Assessment of trace elements contamination and human health risk based on Monte Carlo simulation in a karst groundwater system affected by industrial activities by Liyun Yang, Qixin Wu, Shilin Gao, Meixue Peng, Jianping Zhu, Jie Zeng, Li Shi, Xinghe Li

“…This study investigated the concentration, spatial distribution, quality, health risks and sources of trace elements (TEs) in groundwater within a newly established industrial park in Guiyang, a representative city with a karst landscape. The results indicated that the trace element concentrations followed the order: Ti > Fe > Al > Ni > Cr > Mn > V > Cu > As > Co. …”
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TECHNOLOGY LITERACY AMONG PRIMARY SCHOOL TEACHERS FOR ENHANCING NUMERACY AND LITERACY SKILLS OF EARLY-GRADE PUPILS WITH HEARING IMPAIRMENTS IN TANZANIA by Hamadi Mtani, Shubi Kaijage, Neema Mduma

“… Information Communication Technologies (ICTs) have significantly transformed the educational landscape, and offer substantial benefits for learners with special needs including those with hearing impairments. …”
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Genomic characterization of chronic lymphocytic leukemia in patients of African ancestry by Cecilia Bonolo de Campos, Chantal E. McCabe, Laura A. Bruins, Daniel R. O’Brien, Sochilt Brown, Renee C. Tschumper, Cristine Allmer, Yuan Xiao Zhu, Kari G. Rabe, Sameer A. Parikh, Neil E. Kay, Huihuang Yan, James R. Cerhan, John N. Allan, Richard R. Furman, J. Brice Weinberg, Danielle M. Brander, Diane F. Jelinek, Marta Chesi, Susan L. Slager, Esteban Braggio

“…Abstract Despite the considerable effort to characterize the genomic landscape of chronic lymphocytic leukemia (CLL), published data have been almost exclusively derived from patients of European Ancestry (EA), with significant underrepresentation of minorities, including patients of African Ancestry (AA). …”
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Analysis of toxicity and mechanisms of busulfan in non-obstructive azoospermia: A genomic and toxicological approach integrating molecular docking, single-cell sequencing, and expe... by Yanggang Hong, Qichao Yuan, Yi Wang, Deqi Wang, Xiaoju Guan, Congde Chen

“…Additionally, the immune landscape of NOA-affected testes revealed significant changes in immune cell infiltration, potentially worsening the condition. …”
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Identification of HPV16 E1 and E2-specific T cells in the oropharyngeal cancer tumor microenvironment by Christine McInnis, Lakshmi Srinivasan, Anthony J Coyle, Shilpa Bhatia, Glenn J Hanna, Ann Marie Egloff, Brinda Vijaykumar, Qiaomu Tian, Yanbo Sun, Del Leistritz-Edwards, Charles T Quinn, Ravi Uppaluri, Daniel C Pregibon

“…However, specific virally-encoded epitopes and their corresponding immune responses are not fully defined.Methods To understand the OPSCC immune landscape, we conducted a comprehensive single-cell analysis of HPV16+ and HPV33+ primary tumors and metastatic lymph nodes. …”
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New insights into microbial bile salt hydrolases: from physiological roles to potential applications by Zixing Dong, Shuangshuang Yang, Cunduo Tang, Dandan Li, Dandan Li, Yunchao Kan, Yunchao Kan, Lunguang Yao, Lunguang Yao

“…Gut microbiota-derived bile salt hydrolase (BSH, EC 3.5.1.24), which catalyzes the “gateway” reaction in a wider pathway of bile acid modification, not only shapes the bile acid landscape, but also modulates the crosstalk between gut microbiota and host health. …”
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Bibliometric and visual analysis in the field of electroacupuncture’s analgesia and regulation on negative emotion from 2014 to 2024 by Xubo Huang, Jiajie Gao, Yuxin Ding, Jiali Wang, Junfan Fang, Junfan Fang, Jianqiao Fang, Jianqiao Fang, Junying Du, Junying Du

“…IntroductionThis bibliometric study systematically analyzes the research landscape of electroacupuncture (EA), focusing on its applications in pain relief and emotional regulation from 2014 to 2024. …”
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Regional Medical Campuses in Canada by Aaron Johnston, Amanda Bell, Kristy Penner, Trushar Patel, Grace Perez

“… Background: Regional Medical Campuses (RMCs) are an established part of the Distributed Medical Education (DME) landscape in Canada. Combined model RMCs, offering both preclinical and clinical education have shown promising results in producing physicians who work in rural and regional settings and are currently a key avenue of expansion of medical training in Canada. …”
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Genomic characterization and molecular predictive biomarkers for chemotherapy in patients with metastatic triple-negative breast cancer treated in a real-world setting by Erik Olsson, Henrik Lindman, Evangelos Digkas, Viktoria Thurfjell, Haidar Mir Ali, Ute Krüger, Anna-Karin Wennstig, Marie Sundqvist, Antonios Valachis

“…Further research into the genomic landscape of tumors from patients with rapid progression or exceptional response to different treatment strategies can provide insights into mechanisms of resistance and identify predictive biomarkers.…”
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A bibliometric analysis on delirium in intensive care unit from 2013–2023 by Xin Ma, Qingya Wu, Yue Ran, Xueqin Cao, Hua Zheng, Hua Zheng

“…The application of literature clustering and keyword analysis revealed that future research is poised to delve deeper into areas such as pediatric delirium, risk factors, and the development of preventive and therapeutic strategies.ConclusionThis study employs bibliometric analysis to provide a multifaceted overview of the ICU delirium research landscape over the past decade. By examining the topic from various perspectives, we have not only mapped the current state of ICU delirium research but also illuminated potential avenues for future inquiry and areas of emphasis.…”
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Real-world effectiveness of sofosbuvir/velpatasvir, glecaprevir/pibrentasvir, and sofosbuvir/velpatasvir/voxilaprevir against genotype 3 hepatitis C virus infection: a systematic r... by Liwei Zhuang, Liwei Zhuang, Junnan Li, Yu Zhang, Shibo Ji, Huichun Xing, Huichun Xing

“…IntroductionDirect antiviral agents (DAAs) have dramatically changed the landscape of liver diseases associated with chronic hepatitis C virus (HCV) infection. …”
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Just-In-Time Adaptive Interventions to Promote Behavioral Health: Protocol for a Systematic Review by Lauren M Henry, Morkeh Blay-Tofey, Clara E Haeffner, Cassandra N Raymond, Elizabeth Tandilashvili, Nancy Terry, Miryam Kiderman, Olivia Metcalf, Melissa A Brotman, Silvia Lopez-Guzman

“…ObjectiveThis study aims to systematically review the literature to describe the landscape of existing JITAIs for behavioral health at any stage of intervention development. …”
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Harnessing macrophage-drug conjugates for allogeneic cell-based therapy of solid tumors via the TRAIN mechanism by Bartlomiej Taciak, Maciej Bialasek, Malgorzata Kubiak, Ilona Marszalek, Malgorzata Gorczak, Olha Osadchuk, Daria Kurpiel, Damian Strzemecki, Karolina Barwik, Marcin Skorzynski, Julia Nowakowska, Waldemar Lipiński, Łukasz Kiraga, Jan Brancewicz, Robert Klopfleisch, Łukasz Krzemiński, Emilia Gorka, Anna Smolarska, Irena Padzinska-Pruszynska, Małgorzata Siemińska, Jakub Guzek, Jan Kutner, Marlena Kisiala, Krzysztof Wozniak, Giacomo Parisi, Roberta Piacentini, Luca Cassetta, Lesley M. Forrester, Lubomir Bodnar, Tobias Weiss, Alberto Boffi, Paulina Kucharzewska, Tomasz P. Rygiel, Magdalena Krol

“…This MDC approach thus represents a promising advancement in the therapeutic landscape for solid tumors.…”
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Tumor characteristics and survival rate of axillary metastatic breast cancer patients: a three decades retrospective cohort study by Seyed Mohamad Sadegh Mousavi-kiasary, Mahdis Bayat, Fereshteh Abbasvandi, Batoul Khoundabi, Fatemeh Mousavi, Atieh Akbari, Maryam Bagherian, Afsoon Zandi, Behnam Honarvar, Mohammad Esmaeil Akbari

“…Regarding the crucial impact of the LN status on the survival landscape of breast cancer patients, accurate detection of the involved one and close screening follow-up of patients with more metastatic LNs during the surgery have a high value.…”
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Co-modulation of a circular form of PCDH11Y during neuroendocrine differentiation of prostate cancer by Giovanni Pecoraro, Ilaria Leone, Silvia Nuzzo, Santiago Negueruela, Giovanni Smaldone, Lorena Buono

“…Circular RNAs (circRNAs) have emerged as potential biomarkers due to their stability and tissue-specific expression.MethodsIn this study, we investigated the circRNA landscape during neuroendocrine transdifferentiation (NED) of PC cells using the androgen-sensitive LNCaP and androgen-insensitive DU145 cell lines. …”
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Spatially mapping the tumour immune microenvironments of non-small cell lung cancer by Lysanne Desharnais, Mark Sorin, Morteza Rezanejad, Bridget Liu, Elham Karimi, Aline Atallah, Anikka M. Swaby, Miranda W. Yu, Samuel Doré, Saskia Hartner, Benoit Fiset, Yuhong Wei, Baharak Kadang, Roni Rayes, Philippe Joubert, Sophie Camilleri-Broët, Pierre-Olivier Fiset, Daniela F. Quail, Jonathan D. Spicer, Logan A. Walsh

“…Our findings underscore the importance of analyzing NSCLC histological subtypes separately when investigating the spatial immune landscape, as microenvironmental characteristics and cellular interactions differed by subtype. …”
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Historical and projected forest cover changes in the Mount Kenya Ecosystem: Implications for sustainable forest management by Brian Rotich, Abdalrahman Ahmed, Benjamin Kinyili, Harison Kipkulei

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Methylprednisolone substituted lipid nanoparticles deliver C3 transferase mRNA for combined treatment of spinal cord injury by Haoru Dong, Zongxing He, Shiyi Cai, Haiqiang Ma, Lili Su, Jianfeng Li, Huiying Yang, Rong Xie

“…Currently, the therapeutic landscape for SCI is notably sparse, with limited effective treatment options available. …”
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Characteristics of Land Use Change and Evaluation of Ecological Sensitivity in Chongqing by XIE Xianjian, GOU Qiantao, WU Han

“…[Results] (1) In the study area, the landscape matrix was predominantly composed of farmland, accounting for more than 45% of the total area. …”
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