The road ahead: emerging therapies for primary IgA nephropathy by Edward J. Filippone, Rakesh Gulati, John L. Farber

“…A slowly progressive disease presenting in the young to middle-aged, most patients with reduced eGFR or proteinuria will progress to end-stage kidney disease (ESKD) in their lifetimes. The pathogenesis involves increased production of galactose-deficient IgA1 (Gd-IgA1) that forms immune complexes that deposit in the glomerulus, eliciting mesangial cell proliferation, inflammation, and complement activation. …”
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The Association of TNF-Alpha Inhibitors and Development of IgA Nephropathy in Patients with Rheumatoid Arthritis and Diabetes by Vedran Premužić, Ivan Padjen, Mislav Cerovec, Marijana Ćorić, Bojan Jelaković, Branimir Anić

“…All off our three patients had RA, which lasted 2–4 years, and none of them had a prior history of chronic kidney disease. Two patients were treated with adalimumab while one patient was treated with golimumab. …”
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Fibroblast Growth Factor and Mineral Metabolism Parameters among Prevalent Kidney Transplant Patients by Madhumathi Rao, Priyanka Jain, Temitope Ojo, Gautam Surya, Vaidyanathapuram Balakrishnan

“…Background. Chronic kidney disease (CKD) related mineral bone disorders persist after kidney transplantation, but little is known about the relationship between fibroblast growth factor-23 (FGF-23) and mineral metabolism in prevalent post-transplant patients. …”
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The Effect of teach-back educational method on self-management in hemodialysis patients by Rif'atul Fani, Shinta Wahyusari, Apriyani Puji Hastuti, Chairul Huda Al Husna

“… Introduction: Patients with chronic kidney disease undergoing hemodialysis may experience a decline in physical and psychological conditions such as increased risk of depression and non-compliance in undergoing therapy. …”
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Glycyrrhizin attenuates renal inflammation in a mouse Con A-hepatitis model via the IL-25/M2 axis by Lingyun Li, Yuanyue Zhang, Zhongyan Wang, Xiangyu Chen, Min Fang

“…IL-25 regulates inflammation by modulating type 2 immune responses, but the mechanism by which IL-25 affects kidney disease remains unclear. In this study, we found that the administration of GL enhanced the expression of IL-25 in renal tissues; the latter promoted the generation of type 2 macrophages (M2), which inhibited inflammation in the kidney caused by Con A challenge. …”
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Sickle Cell Nephropathy and Associated Factors among Asymptomatic Children with Sickle Cell Anaemia by Uchenna Modestus Nnaji, Christian Chukwukere Ogoke, Henrietta Uche Okafor, Kingsley I. Achigbu

“…Sickle cell nephropathy (SCN) is a serious complication of sickle cell anaemia (SCA) with asymptomatic onset in childhood and possible progression to chronic kidney disease (CKD). In Southeast Nigeria, few studies have evaluated renal function in paediatric SCA patients for early detection of renal impairment and early intervention to reduce morbidity and mortality. …”
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Research on the global trends of COVID-19 associated acute kidney injury: a bibliometric analysis by Wen-jing Zhao, Rui-zhi Tan, Jing Gao, Hongwei Su, Li Wang, Jian Liu

“…The co-occurrence analysis of author keywords reveals that ‘mortality’, ‘intensive care units’, ‘chronic kidney disease’, ‘nephrology’, ‘renal transplantation’, ‘acute respiratory distress syndrome’, and ‘risk factors’ emerge as the primary areas of focus within the realm of COVID-19 AKI. …”
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Kidney damage on fertility and pregnancy: A Mendelian randomization. by Jin Ren, Qiuyan Huang, Xiaowei Lie, Xingli Tong, Qi Yao, Ge Zhou

“…<h4>Background</h4>Low fertility and adverse pregnancy outcomes are commonly observed in women with chronic kidney disease (CKD). However, a causal relationship between low fertility and adverse pregnancy outcomes with CKD remains unclear. …”
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Regional risk factors associated with adverse outcomes of COVID-19 infection among the older adult: A systematic review and meta-analysis by Olunike Rebecca Abodunrin, Mobolaji Timothy Olagunju, Xinyi Huang, Jianming Wang, Zhibin Hu, Chong Shen

“…Key factors include old age (above 65 years), male gender, symptoms such as fever and dyspnea, and comorbidities like dementia, chronic obstructive pulmonary disease (COPD), chronic heart disease, hypertension, chronic kidney disease, and malnutrition. Laboratory biomarkers such as low oxygen saturation, thrombocytopenia, and elevated D-dimer were also associated with adverse outcomes. …”
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γ-Gammaglutamyl transferase predicts all-cause mortality within three-year intervals in patients undergoing peritoneal dialysis by Yan-Bing Chen, Xiao-Jiang Zhan, Jun Xiao, Heng-Mei Zhu

“…Objectives Peritoneal dialysis (PD) serves as a vital renal replacement therapy for patients with end-stage kidney disease (ESKD). γ-Gamma-glutamyl transferase (γ-GGT) is a recognized predictor of oxidative stress and mortality. …”
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Effects of Unilateral Nephrectomy on Renal Function in Male Spontaneously Diabetic Torii Fatty Rats: A Novel Obese Type 2 Diabetic Model by Yoshiaki Katsuda, Yusuke Kemmochi, Mimi Maki, Ryuhei Sano, Yasufumi Toriniwa, Yukihito Ishii, Katsuhiro Miyajima, Kochi Kakimoto, Takeshi Ohta

“…Induction of 1/2 Nx in SDT fatty rats led to functional and morphological damage to the remnant kidney and to hypertension, which are considered main characteristics of chronic kidney disease, at a younger age compared with the sham group. …”
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Modified Glomerular Filtration Rate-Estimating Equations Developed in Asiatic Population for Chinese Patients with Type 2 Diabetes by Xun Liu, Xilian Qiu, Chenggang Shi, Hui Huang, Jianhua Huang, Ming Li, Tanqi Lou

“…There was also an improvement in chronic kidney disease (CKD) stage misclassification of the Chinese equation 2 (55.0 versus ranged from 61.2 to 64.6%, [P<0.001 for all]). …”
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Serum glutathione peroxidase-3 concentration at diagnosis as a biomarker for assessing disease activity and damage of antineutrophil cytoplasmic antibody-associated vasculitis at d... by Jihye Chung, Jang Woo Ha, Yong-Beom Park, Yong-Beom Park, Sang-Won Lee, Sang-Won Lee

“…Poor outcomes including all-cause mortality, end-stage kidney disease, and cerebrovascular and cardiovascular diseases were also investigated.ResultsThe median age of the study subjects was 63.0 years, 26 and 45 patients were males and females, respectively. …”
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Copious Podocyturia without Proteinuria and with Normal Renal Function in a Young Adult with Fabry Disease by H. Trimarchi, R. Canzonieri, A. Muryan, A. Schiel, A. Araoz, M. Forrester, A. Karl, F. Lombi, J. Andrews, V. Pomeranz, T. Rengel, E. Zotta

“…In this regard, proteinuria is nowadays considered as an early and appropriate marker of kidney disease and of cardiovascular morbidity and mortality. …”
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Diabetes Management and Outcomes among Patients with Type 2 Diabetes Attending a Renal Service by Elizabeth Skalkos, Rohit Rajagopal, David Simmons

“…Insulin treatment was more associated with chronic kidney disease stages 4-5 (adjusted odds ratio (aOR) 2.41, 95% CI 1.07-5.43), retinopathy (aOR 3.10, 95% CI 1.04-9.27), and podiatry review (aOR 5.06, 95% CI 1.20-21.38). …”
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Impaired Fasting Glucose and Diabetes as Predictors for Radial Artery Calcification in End Stage Renal Disease Patients by Katarzyna Janda, Marcin Krzanowski, Mariusz Gajda, Paulina Dumnicka, Danuta Fedak, Grzegorz J. Lis, Piotr Jaśkowski, Jan A. Litwin, Władysław Sułowicz

“…The study comprised 59 stage 5 chronic kidney disease patients (36 hemodialyzed and 23 predialysis). …”
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Retrospective Analysis of Bone Metabolism in Patients on Waiting List for Simultaneous Pancreas-Kidney Transplantation by Simona Kratochvílová, Jana Brunová, Petr Wohl, Věra Lánská, František Saudek

“…We retrospectively compiled biochemical and densitometrical data from 177 patients with T1DM at CKD (chronic kidney disease) stages G4-G5 (115 men, 62 women, median age 40 yr, diabetes duration 23 yr) enrolled on waiting list for SPK for the first time between the years 2011 and 2016. …”
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Frequency and Predictors of Pneumonia After Isolated Coronary Artery Bypass Grafting (CABG): A Single-Center Study by Ozgur Baris, Tugba Asli Onyilmaz, Huseyin Kaya

“…In patients with POP, diabetes mellitus (<i>p</i> = 0.03) and chronic kidney disease (<i>p</i> = 0.048) prevalence was higher, cardiopulmonary bypass (CPB) (<i>p</i> = 0.01) and cross-clamp time (<i>p</i> = 0.003) was longer, LDH levels (<i>p</i> = 0.017) were higher, hemoglobin (<i>p</i> = 0.012) and albumin (<i>p</i> = 0.015) levels were lower, and lymphocyte % (<i>p</i> = 0.04) was lower; prevalence of COPD and length of stay (LOS) in hospital tended to be higher (both <i>p</i> < 0.06). …”
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Synergic Renoprotective Effects of Combined ASC Therapy with RAAS Blockade in Experimental Advanced CKD by Marina P. C. Maires, Krislley R. Pereira, Everidiene K. V. B. Silva, Victor H. R. Souza, Flavio Teles, Paulyana F. Barbosa, Margoth R. Garnica, Felipe M. Ornellas, Irene L. Noronha, Camilla Fanelli

“…Global prevalence of chronic kidney disease (CKD) has increased considerably in the recent decades. …”
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Risk Factors for Mortality in Melioidosis: A Single-Centre, 10-Year Retrospective Cohort Study by Raviraj Menon, Poornima Baby, Anil Kumar V., Sandeep Surendran, Manu Pradeep, Aiswarya Rajendran, Gaayathri Suju, Arathy Ashok

“…Logistic regression analysis indicated that chronic kidney disease (OR = 14.0), CRP >100 IU/L (OR = 6.964), and S. albumin <3 gm/dl (OR = 8.0) were risk factors associated with mortality and can guide in risk stratification. …”
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