Refractory Chronic Hand Eczema Responds to Oral Upadacitinib by Nada Alghamdi, Abdullah AN.Aljalfan, Abdulmajeed S. Alharbi, Omar I.Alrubaish, Serene R.Almuhaidib

Subjects: “…Hand dermatitis, Hand Eczema, Upadacitinib, Janus kinase inhibitor.…”
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4,6-Disubstituted pyrimidine-based microtubule affinity-regulating kinase 4 (MARK4) inhibitors: synthesis, characterization, in-vitro activity and in-silico studies by Ashanul Haque, Khalaf M. Alenezi, Mohd. Saeed Maulana Abdul Rasheed, Md. Ataur Rahman, Saleha Anwar, Shahzaib Ahamad, Dinesh Gupta

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Successful treatment of pyoderma gangrenosum complicated by JAK2V617F mutation-positive myelofibrosis with adalimumab and systemic steroid by Kyohei Shibuta, Koremasa Hayama, Katsuhiro Miura, Hideki Fujita

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Recent approaches in the drug research and development of novel antimalarial drugs with new targets by Chinnappanna Naveen Kumar Reddy, Yennam Gopi, Chaitanya Chaitanya Budagam Haima Naga Venkata, Pottathil Shinu, Borah Pobitra, Venugopala Katharigatta N., Deb Pran Kishore, Mailavaram Raghu Prasad

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The combination of a tyrosine kinase inhibitor and blinatumomab in patients with Philadelphia chromosome–positive acute lymphoblastic leukemia or Philadelphia chromosome‐like acute lymphoblastic leukemia by Xiaoxia Wu, Shenqi Lu, Xinhui Zhang, Zhen Yang, Aining Sun, Depei Wu, Huifen Zhou, Miao Miao

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M2 Macrophages Mediate the Resistance of Gastric Adenocarcinoma Cells to 5-Fluorouracil through the Expression of Integrin β3, Focal Adhesion Kinase, and Cofilin by Daniel Ngabire, Irvine Niyonizigiye, Maheshkumar Prakash Patil, Yeong-Ae Seong, Yong Bae Seo, Gun-Do Kim

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MicroRNA-122 protects against interferon-α-induced hepatic inflammatory response via the Janus kinase–signal transducer and activator of transcription pathway by Fanwei Liu, Bowen Liu, Shanshan Xu, Yinhua Ni, Xiaoli Liu

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Protective Effects of Intravitreal Injection of the Rho-Kinase Inhibitor Y-27632 in a Rodent Model of Nonarteritic Anterior Ischemic Optic Neuropathy (rAION) by Zuohuizi Yi, Liao Chen, Xiaoling Wang, Changzheng Chen, Yiqiao Xing

“…We sought to explore the effects of intravitreal injection of the Rho-kinase inhibitor Y-27632 in a rodent model of nonarteritic anterior ischemic optic neuropathy (rAION). …”
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The activation of Chlamydomonas reinhardtii alpha amylase 2 by glutamine requires its N‐terminal aspartate kinase–chorismate mutase–tyrA (ACT) domain by Lisa Scholtysek, Ansgar Poetsch, Eckhard Hofmann, Anja Hemschemeier

“…This activating effect required the enzyme's N‐terminal aspartate kinase–chorismate mutase–tyrA domain. Gln is the first N assimilation product and not only a central compound for the biosynthesis of N‐containing molecules but also a recognized signaling molecule for the N status. …”
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The Lck Paradox: Because of Inconsistent Experimental Evidence, the Role of the Protein Tyrosine Kinase p56lck in Early Thymic Development Remains Poorly Defined by Klaus Eichmann

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Induction of MAP Kinase Homologues during Growth and Morphogenetic Development of Karnal Bunt (Tilletia indica) under the Influence of Host Factor(s) from Wheat Spikes by Atul K. Gupta, J. M. Seneviratne, G. K. Joshi, Anil Kumar

“…Signaling pathways that activate different mitogen-activated protein kinases (MAPKs) in response to certain environmental conditions, play important role in mating type switching (Fus3) and pathogenicity (Pmk1) in many fungi. …”
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Adiponectin Inhibits LPS-Induced HMGB1 Release through an AMP Kinase and Heme Oxygenase-1-Dependent Pathway in RAW 264 Macrophage Cells by Mohamed Elfeky, Ryuji Kaede, Yuko Okamatsu-Ogura, Kazuhiro Kimura

“…Treatment with compound C, an AMP kinase (AMPK) inhibitor, abolished the increase in HO-1 expression and the suppression of HMGB1 release mediated by adiponectin. …”
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Functional Characterization of the SHIP1-Domains Regarding Their Contribution to Inositol 5-Phosphatase Activity by Spike Murphy Müller, Nina Nelson, Manfred Jücker

Subjects: “…phosphatidylinositide 3-kinase (PI 3-kinase)…”
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Nitric Oxide Activates Apoptosis Signal - Regulating Kinase 1 (ASK 1) Forming S-Nitrosothiols with Reactive Thioredoxin SH-Groups.... by Vadim V. Sumbayev, Inna M. Yasinska

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Inhibition of Apoptosis by the BEACH Domain and WD Repeats of Gene lba that has Key Features of Both Protein Kinase A Anchor and chs1/beige Genes by Jia-Wang Wang, Julie Howson, Tomar Ghansah, John Ninos, William G. Kerr

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Deep learning-based CT radiomics predicts prognosis of unresectable hepatocellular carcinoma treated with TACE-HAIC combined with PD-1 inhibitors and tyrosine kinase inhibitors by Linan Yin, Ruibao Liu, Wei Li, Shijie Li, Xunbo Hou

“…Abstract Objective To develop and validate a computed tomography (CT)-based deep learning radiomics model to predict treatment response and progression-free survival (PFS) in patients with unresectable hepatocellular carcinoma (uHCC) treated with transarterial chemoembolization (TACE)-hepatic arterial infusion chemotherapy (HAIC) combined with PD-1 inhibitors and tyrosine kinase inhibitors (TKIs). Methods This retrospective study included 172 patients with uHCC who underwent combination therapy of TACE-HAIC with TKIs and PD-1 inhibitors. …”
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Crocin Suppresses LPS-Stimulated Expression of Inducible Nitric Oxide Synthase by Upregulation of Heme Oxygenase-1 via Calcium/Calmodulin-Dependent Protein Kinase 4 by Ji-Hee Kim, Ga-Young Park, Soo Young Bang, Sun Young Park, Soo-Kyung Bae, YoungHee Kim

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Interplay of aurora kinase a functional residues and Epstein-barr Nuclear Antigen 1 in Epstein-barr virus associated Gastric cancer using AGS cells by Nidhi Varshney, Siddharth Singh, Meenakshi Kandpal, Vaishali Saini, Erle S. Roberston, Hem Chandra Jha

Subjects: “…Aurora Kinase A…”
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The p110α and p110β Isoforms of Class I Phosphatidylinositol 3-Kinase Are Involved in Toll-Like Receptor 5 Signaling in Epithelial Cells by Sabine M. Ivison, Mohammed A. S. Khan, Nicholas R. Graham, Leila A. Shobab, Yu Yao, Arnawaz Kifayet, Laura M. Sly, Theodore S. Steiner

“…Release of the chemokine IL-8 in response to flagellin involves NF-κB, p38 MAP kinase, and phosphatidylinositol 3-kinase (PI3K). …”
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TaSnRK3.23B, a CBL-interacting protein kinase of wheat, confers drought stress tolerance by promoting ROS scavenging in Arabidopsis by Feiyan Dong, Yide Liu, Huadong Zhang, Yaqian Li, Jinghan Song, Sheng Chen, Shuailei Wang, Zhanwang Zhu, Yan Li, Yike Liu

“…Abstract Background Sucrose non-fermenting-1-related protein kinases (SnRKs) have been implicated in plant growth and stress responses. …”
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