Editorial by Jörg Tremmel, Marisa dos Reis, Joseph Burke, Raphaelle Schwarzberg (†)

“…At the institutional level, our current bodies and decision-making processes already have inherent tendencies towards the recognition and protection of future people, for instance the European Convention on Human Rights has been interpreted progressively. Nevertheless, it requires innovative thinking to imagine alternative provisions that can complement today’s legal architecture but revolutionise our restricted thinking on this topic. …”
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Maternal and neonatal complications of pregnant women with bipolar disorder: a systematic review and meta-analysisResearch in context by Damien Etchecopar-Etchart, Masoud Rahmati, Dong Keon Yon, Lee Smith, Laurent Boyer, Guillaume Fond

“…According to the AMSTAR 2 tool, these results correspond to moderate-quality evidence. Interpretation: Despite substantial heterogeneity observed, our findings suggest the presence of a broad spectrum of complications that may affect both pregnant women with bipolar disorder and their newborns. …”
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Global, regional, and national epidemiology of childhood neuroblastoma (1990–2021): a statistical analysis of incidence, mortality, and DALYsResearch in context by Jusen Nong, Cheng Su, Changhua Li, Congjun Wang, Wei Li, Yong Li, Peng Chen, Yanqiang Li, Zihao Li, Xinjin She, Zuxin Yuan, Sentian Liu, Chao Chen, Qian Liao, Yige Luo, Bo Shi

“…At the national level, India had the highest number of neuroblastoma cases globally in 2021, with 685 cases (95% UI, 404.16–1007.67). Interpretation: The global trends for incidence, mortality, and DALYs related to pediatric neuroblastoma initially increased and then decreased, although an overall increasing trend was observed. …”
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Development and validation of a machine learning-based model to predict survival in patients with cirrhosis after transjugular intrahepatic portosystemic shuntResearch in context by Binlin Da, Huan Chen, Wei Wu, Wuhua Guo, Anru Zhou, Qin Yin, Jun Gao, Junhui Chen, Jiangqiang Xiao, Lei Wang, Ming Zhang, Yuzheng Zhuge, Feng Zhang

“…The RF model outperformed other scoring systems, such as the (Child-Turcotte-Pugh score) CTP, (model for end-stage liver disease) MELD, (sodium MELD) MELD-Na, (Freiburg index of post-TIPS survival) FIPS and (Albumin-Bilirubin) ALBI, showing the highest (area under the curve) AUC of 0.82 (95% CI: 0.72, 0.91) and 0.7 (95% CI: 0.60, 0.79) in predicting 1-year survival across the testing set and external validation cohort. Interpretation: This study developed a RF model that better predicted 1-year survival for patients with cirrhosis after TIPS placement than the other scores. …”
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Implementing a nurse-enabled, integrated, shared-care model involving specialists and general practitioners in early breast cancer post-treatment follow-up (EMINENT): a single-cent... by Raymond J. Chan, Fiona Crawford-Williams, Chad Yixian Han, Lee Jones, Alexandre Chan, Daniel McKavanagh, Marissa Ryan, Christine Carrington, Rebecca L. Packer, Megan Crichton, Nicolas H. Hart, Emma McKinnell, Melissa Gosper, Juanita Ryan, Bethany Crowe, Ria Joseph, Carolyn Ee, Jane Lee, Steven M. McPhail, Katharine Cuff, Laisa Teleni, Jon Emery

“…Number of unplanned hospital presentations at 24-months were low across both intervention (n = 7) and control (n = 4) groups. Interpretation: Nurse-enabled, shared-care arrangements for women with early-stage breast cancer is feasible, and is as safe as specialist-led model of care. …”
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Safety of a co-designed cognitive behavioural therapy intervention for people with type 1 diabetes and eating disorders (STEADY): a feasibility randomised controlled trialResearch... by Marietta Stadler, Natalie Zaremba, Amy Harrison, Jennie Brown, Divina Pillay, Jacqueline Allan, Rachael Tan, Salma Ayis, Emmanouela Konstantara, Janet Treasure, David Hopkins, Khalida Ismail

“…Compared to baseline, STEADY improved in DEPS-R, EDE-QS, GAD-7, PHQ-9 and T1DDS. Interpretation: The STEADY-feasibility RCT demonstrated proof-of-concept for feasibility and mental health improvements in T1DE without deteriorating glycaemic control. …”
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Characterisation of pregnancy-induced alterations in apolipoproteins and their associations with maternal metabolic risk factors and offspring birth outcomes: a preconception and l... by Li Chen, Karen Mei-Ling Tan, Melvin Khee-Shing Leow, Kok Hian Tan, Jerry Kok Yen Chan, Shiao-Yng Chan, Yap Seng Chong, Peter D. Gluckman, Johan G. Eriksson, Markus R. Wenk, Sartaj Ahmad Mir

“…Higher maternal ApoC-I and ApoC-III concentrations at preconception were significantly associated with shorter gestational age of the offspring. Interpretation: We describe the longitudinal landscape of maternal circulating apolipoproteins from preconception to postpartum and their associations with maternal metabolic risk factors and offspring birth outcomes. …”
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Multi-cancer early detection tests for general population screening: a systematic literature review by Ros Wade, Sarah Nevitt, Yiwen Liu, Melissa Harden, Claire Khouja, Gary Raine, Rachel Churchill, Sofia Dias

“…Stakeholders contributed to protocol development, report drafting and interpretation of review findings. Results Over 8000 records were identified. …”
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Unveiling neurogenic biomarkers for the differentiation between sepsis patients with or without encephalopathy: an updated meta-analysis by Jiyun Hu, Wenchao Li, Shucai Xie, Ya Liao, Tao Chen, Xinrun Wang, Weiping Xia, Fang Huang, Zhaoxin Qian, Lina Zhang

“…However, results should be interpreted with caution due to the high heterogeneity among studies.…”
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Hybrid versus vaccine immunity of mRNA-1273 among people living with HIV in East and Southern Africa: a prospective cohort analysis from the multicentre CoVPN 3008 (Ubuntu) studyRe... by Nigel Garrett, Asa Tapley, Aaron Hudson, Sufia Dadabhai, Bo Zhang, Nyaradzo M. Mgodi, Jessica Andriesen, Azwidihwi Takalani, Leigh H. Fisher, Jia Jin Kee, Craig A. Magaret, Manuel Villaran, John Hural, Erica Andersen-Nissen, Guido Ferarri, Maurine D. Miner, Bert Le Roux, Eduan Wilkinson, Richard Lessells, Tulio de Oliveira, Jackline Odhiambo, Parth Shah, Laura Polakowski, Margaret Yacovone, Taraz Samandari, Zvavahera Chirenje, Peter James Elyanu, Joseph Makhema, Ethel Kamuti, Harriet Nuwagaba-Biribonwoha, Sharlaa Badal-Faesen, William Brumskine, Soritha Coetzer, Rodney Dawson, Sinead Delany-Moretlwe, Andreas Henri Diacon, Samantha Fry, Katherine Margaret Gill, Zaheer Ahmed Ebrahim Hoosain, Mina C. Hosseinipour, Mubiana Inambao, Craig Innes, Steve Innes, Dishiki Kalonji, Margaret Kasaro, Priya Kassim, Noel Kayange, William Kilembe, Fatima Laher, Moelo Malahleha, Vongane Louisa Maluleke, Grace Mboya, Kirsten McHarry, Essack Mitha, Kathryn Mngadi, Pamela Mda, Tumelo Moloantoa, Cissy Kityo Mutuluuza, Nivashnee Naicker, Vimla Naicker, Anusha Nana, Annet Nanvubya, Maphoshane Nchabeleng, Walter Otieno, Elsje Louise Potgieter, Disebo Potloane, Zelda Punt, Jamil Said, Yashna Singh, Mohammed Siddique Tayob, Yacoob Vahed, Deo Ogema Wabwire, M. Juliana McElrath, James G. Kublin, Linda-Gail Bekker, Peter B. Gilbert, Lawrence Corey, Glenda E. Gray, Yunda Huang, Philip Kotze, Sharlaa Badal-Faesen, Kagisho Baepanye, Veronique Bailey, Katekani Baloyi-Oseh, Mumtaz Booley, Johannes Louis Botha, Yolande Brown, Valerie Brown, Lisa Bunts, Soritha Coetzer, Myron Cohen, Shirley Collie, Rodney Dawson, Pallabi Deb, Hana El Sahly, Jill El-Khorazaty, Andries Engelbrecht, Marianne Gildea, Dhevium Govender, Jen Hanke, Jayla Harris, Simone Hendricks, Nick Hopkinson, Haley Howell, Nzeera Ketter, Kentse Khuto, Faatima Laher Omar, Leolin Katsidzira, Kim Linton, James Ludwig, Bongile Mabilane, Matshidiso Malefo, Ndiitwani Mamushiana, Daciana Margineantu, Jeanine May, Fatima Mayat, Cindy Molitor, Yeshnee Naidoo, Michelle Nebergall, Alan Nguyen, Sarah Nikles, Bianca Noronha, Melissa Peda, Tamara Phiri, Shanthie Pillay, Sureshnee Pillay, Lori Proulx-Burns, Laurie Rinn, Lisa Sanders, Carrie Sopher, Smitha Sripathy, Michael Stirewalt, Houriiyah Tegally, Sara Thiebaud, Alicia Toledano, Stephanie Van Wyk, Shamaya Whitby, Stephany Wilcox, Eduan Wilkinson, Haven Wilvich, Charles Wiysonge, Nelisiwe Xaba, Ntokozo Xulu

“…Twenty PLWH had persistent SARS-CoV-2 virus at least 50 days. Interpretation: Hybrid immunity was associated with superior protection from COVID-19 compared to vaccine immunity with the ancestral mRNA-1273 vaccine. …”
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Effectiveness of a universal film intervention in reducing violence against children and increasing positive parenting among migrant and displaced caregivers from Myanmar: a commun... by Amanda Sim, Khaing Zar Lwin, Stephanie Eagling-Peche, G.J. Melendez-Torres, Seema Vyas, Francisco Calderon, Tawanchai Jirapramukpitak, Jamie Lachman, Sureeporn Punpuing, Andrea Gonzalez, Mary Soan, Nway Nway Oo, Ivet Castello Mitjans, Greg Tyrosvoutis, Eve Puffer

“…There were no reported adverse effects. Interpretation: Universal parenting interventions using a film-based entertainment-education approach can effectively reduce physical violence against children and increase positive parenting, with potential for scalability in low-resource settings. …”
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homeRNA self-blood collection enables high-frequency temporal profiling of presymptomatic host immune kinetics to respiratory viral infection: a prospective cohort studyResearch in... by Fang Yun Lim, Hannah G. Lea, Ashley M. Dostie, Soo-Young Kim, Tammi L. van Neel, Grant W. Hassan, Meg G. Takezawa, Lea M. Starita, Karen N. Adams, Michael Boeckh, Joshua T. Schiffer, Ollivier Hyrien, Alpana Waghmare, Erwin Berthier, Ashleigh B. Theberge

“…Finally, elevated baseline expression of antimicrobial peptides was observed in exposed-uninfected individuals. Interpretation: We demonstrated that unsupervised self-collection and stabilization of capillary blood can be applied to natural infection studies to characterize detailed early host immune kinetics at a temporal resolution comparable to that of human challenge studies. …”
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Functionally important respiratory symptoms and continued cigarette use versus e-cigarette switching: population assessment of tobacco and health study waves 2-6Research in context by James D. Sargent, Kristin Lauten, Kathryn C. Edwards, Susanne E. Tanski, Todd A. MacKenzie, Laura M. Paulin, Mary F. Brunette, Maciej L. Goniewicz, Amanda Malasky, Debra Stark, Fernando B. de Moura, Holly Griffin, Kimberly H. Nguyen, Eric Backlund, Heather L. Kimmel, John H. Kingsbury, Jenny E. Ozga, K Michael Cummings, Andrew Hyland

“…The RRs for exclusive e-cigarette use with a cutoff of ≥3 for respiratory symptom worsening and improvement were not significant (0.74 [0.53, 1.05] and 1.20 [0.95, 1.51] respectively) but were significant in an unweighted analysis that included partial data for individuals lost to follow-up (0.74 [0.57, 0.95] and 1.21 [1.06, 1.39] respectively). Interpretation: Switching completely from past 30-day use of cigarettes to e-cigarettes had short-term beneficial associations with functionally important respiratory symptoms similar to quitting tobacco completely. …”
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Sex differences in the peripheral levels of cytokines during 12-month antipsychotic treatment in a drug-naïve schizophrenia spectrum cohort by I. Ratke, A. Torsvik, C.A. Bartz-Johannessen, F. Fathian, I. Joa, S.M. Klæbo Reitan, E.M. Løberg, M. Rettenbacher, S. Skrede, V.M. Steen, E. Johnsen, R.A. Kroken

“…CRP levels did not differ between sexes at baseline or during the study period and did not change significantly during treatment with antipsychotics in either sex. Interpretation: We found significant sex differences in serum cytokine changes in drug-naïve patients with schizophrenia during treatment with antipsychotics. …”
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Development, validation, and clinical application of a machine learning model for risk stratification and management of cervical cancer screening based on full-genotyping hrHPV tes... by Binhua Dong, Zhen Lu, Tianjie Yang, Junfeng Wang, Yan Zhang, Xunyuan Tuo, Juntao Wang, Shaomei Lin, Hongning Cai, Huan Cheng, Xiaoli Cao, Xinxin Huang, Zheng Zheng, Chong Miao, Yue Wang, Huifeng Xue, Shuxia Xu, Xianhua Liu, Huachun Zou, Pengming Sun

“…The optimal XGBoost model obtained similar results in predicting CIN3+. Interpretation: We developed a cervical cancer screening risk prediction model that employs hrHPV full genotyping and simple test results to achieve risk prediction and stratified management for colposcopy referrals. …”
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Rapid molecular assays versus blood culture for bloodstream infections: a systematic review and meta-analysisResearch in context by Gabriella Anna Rapszky, Uyen Nguyen Do To, Veronika Eszter Kiss, Tamás Kói, Anna Walter, Dorottya Gergő, Fanni Adél Meznerics, Márton Rakovics, Szilárd Váncsa, Lajos Vince Kemény, Dezső Csupor, Péter Hegyi, Michael R. Filbin, Csaba Varga, Bánk G. Fenyves

“…Risk of bias was judged to be high in all included articles. Interpretation: Despite their shorter turnaround time, low sensitivity means RMAs cannot replace BCs. …”
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Dynamic changes and future trend predictions of the global burden of anxiety disorders: analysis of 204 countries and regions from 1990 to 2021 and the impact of the COVID-19 pande... by Si Chen, Wei Huang, Min Zhang, Yan Song, Chunshan Zhao, Hongwei Sun, Yanyu Wang, Jihong Wang, Yali Sun, Lei Zhou, Yan Zhu, HongYuan Wang, ZhengYang Xu, YuRui Bai, Cheng Chang

“…It is also anticipated that the prevalence of anxiety disorders among the 15–19 age group will exceed that of other age groups by 2050. Interpretation: The COVID-19 pandemic has significantly impacted the future burden of anxiety disorders, necessitating greater attention towards young individuals, particularly women. …”
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AKRASIJA IR SUBJEKTAS EGONOMIKOJE by Zenonas Norkus

“…This renovation is interpreted as continuation and rational reconstruction of the traditional discourse on the "multiple self". …”
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Grain Yield Stability Analysis of Lentil Genotypes by AMMI Indices by Payam Pezeshkpour, Reza Amiri, Iraj Karami, Amir Mirzaei

“…In multi-environment experiments, lentil yield is influenced by the genetic structure, environment, and genotype × environment interaction. To better interpret the genotype × environment interaction, the additive main effects and multiplicative interaction (AMMI) model is one of the most common methods in the study of multi-environment experiments. …”
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La datation des aqueducs lyonnais : un état des lieux by Aldo Borlenghi, Catherine Coquidé

“…However, given the fact that the Yzeron canal is a masonry structure –though it has undergone numerous repairs– interpreting this wooden structure is not easy. If it is indeed a pipe linked to the Yzeron, it could indicate an ancient state, a diversion introduced during repair works or a pipe taking water to a few neighbourhoods.The Brévenne aqueduct, whose original name would seem to have been Aqua Claudia Augusta according to the inscription on the Clos du Verbe Incarné fountain, dates from the 40s or even 50s AD. …”
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