Single‐cell dissection reveals immunosuppressive F13A1+ macrophage as a hallmark for multiple primary lung cancers by Chenglin Yang, Jiahao Qu, Jingting Wu, Songhua Cai, Wenyi Liu, Youjun Deng, Yiran Meng, Liuqing Zheng, Lishen Zhang, Li Wang, Xiaotong Guo

“…Methods We performed a comparative single‐cell RNAsequencing (scRNA‐seq) analysis on tumour and adjacent para‐tumour tissues fromMPLC and SPLC patients to comparatively evaluate their immunological landscapes.Additionally, multiplex immunofluorescence (mIF) staining and independentvalidation datasets were used to confirm findings. …”
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Identification of new candidate genes for the hereditary predisposition to uveal melanoma: IGCMU trial by Mélanie Godiveau, Mélanie Godiveau, Mélanie Godiveau, Angeline Ginzac, Angeline Ginzac, Angeline Ginzac, Yannick Bidet, Yannick Bidet, Flora Ponelle-Chachuat, Flora Ponelle-Chachuat, Maud Privat, Maud Privat, Xavier Durando, Xavier Durando, Xavier Durando, Xavier Durando, Mathias Cavaillé, Mathias Cavaillé, Mathis Lepage, Mathis Lepage

“…This study could also contribute to a better understanding of the genetic landscape of UM, potentially leading to more personalized and effective options for its detection.Trial registrationClinicalTrials.gov, identifier NCT06550674, registered in August 2024. …”
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Heterogeneity of cancer-associated fibroblast subpopulations in prostate cancer: Implications for prognosis and immunotherapy by Chen Ding, Jiange Wang, Jie Wang, Jiqiang Niu, Zhikai Xiahou, Zhou Sun, Zhenzhen Zhao, Dongyang Zeng

“…Moreover, we identified key genes linked to patient outcomes and immune landscape alterations, reinforcing the prognostic significance of CAF characteristics in this context. …”
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Numerical modelling of the hydrodynamics driven by tidal flooding of the land surface after dyke breaching by Rachel A. Burns, Ryan P. Mulligan, Megan Elliott, Danika van Proosdij, Enda Murphy

“…A numerical model with an unstructured flexible mesh (Delft3D-FM) was applied to examine the impacts of tidal flooding from a river channel, through the dyke breach and across the previously agricultural landscape that was historically a salt marsh. The model was used to simulate the hydrodynamics inside and around the breach before and after seawater flooding during spring tides, to evaluate the initial impacts of this nature-based method of managed dyke realignment. …”
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Tumor characteristics and survival rate of axillary metastatic breast cancer patients: a three decades retrospective cohort study by Seyed Mohamad Sadegh Mousavi-kiasary, Mahdis Bayat, Fereshteh Abbasvandi, Batoul Khoundabi, Fatemeh Mousavi, Atieh Akbari, Maryam Bagherian, Afsoon Zandi, Behnam Honarvar, Mohammad Esmaeil Akbari

“…Regarding the crucial impact of the LN status on the survival landscape of breast cancer patients, accurate detection of the involved one and close screening follow-up of patients with more metastatic LNs during the surgery have a high value.…”
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AI in Marketing Management: Executive Perspectives from Companies

“…By offering a comprehensive understanding of the enablers and barriers to AI adoption, this research equips companies to harness AI's full potential, enhancing their competitive advantage in an increasingly digital landscape…”
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Metabolically activated and highly polyfunctional intratumoral VISTA+ regulatory B cells are associated with tumor recurrence in early-stage NSCLC by Domenico Lo Tartaro, Beatrice Aramini, Valentina Masciale, Nikolaos Paschalidis, Francesco Demetrio Lofaro, Anita Neroni, Rebecca Borella, Elena Santacroce, Alin Liviu Ciobanu, Anna Valeria Samarelli, Federica Boraldi, Daniela Quaglino, Alessandra Dubini, Michele Gaudio, Gloria Manzotti, Francesca Reggiani, Federica Torricelli, Alessia Ciarrocchi, Antonino Neri, Federica Bertolini, Massimo Dominici, Pier Luigi Filosso, Franco Stella, Lara Gibellini, Sara De Biasi, Andrea Cossarizza

“…In this study, using polychromatic flow cytometry, mass cytometry, and spatial transcriptomics we explored the intricate landscape of B cell phenotypes, bioenergetics, and their interaction with T cells in NSCLC. …”
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Contribution of Spatial Heterogeneity and Temporal-Spatial Change of Ecosystems to the Thermal Environment of Tourist Destinations: A Case Study of Sichuan-Chongqing Region, China by Dechao Chen, Xinliang Xu, Huailong Jiang, Zongyao Sun, Luo Liu, Zhi Qiao

“…Based on the diurnal differences of the contribution indices, cities can be divided into three types: the day-night heat source type, the day-sink and night-source type, and the day-night heat sink type. (2) The farmland and the grassland ecosystems are the most important source and sink landscapes in the thermal environment of the Sichuan-Chongqing Region, respectively. (3) The region is affected by the spatial arrangement of the internal ecosystems and its own development conditions, and, consequently, there are significant temporal-spatial variations and role transitions between heat source and heat sink regarding the contribution of different ecosystem types to the thermal environment of individual cities. …”
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Access to Diagnostics and Treatment for People With Metastatic EGFR-Positive NSCLC: Lessons From Project PRIORITY by Jill Feldman, MA, Ivy Elkins, MBA, Zofia Piotrowska, MD, Bellinda L. King-Kallimanis, PhD, Tendai Chihuri, MD, Carly Johnson, BS, Alecia Clary, PhD, Teri Kennedy, MA, Upal Basu Roy, PhD, MPH

“…Introduction: The treatment landscape for people diagnosed with EGFR-mutated (EGFR-m) NSCLC has rapidly evolved, yet there remains limited self-reported information about the lived experience. …”
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From bench to bedside: Developing CRISPR/Cas-based therapy for ocular diseases by Qing Zhao, Linxin Wei, Youxin Chen

“…This review summarizes the application strategies and delivery methods of CRISPR/Cas, discusses recent progress in CRISPR/Cas-based disease models and therapies, and provides an overview of the landscape of clinical trials. Current obstacles and future directions regarding the bench-to-bedside transition are also discussed.…”
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Physiological and behavioural resistance of malaria vectors in rural West-Africa: a data mining study to address their fine-scale spatiotemporal heterogeneity, drivers, and predict... by Taconet, Paul, Soma, Dieudonné Diloma, Zogo, Barnabas, Mouline, Karine, Simard, Frédéric, Koffi, Alphonsine Amanan, Dabiré, Roch Kounbobr, Pennetier, Cédric, Moiroux, Nicolas

“…The explanatory variables covered a wide range of potential environmental determinants of vector resistance to insecticide or behavioural resistance phenotypes: vector control, human availability and nocturnal behaviour, macro and micro-climatic conditions, landscape, etc. The resulting models revealed many statistically significant associations, although their predictive powers were overall weak. …”
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Out-of-phase relationship of Holocene moisture variations between the northeastern and southeastern Tibetan plateau and its societal impacts by Duo Wu, Minmin Ma, Yongxiu Lu, Shilong Guo, Tao Wang, Xuyi Ma, Guanghui Dong

“…Decreasing moisture in YNP promoted the expansion of an open landscape, which affected the development of agriculture during the period of ∼4600‒2200 BP. …”
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Water resources carrying capacity before and after volcanic eruption by M. Dede, S.B. Wibowo, Y. Prasetyo, I.W. Nurani, P.B. Setyowati, S. Sunardi

“…The eruption of Mount Merapi in 2010 changed the landscape and community livelihoods due to the redistribution of a large volume of volcanic materials. …”
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Tiny clue reveals the general trend: a bibliometric and visualized analysis of renal microcirculation by Bing Wang, Mengting Xu, Sunjing Fu, Yingyu Wang, Hao Ling, Yuan Li, Bingwei Li, Xueting Liu, Qin Ouyang, Xiaoyan Zhang, Ailing Li, Xu Zhang, Mingming Liu

“…‘Cardiovascular outcome’ and ‘diabetic kidney diseases’ were identified as keywords in their burst period over the past three years.Conclusion Our bibliometric analysis illuminates the contours of nephrology and microcirculation research, revealing a landscape ripe for challenges and the seeds of future scientific innovation. …”
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Integrative genomic analyses combined with molecular dynamics simulations reveal the impact of deleterious mutations of Bcl-2 gene on the apoptotic machinery and implications in ca... by Ghazi Elamin, Ghazi Elamin, Zhichao Zhang, Depika Dwarka, Kabange Kasumbwe, John Mellem, Nompumelelo P. Mkhwanazi, Paradise Madlala, Paradise Madlala, Mahmoud E. S. Soliman

“…Following 500 ns, MD simulations showed that these mutations caused a significant distortion in the protein conformational, protein-protein interactions (PPIs), and drug binding landscape compared to Bcl-2WT.ConclusionDespite being a predictive study, the findings presented in this report would offer a perspective insight for further experimental investigation, rational drug design, and cancer gene therapy.…”
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CADD-based discovery of novel oligomeric modulators of PKM2 with antitumor activity in aggressive human glioblastoma models by Maia Cabrera, Romina Armando, Ian Czarnowski, Patricio Chinestrad, Ramiro Blanco, Alejandra Zinni, Daniel Gómez, Diego L. Mengual Gómez, Pablo Lorenzano Menna

“…ADMET studies further highlighted their strong potential as lead PKM2 inhibitors for GBM treatment.Molecular dynamics (MD) simulations and post-MD analyses, including Dynamic Cross-Correlation Maps (DCCM), Probability Density Function (PDF), and Free Energy Landscape (FEL), confirmed the stability of the protein-ligand interactions and highlighted critical residues at the dimer-dimer interface. …”
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Unveiling vegetation recovery dynamics in Andean grasslands along a trans-Andean natural gas pipeline by Fiorella Eduardo-Palomino, Héctor Chuquillanqui, Reynaldo Linares-Palomino

“…The study area was divided into 12 large ecological landscape units (ELUs) to facilitate data comparison and interpretation. …”
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Identification and quantification of transposable element transcripts using Long-Read RNA-seq in Drosophila germline tissues by Rebollo, Rita, Gerenton, Pierre, Cumunel, Eric, Mary, Arnaud, Sabot, François, Burlet, Nelly, Gillet, Benjamin, Hughes, Sandrine, S. Oliveira, Daniel, Goubert, Clément, Fablet, Marie, Vieira, Cristina, Lacroix, Vincent

“…Overall, this first comparison of TEs between testes and ovaries uncovers differences in their transcriptional landscape, at the subclass and insertion level.…”
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Genomic characterization and molecular predictive biomarkers for chemotherapy in patients with metastatic triple-negative breast cancer treated in a real-world setting by Erik Olsson, Henrik Lindman, Evangelos Digkas, Viktoria Thurfjell, Haidar Mir Ali, Ute Krüger, Anna-Karin Wennstig, Marie Sundqvist, Antonios Valachis

“…Further research into the genomic landscape of tumors from patients with rapid progression or exceptional response to different treatment strategies can provide insights into mechanisms of resistance and identify predictive biomarkers.…”
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A spatiotemporal optimization engine for prescribed burning in the Southeast US by Reetam Majumder, Adam J. Terando, J. Kevin Hiers, Jaime A. Collazo, Brian J. Reich

“…Many ecosystems in the Southeast US are dependent upon frequent low-intensity surface fires to sustain native biodiversity, ecosystem services, and endangered species populations. Today, landscape-scale prescribed fire is required to manage these systems for conservation objectives and to mitigate wildland fire risk. …”
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