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4301
Modulation of myeloid and T cells in vivo by Bruton’s tyrosine kinase inhibitor ibrutinib in patients with metastatic pancreatic ductal adenocarcinoma
Published 2023-01-01“…Patients with partial clinical responses had more diverse T and B cell receptor repertoires prior to therapy initiation.Conclusion Ibrutinib monotherapy skewed the immune landscape both in the circulation and TME towards activated T cells, monocytes and DCs. …”
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4302
Impacts of genomic alterations on the efficacy of HER2-targeted antibody–drug conjugates in patients with metastatic breast cancer
Published 2025-01-01“…Abstract Background HER2-targeted antibody–drug conjugates (ADCs) have revolutionized the treatment landscape of metastatic breast cancer. However, the efficacy of these therapies may be compromised by genomic alterations. …”
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4303
High Ki67 expression, HER2 overexpression, and low progesterone receptor levels in high-grade DCIS: significant associations with clinical practice implications
Published 2025-01-01“…These findings offer novel insights into the surrogate immunomolecular subtyping landscape of DCIS, potentially refining risk stratification and therapeutic approaches. …”
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4304
Integrating single-cell RNA-Seq and bulk RNA-Seq data to explore the key role of fatty acid metabolism in hepatocellular carcinoma
Published 2025-01-01“…Further analytical procedures involved functional enrichment analysis, evaluation of immune infiltration, and examination of the mutation landscape.PTGES3 was identified as a pivotal gene associated with lipid metabolism. …”
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4305
The state of paediatric deceased-organ donation at a South African tertiary public- sector hospital: A 14-year analysis
Published 2024-04-01“…To identify in-hospital barriers to organ donation and gain a better understanding of the paediatric donor landscape. Methods. A retrospective descriptive study of consecutive deceased-donor referrals at Red Cross War Memorial Children’s Hospital over a 14-year period, from 1 January 2007 to 31 December 2020. …”
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4306
Complex Study of Settlements Dating from the Paleolithic to Medieval Period in the Ural Mountains on the Border of Europe and Asia
Published 2025-01-01“…Soil, geochemical, microbiological, and archeological studies were conducted at eight settlements dating from the Paleolithic to Late Medieval and Modern Ages near the southern Trans-Urals Mountains, Russia. The forest-steppe landscapes, rivers, and abundant mineral resources have attracted people to the region since ancient times. …”
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4307
Work-related burnout and its associated factors among kindergarten teachers: a multi-center cross-sectional study in Ethiopia
Published 2025-01-01“…To address this issue, interventions focused at reducing work–family conflicts, increasing job satisfaction, and improving the school environment are necessary to support teachers’ well-being, benefiting both young students and the broader educational landscape.…”
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4308
Pan-cancer analysis of the transcriptional expression of histone acetylation enzymes in solid tumors defines a new classification scheme for gliomas
Published 2025-01-01“…However, systematic characterization of the transcriptomic landscape and clinical relevance of HATs and HDACs in pan-cancer contexts remains lacking.MethodsTranscriptome and clinical data of 9,483 patients across 31 tumor types from The Cancer Genome Atlas were collected for systematic pan-cancer analysis. …”
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4309
High-resolution 4D electrical resistivity tomography and below-ground point sensor monitoring of High Arctic deglaciated sediments capture zero-curtain effects, freeze–thaw transit...
Published 2025-01-01“…Novel insights into soil moisture dynamics throughout the spring melt will help parameterize models of biological activity to build a more predictive understanding of newly emerging terrestrial landscapes and their impact on carbon and nutrient cycling.…”
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4310
Spatio-temporal dynamics of speleothem growth and glaciation in the British Isles
Published 2025-01-01“…Further study of leads and lags in speleothem growth compared to surface deposition may provide new insights into landscape-scale dynamics during ice sheet growth and retreat.…”
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4311
La mise en œuvre d’un aqueduc : l’exemple de la Brévenne à Lyon
Published 2023-12-01“…Ultimately, although none of the components of the canal adheres strictly to a single template, it remains a coherent structure, while water containment –particularly on this channel– is the main concern.This stratigraphic reading cannot be separated from the planimetric perspective, made necessary by the requirement to break down a large scale construction in order to handle uneven landscapes and to employ a variety of hydraulic engineering techniques. …”
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4314
Implementation of Compensation-Sensitive Shot-Style-Feedback of Aiming Point Training Data at the Swiss Shooting Federation
Published 2025-01-01“…In our view, this project serves as a good example of how challenging real-world problems brought up by coaches and embedded scientists can be jointly structured and solved at federation and university level, and how their solution can ultimately lead to practical tools reshaping and improving a federation’s process landscape. References Tartaruga, D., & Kredel, R. (2021). …”
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4315
Modelling height to crown base using non-parametric methods for mixed forests in China
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4316
Multicultural values: meeting point of two forces in developing Islamic education
Published 2024-12-01“…Cultural context: the findings are contextualized within the cultural and educational landscape of multicultural Islamic institutions, which may limit their transferability to other cultural or religious contexts. …”
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4317
Detecting Deception and Ensuring Data Integrity in a Nationwide mHealth Randomized Controlled Trial: Factorial Design Survey Study
Published 2025-01-01“… BackgroundSocial behavioral research studies have increasingly shifted to remote recruitment and enrollment procedures. This shifting landscape necessitates evolving best practices to help mitigate the negative impacts of deceptive attempts (eg, fake profiles and bots) at enrolling in behavioral research. …”
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4318
Toward Understanding of Quiet Human Resource Management Theory in Iranian Organizations: Theoretical Origins, Conceptual Narration and its Consequences
Published 2024-11-01“…ObjectiveThe concept of "quiet" human resource management (HRM) has gained significant attention in recent years, particularly in response to the pervasive hustle culture and competitive organizational landscapes exacerbated by challenging economic conditions. …”
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L’officier de police, le checkpoint et l’interrogatoire : les spatialités des performances sécuritaires dans le centre-ville du Caire
Published 2023-12-01“…Checkpoints produce a security landscape whose perceptions vary between tranquility and familiarity on the one hand, and insecurity and uncertainty on the other. …”
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4320
Spatial predictors of landowners' engagement in the restoration of the Brazilian Atlantic Forest
Published 2025-01-01“…Engagement with forest restoration is highest where there are more people and lower travel times to cities, suggesting restoration can potentially deliver ecological benefits in some of Brazil's most degraded landscapes. Read the free Plain Language Summary for this article on the Journal blog.…”
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