Investigation of the Protective Effects of Dexmedetomidine, Midazolam, Propofol, and Intralipid on Oxidative Stress and Inflammation in Rats with Lidocaine-Induced Toxicity by Kucun MK, Guler EM, Saracoglu A, Yildirim M, Demirtas C, Serdogan F, Beyaztas H, Aktas S, Kacan M, Gaszynski T, Ratajczyk P, Saracoglu KT

“…Mustafa Kemal Kucun,1 Eray Metin Guler,2,3 Ayten Saracoglu,4 Mehmet Yildirim,5 Cumaali Demirtas,5 Ferda Serdogan,6 Hakan Beyaztas,2,7 Selman Aktas,8 Merve Kacan,9 Tomasz Gaszynski,10 Pawel Ratajczyk,10 Kemal Tolga Saracoglu11 1Department of Anesthesiology and Intensive Care, Bartin State Hospital, Bartin, Turkey; 2Department of Medical Biochemistry, Hamidiye Faculty of Medicine, University of Health Sciences Turkey, Istanbul, Türkiye; 3Department of Medical Biochemistry, Hamidiye Institute of Health Sciences, University of Health Sciences Turkey, Istanbul, Türkiye; 4Department of Anesthesiology, ICU & Perioperative Medicine Aisha Bint Hamad Al Attiyah Hospital HMC, Doha, Qatar; 5Department of Physiology, Hamidiye Faculty of Medicine, University of Health Sciences, Istanbul, Turkey; 6Department of Anesthesiology and Intensive Care, Turhal State Hospital, Tokat, Turkey; 7Department of Medical Biochemistry, HaydarpasaNumune Health Application and Research Center, University of Health Sciences Turkey, Istanbul, Türkiye; 8University of Health Sciences, Hamidiye Faculty of Medicine, Department of Biostatistics and Medical Informatics, Istanbul, Turkey; 9Department of Anesthesiology and Intensive Care, Kocaeli City Hospital, Kocaeli, Turkey; 10Department of Anesthesiology and Intensive Therapy, Medical University of Lodz, Lodz, Poland; 11Department of Anesthesiology, ICU & Perioperative Medicine Hazm Mebaireek General Hospital HMC, Industrial Area Ar-Rayyan, Doha, QatarCorrespondence: Mustafa Kemal Kucun, Department of Anesthesiology and Intensive Care, Bartın State Hospital, Bartın, Turkey, Email mustafakemalkucun@hotmail.comAim: The aim of this study was to compare the effects of dexmedetomidine, midazolam, propofol, and intralipid on lidocaine-induced cardiotoxicity and neurotoxicity.Methods: Forty-eight male Sprague-Dawley rats were randomly divided into six groups (n = 8 per group): control (C), lidocaine (L), lidocaine + dexmedetomidine (LD), lidocaine + midazolam (LM), lidocaine + propofol (LP), and lidocaine + intralipid (LI). …”
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Whole genome sequencing in early onset advanced heart failure by Erik Linnér, Tomasz Czuba, Olof Gidlöf, Jakob Lundgren, Entela Bollano, Maria Hellberg, Selvi Celik, Neha Pimpalwar, Philipp Rentzsch, Molly Martorella, Anders Gummesson, Olle Melander, Sebastian Albinsson, Göran Dellgren, Jan Borén, Anders Jeppsson, R. Thomas Lumbers, Sonia Shah, Johan Nilsson, Pradeep Natarajan, Tuuli Lappalainen, Malin Levin, Hans Ehrencrona, J. Gustav Smith

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AI-based analysis of fetal growth restriction in a prospective obstetric cohort quantifies compound risks for perinatal morbidity and mortality and identifies previously unrecogniz... by Raquel M. Zimmerman, Edgar J. Hernandez, Mark Yandell, Martin Tristani-Firouzi, Robert M. Silver, William Grobman, David Haas, George Saade, Jonathan Steller, Nathan R. Blue

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Influence of spouting period on microbiological and nutritional attribute of sesame seed flour by Joseph Oghenewogaga Owheruo, Patrick Othuke Akpoghelie, Great Iruoghene Edo, Emad Yousif, Agatha Ngukuran Jikah, Priscillia Nkem Onyibe, Ufuoma Ugbune, Endurance Fegor Isoje, Ufuoma Augustina Igbuku, Helen Avuokerie Ekokotu, Ephraim Evi Alex Oghroro, Joel Okpoghono, Arthur Efeoghene Athan Essaghah, Joy Johnson Agbo

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Aspergillus fumigatus Influences Gasdermin-D-Dependent Pyroptosis of the Lung via Regulating Toll-Like Receptor 2-Mediated Regulatory T Cell Differentiation by Wei Yan, Yi-si Zhao, Ke Xie, Yu Xing, Fang Xu

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Biological arrow of time: emergence of tangled information hierarchies and self-modelling dynamics by Mikhail Prokopenko, Paul C W Davies, Michael Harré, Marcus G Heisler, Zdenka Kuncic, Geraint F Lewis, Ori Livson, Joseph T Lizier, Fernando E Rosas

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Effect of glucagon-like peptide-1 receptor agonists on vascular risk factors among adults with type 2 diabetes and established atherosclerotic cardiovascular disease by Aaron King, Xi Tan, Neil Dhopeshwarkar, Rhonda Bohn, Katherine Dea, Charles E. Leonard, Adam de Havenon

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Systematic multiomics analysis and in vitro experiments suggest that ITGA5 could serve as a promising therapeutic target for ccRCC by Xiangxian Che, Xi Tian, Zhenda Wang, Shuxuan Zhu, Shiqi Ye, Yue Wang, Yihan Chen, Yiyun Huang, Aihetaimujiang Anwaier, Peifeng Yao, Yijia Chen, Keting Wu, Yifei Liu, Wenhao Xu, Hailiang Zhang, Dingwei Ye

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Etoposide targets 2A protease to inhibit enterovirus 71 replication by Qinqin Liang, Sai Shi, Qingjie Zhang, Yaxin Wang, Sheng Ye, Binghong Xu

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Fermented sugarcane juice-derived probiotic Levilactobacillus brevis RAMULAB54 enhances lipid metabolism and glucose homeostasis through PPAR-γ activation by V. B. Chandana Kumari, Ramith Ramu, Sujay S. Huligere, Shashank M. Patil, Shivasharanappa Nayakvadi, Sharath Bijoor, Uma Venkateswaran Manjappara, Mohammad Z. Ahmed, Ling Shing Wong

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Neurological history both twinned and queried by generative artificial intelligence by Jung-Hyun Lee, Jung-Hyun Lee, Jung-Hyun Lee, Eunhee Choi, Sergio L. Angulo, Sergio L. Angulo, Robert A. McDougal, Robert A. McDougal, Robert A. McDougal, Robert A. McDougal, William W. Lytton, William W. Lytton, William W. Lytton

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Pengembangan Aplikasi E-Learning Edu IT : Pembuatan Aplikasi Ujian Essay Online serta Upload Download Materi Kuliah by Maria Bellaniar Ismiati, Latius Hermawan

“…This research will temporarily be tested to information and informatics systems students. The creation of this application can help the conventional process to evolve using technology and in real time. …”
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Immunogenetics of longevity and its association with human endogenous retrovirus K by Lisa M. James, Lisa M. James, Lisa M. James, Apostolos P. Georgopoulos, Apostolos P. Georgopoulos, Apostolos P. Georgopoulos, Apostolos P. Georgopoulos

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Personalised Lung Cancer Screening (PLuS) study to assess the importance of coexisting chronic conditions to clinical practice and policy: protocol for a multicentre observational... by Yi Guo, Dongyu Zhang, Rafael Meza, Jihyoun Jeon, Dejana Braithwaite, Gerard A Silvestri, Michael K Gould, Jiang Bian, Bruno Hochhegger, Shama D Karanth, Christopher G Slatore, Martin Tammemagi, Mattthew Schabath, Meghann Wheeler, Frederic J Kaye

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Anticancer Peptides Classification Using Long-Short-Term Memory With Novel Feature Representation by Nazer Al Tahifah, Muhammad Sohail Ibrahim, Erum Rehman, Naveed Ahmed, Abdul Wahab, Shujaat Khan

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Prediction of Distant Metastasis of Renal Cell Carcinoma Based on Interpretable Machine Learning: A Multicenter Retrospective Study by Dong J, Duan M, Liu X, Li H, Zhang Y, Zhang T, Fu C, Yu J, Hu W, Peng S

“…Jinkai Dong,1,* Minjie Duan,2,3,* Xiaozhu Liu,4,* Huan Li,5 Yang Zhang,6 Tingting Zhang,7 Chengwei Fu,1 Jie Yu,8 Weike Hu,9 Shengxian Peng9,* 1Senior Department of Urology, the Third Medical Center of PLA General Hospital, Beijing, People’s Republic of China; 2Medical School of Chinese PLA, Beijing, People’s Republic of China; 3Medical Innovation Research Department, Chinese PLA General Hospital, Beijing, People’s Republic of China; 4Emergency and Critical Care Medical Center, Beijing Shijitan Hospital, Capital Medical University, Beijing, People’s Republic of China; 5Chongqing College of Electronic Engineering, Chongqing, People’s Republic of China; 6College of Medical Informatics, Chongqing Medical University, Chongqing, People’s Republic of China; 7Department of Endocrinology, Fifth Medical Center of Chinese PLA Hospital, Beijing, People’s Republic of China; 8Department of Medical Imaging, The Affiliated Taian City Central Hospital of Qingdao University, Taian, People’s Republic of China; 9Scientific Research Department, First People’s Hospital of Zigong City, Zigong, People’s Republic of China*These authors contributed equally to this workCorrespondence: Shengxian Peng, Scientific Research Department, First People’s Hospital of Zigong City, No. 42, 1st Street, Shangyihao, ZiLiuJing District, ZiGong, SiChuan, 643000, People’s Republic of China, Email 13258280319@163.comBackground: : The traditional tool for predicting distant metastasis in renal cell carcinoma (RCC) is still insufficient. …”
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THE APPLICATION OF IOT (INTERNET OF THINGS) FOR SMART HOUSING ENVIRONMENTS AND INTEGRATED ECOSYSTEMS by Andi Hildayanti, M Sya'Rani Machrizzandi

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OUTPOST: A comprehensive analysis software for whole‐metagenome shotgun sequencing incorporating group stratification by Yihang Zhou, Jihong Zheng, Wenqi Song, Xinyi Yan, Li Du, Zhonglin Ma, Yanbin Fu, Zhaohui Ouyang, Yuchen Xiao, Zhuoqun Liu, Feng Tian, Jason Wing Hon Wong, Jen Hao David Shih, Shikang Liang, Honglei Tian, Liu Liu, Ke Wei, Chao Zhang, Jiangtao Li, Xiaozhu Wang

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Preventable hospitalizations through ED: does the number of hospital beds matter under the global budget in a single-payer system in Taiwan? by Hsueh-Fen Chen, Hsueh-Fen Chen, Hsueh-Fen Chen, Hui-Min Hsieh, Hui-Min Hsieh, Hui-Min Hsieh, Wei-Shan Chang

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COVID-19 pandemic and vaccination rate in patients with psoriasis treated with biologics: A single center experience by Milčić Danijela, Malinić Marija, Ćirković Anđa, Krupniković Doroteja, Milinković-Srećković Mirjana

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