Regenerative Therapy of Type 1 Diabetes Mellitus: From Pancreatic Islet Transplantation to Mesenchymal Stem Cells by Nadine E. Rekittke, Meidjie Ang, Divya Rawat, Rahul Khatri, Thomas Linn

“…Islet transplantation to portal vein provides an approach to compensate for loss of insulin producing cells. Clinical trials demonstrated that even partial islet graft function reduces severe hypoglycemic events in patients. …”
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Oral Administration of the Endocannabinoid Anandamide during Lactation: Effects on Hypothalamic Cannabinoid Type 1 Receptor and Food Intake in Adult Mice by Carolina Aguirre, Valeska Castillo, Miguel Llanos

“…We have previously shown that administration of the endocannabinoid anandamide (AEA) during lactation leads to overweight, increased body fat accumulation, and insulin resistance in adult mice. This study was designed to elucidate if these effects are due to increased food intake, stimulated by an augmented abundance and binding ability of the hypothalamic cannabinoid type 1 receptor (CB1R). …”
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Concentrations of Selected Adipokines, Interleukin-6, and Vitamin D in Patients with Papillary Thyroid Carcinoma in Respect to Thyroid Cancer Stages by Jakub Warakomski, Ewa Romuk, Barbara Jarząb, Jolanta Krajewska, Lucyna Siemińska

“…No significant relationships between serum concentrations of leptin, adiponectin, chemerin, IL-6, vitamin D, and tumor size in PTC were found. Although insulin resistance represented by the HOMA index was associated with anthropometric variables and with serum leptin, adiponectin, chemerin, and IL-6 concentrations, in our study, no statistically significant relations with PTC staging were identified.…”
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Hypoglycemic polysaccharides from Auricularia auricula and Auricularia polytricha inhibit oxidative stress, NF-κB signaling and proinflammatory cytokine production in streptozotoci... by Huan Xiang, Dongxiao Sun-Waterhouse, Chun Cui

“…This is the first report to compare the effectiveness of AAP and APP in combating streptozotocin-induced oxidative stress and diabetes-related changes in mice (body weight, fasting blood glucose, serum insulin, proinflammatory mediator and cytokines, oxidative stress-related products, antioxidant enzymes). …”
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Orexitropic Signaling Proteins in Obese Children by Ljiljana Saranac, Bojko Bjelakovic, Hristina Stamenkovic, Borislav Kamenov

“…Adipose tissue is not only the main organ for energy storage, but it also has endocrine properties, producing “adipokines” responsible for energy homeostasis, insulin sensitivity, and inflammation. Leptin, produced by adipocytes, is the key hormone in appetite regulation and suppression of orexigenic, hypothalamic neuropeptide Y (NPY). …”
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Adaptation of the sulfophosphovanillin method of analysis of total lipids for various biological objects as exemplified by <i>Drosophila melanogaster</i> by M. A. Eremina, N. E. Gruntenko

“…To test the effectiveness of the modified method, we measured the content of total lipids in D. melanogaster females carrying hypomorphic mutations of the dilp6 and dfoxo insulin signaling pathway genes compared to the wild-type Canton-S line, and showed that dilp6 took part in the regulation of fat metabolism, while dfoxo did not. …”
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Characteristics of type 2 diabetes mellitus patients at Puskesmas Sanden: A cross sectional study by Sari Dina Fitria, Sukirto Novi Wijayanti, Arifin Zainul, Devi Noor Rahmawati Evita, Irmawan Rano, Yuniasih Dewi, Masduki Imam

“…Type 2 diabetes mellitus (T2DM) is a chronic disease characterized by insulin resistance and hyperglycemia. T2DM is a serious public health problem with increasing prevalence throughout the world. …”
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Metformin: A Potential Drug for COVID-19 by Anjali Devi Bettadapura Shankara Rao, Sujatha Puttalingaiah, Ananth B Koushik, Jadeppa Gowda

“…Though the main action of metformin is to inhibit hepatic gluconeogenesis, it is also known to increase insulin sensitivity and is used in the treatment of obesity and polycystic ovarian disease. …”
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Effects of dietary compound acidifier (Biomin) on the growth, anti-oxidation, immunity, and intestinal health of juvenile channel catfish (Ictalurus punctatus) by Junyu Yan, Kai Luo, Bo Wang, Jiaxin He, Can Li, Jiang Zhou, Wenhao Lai, Xin Zhou, Jingwei Ye, Mingzhu Pan, Yingbing Su, Weihua Gao, Kai Guo, Chengmin Zhao

“…The expression levels of gh (growth hormone), ghr (growth hormone receptor), igf-1 (insulin-like growth factors 1), igf-2, igfbp-1 (insulin-like growth factor-binding proteins-1), igfbp-2 and igfbp-3 in the liver of the 0.10 % group were significantly higher than the control and 0.08 % groups (P < 0.05). …”
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A Comparative Study of Health Efficacy Indicators in Subjects with T2DM Applying Power Cycling to 12 Weeks of Low-Volume High-Intensity Interval Training and Moderate-Intensity Con... by Jun Li, Wei Cheng, Haifeng Ma

“…Based on the blood index data of their medical examination results which comprised blood pressure, fasting blood glucose, hemoglobin A1c (HbA1c), and insulin, 37 volunteers were included in the study. …”
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Natural products targeting AMPK signaling pathway therapy, diabetes mellitus and its complications by Min Li, Lu Ding, Lu Ding, Liyan Cao, Zepeng Zhang, Xueyan Li, Zirui Li, Qinjing Xia, Kai Yin, Siyu Song, Zihan Wang, Haijian Du, Daqing Zhao, Xiangyan Li, Zeyu Wang, Zeyu Wang

“…This condition typically stems from either insufficient insulin secretion or a functional defect in the insulin itself. …”
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Paracrine role of endothelial IGF-1 receptor in depot-specific adipose tissue adaptation in male mice by Cheukyau Luk, Katherine I. Bridge, Nele Warmke, Katie J. Simmons, Michael Drozd, Amy Moran, Amanda D. V. MacCannell, Chew W. Cheng, Sam Straw, Jason L. Scragg, Jessica Smith, Claire H. Ozber, Chloe G. Wilkinson, Anna Skromna, Natallia Makava, Hiran A. Prag, T. Simon Futers, Oliver I. Brown, Alexander-Francisco Bruns, Andrew MN Walker, Nicole T. Watt, Romana Mughal, Kathryn J. Griffin, Nadira Y. Yuldasheva, Sunti Limumpornpetch, Hema Viswambharan, Piruthivi Sukumar, David J. Beech, Antonio Vidal-Puig, Klaus K. Witte, Michael P. Murphy, Richard C. Hartley, Stephen B. Wheatcroft, Richard M. Cubbon, Lee D. Roberts, Mark T. Kearney, Natalie J. Haywood

“…We explore the role of endothelial insulin-like growth factor-1 receptor (IGF-1R), as a paracrine modulator of white adipose phenotype. …”
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All-Cause Mortality Risk of Metabolically Healthy Obese Individuals in NHANES III by C. M. Durward, T. J. Hartman, S. M. Nickols-Richardson

“…Metabolic health was defined as: (1) homeostasis model assessment-insulin resistance (HOMA-IR) <2.5; (2) ≤2 Adult Treatment Panel (ATP) III metabolic syndrome criteria; (3) combined definition using ≤1 of the following: HOMA-IR ≥1.95 (or diabetes medications), triglycerides ≥1.7 mmol/L, HDL-C <1.04 mmol/L (males) or <1.30 mmol/L (females), LDL-C ≥2.6 mmol/L, and total cholesterol ≥5.2 mmol/L (or cholesterol-lowering medications). …”
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Impact of Diabetes on Cardiovascular Disease: An Update by Alessandra Saldanha de Mattos Matheus, Lucianne Righeti Monteiro Tannus, Roberta Arnoldi Cobas, Catia C. Sousa Palma, Carlos Antonio Negrato, Marilia de Brito Gomes

“…The purpose of this paper is to describe the association between poor glycemic control, oxidative stress, markers of insulin resistance, and of low-grade inflammation that have been suggested as putative factors linking diabetes and cardiovascular disease.…”
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Identification of Novel GCK and HNF4α Gene Variants in Japanese Pediatric Patients with Onset of Diabetes before 17 Years of Age by Rumi Katashima, Mari Matsumoto, Yuka Watanabe, Maki Moritani, Ichiro Yokota

“…We investigated 45 Japanese pediatric patients based on the following clinical criteria: development of diabetes before 17 years of age, a family history of diabetes, testing negative for glutamate decarboxylase-65 (GAD 65) antibodies and insulinoma-2-associated autoantibodies (IA-2A), no significant obesity, and evidence of endogenous insulin production. Genetic screening for MODY1 (HNF4α), MODY2 (GCK), MODY3 (HNF1α), and MODY5 (HNF1β) was performed by direct sequencing followed by multiplex ligation amplification assays. …”
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San-Huang-Yi-Shen Capsule Ameliorates Diabetic Kidney Disease through Inducing PINK1/Parkin-Mediated Mitophagy and Inhibiting the Activation of NLRP3 Signaling Pathway by Hanzhou Li, Yuansong Wang, Xiuhai Su, Qinghai Wang, Shufang Zhang, Wenjuan Sun, Tianyu Zhang, Mengxue Dong, Zhaiyi Zhang, Shuquan Lv

“…Our result showed that SHYS could alleviate DKD through reducing the body weight loss, decreasing the levels of fasting blood glucose (FBG), and improving the renal function, insulin resistance (IR), and inhibiting inflammatory response and oxidative stress in the kidney. …”
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Assessment of Tools for Marker-Assisted Selection in a Marine Commercial Species: Significant Association between MSTN-1 Gene Polymorphism and Growth Traits by Irma Sánchez-Ramos, Ismael Cross, Jaroslav Mácha, Gonzalo Martínez-Rodríguez, Vladimir Krylov, Laureana Rebordinos

“…Polymorphisms have been studied in five candidate genes influencing growth in gilthead seabream (Sparus aurata): the growth hormone (GH), insulin-like growth factor-1 (IGF-1), myostatin (MSTN-1), prolactin (PRL), and somatolactin (SL) genes. …”
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Tacrolimus Protects Podocytes from Apoptosis via Downregulation of TRPC6 in Diabetic Nephropathy by Ruixia Ma, Ying Wang, Yan Xu, Rui Wang, Xianghua Wang, Ning Yu, Minghui Li, Yan Zhou

“…After treatment with FK506, we measured 24-hour urinary albumin-to-creatinine ratios and creatinine clearance rates as well as major biochemical parameters such as glucose, insulin, serum creatinine, urea nitrogen, total cholesterol, triglycerides, alanine transaminase, and aspartate aminotransferase. …”
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Clinical benefits of central pancreatectomy for a patient with pancreatic schwannoma and diabetes by Long Cheng Zhao, Zi Ye Li, Fan Wu, Yue Hu, Bai Lin Wang

“…At the same time, the patient’s blood glucose remained basically stable by insulin therapy, which was adjusted to oral antidiabetic medications in about 40 days after surgery. …”
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Morphologic Features of Extrahepatic Manifestations of Hepatitis C Virus Infection by Huaibin M. Ko, Juan C. Hernandez-Prera, Hongfa Zhu, Steven H. Dikman, Harleen K. Sidhu, Stephen C. Ward, Swan N. Thung

“…Other HCV-associated entities include porphyria cutanea tarda, lichen planus, necrolytic acral erythema, membranous glomerulonephritis, diabetic nephropathy, B-cell non-Hodgkin lymphomas, insulin resistance, sialadenitis, sicca syndrome, and autoimmune thyroiditis. …”
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