Beta-Thalassemia Major and Female Fertility: The Role of Iron and Iron-Induced Oxidative Stress by Paraskevi Roussou, Nikolaos J. Tsagarakis, Dimitrios Kountouras, Sarantis Livadas, Evanthia Diamanti-Kandarakis

“…Thus, although spontaneous fertility can occur, the majority of females with BTM is infertile due to hypogonadotropic hypogonadism (HH) and need assisted reproductive techniques. …”
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The Unforeseen Diagnosis: Hyperparathyroidism-Jaw Tumour Syndrome Case Report and Review of the Literature by Maxim Barnett, Farhan Ahmed, Radu Mihai, Asha Rattan, Malik Asif Humayun

“…This disorder is characterised by multiple pleiotropic phenomena, including recurrent primary hyperparathyroidism (and the effects of hypercalcaemia), neoplasms (such as uterine, renal, mandibular, and maxillary), and infertility. A patient not conforming to the classic candidacy for primary hyperparathyroidism requires consideration for a familial cause. …”
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A Retrospective Descriptive Study on Caesarean Isthmocele: A Delayed and Under-recognised Complication of Caesarean Section by Maneesha Shrivastava, Varuna Pathak, Sushruta Shrivastava

“…Out of 43 patients, eight presented with Abnormal Uterine Bleeding (AUB), three had secondary infertility, and 32 presented with Caesarean Scar Ectopic Pregnancy (CSEP) and its complications. …”
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Vaginal bleeding during pregnancy: a retrospective cohort study assessing maternal and perinatal outcomes by Maroun Matar, Georges Yared, Christopher Massaad, Kariman Ghazal

“…However, a history of infertility and progesterone treatment during pregnancy was significantly associated with bleeding episodes. …”
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Psycho-emotional stress, folliculogenesis, and reproductive technologies: clinical and experimental data by A. L. Levinson, T. N. Igonina, I. N. Rozhkova, E. Yu. Brusentsev, S. Ya. Amstislavsky

“…Medical treatment of infertility may also be considered as a stress factor, especially when infertility lasts for years and is aggravated with emotional frustration. …”
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Association of Beta-Thalassaemia and Hypogonadotropic Hypogonadism by Angela Vidal, Carolin Dhakal

“…Because of the various treatments, a secondary endocrinopathy due to iron overload—haemosiderosis—can occur, causing hypopituitarism leading to hypogonadotropic hypogonadism (HH) and infertility. We present a case of secondary amenorrhoea in a patient with beta-thalassaemia and a history of multiple therapies in her adolescence, such as multiple transfusions, chemotherapy, and allogeneic bone marrow transplantation, who presented with HH and premature ovarian insufficiency.…”
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Pathogenesis of Endometriosis and Uterine Fibroids by Pasquapina Ciarmela, Hilary Critchley, Gregory M. Christman, Fernando M. Reis

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Endometrial Receptivity–Lessons from “Omics” by Louie Ye, Evdokia Dimitriadis

“…Drawing on findings from various branches of “omics”, including genomics, epigenomics, transcriptomics, proteomics, lipidomics, metabolomics, and microbiomics, this narrative review aims to (1) discuss mechanistic insights on endometrial receptivity and its implication in infertility; (2) highlight advances in investigations for endometrial receptivity; and (3) discuss novel diagnostic and therapeutic strategies that may improve reproductive outcomes.…”
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Sperm DNA fragmentation index: limited effectiveness on predicting embryo quality in assisted reproduction technology treatments by Huan Jiang, Xiaolu Xia, Ying Luo, Haiyan Pan, Shihao Qu, Jianying Xu

“…Abstract Purpose Prior sperm DNA fragmentation index (DFI) thresholds for diagnosing male infertility and predicting assisted reproduction technology (ART) outcomes fluctuated between 15 and 30%, with no agreed standard. …”
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The Effect of Maternal Body Mass Index on in Vitro Fertilization-Intracytoplasmic Sperm Injection Treatment: A Prospective Comparative Study by Zeynep Ozturk Inal, Hasan Ali Inal

“…Results: While there were no differences between the groups in terms of age, smoking status, etiology of infertility, thyroid-stimulating hormone, prolactin levels, antral follicle count, and stimulation protocol (p>0.05), there was a significant statistical difference in terms of body mass index, duration of infertility, baseline follicle-stimulating hormone, luteinizing hormone, estradiol (E2), duration of stimulation, total gonadotropin dose required, peak E2 levels, progesterone levels, endometrial thickness on hCG administration, and cycle cancellation rate (p<0.05). …”
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Impact of Long-term Polyvinylpyrrolidone Exposure on Gene Expression, Chromatin Structure, and Malondialdehyde Levels in Human Sperm by Mojdeh Sabour, Mahmood Dehghani Ashkezari, Azam Agharahimi, Seyed Morteza Seifati, Seyed Mehdi Kalantar

“…Since PVP is used widely in infertility centers, it is noteworthy to investigate the side effects of this agent. …”
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The Maternal Cytokine and Chemokine Profile of Naturally Conceived Gestations Is Mainly Preserved during In Vitro Fertilization and Egg Donation Pregnancies by Alicia Martínez-Varea, Begoña Pellicer, Vicente Serra, David Hervás-Marín, Alicia Martínez-Romero, José Bellver, Alfredo Perales-Marín, Antonio Pellicer

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Nicotinamide riboside supplementation ameliorates ovarian dysfunction in a PCOS mouse model by Zhenye Zhu, Min Lei, Ruizhi Guo, Yining Xu, Yanqing Zhao, Chenlu Wei, Qingling Yang, Yingpu Sun

“…Abstract Polycystic ovary syndrome (PCOS) is the leading cause of anovulatory infertility among women of reproductive age, yet the range of effective treatment options remains limited. …”
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Predicting the Health‐Promoting Lifestyle Profile of Pregnant Women Based on Their Health Literacy Levels: A Cross‐Sectional Study by Nastaran Rafat, Fatemeh Bakouei, Hajar Adib‐Rad, Hossein‐Ali Nikbakht, Sareh Bakouei

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Calcified Leiomyomata Presenting as Recurrent Pregnancy Loss by Mohammad Marwan Alhalabi, Ameer Kakaje, Marwan Alhalabi

“…We report a very rare case of a large calcified leiomyomata which caused secondary infertility and pregnancy loss of 7 pregnancies due to spontaneous abortions.…”
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Shifting Parenthood to Advanced Reproductive Ages: Trends, Causes and Consequences by Tomáš Sobotka

“…It reviews consequences of delayed childbearing for individuals, couples, their children and society and discusses the limited role of assisted reproduction in offsetting the age-related rise in infertility. The individual social and economic advantages of late parenthood may outweigh the biological advantage of early parenthood. …”
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L’épée de Damoclès by Giulia Colavolpe Severi

“…This article presents the first results of qualitative research conducted in France from February to June 2012, through sixteen semi-structured interviews with women exposed in utero to diethylstilbestrol (DES), a teratogenic molecule that influences the development of the reproductive apparatus by provoking anomalies liable to cause infertility. The aim of this article is to describe what women exposed in utero to DES have experienced in their bodies in relation to pregnancy. …”
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Thiazolidinediones and Fertility in Polycystic Ovary Syndrome (PCOS) by Pascal Froment, Philippe Touraine

“…Polycystic ovary syndrome (PCOS) is the most frequent cause of female infertility. The treatment of PCOS patients with insulin sensitizers, such as metformin or thiazolidinediones, increases the ovulation rate and the number of successful pregnancies. …”
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Clinical Pregnancy and Miscarriage Rates in relation to Vitamin D Supplementation among women with Hyper Androgenic PCOS: A prospective study by Sherif Sobhy Menshawy Khalifa, Wael Gaber Eldamaty, Ahmed Tharwat Abo Dakika, Mohamed Zaeim Hafez Ahmed, Muhammad Abdelbaeth Hassan Elfiky, Ghada Adel Hegazy

“…Determining 25(OH)D status as part of a routine infertility assessment may therefore be advantageous.…”
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Is There a Role of 25-Hydroxy Vitamin D in the Pathogenesis of Mild and Moderate-to-Severe Endometriosis? by Nevin Tuten, Serdar Acikgoz, Zahid Mammadov, Eduard Malik, Abdullah Tuten, Onur Guralp

“…The serum 25-hydroxy vitamin D levels had no correlation with the presence of infertility, deep infiltrating endometriosis, or Douglas pouch obliteration. …”
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