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Ion Channels and Zinc: Mechanisms of Neurotoxicity and Neurodegeneration
Published 2012-01-01“…Ionotropic glutamate receptors, such as NMDA, AMPA and kainate receptors, are ligand-gated ion channels that mediate much of the excitatory neurotransmission in the brain. …”
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Ion Channel Activities in Neural Stem Cells of the Neuroepithelium
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Ion Channels in Inflammatory Processes: What Is Known and What Is Next?
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Microglial Ion Channels as Potential Targets for Neuroprotection in Parkinson’s Disease
Published 2013-01-01“…Further, we discuss the potential of microglial ion channels to serve as novel targets for neuroprotection in PD.…”
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Acid-Sensing Ion Channels as Potential Therapeutic Targets in Neurodegeneration and Neuroinflammation
Published 2017-01-01“…Acid-sensing ion channels (ASICs) are a family of proton-sensing channels that are voltage insensitive, cation selective (mostly permeable to Na+), and nonspecifically blocked by amiloride. …”
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Porous Materials to Support Bilayer Lipid Membranes for Ion Channel Biosensors
Published 2011-01-01“…To identify materials suitable as membrane supports for ion channel biosensors, six filter materials of varying hydrophobicity, tortuosity, and thickness were examined for their ability to support bilayer lipid membranes as determined by electrical impedance spectroscopy. …”
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Ion channel classification through machine learning and protein language model embeddings
Published 2024-11-01Subjects: “…ion channels…”
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Ion channel traffic jams: the significance of trafficking deficiency in long QT syndrome
Published 2025-01-01“…Abstract A well-balanced ion channel trafficking machinery is paramount for the normal electromechanical function of the heart. …”
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Electromagnetic Waves Dispersion and Interaction of an Annular Beam-Ion Channel System in Plasma Waveguide
Published 2017-01-01“…A linear theory for the electromagnetic properties and interactions of an annular beam-ion channel system in plasma waveguide is presented. …”
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Ion Channel Expression and Characterization in Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes
Published 2018-01-01“…Carbachol alone showed no effect on the tested ion channel currents. Conclusion. Our data demonstrate that most ion channels, which are present in healthy or diseased cardiomyocytes, exist in hiPSC-CMs. …”
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The effect of triple CFTR modulator therapy and azithromycin on ion channels and inflammation in cystic fibrosis
Published 2024-12-01“…As AZ has been reported to require CF transmembrane conductance regulator (CFTR) to be able to reduce interleukin (IL)-8 and given the emergence of highly effective CFTR “triple” modulator therapy (elexacaftor/tezacaftor/ivacaftor; ETI), the aim of this study was to investigate the effect of AZ and ETI, singly and in combination, on ion channel activity and to assess the potential anti-inflammatory effects. …”
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Research Progress on Natural Products’ Therapeutic Effects on Atrial Fibrillation by Regulating Ion Channels
Published 2022-01-01“…Antiarrhythmic drugs (AADs) have a therapeutic effect on atrial fibrillation (AF) by regulating the function of ion channels. However, several adverse effects and high recurrence rates after drug withdrawal seriously affect patients’ medication compliance and clinical prognosis. …”
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Phytochemical-based therapeutics from traditional eastern medicine: analgesic effects and ion channel modulation
Published 2025-01-01Subjects: Get full text
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Astrocytic Acid-Sensing Ion Channel 1a Contributes to the Development of Epileptic Cognitive Impairment
Published 2025-01-01“…Reactive astrogliosis and acidosis, common features of epileptogenic lesions, express a high level of astrocytic acid-sensing ion channel-1a (ASIC1a), a proton-gated cation channel and key mediator of responses to neuronal injury. …”
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The Flatworm Macrostomum lignano Is a Powerful Model Organism for Ion Channel and Stem Cell Research
Published 2012-01-01“…Bioelectrical signals generated by ion channels play crucial roles in many cellular processes in both excitable and nonexcitable cells. …”
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TRPM7 and TRPM8 Ion Channels in Pancreatic Adenocarcinoma: Potential Roles as Cancer Biomarkers and Targets
Published 2012-01-01“…Transient receptor potential (TRP) ion channels are essential for normal functions and health by acting as molecular sensors and transducing various stimuli into cellular and physiological responses. …”
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Fast Atomic Charge Calculation for Implementation into a Polarizable Force Field and Application to an Ion Channel Protein
Published 2015-01-01“…Class I and II force fields mostly calculate with fixed atomic charges which can cause inadequate descriptions for highly charged molecules, for example, ion channels or metalloproteins. Changes in charge distributions can be included into molecular mechanics calculations by various methods. …”
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Ion Flux Dependent and Independent Functions of Ion Channels in the Vertebrate Heart: Lessons Learned from Zebrafish
Published 2012-01-01“…Ion channels orchestrate directed flux of ions through membranes and are essential for a wide range of physiological processes including depolarization and repolarization of biomechanical activity of cells. …”
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