Partial rejuvenation of the spermatogonial stem cell niche after gender-affirming hormone therapy in trans women by Emily Delgouffe, Samuel Madureira Silva, Frédéric Chalmel, Wilfried Cools, Camille Raets, Kelly Tilleman, Guy T'Sjoen, Yoni Baert, Ellen Goossens

“…The Leydig cells also exhibited a distribution analogous to peripubertal tissue, accompanied by a reduced insulin-like factor 3 expression. Although most peritubular myoid cells expressed alpha-smooth muscle actin 2, the expression pattern was disturbed. …”
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Effect of different feeding regimes in amur common carp fingerlings: compensatory growth, physio-metabolic responses, and expression of IGF-1 gene by Chowdhury Arka, Ghosh Tapas Kumar, Khatua Sanjib, Hore Sayani, Kumari Palak, Kajal Kumari, Jana Prasanta

“…In the current study, elevated (P < 0.05) level of hepatic superoxide dismutase, catalase, glutathione peroxidase activity and Insulin like growth factor 1 and reduced (P < 0.05) blood glucose level, parallel to the degree of starvation was also evidenced. …”
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Insights from Dysregulated mRNA Expression Profile of β-Cells in Response to Proinflammatory Cytokines by Zhen Wang, Kunlin Huang, Jing Xu, Jia Liu, Ying Zheng

“…Chronic exposure of β-cells to proinflammatory cytokines is known to regulate the expression of many genes, subsequently resulting in the impairment of some signaling pathways involved with insulin production and secretion and/or β-cell apoptosis. …”
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Association between Mediterranean diet and metabolic health status among adults was not mediated through serum adropin levels by Maryam Shafiei, Donya Poursalehi, Sobhan Mohammadi, Farnaz Shahdadian, Zahra Hajhashemy, Parisa Rouhani, Elahe Mokhtari, Parvane Saneei

“…Fasting blood samples were drawn to measure serum adropin concentrations, blood glucose, triglycerides, high-density lipoprotein cholesterol, high sensitive C-reactive protein and insulin. Metabolic unhealthy (MU) status was defined as having ≥ 2 cardio-metabolic risk factors. …”
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Synthesis and Evaluation of Optical and PET GLP-1 Peptide Analogues for GLP-1R Imaging by Babak Behnam Azad, Vanessa Rota, Lihai Yu, Rebecca Mcgirr, André H. St. Amant, Ting-Yim Lee, Savita Dhanvantari, Leonard G. Luyt PhD

“…The optical GLP-1 probe strongly colocalized with immunofluorescence for insulin and glucagon, and more weakly with amylase (exocrine pancreas) and cytokeratin 19 (ductal cells), confirming its application for in situ GLP-1R imaging in various pancreatic cell types. …”
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Effects of switching from MiniMed™ 640G to 770G on continuous glucose monitoring metrics and DTR‐QOL scores: An observational study of Japanese people with type 1 diabetes mellitus... by Toshiki Kogai, Junko Sato, Haruna Yasuda, Tatsuhiro Ayame, Azusa Ozaki, Eri Takagi, Mami Koshibu, Yuya Nishida, Fuki Ikeda, Hirotaka Watada

“…ABSTRACT Aims/Introduction We evaluated the effect of the MiniMed™ 770G, an insulin pump using hybrid closed‐loop technology, on blood glucose management and quality of life in Japanese people with type 1 diabetes. …”
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Triglyceride-glucose index is associated with microcirculatory resistance in patients with type 2 diabetes and STEMI undergoing primary PCI by Guoyu Wang, Cen Xu, Jian Wang, Zhimei Teng, Xiang Sha, Kai Xu, Ruzhu Wang, Li Zhu

“…Abstract The triglyceride-glucose (TyG) index is emerging as a promising marker for insulin resistance and serves as an independent risk predictor for cardiovascular outcomes. …”
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Development and validation of a risk prediction model for PICC-related venous thrombosis in patients with cancer: a prospective cohort study by Zeyin Hu, Mengna Luo, Ruoying He, Zhenming Wu, Yuying Fan, Jia Li

“…Four risk factors were identified as key predictors of PICC-RVT, including “diabetes requiring insulin (OR: 8.016; 95% CI 1.157–55.536), major surgery (within 1 month and operation time > 45 minutes) (OR: 0.023; 95% CI 1.296–30.77), reduced limb activities of the PICC arm (OR: 6.687; 95% CI 2.024–22.09)” and “catheter material (OR: 3.319; 95% CI 0.940–11.723)”. …”
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Unveiling nature’s antidiabetic potential in Berberis orthobotrys seeds for alloxan-induced diabetic rats by Ali Imran Abid, Hira Muzammel, Mohsin Javed, Muhammad Muntazir Iqbal, Sajid Mahmood, Ammar Zidan, Fadi Jaber, K. K. Mujeeb Rahman, Ali Bahadur, Shahid Iqbal, Muhammad Saad, Ayed A. Dera, Yousif A. Asiri, Abd-ElAziem Farouk, Salman Aloufi

“…The primary metabolite Berberine, which was qualitatively detected by GC-MS in blood and urine samples of rats, may be the alkaloid in command of insulin release or recovery of beta cells after alloxan destruction. …”
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First Report on Association of Hyperuricemia with Type 2 Diabetes in a Vietnamese Population by Tran Quang Binh, Pham Tran Phuong, Nguyen Thanh Chung, Bui Thi Nhung, Do Dinh Tung, Tran Quang Thuyen, Duong Tuan Linh, Bui Thi Thuy Nga, Nguyen Anh Ngoc, Le Danh Tuyen

“…Uric acid is a powerful free-radical scavenger in humans, but hyperuricemia may induce insulin resistance and beta-cell dysfunction. The study aimed to evaluate the association between hyperuricemia and hyperglycemia, considering the confounding factors in a Vietnamese population. …”
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Preventive Effect of Salicylate and Pyridoxamine on Diabetic Nephropathy by Tarek Kamal Abouzed, Seiichi Munesue, Ai Harashima, Yusuke Masuo, Yukio Kato, Khaled Khailo, Hiroshi Yamamoto, Yasuhiko Yamamoto

“…Treatment with long-acting insulin (Levemir 2 units/kg twice a day) was used as a control. …”
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Nutrient status alters developmental fates via a switch in mitochondrial homeodynamics by Jie Zhang, Suning Liu, Yang Li, Guanfeng Xu, Huimin Deng, Kirst King-Jones, Sheng Li

“…Pre-NRC starvation reduces prothoracicotropic neuropeptide hormone signaling, insulin signaling, and TORC1 activity in PG cells, which prevent mitochondrial fragmentation and import of Disembodied, a key steroidogenic enzyme. …”
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3β-Hydroxysteroid-Δ24 Reductase (DHCR24) Protects Pancreatic β Cells from Endoplasmic Reticulum Stress-Induced Apoptosis by Scavenging Excessive Intracellular Reactive Oxygen Speci... by Yang Li, Xude Wang, Baoyu Yang, Haozhen Wang, Zhenzhong Ma, Ziyin Lu, Xiuli Lu, Bing Gao

“…There is accumulating evidence showing that apoptosis induced by endoplasmic reticulum (ER) stress plays a key role in pancreatic β cell dysfunction and insulin resistance. 3β-Hydroxysteroid-Δ24 Reductase (DHCR24) is a multifunctional enzyme located in the endoplasmic reticulum (ER), which has been previously shown to protect neuronal cells from ER stress-induced apoptosis. …”
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Small spheroids for head and neck cartilage tissue engineering by Sven Reutter, Johann Kern, Yvonne Jakob, Nicole Rotter, David Gvaramia

“…Furthermore, we evaluated the influence of key chondrogenic cytokines, such as transforming growth factor (TGF)-β, connective tissue growth factor (CTGF), and insulin-like growth factor (IGF)-1, on spheroid morphology and the production of cartilage extracellular matrix (ECM) components. …”
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Ability of Different Measures of Adiposity to Identify High Metabolic Risk in Adolescents by Carla Moreira, Rute Santos, Susana Vale, Paula C. Santos, Sandra Abreu, Ana I. Marques, Luísa Soares-Miranda, Jorge Mota

“…We measured fasting glucose, insulin, total cholesterol (TC), HDL-cholesterol, triglycerides, and systolic blood pressure. …”
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Positive Expression of IGFBP2 as a Novel Prognostic Biomarker for Patients with Lower-Grade Gliomas by Yanguo Li, Jiawei Fan, Zhuo Shen, Jun Zhang, Xuemei Yin, Fang Han, Wenfei Li

“…Background: Previous studies have identified insulin-like growth factor-binding protein 2 (IGFBP2) as a target gene associated with the prognosis of various malignant cancers. …”
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Improved Diet Quality in Elite and Entry-Level Military Women Compared With Civilian-Matched Counterparts by Tyler E Oliver, Soothesuk Kusumpa, Laura J Lutz, James P McClung, Holly L McClung

“…Biomarkers associated with cardiometabolic disease risk (lipid profile, glucose, and insulin) improved in FEW and BCT compared with that in NHANES groups. …”
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Impact of triglyceride-glucose index on risk of cardiovascular disease among non-diabetic hypertension patients: a 10-year prospective cohort study by Xin Chen, Jinyou Yang, Dan Wang, Jiali Liu, Hang Jin, Yongqing Zhang, Quanyong Xiang

“…Abstract Background Triglyceride-glucose (TyG) index was regarded as a cost-efficient and reliable clinical surrogate marker for insulin resistance (IR), which was significantly correlated with cardiovascular disease (CVD). …”
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MicroRNA-28-5p Regulates Liver Cancer Stem Cell Expansion via IGF-1 Pathway by Qing Xia, Tao Han, Pinghua Yang, Ruoyu Wang, Hengyu Li, Jin Zhang, Xinfeng Zhou

“…Mechanistically, we found that insulin-like growth factor-1 (IGF-1) was a direct target of miR-28-5p in liver CSCs, and the effects of miR-28-5p on liver CSC’s self-renewal and tumorigenesis were dependent on IGF-1. …”
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Gut microbiota remodeling drived by dietary millet protein prevents the metabolic syndrome by Shuhua Shan, Ruopeng Yin, Jiangying Shi, Lizhen Zhang, Jiaqi Zhou, Qinqin Qiao, Xiushan Dong, Wenjing Zhao, Zhuoyu Li

“…The obesity, chronic inflammation, insulin resistance in MetS mouse models were abolished after EMBP treatment. …”
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