Endothelial cell Piezo1 promotes vascular smooth muscle cell differentiation on large arteries by Javier Abello, Ying Yin, Yonghui Zhao, Josh Maurer, Jihui Lee, Cherokee Bodell, Jahmiera Richee, Abigail J. Clevenger, Zarek Burton, Megan E. Goeckel, Michelle Lin, Stephanie Grainger, Carmen M. Halabi, Shreya A. Raghavan, Rajan Sah, Amber N. Stratman

“…Here, we demonstrate the involvement of the mechanosensitive ion channel, Piezo1, in promoting arterial accumulation of vascular smooth muscle cells (vSMCs) during zebrafish development. …”
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The interaction of tPA with NMDAR1 drives neuroinflammation and neurodegeneration in α-synuclein-mediated neurotoxicity by Daniel Torrente, Enming J. Su, Alí Francisco Citalán-Madrid, Gerald P. Schielke, Daniel Magaoay, Mark Warnock, Tamara Stevenson, Kris Mann, Flavie Lesept, Nathalie Delétage, Manuel Blanc, Erin H. Norris, Denis Vivien, Daniel A. Lawrence

“…Finally, treatment of mice with glunomab, a neutralizing antibody that selectively blocks tPA binding to the N-methyl-D-aspartate receptor-1 (NMDAR1) without affecting NMDAR1 ion channel function, identifies the tPA interaction with NMDAR1 as necessary for tPA-mediated neuroinflammation and neurodegeneration in response to α-synuclein-mediated neurotoxicity. …”
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Inducible Fgf13 ablation alleviates cardiac fibrosis via regulation of microtubule stability by Wang Cong, Wang Xiangchong, Zhang Yiyi, Mi Yuan, Han Yanxue, Zhi Yaxin, Zhao Ran, Cui Nanqi, Ma Qianli, Zhang Huaxing, Xue Dazhong, Qiao Ruoyang, Han Jiabing, Yu Yulou, Li Jiaxuan, Shaiea Mohammed, Liu Demin, Gu Guoqiang, Wang Chuan

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Membrane Currents in Airway Smooth Muscle: Mechanisms and Therapeutic Implications by Luke J Janssen

“…Changes included a transient activation of chloride ion channels and prolonged suppression of potassium ion channels; both changes are triggered by release of internally sequestered calcium ion and in turn cause opening of voltage-dependent calcium channels. …”
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Functional large-conductance calcium and voltage-gated potassium channels in extracellular vesicles act as gatekeepers of structural and functional integrity by Shridhar Sanghvi, Divya Sridharan, Parker Evans, Julie Dougherty, Kalina Szteyn, Denis Gabrilovich, Mayukha Dyta, Jessica Weist, Sandrine V. Pierre, Shubha Gururaja Rao, Dan R. Halm, Tingting Chen, Panagiotis S. Athanasopoulos, Amalia M. Dolga, Lianbo Yu, Mahmood Khan, Harpreet Singh

“…EVs are known to possess ion channels and transporters in their membrane but neither the function nor the role of these channels in EVs is known. …”
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Hyperkalemia Induced Brugada Phenocopy: A Rare ECG Manifestation by Muhammad Ameen, Ghulam Akbar, Naeem Abbas, Ghazi Mirrani

“…Brugada syndrome (BrS) is an inherited disorder of cardiac ion channels characterized by peculiar ECG findings predisposing individuals to ventricular arrhythmias, syncope, and sudden cardiac death (SCD). …”
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Targeting ion homeostasis in metabolic diseases: Molecular mechanisms and targeted therapies by Yanjiao Zhang, Kaile Ma, Xinyi Fang, Yuxin Zhang, Runyu Miao, Huifang Guan, Jiaxing Tian

“…Furthermore, the article explores pharmacological strategies that target ion channels and transporters, including existing drugs and emerging drugs under development. …”
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The role of TASK-1 and TRPV1 channels in the male reproductive system by Dawon Kang, Eun-A Ko

“…Research has highlighted the importance of various ion channels and proteins in testicular function. The TWINK-related acid-sensitive potassium channel 1 (TASK-1), a two-pore channel, is vital for several physiological functions in the testis. …”
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Small G Proteins Dexras1 and RHES and Their Role in Pathophysiological Processes by Ashish Thapliyal, Rashmi Verma, Navin Kumar

“…Both these GTPases are capable of modulating calcium ion channels which in turn can potentially modulate neurosecretion/hormonal release. …”
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Neuromodulation with chemicals: Opportunities and challenges by Yifei Pan, Cong Pan, Lanqun Mao, Ping Yu

“…By regulating the concentration of specific chemicals, receptors on the neuron cell membrane can be modulated to activate or inhibit, thereby influencing specific ion channels and facilitating neuromodulation. This review introduces several chemical modulation techniques, such as microinjection, electrode/nanoparticle-based chemical delivery methods, in situ electrochemical synthesis and chemogenetics. …”
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Autophagy-lysosome pathway in insulin & glucagon homeostasis by Yi Wu, Yi Wu, Yi Wu, Hui Wang, Huoyan Xu

“…They utilize different ion channels and transporters to complete the mission in degradation, trafficking, nutrient sensing and integration of various metabolic pathways to maintain cellular homeostasis. …”
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Brugada syndrome update by Tingting Xu, Shaokun Wang, Jiawen Wang, Jihong Xing

“…Brugada syndrome (BrS), a genetic disorder affecting cardiac ion channels, predominantly manifests due to mutations that impair the function of the Nav1.5 sodium channel’s α-subunit. …”
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Molecular Mechanisms of Oxytocin Signaling at the Synaptic Connection by Jan Bakos, Annamaria Srancikova, Tomas Havranek, Zuzana Bacova

“…The presence of oxytocin receptors in the presynaptic and postsynaptic membranes and the direct effects of oxytocin on neuronal excitability by regulating the activity of ion channels in the cell membrane implicate that alterations in oxytocin signaling could be involved in synaptopathies. …”
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Transmembrane voltage-gated nanopores controlled by electrically tunable in-pore chemistry by Makusu Tsutsui, Wei-Lun Hsu, Chien Hsu, Denis Garoli, Shukun Weng, Hirofumi Daiguji, Tomoji Kawai

“…Abstract Gating is a fundamental process in ion channels configured to open and close in response to specific stimuli such as voltage across cell membranes thereby enabling the excitability of neurons. …”
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Palmitoylation as a Functional Regulator of Neurotransmitter Receptors by Vladimir S. Naumenko, Evgeni Ponimaskin

“…Palmitoylation also represents a common posttranslational modification of the neurotransmitter receptors, including G protein-coupled receptors (GPCRs) and ligand-gated ion channels (LICs). From the functional point of view, palmitoylation affects a wide span of neurotransmitter receptors activities including their trafficking, sorting, stability, residence lifetime at the cell surface, endocytosis, recycling, and synaptic clustering. …”
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P2Y Receptors in Synaptic Transmission and Plasticity: Therapeutic Potential in Cognitive Dysfunction by Segundo J. Guzman, Zoltan Gerevich

“…We show that P2Y receptors inhibit the release of neurotransmitters, modulate voltage- and ligand-gated ion channels, and differentially influence the induction of synaptic plasticity in the prefrontal cortex, hippocampus, and cerebellum. …”
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Label free, capillary-scale blood flow mapping in vivo reveals that low-intensity focused ultrasound evokes persistent dilation in cortical microvasculature by YuBing Y. Shen, Jyoti V. Jethe, Ashlan P. Reid, Jacob Hehir, Marcello Magri Amaral, Chao Ren, Senyue Hao, Chao Zhou, Jonathan A. N. Fisher

“…An increasing body of research has identified mechanosensitive ion channels that can be modulated by FUS and support acute electrical activity in neurons. …”
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Compatibility of pronounced detachment with improved confinement on HL-2A tokamak by Ting Wu, Min Xu, Zhuo Wang, Lin Nie, Zhanhui Wang, Jinming Gao, Yihang Chen, Yiren Zhu, Yi Zhang, Liang Liu, Dong Li, Kai Zhang, Rui Ke, Xiaoxue He, Zengceng Yang, Xin Yu, Na Wu, Zhihui Huang, Kaiyang Yi, Weice Wang, Longwen Yan, Yonggao Li, Ting Long, Renxu Wang, Wenjing Tian, Zhe Wang, Laizhong Cai, Yi Yu

“…Edge turbulence and turbulent transport through ion channels decrease significantly, which could result from reduced free energy source due to edge cooling. …”
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TransLeish: Identification of membrane transporters essential for survival of intracellular Leishmania parasites in a systematic gene deletion screen by Andreia Albuquerque-Wendt, Ciaran McCoy, Rachel Neish, Ulrich Dobramysl, Çağla Alagöz, Tom Beneke, Sally A. Cowley, Kathryn Crouch, Richard J. Wheeler, Jeremy C. Mottram, Eva Gluenz

“…A total of 312 protein components of small molecule carriers, ion channels and pumps were identified and targeted in a CRISPR-Cas9 gene deletion screen in the promastigote form, yielding 188 viable null mutants. …”
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Chloride intracellular channel CLIC3 mediates fibroblast cellular senescence by interacting with ERK7 by Changjiao Luan, Yue Gao, Jun Zhao, Xiaohui Zhang, Chaofan Wang, Wentao Sun, Yucheng Li, Xinxing Yang, Jiaxiao Chen, Weili Liu, Weijuan Gong, Xingjie Ma

“…Recent studies have emphasized the roles of ion channels as key mediators of CS. Nonetheless, the roles and regulatory mechanisms of chloride intracellular channels (CLICs) during CS remain largely unexplored. …”
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