, Saira Shahzadi, Muhammad Shahid

“…IR data showed that the ligand acts in a bidentate manner. NMR data revealed the four coordinate geometry in solution state. …”
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Combination of Anti-programmed Cell Death Protein 1 and Antiangiogenesis Displaying a Response Disparity between Pulmonary and Nonpulmonary Metastases by Bing-Syuan Chung, Peng-Chan Lin, Shang-Hung Chen, Yu-Min Yeh

“…Targeting the vascular endothelial growth factor-mediated immune suppression is a strategy to overcome the resistance of anti-programmed cell death protein 1/programmed death-ligand 1 (anti-PD-1/PD-L1) therapy. Here, we present two cases, including one case with leiomyosarcoma and the other one with microsatellite-stable colorectal cancer, receiving the combination of pembrolizumab and lenvatinib as salvage treatment. …”
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Safe Administration of anti-PD-L1 Atezolizumab in a Patient with Metastatic Urothelial Cell Carcinoma and End-Stage Renal Disease on Dialysis by Alessandro Parisi, Alessio Cortellini, Katia Cannita, Melissa Bersanelli, Corrado Ficorella

“…Anti-PD-L1 (programmed cell death-ligand 1) agents, such as atezolizumab, have been approved for the treatment of different advanced cancers. …”
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Novel Xanthene-1,8-dione Derivatives Containing the Benzylic Ether Tail as Potent Cytotoxic Agents: Design, Synthesis, In Vitro, and In Silico Studies by Ahmad Ebadi, Aref Karimi, Asrin Bahmani, Zahra Najafi, Gholamabbas Chehardoli

“…Docking results showed 4a could interact with DNA as intercalation. Calculated ligand efficiency of compound 4a was more than daunomycin. …”
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Inhibitors of Complement Activity in Human Breast-Milk: A Proposed Hypothesis of Their Physiological Significance by Michael Oladipo Ogundele

“…These include lysozyme, lactoferrin, lactalbumin alpha and other ligand chelators, complement regulator proteins and other specific soluble inhibitors of complement activation. …”
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Synthesis, Characterization and Spectroscopic Studies of A Novel 2-[(E)-[(2,4-dichlorophenyl)imino]methyl]phenol Schiff Base and Its Metal Complexes by Eman Turky Shamkhy, Isam Hussain T. Al-Karkhi

“…These compounds have been characterized by a variety of physico-chemical and spectroscopic techniques. The ligand and its metal complexes were expected to show an interesting bioactivity and cytotoxicity.…”
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Recent Advances in Potential Clinical Application of Ghrelin in Obesity by Christine Delporte

“…Ghrelin is the natural ligand of the growth hormone secretagogue receptor (GHS-R1a). …”
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Invariant Natural Killer T Cells as Key Players in Host Resistance against Paracoccidioides brasiliensis by Joes Nogueira-Neto, Flavio V. Loures, Alessandra S. Schanoski, David A. G. Andrade, Michelangelo B. Gonzatti, Tania A. Costa, Bruno C. Vivanco, Patrícia Xander, Daniela S. Rosa, Vera L. G. Calich, Alexandre C. Keller

“…Besides, the activation of iNKT cells in vivo by administration of the exogenous iNKT ligand α-galactosylceramide (α-GalCer) improved host resistance to P. brasiliensis infection. …”
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Assessing the efficacy of iso-mukaadial acetate and betulinic acid against selected Plasmodium falciparum glycolytic pathway proteins: in silico and in vitro studies by Lindiwe Khumbuzile Zuma, Ofentse Jacob Pooe, Nonduduzo Hlengiwe Mabaso, John Alake, Vincent A. Obakachi, Sinethemba Yakobi, Nothando Gasa, Rajshekhar Karpoormath, Mthokozisi Simelane

“…Recombinant PfLDH and PfHk were independently expressed in E. coli BL21 (DE3) cells and subsequently purified using affinity chromatography. Protein–ligand interaction studies probed in silico and in vitro approaches. …”
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