Optimasi Data Tidak Seimbang pada Interaksi Drug Target dengan Sampling dan Ensemble Support Vector Machine by Nabila Sekar Ramadhanti, Wisnu Ananta Kusuma, Annisa Annisa

“…Metode ini sudah diuji pada dataset Nuclear Receptor, G-Protein Coupled Receptor dan Ion Channel dengan rasio ketidakseimbangannya sebesar 14.6%, 32.36%, dan 28.2%. …”
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Epidural Analgesia with Ropivacaine during Labour in a Patient with a SCN5A Gene Mutation by A. L. M. J. van der Knijff-van Dortmont, M. Dirckx, J. J. Duvekot, J. W. Roos-Hesselink, A. Gonzalez Candel, C. D. van der Marel, G. P. Scoones, V. F. R. Adriaens, I. J. J. Dons-Sinke

“…SCN5A gene mutations can lead to ion channel defects which can cause cardiac conduction disturbances. …”
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Atrial Fibrillation and Long QT Syndrome Presenting in a 12-Year-Old Girl by Jonathan W. Knoche, Kate M. Orland, Craig T. January, Kathleen R. Maginot

“…Long QT syndrome (LQTS), likewise, can be both acquired and inherited with mutations leading to abnormalities in cardiac ion channel function. Mutations in KCNQ1 are the most common cause of LQTS. …”
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Elucidating genetic intersections: Co-differentially expressed genes in myasthenia gravis and idiopathic inflammatory myopathies and their role in comorbid pathogenesis by Wenqu Yang, Feng Liang

“…Results: Four co-DEGs were identified between MG and IIM, associated with neurotransmitter transport and ion channel regulation. The nomogram model, incorporating three of these co-DEGs, showed high predictive accuracy for MG with IIM complications, with an area under the ROC curve of 0.94. …”
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Overview of Novel Antipsychotic Drugs: State of the Art, New Mechanisms, and Clinical Aspects of Promising Compounds by Letizia Biso, Marco Carli, Marco Scarselli, Biancamaria Longoni

“…In particular, we analyzed the main classes of investigational antipsychotics, such as monoamine, glutamate, acetylcholine, cannabinoid receptor modulators, enzyme inhibitors, ion channel modulators, and mixed receptor modulators. …”
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Finite volume modeling of neural communication: Exploring electrical signaling in biological systems by Muzammal Saleem, Muhammad Saqib, Badar Saad Alshammari, Shahid Hasnain, Amjad Ayesha

“…The Hodgkin–Huxley model offers an analytically representation of how neurons produce and propagate these action potentials by accounting for key factors, including membrane potential variations influenced by ion channel conductances. These ion channels regulate ion movement across cell membranes, which is essential for neuronal activity. …”
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Idiopathic Generalized Epilepsy and Hypokalemic Periodic Paralysis in a Family of South Indian Descent by Muthiah Subramanian, N. Senthil, S. Sujatha

“…Inherited channelopathies are a heterogeneous group of disorders resulting from dysfunction of ion channels in cellular membranes. They may manifest as diseases affecting skeletal muscle contraction, the conduction system of the heart, nervous system function, and vision syndromes. …”
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KCNJ11: Genetic Polymorphisms and Risk of Diabetes Mellitus by Polin Haghvirdizadeh, Zahurin Mohamed, Nor Azizan Abdullah, Pantea Haghvirdizadeh, Monir Sadat Haerian, Batoul Sadat Haerian

“…This channel is a heteromeric protein, composed of four inward-rectifier potassium ion channel (Kir6.2) tetramers, which form the pore of the KATP channel, as well as sulfonylurea receptor 1 subunits surrounding the pore. …”
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Progesterone Changes the Pregnancy-Induced Adaptation of Cardiomyocyte Kv2.1 Channels via MicroRNA-29b by Shuang Liang, Yu-Shuang Sun, Lu Li, Yao Long, Meng Wang, Hou-Zhi Yang, Chun-Di Li, Yan Wang, Shan-Shan Li, Xu Chen, Xin Jin

“…In this study, we investigated the cardiac repolarization and ion channel expression in pregnant subjects and mice models and studied the effects of P4 administrations on these pregnancy-mediated adaptations. …”
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Intrathecal Resiniferatoxin Modulates TRPV1 in DRG Neurons and Reduces TNF-Induced Pain-Related Behavior by M. Leo, M. Schulte, L.-I. Schmitt, M. Schäfers, C. Kleinschnitz, T. Hagenacker

“…Previous studies suggest interactions between tumor necrosis factor- (TNF-) alpha and TRPV1, resulting in a modulation of ion channel function and protein expression in sensory neurons. …”
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Ca²⁺/Calmodulin-Dependent Protein Kinase II (CaMKII) Regulates Basal Cardiac Pacemaker Function: Pros and Cons by Tatiana M. Vinogradova, Edward G. Lakatta

“…The spontaneous firing of the sinoatrial (SA) node, the physiological pacemaker of the heart, is generated within sinoatrial nodal cells (SANCs) and is regulated by a “coupled-clock” pacemaker system, which integrates a “membrane clock”, the ensemble of ion channel currents, and an intracellular “Ca²⁺ clock”, sarcoplasmic reticulum-generated local submembrane Ca²⁺ releases via ryanodine receptors. …”
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A TRPM4 Inhibitor 9-Phenanthrol Inhibits Glucose- and Glucagon-Like Peptide 1-Induced Insulin Secretion from Rat Islets of Langerhans by Zuheng Ma, Anneli Björklund, Md. Shahidul Islam

“…Pancreatic β-cells express several ion channels of the transient receptor potential family, which play important roles in mediating the stimulus-secretion coupling. …”
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Dendritic excitations govern back-propagation via a spike-rate accelerometer by Pojeong Park, J. David Wong-Campos, Daniel G. Itkis, Byung Hun Lee, Yitong Qi, Hunter C. Davis, Benjamin Antin, Amol Pasarkar, Jonathan B. Grimm, Sarah E. Plutkis, Katie L. Holland, Liam Paninski, Luke D. Lavis, Adam E. Cohen

“…Collisions of dSpikes with synaptic inputs triggered calcium channel and N-methyl-D-aspartate receptor (NMDAR)-dependent dendritic plateau potentials and accompanying complex spikes at the soma. This hierarchical ion channel network acts as a spike-rate accelerometer, providing an intuitive picture connecting dendritic biophysics to associative plasticity rules.…”
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Myocardial Ischemia and Diabetes Mellitus: Role of Oxidative Stress in the Connection between Cardiac Metabolism and Coronary Blood Flow by Paolo Severino, Andrea D’Amato, Lucrezia Netti, Mariateresa Pucci, Fabio Infusino, Viviana Maestrini, Massimo Mancone, Francesco Fedele

“…In the cross-talk between myocardial metabolism and coronary blood flow (CBF), ion channels have a main role, and, in diabetic patients, they are involved in the pathophysiology of IHD. …”
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Structure- and Ligand-Based Virtual Screening for Identification of Novel TRPV4 Antagonists by Atefeh Saadabadi, Linda Wilkman, Marja Rantanen, Ari-Pekka Koivisto, Outi M. H. Salo-Ahen

“…To identify potential TRPV4 inhibitors for drug development, we screened a library of ion channel-modulating compounds using both structure- and ligand-based virtual screening approaches. …”
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Omega-3 Fatty Acids and Vitamin D in Cardiology by Norbert Güttler, Kirila Zheleva, Mariana Parahuleva, Ridvan Chasan, Mehmet Bilgin, Christiane Neuhof, Mehmet Burgazli, Bernd Niemann, Ali Erdogan, Andreas Böning

“…Experimental studies show effects on membrane structure and associated functions, ion channel properties, genetic regulation, and production of anti-inflammatory mediators. …”
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A comprehensive review of remimazolam for sedation by Nazir Noor, Rhorer Legendre, Alexandra Cloutet, Ahish Chitneni, Giustino Varrassi, Alan D. Kaye

“…This is provided by the benzodiazepine molecule binding and causing a conformational change to the chloride ion channel to cause hyperpolarization and thus inhibition of the central nervous system. …”
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Genome Sequencing Reveals the Adaptation of Chickens to High Altitudes in Different Regions by Yizhou Hu, Xing Li, Qixin Guo, Lan Huang, Hao Bai, Guobin Chang

“…Functional annotation of the genes showed that they are primarily involved in energy metabolism, ion channel activity, and blood pressure regulation. …”
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The effect of continuous positive airway pressure therapy on atrial fibrillation in patients with obstructive sleep apnea by Jiancheng Hu, Siyuan Zuo, Jiahui Qian, Fangfang Cheng, Dengji Wang, Yanyan Deng, Dasheng Lu, Dasheng Lu

“…The intricate pathophysiological pathways linking OSA to AF encompass chronic intermittent hypoxia, disruptions in the autonomic nervous system, inflammatory responses, and alterations in ion channel function. Continuous positive airway pressure (CPAP) therapy emerges as the frontline treatment for moderate to severe OSA, effectively alleviating symptomatic manifestations and potentially mitigating cardiovascular risks. …”
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Comparative lipidome and transcriptome provide novel insights into zero-valent iron nanoparticle-treated Fremyella diplosiphon by Yavuz S. Yalcin, Samson Gichuki, Huan Chen, Anithachristy Sigamani Arumanayagam, Shyama Malika Malwalage, Viji Sitther

“…While the expression of iron uptake and ion channel genes was downregulated, genes coding for photosynthesis, pigment, and antioxidant enzymes were significantly (p < 0.05) upregulated in B481-SD treated with 3.2 mg L−1 nZVIs compared to the untreated control. …”
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