Apical periodontitis in inflammatory bowel disease: a meta-analysis at patient and tooth level by Giusy Rita Maria La Rosa, Alejandro Ismael Lorenzo-Pouso, Vito Carlo Alberto Caponio, Mariangela Valentina Puci, Mariangela Valentina Puci

“…Apical periodontitis (AP) is the local inflammation of periapical tissues originating from the dental pulp disease. …”
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Regulation of senescence-associated secretory phenotypes in osteoarthritis by cytosolic UDP-GlcNAc retention and O-GlcNAcylation by Donghyun Kang, Jeeyeon Lee, Geunho Yook, Sehan Jeong, Jungkwon Shin, Mi-Sung Kim, Yi-Jun Kim, Hyeryeon Jung, Jinsung Ahn, Tae Woo Kim, Moon Jong Chang, Chong Bum Chang, Seung-Baik Kang, Won Ho Yang, Yong-ho Lee, Jin Won Cho, Eugene C. Yi, Chanhee Kang, Jin-Hong Kim

“…Our findings elucidate the role of UDP-GlcNAc compartmentalization in regulating secretory pathways associated with chronic joint inflammation, providing a senostatic strategy for the treatment of OA.…”
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A truncated pre-F protein mRNA vaccine elicits an enhanced immune response and protection against respiratory syncytial virus by Min Lin, Yifan Yin, Xiaomeng Zhao, Chen Wang, Xueqing Zhu, Letao Zhan, Li Chen, Siling Wang, Xue Lin, Jun Zhang, Ningshao Xia, Zizheng Zheng

“…Importantly, when administered to pregnant female cotton rats, LC2DM-LNP ensured the transfer of pre-F-specific antibodies to the offspring and provided protection against RSV without increasing lung inflammation. Our findings suggest that LC2DM-LNP could serve as an alternative RSV vaccine candidate for high-risk groups.…”
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Comparative Efficacy of NAFLD Therapies and Biomarker Associations: A Meta-Analysis Based on Liver Fat Content by Haoxiang Zhu, Ling Xu, Yinhua Lv, Juan Yang, Jihan Huang, Qingshan Zheng, Guang Ji, Lujin Li

“…Drugs such as fibroblast growth factor agonists, and those targeting adipocytes, inflammation, or fibrosis, showed greater efficacy in reducing LFC compared to Resmetirom, which has an efficacy of reducing LFC by 5.2%. …”
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Lethal necrotizing granulomatous vasculitis after bariatric surgery and bilateral mammaplasty by O. V. Blagova, D. Kh. Aynetdinova, A. V. Nedostup, N. A. Novikova, Ye. A. Kogan, Yu. V. Lerner, L. V. Kozlovskaya, V. V. Rameyev, N. A. Mukhin

“…Autopsy revealed the signs of vasculitis with involvement of the brain, skin, mediastinal lymphnodes, lungs, as well as the signs of chronic inflammation, atrophy of breast gland lobules, embolization of the focal lymphatics by the implant substance, ulceronecrotic enteritis of defunctioning bowel, severe liver steatosis with the chronic vitamin deficiency. …”
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Wound-healing activity of solvent fractions and antiinflammatory activity of crude extract and solvent fractions of Acokanthera schimperi Schweinf (Apocynaceae) leaves in mice mode... by Workineh Woldeselassie Hammeso, Tesfaye Yimer, Getnet Tadege, Wakuma Wakene Jifar, Dejen Nureye

“…The extract (hydromethanolic) and solvent fractions also showed notable dose-related decreases in inflammation. Conclusion: The study's findings supported A. schimperi's traditional use as a wound healing agent by showing that the solvent fractions of the plant's leaves promoted wound healing, at least in part, through their anti-inflammatory effect.…”
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Bergapten alleviates senescence of chondrocytes in osteoarthritis by YE Yuanlan, LIU Kaiwen, PAN Yiming

“…After the cells were treated with 0~50 μmol/L bergapten for 24, 48 or 72 h, CCK-8 assay, RT-qPCR and immunofluorescence assay were used to detect the proliferation and apoptosis, and the expression of the molecules related to proliferation, inflammation and senescence (senescence associated secretory phenotype, SASP). …”
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The Effect of Rosuvastatin on a murine model of deep vein thrombosis by Megan E. Barney, Shenghao Zhou, Anh Le-Cook, Naly Setthavongsack, Gabriel Nager, Jennifer M. Loftis, Randy L. Woltjer, Monica Hinds, Khanh P. Nguyen

“…We hypothesize that statins may reduce the inflammation that may be associated with the development of post thrombotic syndrome (PTS). …”
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Enhanced penetration and biofilm eradication by sophorolipid micelles encapsulating Honokiol: a comprehensive solution for biofilm-associated lung infections by Shiyu Lin, Xiaojuan Li, Wei Zhang, Gang Shu, Tim Tolker-Nielsen, Haohuan Li, Funeng Xu, Juchun Lin, Guangneng Peng, Li Zhang, Hualin Fu

“…Biofilm infections are as predominant in acute pneumonia as in chronic cases, inducing similar lung inflammation. In a murine model of pneumonia infected by S. aureus, HK-SL Ms significantly reduced the bacterial load in the lungs, decreased inflammatory factor levels, and repaired lung tissue damage. …”
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Reshaping lipid metabolism with long-term alternate day feeding in type 2 diabetes mice by Eleni Beli, Yuanqing Yan, Leni Moldovan, Todd A. Lydic, Preethi Krishman, Sarah A. Tersey, Yaqian Duan, Tatiana E. Salazar, James M. Dominguez, Dung V. Nguyen, Abigail Cox, Sergio Li Calzi, Craig Beam, Raghavendra G. Mirmira, Carmella Evans-Molina, Julia V. Busik, Maria B. Grant

“…We demonstrated using lipidomic, microbiome, metabolomic and liver transcriptomic studies that chronic IF improved carbohydrate utilization and glucose homeostasis without weight loss and reduced white adipose tissue inflammation and significantly impacted lipid metabolism in the liver. …”
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Association between Air Pollution and Risk of Hospital Admission for Pediatric Pneumonia in a Tropical City, Kaohsiung, Taiwan by Peng-Huei Liu, Kuo-Chen Huang, Yu-Lun Tseng, I-Min Chiu, Hsiu-Yung Pan, Fu-Jen Cheng

“…Abstract Recent evidences have shown that particulate matter (PM) and other air pollutants are associated with pulmonary and systemic inflammation; however, the relationship between air pollutants and the risk of admission for pediatric pneumonia has not been well surveyed. …”
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Abnormal Expression of Peripheral Blood Leukocyte Surface Markers in Retinopathy of Prematurity Patients by Guo R, Cheng F, Meng XJ, Fan JM, Lu YL, Ma XH, Qiao X, Li JH

“…Elevated CD81 and Th17 levels suggest inflammation linked to neutrophils and lymphocytes.Keywords: flow cytometry, inflammatory response, lymphocytes, neutrophils, retinopathy of prematurity…”
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Lactobacillus fermentum B153 from human colostrum modulates intestinal immunity and gut microbiota in obese mice model by Juqing Huang, Xiaohui Cai, Xiaoyan Liu, Gongti Lai, Xuefang Guan, Bingyan Chen, Qi Wang

“…The results indicate that treatment with L. fermentum B153 significantly decreased the perirenal adipose index and increased the villus height to crypt depth (V/C) ratio in both the ileum and jejunum of obese mice. Intestinal inflammation induced by the high-fat diet was alleviated by L. fermentum B153, as evidenced by the upregulation of E-cadherin and IL-6 mRNA expression, alongside the downregulation of TNF-α mRNA expression. …”
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Mechanism of podophyllotoxin-induced ovarian toxicity via the AMPK/TSC1/mTOR/ULK1 axis in rats on the basis of toxicological evidence chain (TEC) concept by Jingjing Li, Yanzhao Zhang, Mingyue Wei, Junjie He, Huifeng Ma, Zilong Chen, Jiajia Duan, Chuanxin Liu

“…The pathological results suggested that the rat ovaries were significantly damaged, and the histological results revealed Th17 cell differentiation, necroptosis, Hspa9 expression, and other pathways or targets related to inflammation, necroptosis/apoptosis or autophagy. Conclusion: Podophyllotoxin exerts toxic effects by altering autophagy through the AMPK/TSC1/mTOR/ULK1 signalling pathway. …”
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Investigating the Use of Generative Adversarial Networks-Based Deep Learning for Reducing Motion Artifacts in Cardiac Magnetic Resonance by Ma ZP, Zhu YM, Zhang XD, Zhao YX, Zheng W, Yuan SR, Li GY, Zhang TL

“…Ze-Peng Ma,1,2,* Yue-Ming Zhu,3,* Xiao-Dan Zhang,4 Yong-Xia Zhao,1 Wei Zheng,3 Shuang-Rui Yuan,1 Gao-Yang Li,1 Tian-Le Zhang1 1Department of Radiology, Affiliated Hospital of Hebei University/ Clinical Medical College, Hebei University, Baoding, 071000, People’s Republic of China; 2Hebei Key Laboratory of Precise Imaging of inflammation Tumors, Baoding, Hebei Province, 071000, People’s Republic of China; 3College of Electronic and Information Engineering, Hebei University, Baoding, Hebei Province, 071002, People’s Republic of China; 4Department of Ultrasound, Affiliated Hospital of Hebei University, Baoding, Hebei Province, 071000, People’s Republic of China*These authors contributed equally to this workCorrespondence: Xiao-Dan Zhang, Department of Ultrasound, Affiliated Hospital of Hebei University, No. 212 of Yuhua East Road, Lianchi District, Baoding, 071000, People’s Republic of China, Tel +86 17325535302, Email xiaodanzhangzxd@126.comObjective: To evaluate the effectiveness of deep learning technology based on generative adversarial networks (GANs) in reducing motion artifacts in cardiac magnetic resonance (CMR) cine sequences.Methods: The training and testing datasets consisted of 2000 and 200 pairs of clear and blurry images, respectively, acquired through simulated motion artifacts in CMR cine sequences. …”
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Effect of periodontal therapy on endothelial function and serum biomarkers in patients with periodontitis and established cardiovascular disease: a pilot study by Ana Molina, Nagore Ambrosio, María Molina, Eduardo Montero, Leire Virto, David Herrera, Elena Figuero, Mariano Sanz

“…Endothelial function (flow-mediated dilation [FMD]) and carotid intima-media thickness (cIMT) at baseline, 3 and 6 months, and serum markers of inflammation and cell adhesion at 3 days, 10 days, 3 and 6 months after therapy, were evaluated. …”
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Ginseng-derived Nanoparticles Inhibit Lung Cancer Cell Growth by Promoting Macrophage M1 Polarization by Liangliang FAN, Limei REN, Song YANG, Wenjing LI, Yueming ZHAO, Ronghua ZHAO, Daqing ZHAO, Jiawen WANG

“…Simultaneously, GDNPs-CM promoted the expression levels of inflammation-related proteins, such as TLR4, MyD88, NF-κB, iNOS, and COX-2 in A549 cells (P<0.05, P<0.01). …”
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Clinicopathological relationship between PM2.5 exposure and acute exacerbations of chronic obstructive pulmonary disease by Anfeng Cui, Yingying Shao, Yang Wang, Haodong Wang, Jiayi Song, Caiji Liu, Ningning Shen, Zhiqing Yang, Wangliang Zhang, Tiane Luo, Chen Wang

“…Conclusion: Elevated PM2.5 exposure significantly increases the risk of AECOPD, linked to heightened inflammation, pulmonary fibrosis, and diminished pulmonary function, and the majority of these patients are over 60 years old or are smokers. …”
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Development of delayed pulmonary toxicities and transcriptional changes in pre-existing interstitial lung disease mice after partial thoracic irradiation by Jiamei Fu, Xinglong Liu, Yuchuan Zhou, Shengnan Zhao, Liang Zeng, Yan Pan, Jianghong Zhang, Kevin M. Prise, Chunlin Shao, Yaping Xu

“…DAD with progressive inflammation and fibrosis in bilateral lungs contributed to severe or even fatal complications after partial thoracic irradiation. …”
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uN2CpolyG-mediated p65 nuclear sequestration suppresses the NF-κB-NLRP3 pathway in neuronal intranuclear inclusion disease by Yu Shen, Kaiyan Jiang, Dandan Tan, Min Zhu, Yusen Qiu, Pencheng Huang, Wenquan Zou, Jianwen Deng, Zhaoxia Wang, Ying Xiong, Daojun Hong

“…Emerging clinical evidence suggests that inflammation contributes to NIID pathogenesis, yet the underlying molecular mechanisms remain elusive. …”
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