Effect of genomic regions harboring putative lethal haplotypes on reproductive performance in closed experimental selection lines of Nellore cattle by Gustavo R. D. Rodrigues, Joslaine N. S. G. Cyrillo, Lúcio F. M. Mota, Patrícia I. Schmidt, Júlia P. S. Valente, Eduarda S. Oliveira, Lúcia G. Albuquerque, Luiz F. Brito, Maria E. Z. Mercadante

“…The gene networks were involved in metabolic pathways including ovarian steroidogenesis, oocyte meiosis, and insulin secretion. Matings between carrier dam and carrier sire led to a reduction of up to -203.46% in pregnancy success probability, an increase of 275.15% in probability of pregnancy loss, 295.03% for stillbirth occurrence, and 301.40% for pre-weaning mortality when compared to non-carrier dam and sire matings. …”
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Medroxyprogesterone Acetate Plus Metformin to Prevent Persistent Endometrial Hyperplasia by Vakkas Korkmaz, Enis Özkaya, Tuncay Küçüközkan, Fadıl Kara, Yasemin Çekmez, Hilal Korkmaz

“…Seventy two of these women were administered cylic oral medroxyprogesterone acetate 10 mg/day for 3 months, 62 of these women were also receiving metformin 1000 mg/day due to preexisting insulin resistance and and all subjects underwent control endometrial sampling after treatment. …”
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Options of dyslipidemia treatment at non-alcoholic fatty liver disease by M. V. Mayevskaya, M. A. Morozova

“…Results of several studies published at the moment demonstrate that at NAFLD lipid metabolism markers, and serum transaminase levels normalize, sensitivity to insulin increases, the liver histology pattern improves at phenofibrate treatment. …”
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Patient Preference for Once-Weekly Dosing in Type 2 Diabetes Mellitus in Japan by Rohini Sen, Alan L. Shields, Koichiro Atsuda

“…Patients with T2DM were categorized into one of the three groups: (1) patients on treatment with oral hypoglycemic agent(s) only, (2) patients on combination treatment with oral hypoglycemic agent(s) and insulin, and (3) patients diagnosed with or suspected to have T2DM with no current or past experience with T2DM drug treatment (treatment naïve). …”
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Effects of White Quinoa Polysaccharide on Regulation of Glucolipid Metabolism in Type 2 Diabetic Mice by Yanqing ZANG, Yingying CHUANG, Changyuan WANG, Yang CAO

“…Results showed that compared with diabetic mice, WQP intake could significantly inhibit the increase of body weight and FBG, improve OGTT, and alleviate insulin resistance in diabetic mice. At the same time, the total cholesterol (TC) content of diabetic mice decreased by 19%, and the low-density lipoprotein cholesterol (LDL-C) content decreased by 33%. …”
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Triglyceride glucose index as a biomarker for heart failure risk in H-type hypertension patients by Zhengwen Xu, Xisheng Yan, Dongsheng Li, Xiaodong Huang

“…The Triglyceride-Glucose (TyG) index, a surrogate for insulin resistance, may predict HF in this group, though its specific role requires clarification. …”
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Association between CAPN-10 gene variant and diabetes mellitus in Nigeria: a review by David Olufemi Adebo, Mathew Folaranmi Olaniyan, Christian Onosetale Ugege, Odekunle Bola Odegbemi

“…Abstract Background Type 2 Diabetes Mellitus (T2DM) is a significant global health concern characterised by insulin resistance and chronic hyperglycemia. Genetic factors, particularly variations in the CAPN-10 gene, have been implicated in T2DM susceptibility across diverse populations. …”
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Impact of Hospitalization on Continuation of SGLT2 Inhibitors and GLP-1 Receptor Agonists for Comorbidities in Patients with Type 2 Diabetes by Bethany Murphy, Simran Chahal, Elleigh Shepherd, Nicole Taylor, Austin Camp

“…Because guidelines typically recommend insulin for inpatient treatment of T2DM, there is potential these therapies may be negatively impacted by hospitalization. …”
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Efficacy and Safety of Bicyclol Treatment for Non-Alcoholic Fatty Liver Disease: Results of a Cohort Study by I. Yu. Pirogova, S. V. Yakovleva, T. V. Neuymina, S. P. Sinitsyn, V. S. Chulkov, T. N. Shamaeva

“…Bicyclol therapy in NAFLD is accompanied by positive dynamics of inflammation activity markers, insulin resistance and lipid spectrum, which suggests a positive dynamics of the stages of liver fibrosis and steatosis.…”
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Impact of COVID-19 on metabolic parameters in patients with type 2 diabetes mellitus by Motahare Shabestari, Forouzan Salari, Reyhaneh Azizi, Akram Ghadiri-Anari, Nasim Namiranian

“…Conclusion T2DM patients with mild to moderate COVID-19 infection exhibited improvements in TC, TG, BMI, and insulin-related indices. Lockdown restrictions were associated with decreased TC and LDL-C levels in T2DM patients without a history of COVID-19 infection.…”
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A Multivariate prediction model for amlodipine therapeutic efficacy in pediatric primary hypertension by Yao Lin, Hui Wang, Yaqi Li, Yang Liu, Yanyan Liu, Hongwei Zhang, Yanjun Deng, Lin Shi

“…After statistical adjustment, 4 variables were found to be independently associated with therapeutic efficacy, including hyperinsulinemia (OR = 3.000, 95% CI: 1.409-6.386, p  = 0.004), insulin resistance (OR = 2.354, 95% CI: 1.032-5.370, p = 0.042), the baseline plasma Endothelin-1 level (OR = 0.627, 95% CI: 0.532-0.740, p < 0.001) and amlodipine dosages (OR = 1.743, 95% CI: 1.400-2.169, p <0.001). …”
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Practical Aspects of Clinical Manifestations, Pathogenesis and Therapy of Alcoholic Liver Disease and Non-alcoholic Fatty Liver Disease: Expert Opinion by V. V. Tsukanov, M. F. Osipenko, E. V. Beloborodova, M. A. Livzan, I. B. Khlynov, S. A. Alekseenko, Yu. P. Sivolap, J. L. Tonkikh, A. V. Vasyutin

“…In the treatment of NAFLD, diet and lifestyle modification, weight loss, the use of insulin sensitizers, vitamin E, statins (in the presence of hyperlipidemia) and drugs with metabolic activity are effective.Currently, a point of view is being actively expressed about the synergism of the action of alcohol and the metabolic syndrome on the development of fibrosis, cirrhosis, and hepatocellular carcinoma. …”
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Glucagon-like peptide 1 receptor agonists in obesity treatment - a literature review by Aleksander Jentkiewicz, Esmail Haj Obeid, Jakub Ulrych, Jan Krupa, Maciej Malinowski, Michał Krasowski, Alicja Kalinowska, Wiktoria Pietras, Adrian Kozieł, Zofia Kurek

“…Gastric emptying and insulin secretion are also affected by GLP-1 RAs. …”
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We Are on the Verge of Breakthrough Cures for Type 1 Diabetes, but Who Are the 2 Million Americans Who Have It? by Rebecca Smith, Samara Eisenberg, Aaron Turner-Phifer, Jacqueline LeGrand, Sarah Pincus, Yousra Omer, Fei Wang, Bruce Pyenson

“…Innovative treatments have standardized insulin delivery and improved outcomes for patients, but patients’ access to such technologies depends on social determinants of health, including insurance coverage, proper diagnosis, and appropriate patient supports. …”
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Relationship of METS-IR with cardiometabolic multimorbidity in China: a nationwide longitudinal cohort study by Chunyan Zhou, Yanyu Zhang, Xiaoyi Liu, Chenyu He, Shiyang Li, Shiyang Li

“…This study aimed to explore the association between the metabolic score for insulin resistance (METS-IR) and the incidence of CMM.MethodsThis study included 6,977 individuals in the CHARLS database. …”
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GLP-1 Receptor Agonists’ Impact on Fertility - A Review by Joanna Wojda, Katarzyna Lesiczka-Fedoryj, Anna Walczak, Zuzanna Kościuszko, Adam Sobiński, Matylda Czerwonka, Katarzyna Kurza, Julianna Podolec, Silvia Ciraolo, Agnieszka Kulczycka-Rowicka

“…They manage glucose metabolism, appetite, as well as insulin secretion. Alongside their metabolic influence, research demonstrates that GLP-1 analogs may have an effect on the reproductive system, involving fertility via metabolic and hormonal pathways.     …”
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Protein tyrosine phosphatase delta is a STAT3-phosphatase and suppressor of metabolic liver disease by Thomas F Baumert, Charlotte Bach, Patrick Pessaux, Catherine Schuster, Frank Jühling, Sarah C Durand, Yujin Hoshida, Fabien Zoulim, Atish Mukherji, Naoto Fujiwara, Marine A Oudot, Armando Andres Roca Suarez, Michel L Tremblay, Barbara Testoni, Joachim Lupberger, Romain Parent, Laurent Mailly, Nassim Dali-Youcef, Emanuele Felli, Maria Saez-Palma, Julien Moehlin, Alessia Virzì, Nicolas Brignon, Eugenie Schaeffer, Romain Martin, Laura Meiss-Heydmann, Zakaria Boulahtouf, Lea Girard, Emma Osswald, Carole Jamey, Daniel Brumaru, Bhuvaneswari Koneru

“…During MASH, low PTPRD led to increased liver steatosis in Ptprd+/− mice and a pronounced unfolded protein response, which impacts insulin signalling. Accordingly, silencing of PTPRD blunted insulin-induced AKT phosphorylation. …”
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Triglyceride-glucose index is associated with microcirculatory resistance in patients with type 2 diabetes and STEMI undergoing primary PCI by Guoyu Wang, Cen Xu, Jian Wang, Zhimei Teng, Xiang Sha, Kai Xu, Ruzhu Wang, Li Zhu

“…Abstract The triglyceride-glucose (TyG) index is emerging as a promising marker for insulin resistance and serves as an independent risk predictor for cardiovascular outcomes. …”
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Development and validation of a risk prediction model for PICC-related venous thrombosis in patients with cancer: a prospective cohort study by Zeyin Hu, Mengna Luo, Ruoying He, Zhenming Wu, Yuying Fan, Jia Li

“…Four risk factors were identified as key predictors of PICC-RVT, including “diabetes requiring insulin (OR: 8.016; 95% CI 1.157–55.536), major surgery (within 1 month and operation time > 45 minutes) (OR: 0.023; 95% CI 1.296–30.77), reduced limb activities of the PICC arm (OR: 6.687; 95% CI 2.024–22.09)” and “catheter material (OR: 3.319; 95% CI 0.940–11.723)”. …”
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USP5 stabilizes YTHDF1 to control cancer immune surveillance through mTORC1-mediated phosphorylation by Na Shao, Lei Xi, Yangfan Lv, Muhammad Idris, Lin Zhang, Ya Cao, Jingyi Xiang, Xi Xu, Belinda X. Ong, Qiongyi Zhang, Xu Peng, Xiaoyan Yue, Feng Xu, Chungang Liu

“…Here, we report that USP5 interacts with YTHDF1, stabilizing it by removing K11-linked polyubiquitination. Insulin activates mTORC1, phosphorylating USP5 and promoting its dimerization, which binds to and protects YTHDF1 from degradation. …”
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