Distinguishing rheumatoid arthritis from psoriatic arthritis by Joseph F Merola, Luis R Espinoza, Roy Fleischmann

“…In PsA, levels of interleukin (IL)-1β, IL-6, IL-17, IL-22, IL-23, interferon-γ and tumour necrosis factor-α (TNF-α) are elevated, and in RA, levels of IL-1, IL-6, IL-22, IL-33, TNF-α, chemokine ligand 11 and chemokine C-X-C motif ligand 13 are elevated. …”
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Downregulated Copper Homeostasis-Related Gene FOXO1 as a Novel Indicator for the Prognosis and Immune Response of Breast Cancer by Rong Zeng, Bi Peng, Emin Peng

“…Moreover, FOXO1 expression was positively associated with multiple immune checkpoints, such as sialic acid-binding immunoglobulin-like lectin 15 (SIGLEC15), indoleamine 2,3-dioxygenase 1 (IDO1), programmed cell death 1 ligand 1 (PD-L1/CD274), hepatitis A virus cellular receptor 2 (HAVCR2), programmed cell death 1 (PDCD1), cytotoxic T lymphocyte antigen 4 (CTLA4), and programmed cell death 1 ligand 2 (PDCD1LG2). …”
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New Ternary Transition Metal Complexes of 2-{[(2-aminophenyl)imino] methyl}Phenol and Metformin: Synthesis, Characterization and Antimicrobial Activity by S. S. Sharma, J. V. Ramani, D. P. Dalwadi, J. J. Bhalodia, N. K. Patel, D. D. Patel, R. K. Patel

“…The metformin acts as a bidentate ligand and Schiff base of o-phynelendiamine and salicylaldehyde acts as a tridentate ligand. …”
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Immunoinformatics Approach for Epitope-Based Peptide Vaccine Design and Active Site Prediction against Polyprotein of Emerging Oropouche Virus by Utpal Kumar Adhikari, Mourad Tayebi, M. Mizanur Rahman

“…Our approach was to identify the epitope-based vaccine candidates as well as the ligand-binding pockets through the use of immunoinformatics. …”
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Stable and inert manganese complexes for magnetic resonance imaging by Ndiaye, Daouda, Tóth, Éva

“…We specifically focus on the molecular ligand design, including linear, macrocyclic and bicyclic (bispidine) chelators that allowed for substantially enhanced kinetic inertness of the complexes, as well as for ligand selectivity for Mn$^{2+}$ versus the main biological competitor Zn$^{2+}$. …”
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Nobiletin Decreases Inflammatory Mediator Expression in Tumor Necrosis Factor-Stimulated Human Periodontal Ligament Cells by Yoshitaka Hosokawa, Ikuko Hosokawa, Kazumi Ozaki

“…Our results demonstrated that nobiletin treatment could decrease the expressions of inflammatory cytokines (C-X-C motif chemokine ligand (CXCL)10, C-C motif chemokine ligand (CCL)2, and interleukin- (IL-) 8), matrix metalloproteinases (MMPs) (MMP1 and MMP3), and prostaglandin-endoperoxide synthase 2 (PTGS2) in TNF-stimulated HPDLCs. …”
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Bevacizumab Demonstrates Prolonged Disease Stabilization in Patients with Heavily Pretreated Metastatic Renal Cell Carcinoma: A Case Series and Review of the Literature by Nicole M. Agostino, Rebecca Gingrich, Joseph J. Drabick

“…Bevacizumab, a monoclonal antibody directed against the ligand, VEGF, has shown activity against RCC as a single agent in patients who had failed prior cytokine therapy and as first line therapy in combination with interferon. …”
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Crystal and Molecular Structure of Bis(2,2-diphenyl-N-(di-n-propylcarbamothioyl) acetamido)copper(II) Complex by Hakan Arslan, Ulrich Flörke, Demet Sezgin Mansuroglu

“…The crystal structure confirms that the complex is a mononuclear copper(II) complex and the 2,2-diphenyl-N-(di-n-propyl-carbamothioyl)acetamide ligand is a bidentate chelating ligand, coordinating to the copper atom through the thiocarbonyl and carbonyl groups. …”
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Synthesis, Characterization, Antimicrobial, DNA Cleavage, and Antioxidant Studies of Some Metal Complexes Derived from Schiff Base Containing Indole and Quinoline Moieties by Mahendra Raj Karekal, Vivekanand Biradar, Mruthyunjayaswamy Bennikallu Hire Mathada

“…In order to evaluate the effect of metal ions upon chelation, both the ligand and its metal complexes were screened for their antibacterial and antifungal activities by minimum inhibitory concentration (MIC) method. …”
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Neural Differentiation of Human Adipose Tissue-Derived Stem Cells Involves Activation of the Wnt5a/JNK Signalling by Sujeong Jang, Jong-Seong Park, Han-Seong Jeong

“…In addition, the expression levels of most Fzds and LRP5/6 ligand were decreased, but not Fzd3 and Fzd5. Furthermore, Dvl1 and RYK expression levels were downregulated in NI-hADSCs. …”
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Synthesis, Crystal Structures, and DNA Binding Properties of Zinc(II) Complexes with 3-Pyridine Aldoxime by Konstantis F. Konidaris, Rigini Papi, Eugenia Katsoulakou, Catherine P. Raptopoulou, Dimitrios A. Kyriakidis, Evy Manessi-Zoupa

“…The ZnII ion is five-coordinated, surrounded by four oxygen atoms of two acac- moieties and by the pyridyl nitrogen atom of the (3-py)CHNOH ligand. Molecules of 1 interact with the water lattice molecules forming a 2D hydrogen-bonding network. …”
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Potential of cumin essential oil as inhibitor of deamination during ensiling process: A meta-analysis and in-silico approach by Susanto Irwan, Mahendra Fachrur R., Rahmadani Mardiah, Ridwan Roni, Jayanegara Anuraga

“…This work examines the relationship between the ligand of Cumin EOs and the particular glutamate dehydrogenase (GDH) receptor specific from Clostridium sp., a common contaminant in silage. …”
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Light-Emitting Polymer Nanocomposites by Kyle Gipson, Brett Ellerbrock, Kathryn Stevens, Phil Brown, John Ballato

“…Inorganic nanoparticles doped with optically active rare-earth ions and coated with organic ligands were synthesized in order to create fluorescent polymethyl methacrylate (PMMA) nanocomposites. …”
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Signaling Crosstalk between PPARγ and BMP2 in Mesenchymal Stem Cells by Ichiro Takada, Yoshiko Yogiashi, Shigeaki Kato

“…In particular, cytokines and Wnt family proteins suppress the ligand-inducible transactivation function of PPARγ and attenuate adipogenesis/osteoblastogenesis switching in mesenchymal stem cells (MSCs). …”
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AI-driven prediction of drug activity against Toxoplasma gondii: Data augmentation and deep neural networks for limited datasets by Natalia V. Karimova, Ravithree D. Senanayake

“…The predicted pIC50 values were further used to calculate ligand efficiency (LE), binding efficiency index (BEI), lipophilic ligand efficiency (LLE), and surface efficiency index (SEI), identifying the most promising TgDHFR inhibitors for further investigation. …”
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Transition Metal(II) Complexes with Cefotaxime-Derived Schiff Base: Synthesis, Characterization, and Antimicrobial Studies by Aurora Reiss, Mariana Carmen Chifiriuc, Emilia Amzoiu, Cezar Ionuţ Spînu

“…New [ML2(H2O)2] complexes, where M = Co(II), Ni(II), Cu(II), and Zn(II) while L corresponds to the Schiff base ligand, were synthesized by condensation of cefotaxime with salicylaldehyde in situ in the presence of divalent metal salts in ethanolic medium. …”
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Molecular docking of phytosterols in Stenochlaena palustris as anti-breast cancer by Dona Marisa, Lisda Hayatie, Siti Juliati, Eko Suhartono, Noer Komari

“…Molecular docking parameters included Gibb's free energy and interactions between ligand and protein. ADMET properties were analyzed using pkCSM and SwissADME. …”
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The Synthesis, Characterization and Biological Activity of Some Metal Ions Complexes with Schiff’s Bases Derived from Reaction of 3-Hydrazone-1,3- Dihydro-Indole-2-One with 2- Pyri... by safa sami Muwafaq, Naser Shaalan

“…      Novel complexes were synthesized from Schiff base ligand (L) produced by reacting 3-hydrocyclo-1,3-dihydro-indole-2-one (A) with 2-pyridine carboxaldehyde in an ethanol medium. …”
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Allostery can convert binding free energies into concerted domain motions in enzymes by Nicole Stéphanie Galenkamp, Sarah Zernia, Yulan B. Van Oppen, Marco van den Noort, Andreas Milias-Argeitis, Giovanni Maglia

“…Our findings reveal that allosteric interactions between ligands and cofactor enable converting binding energies into directional conformational changes of the two catalytic domains of AK. …”
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TLR2 Elicits IL-17-Mediated RANKL Expression, IL-17, and OPG Production in Neutrophils from Arthritic Mice by Viktoriya Milanova, Nina Ivanovska, Petya Dimitrova

“…We investigated the ability of neutrophils to express receptor activator of nuclear factor kappa-B ligand (RANKL), to secrete osteoprotegerin (OPG), and to produce IL-17. …”
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