Narrative Literature Review of Potential Atrial Fibrillation Mechanism of Action Induced by Discontinuation of Benzodiazepines by Agnė Okulevičiūtė, Gabija Laubner Sakalauskienė

“…The interaction between benzodiazepines and peripheral benzodiazepine receptors may influence calcium ion channels, affecting cardiac action potential and contractility, and discontinuation of these medications can potentially contribute to atrial fibrillation. …”
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Advances in antiviral strategies targeting mosquito-borne viruses: cellular, viral, and immune-related approaches by Ayyaz Khan, Zakirullah, Shahid Wahab, Seong-Tshool Hong

“…It also highlights recent advances in antiviral strategies targeting host factors such as lipid metabolism, ion channels, and proteasomes, as well as viral targets like NS2B-NS3 proteases and nonstructural proteins. …”
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Interneuron FGF13 regulates seizure susceptibility via a sodium channel-independent mechanism by Susan Lin, Aravind R Gade, Hong-Gang Wang, James E Niemeyer, Allison Galante, Isabella DiStefano, Patrick Towers, Jorge Nunez, Maiko Matsui, Theodore H Schwartz, Anjali Rajadhyaksha, Geoffrey S Pitt

“…Developmental and epileptic encephalopathies (DEEs), a class of devastating neurological disorders characterized by recurrent seizures and exacerbated by disruptions to excitatory/inhibitory balance in the brain, are commonly caused by mutations in ion channels. Disruption of, or variants in, FGF13 were implicated as causal for a set of DEEs, but the underlying mechanisms were clouded because FGF13 is expressed in both excitatory and inhibitory neurons, FGF13 undergoes extensive alternative splicing producing multiple isoforms with distinct functions, and the overall roles of FGF13 in neurons are incompletely cataloged. …”
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GsMTx-4 combined with exercise improves skeletal muscle structure and motor function in rats with spinal cord injury. by Xin Zhang, Xinyu Liu, Qianxi Li, Chenyu Li, Xinyan Li, Jinghua Qian, Jianjun Li, Xuemei Li

“…It has been reported that GsMTx-4, a specific blocker of the mechanosensitive ion channels Piezo1, can protect the integrity of the neuromuscular junction and promote nerve regeneration, and thus has the potential as a therapeutic agent for SCI. …”
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Evaluation of the cardiotoxicity of Echinochrome A using human induced pluripotent stem cell-derived cardiac organoids by Su-Jin Lee, Eunji Kim, Yeeun Jeong, Jae Boum Youm, Hyoung Kyu Kim, Jin Han, Elena A. Vasileva, Natalia P. Mishchenko, Sergey A. Fedoreyev, Valentin A. Stonik, Sung Joon Kim, Hyang-Ae Lee

“…The hCOs, characterized by expression of key cardiac markers (cTnT) and functional ion channels (Cav1.2, Nav1.5, hERG), exhibited structural and electrophysiological properties reflective of human cardiac physiology. …”
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Reversible Ca2+ signaling and enhanced paracellular transport in endothelial monolayer induced by acoustic bubbles and targeted microbeads by Jiawei Lin, Chaofeng Qiao, Hao Jiang, Zhihui Liu, Yaxin Hu, Wei Liu, Yu Yong, Fenfang Li

“…At the conditions evoking reversible Ca2+ signaling, intracellular Ca2+ release and reactive oxygen species played key roles for microbubbles induced Ca2+ signaling while activation of mechanosensitive ion channels was essential for the case of microbeads. …”
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Deep proteomics and network pharmacology reveal sex- and age-shared neuropathic pain signatures in mouse dorsal root ganglia by Sabrina Grundtner, Julia R. Sondermann, Feng Xian, Daniel Malzl, Daniel Segelcke, Esther M. Pogatzki-Zahn, Jörg Menche, David Gómez-Varela, Manuela Schmidt

“…We quantified over 12,000 proteins, including notable ion channels involved in pain, highlighting the sensitivity of our approach. …”
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A Possible Involvement of Ion Transporter in Tumor Necrosis Factor α and Cycloheximide-Induced Apoptosis of Endothelial Cells by Hiroshi Fujita, Ikuo Morita, Sei-itsu Murota

“…We examined the tumor necrosis factor α (TNFα)-induced apoptosis of vascular endothelial cells from the standpoint of ion channels. Cultured vascular endothelial cells from bovine carotid artery were used. …”
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Transfer of optogenetic vectors into the brain of neonatal animals to study neuron functions during subsequent periods of development by D. A. Lanshakov, U. S. Drozd, T. A. Zapara, N. N. Dygalo

“…Optogenetics, that is, the control of cell activity using light-sensitive ion channels opsins with light of a specific wavelength, is increasingly being used to study activities and functions of neurons. …”
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Candidate SNP markers of changes in the expression levels of the human <i>SCN9A</i> gene as a hub gene for pain generation, perception, response and anesthesia by P. A. Dotsenko, K. A. Zolotareva, R. A. Ivanov, I. V. Chadaeva, N. L. Podkolodnyy, V. A. Ivanisenko, P. S. Demenkov, S. A. Lashin, M. P. Ponomarenko

“…Next, with our tool called ANDSystem, we found that phosphorylation of ion channels is a centerpiece in pain generation, perception, response and anesthesia, on which the efficiency of signal transduction from the peripheral to the central system depends. …”
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Binding of LncDACH1 to dystrophin impairs the membrane trafficking of Nav1.5 protein and increases ventricular arrhythmia susceptibility by Genlong Xue, Jiming Yang, Yang Zhang, Ying Yang, Ruixin Zhang, Desheng Li, Tao Tian, Jialiang Li, Xiaofang Zhang, Changzhu Li, Xingda Li, Jiqin Yang, Kewei Shen, Yang Guo, Xuening Liu, Guohui Yang, Lina Xuan, Hongli Shan, Yanjie Lu, Yang Baofeng, Zhenwei Pan

“…Long noncoding RNAs (lncRNAs) are involved in the regulation of cardiac ion channels, while their influence on sodium channels remains unexplored. …”
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Therapeutic Efficacy of <i>Lavandula dentata</i>’s Oil and Ethanol Extract in Regulation of the Neuroinflammation, Histopathological Alterations, Oxidative Stress, and Restoring Ba... by Aziza Antar, Eman S. Abdel-Rehiem, Areej A. Al-Khalaf, Abdelaziz S. A. Abuelsaad, Mohamed Abdel-Gabbar, Gaber M. G. Shehab, Ayman M. Abdel-Aziz

“…<b>Results</b>: The investigation revealed that the extract and essential oils obtained from <i>L. dentata</i> L. exhibited the ability to improve the modulation of electrolytes and ions across voltage- and ligand-gated ion channels. Furthermore, it was revealed that they could decrease neuronal excitability by facilitating repolarization. …”
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iTRAQ-based quantitative proteomic analysis of herbicide stress in Avena ludoviciana Durieu by Hossein Adim, Leila Fahmideh, Barat Ali Fakheri, Hamid Najafi Zarrini, Hamidreza Sasanfar

“…In the resistant A. ludoviciana populations, in addition to the activation of enzymatic and non-enzymatic defense systems, other strategies such as reduced photosynthesis and respiration, increased transcription and translation activity, enhanced lipid metabolism, regulation of cellular processes and homeostasis, and up-regulation of proteins associated with signaling and ion channels play a role in resistance to herbicide. …”
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