Developmental and Epileptic Encephalopathy: Pathogenesis of Intellectual Disability Beyond Channelopathies by Alexandra D. Medyanik, Polina E. Anisimova, Angelina O. Kustova, Victor S. Tarabykin, Elena V. Kondakova

“…Many genes mutated in DEEs encode ion channels, causing current conduction disruptions known as channelopathies. …”
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Synaptic signatures and disease vulnerabilities of layer 5 pyramidal neurons by Gabriele Marcassa, Dan Dascenco, Blanca Lorente-Echeverría, Danie Daaboul, Jeroen Vandensteen, Elke Leysen, Lucas Baltussen, Andrew J. M. Howden, Joris de Wit

“…We find distinct synaptic signatures of L5 IT and PT neurons that are defined by proteins regulating synaptic organization and transmission, including cell-surface proteins (CSPs), neurotransmitter receptors and ion channels. In addition, we find a differential vulnerability to disease, with a marked enrichment of autism risk genes in the synaptic signature of L5 IT neurons compared to PT neurons. …”
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Functional Properties of Human Stem Cell-Derived Neurons in Health and Disease by Jason P. Weick

“…These features critically depend on the coordinated expression and localization of hundreds of ion channels and receptors, as well as scaffolding and signaling molecules. …”
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Approaches to the Modulation of Abdominal Pain by Emeran A Mayer, Tony Lembo, Lin Chang

“…Even though the precise mechanisms and sites underlying these alterations remain incompletely understood, plausible targets for the development of effective pharmacological treatments are receptors on peripheral terminals of visceral afferent nerves (opioids and serotonin), ion channels and receptors on dorsal horn neurons within the spinal cord (opioids, glutamate, calcitonin gene-related peptide and neurokinin-1), and supraspinal targets in the brainstem within the limbic system and in the prefrontal cortex (serotonin, catecholamines, dopamine and acetylcholine). …”
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Using Protein Painting Mass Spectrometry to Define Ligand Receptor Interaction Sites for Acetylcholine Binding Protein by Alexandru Graur, Natalie Erickson, Nadine Kabbani

“…Nicotinic acetylcholine receptors (nAChRs) are a family of ligand-gated ion channels expressed in nervous and non-nervous system tissue important for memory, movement, and sensory processes. …”
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Promoting Articular Cartilage Regeneration through Microenvironmental Regulation by Kai Liu, Bingjun Zhang, Xiaoling Zhang

“…We find that regulating the opening of mechanosensitive ion channels, regulating the expression of HIF-1, delivering growth factors, and clearing senescent cells can promote the formation of articular cartilage regeneration microenvironment. …”
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Genotype-phenotype insights of pediatric dilated cardiomyopathy by Ying Dai, Yan Wang, Youfei Fan, Bo Han

“…Research has shown that DCM exhibits notable genetic heterogeneity, with over 100 DCM-related genes identified to date, primarily involving functions such as calcium handling, the cytoskeleton, and ion channels. As human genomic variations are linked to phenotypes, DCM phenotypes are influenced by numerous genetic variations across the entire genome. …”
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Biophysical modeling and experimental analysis of the dynamics of C. elegans body-wall muscle cells. by Xuexing Du, Jennifer Crodelle, Victor James Barranca, Songting Li, Yunzhu Shi, Shangbang Gao, Douglas Zhou

“…Specifically, by conducting voltage clamp and mutant experiments, we identify key ion channels, particularly the L-type voltage-gated calcium channel (EGL-19) and potassium channels (SHK-1, SLO-2), which are crucial for generating action potentials. …”
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Proinflammatory Cytokines and Potassium Channels in the Kidney by Kazuyoshi Nakamura, Hikaru Hayashi, Manabu Kubokawa

“…In the kidney, functions of transporters and ion channels along the nephron are also affected by some cytokines. …”
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Electromagnetic Signaling Outperforms Quorum Sensing in Bacterial Biofilms: A Communication Channel Capacity Perspective by Navid Barani, Kamal Sarabandi

“…There is a growing body of theoretical and experimental evidence that in addition to the biochemical signaling using auto-inducers and ion channels, biological cells and more specifically certain bacterial biofilms can transmit and receive electromagnetic (EM) waves as a means of communication. …”
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Conditional KCa3.1-transgene induction in murine skin produces pruritic eczematous dermatitis with severe epidermal hyperplasia and hyperkeratosis. by Javier Lozano-Gerona, Aida Oliván-Viguera, Pablo Delgado-Wicke, Vikrant Singh, Brandon M Brown, Elena Tapia-Casellas, Esther Pueyo, Marta Sofía Valero, Ángel-Luis Garcia-Otín, Pilar Giraldo, Edgar Abarca-Lachen, Joaquín C Surra, Jesús Osada, Kirk L Hamilton, Siba P Raychaudhuri, Miguel Marigil, Ángeles Juarranz, Heike Wulff, Hiroto Miura, Yolanda Gilaberte, Ralf Köhler

“…Ion channels have recently attracted attention as potential mediators of skin disease. …”
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The Calcium Sensor CBL-CIPK Is Involved in Plant’s Response to Abiotic Stresses by S. M. Nuruzzaman Manik, Sujuan Shi, Jingjing Mao, Lianhong Dong, Yulong Su, Qian Wang, Haobao Liu

“…Recent studies established that this complex regulates downstream targets like ion channels and transporters in adverse stages conditions. …”
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Advances in the treatment of glioma-related signaling pathways and mechanisms by metformin by Xingyuan Ma, Xingyuan Ma, Chao Sun, Xiao Ding, Yuhang Zhang, Yuhang Zhang, Tingzhen Deng, Tingzhen Deng, Yatao Wang, Yatao Wang, Haijun Yang, Haijun Yang, Ruiwen Ding, Ruiwen Ding, Haotian Li, Haotian Li, Dawen Wang, Dawen Wang, Maohua Zheng, Maohua Zheng

“…This review explores the multiple mechanisms through which metformin exerts its antitumor effects, focusing on signaling pathways such as AMPK/mTOR, ferroptosis, autophagy, apoptosis and chloride ion channels (CLIC1). Metformin’s inhibition of glioma proliferation involves complex cellular processes, including mitochondrial dysfunction, increased reactive oxygen species (ROS) production, and modulation of immune responses. …”
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From pain to meningitis: bacteria hijack nociceptors to promote meningitis by Huazhen Liu, Xingxing Kong, Yuqin Zeng, Jinyun Chen, Zhanpeng Chen, Lanlan Liu, Quan Ma, Xuhui Liu, Xuhui Liu, Shuihua Lu

“…This review examines the interactions between bacteria and meningeal nociceptors, focusing on their direct and indirect activation via ion channels, such as transient receptor potential vanilloid-1 (TRPV1) and transient receptor potential ankyrin 1 (TRPA1), or through the release of neuropeptides like calcitonin gene-related peptide (CGRP). …”
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Advanced Piezoelectric Materials, Devices, and Systems for Orthopedic Medicine by Jingkai Zhang, Chang Liu, Jun Li, Tao Yu, Jing Ruan, Fan Yang

“…Recent studies showed that piezoelectricity can impact microenvironments by regulating molecular sensors including ion channels, cytoskeletal elements, cell adhesion proteins, and other signaling pathways. …”
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High-performance solid-state proton gating membranes based on two-dimensional hydrogen-bonded organic framework composites by Dandan Lei, Yixiang Wang, Qixiang Zhang, Shuqi Wang, Lei Jiang, Zhen Zhang

“…Abstract Biological ion channels exhibit strong gating effects due to their zero-current closed states. …”
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Identification and analysis of prognostic ion homeostasis characteristics in kidney renal clear cell carcinoma by Xiangmin Zhang, Xiongxian Qian, Yong Zhao, Maofei Ye, Liyang Li, Jian Chu

“…It has been shown that ion channels are important targets for anti-tumor therapy. …”
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Simultaneous Determination of Three Active Forms of Vitamin B12 In Situ Produced During Fermentation by LC-MS/MS by Zhihao Fan, Yajie Li, Xia Fan, Pei Wang, Runqiang Yang, Chong Xie

“…Meanwhile, the quantitative result of this method is not affected by pseudo-VB12 because the selected ion channels include fragments of active VB12. Maintaining light-shielding during extraction and purification is essential, as light exposure during the process can decrease the content of detected VB12 by about 30%. …”
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Insecticide resistant Anopheles from Ethiopia but not Burkina Faso show a microbiota composition shift upon insecticide exposure by Netsanet Worku, Antoine Sanou, Juliane Hartke, Marion Morris, Fatoumata Cissé, Salimata Ouédraogo, Madou Tapsoba, Nicola Vallon, Tewodros Debebe Akilu, Ligabaw Worku, Moussa Wamdaogo Guelbeogo, Victoria A. Ingham

“…To further understand resistance in this An. arabiensis population, we performed RNAseq and saw differential expression of detoxification genes associated with insecticide resistance and changes in respiration, metabolism and synapse-related ion channels. Conclusions Our results indicate that, in addition to changes in the transcriptome, microbiota can contribute to insecticide resistance in certain settings. …”
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Capacitance Measurements of Exocytosis From AII Amacrine Cells in Retinal Slices by Espen Hartveit, Margaret Veruki

“…During neuronal synaptic transmission, the exocytotic release of neurotransmitters from synaptic vesicles in the presynaptic neuron evokes a change in conductance for one or more types of ligand-gated ion channels in the postsynaptic neuron. The standard method of investigation uses electrophysiological recordings of the postsynaptic response. …”
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