Aerodynamic energy consumption analysis of divided evacuated tube transportation system by Ziwei Zhang, Yingxue Wang, Guanqing Wang, Feilong Li, Dengke Wang, Jianjun Luo

“…The positional relationship between HST and gas waves infected aerodynamic energy consumption. By figuring out the spatiotemporal variation of tube gas, the theoretical energy estimation scheme for aerodynamic energy consumption with various cases was put forward, then the rationality and accuracy of which was verified by numerical simulation with prediction error less than 8%. …”
Get full text

Deep eutectic solvent enhances antibacterial activity of a modular lytic enzyme against Acinetobacter baumannii by Aleksandra Maria Kocot, Tomasz Swebocki, Karolina Ciemińska, Adrianna Łupkowska, Małgorzata Kapusta, Dennis Grimon, Ewa Laskowska, Anna-Karina Kaczorowska, Tadeusz Kaczorowski, Rabah Boukherroub, Yves Briers, Magdalena Plotka

“…Effectiveness in lowering the MIC value of MLE-15 as well as protection against antibiotic-tolerant persister cells, indicate that MLE-15 and reline combination is a promising candidate for effective therapies in bacterial infections, which is especially important in the light of the global crisis of antimicrobial resistance.…”
Get full text

Association Between Single-Nucleotide Polymorphisms in <i>Toll-like Receptor 3</i> (<i>tlr3</i>), <i>tlr7</i>, <i>tlr8</i> and <i>tirap</i> Genes with Severe Symptoms in Children P... by Adriana Souza Andrade, Aline Almeida Bentes, Lilian Martins Diniz, Silvia Hees Carvalho, Erna Geessien Kroon, Marco Antonio Campos

“…Our analyses suggest an association between SNPs in innate immune response genes and severity of symptoms in children with COVID-19 (or SARS-CoV-2 infected children).…”
Get full text

Systematic Review of Surgical Care in the Incarcerated Population: Identifying Knowledge Gaps for Future Research by Totadri Dhimal, MD, Paula Cupertino, PhD, Aqsa Ghaffar, BS, Yue Li, PhD, Xueya Cai, PhD, Cristopher Soto, BS, Megha Ramaswamy, PhD, MPH, Bruce W. Herdman, PhD, Fergal J. Fleming, MD, MPH, Anthony Loria, MD, MSCI

“…Notable complications, such as nonfusion and postarthroplasty infections, were more prevalent in incarcerated individuals compared with nonincarcerated individuals. …”
Get full text

Systematic review and bayesian network meta-analysis: comparative efficacy and safety of six commonly used biologic therapies for moderate-to-severe Crohn’s disease by Haohang Su, Haohang Su, Shengwei Xiao, Zhiqing Liang, Zhiqing Liang, Tianrong Xun, Jinfang Zhang, Jinfang Zhang, Xixiao Yang, Xixiao Yang

“…Risankizumab has the lowest risk of adverse events (SUCRA 84.81), serious adverse events (SUCRA 94.23), and serious infections (SUCRA 79.73) in induction therapy. Adalimumab and the 10 mg/kg regimen of Infliximab rank highest for maintaining clinical remission.ConclusionThis analysis suggests that Infliximab in combination with azathioprine may be preferred biologic agents for induction therapy in TNF antagonist-naïve patients. …”
Get full text

Prevalence, Characterization, and Proteomic Relatedness Among β-Lactam-Resistant Bacteria Throughout the Poultry Production Chain in Greece by Anestis Tsitsos, Alexandros Damianos, Konstantinos Kiskinis, Vasilios Tsiouris, Ilias Tirodimos, Nikolaos Soultos, Anna Papa, Vangelis Economou

“…Extended-spectrum-β-lactamase (ESBL) and carbapenemase-producing <i>Escherichia coli</i>, <i>Klebsiella pneumoniae</i> and <i>Acinetobacter</i> spp. are associated with hospital-acquired infections and are commonly isolated across the poultry food production chain. …”
Get full text

Clinical and Mycobacterium tuberculosis strain characteristics of tuberculosis patients with diabetes mellitus in Changping District, Beijing, China by Xiaolong Cao, Zexuan Song, Ping He, Xinyue Li, Nan Lei, Qian Sun, Xue Wang, Ruida Xing, Bing Zhao, Xinyu Yang, Zhiguo Zhang, Yanlin Zhao

“…This study aims to develop targeted prevention and management strategies, offering crucial guidance for treating co-infections of TB and DM and controlling disease spread.…”
Get full text

Selective suppression of influenza A/H5N1 virus replication <i>in vitro</i> using nanocomplexes consisting of siRNA and aminopropylsilanol nanoparticles by Marina N. Repkova, Asya S. Levina, Oleg Yu. Mazurkov, Elena V. Makarevich, Ekaterina I. Filippova, Natalya A. Mazurkova, Valentina F. Zarytova

“…The antiviral activity of the proposed nanocomplexes has been studied on MDCK cells infected with the influenza A/H5N1 virus. It has been shown that the double-stranded siRNA molecules in the nanocomplexes, which act by the RNA interference mechanism, are more efficient in inhibiting the replication of the influenza virus than the corresponding single-stranded RNA fragments. …”
Get full text

The effect of meningococcal vaccines on new generation of systemic inflammatory markers in children by Omer Okuyan, Neval Elgormus, Seyma Dumur, Ugurcan Sayili, Hafize Uzun

“…Aim: Immunization with meningococcal vaccine (MV) is the most effective measure to control and prevent the transmission of meningococcal infections. In this study, in order to support the appropriate use of various MVs in the prevention of meningococcal meningitis (MM), the effects of MVs, especially single-dose and inter-booster administered, on inflammatory parameters in < 5-year-old children were investigated. …”
Get full text

High Human Immunodeficiency Virus (HIV) Viral Load and Coinfection with Viral Hepatitis Are Associated with Liver Enzyme Abnormalities among HIV Seropositive Patients on Antiretrov... by Shabani Iddi, Caroline A. Minja, Vitus Silago, Asteria Benjamin, Jastine Mpesha, Shimba Henerico, Benson R. Kidenya, Stephen E. Mshana, Mariam M. Mirambo

“…This study investigated factors associated with liver enzymes abnormalities among human immunodeficiency virus (HIV) infected individuals on ART from the Lake Victoria zone, Tanzania. …”
Get full text

Robust and Long-Lasting Immunity and Protection in Mice Induced by Lipopolyplex-Delivered mRNA Vaccines Expressing the Prefusion Protein of Respiratory Syncytial Virus by Xuchang Shan, Ruiwen Han, Xueting Cheng, Jialuo Bing, Zhenyong Qi, Shucai Sun, Tangqi Wang, Qiaohong Chu, Yao Deng, Desheng Zhai, Wenjie Tan

“…Respiratory syncytial virus (RSV) is the leading cause of lower respiratory tract infections in infants and children. mRNA vaccines based on the lipopolyplex (LPP) platform have been previously reported, but they remain unapplied in RSV vaccine development. …”
Get full text

Venetoclax plus low-intensity chemotherapy for adults with acute lymphoblastic leukemia by Marlise R. Luskin, Shai Shimony, Julia Keating, Eric S. Winer, Jacqueline S. Garcia, Richard M. Stone, Elias Jabbour, Yael Flamand, Kristen Stevenson, Jeremy Ryan, Zhihong Zeng, Anthony Letai, Marina Konopleva, Nitin Jain, Daniel J. DeAngelo

“…The most common nonhematologic adverse events were grade ≥3 infections. There were no deaths within 60 days. There was no tumor lysis syndrome, hepatotoxicity, prolonged cytopenias, or early discontinuation for toxicity. …”
Get full text

Phytochemical Profiling, GC-MS Analysis and Antibacterial Activity of Sida acuta leave Extracts Against Helicobacter pylori by Kamoldeen Ajijolakewu, Ayobami Elias Ajadi, S A Ayoola, Sheriffdeen Issa Bale, Taiwo Ayodeji Sorunke, Saheed Abayomi Onifade, Tomisin Oyawoye

“…These findings suggest that Sida acuta possesses antibacterial properties that may be beneficial in treating ulcer-related H. pylori infections. …”
Get full text

Effects of the in ovo injection of an Escherichia coli vaccine on the hatchability and subsequent early post hatch characteristics of commercial layer chicks by K.E.C. Elliott, L.L. Lindsey, J.D. Evans, S.A. Leigh, K.J. Robinson, S.A. Fatemi, A. Mousstaaid, P.D. Gerard, J. L Purswell, E.D. Peebles

“…The Poulvac E. coli vaccine (PECV) (Zoetis, Parsippany, NJ) may be administered to poultry post hatch via coarse spray or in drinking water to protect against APEC infections. The purpose of this experiment was to in ovo vaccinate commercial layers with various doses of the PECV to evaluate hatchability and post hatch development of the chicks through 21 d of age. …”
Get full text

Protocol for faecal microbiota transplantation in irritable bowel syndrome: the MISCEAT study – a randomised, double-blind cross-over study using mixed microbiota from healthy dono... by Lenka Kramna, Ondrej Cinek, Jakub Hurych, Jiri Vejmelka, Lucie Hlinakova, Vladyslav Larionov, Michal Kulich, Pavel Kohout

“…Therefore, faecal microbiota transplantation, whose effect and safety have been proven in Clostridioides difficile infections, may hold promise in other conditions, including IBS. …”
Get full text

Impact of Granulocyte Colony-Stimulating Factor (G-CSF) on Clinical Outcomes in Allogeneic Hematopoietic Cell Transplantation: Does Speeding Up Neutrophil Engraftment Make a Differ... by Ahmed Alnughmush, MD, Ayman Sayyed, MD, Mats Remberger, PhD, Eshrak AL-Shaibani, MD, Carol Chen, BSc, Caden Chiarello, Ivan Pasic, MD, Igor Novitzky-Basso, MD, Arjun Datt Law, MD, Wilson Lam, MD, Dennis (Dong Hwan) Kim, MD, Armin Gerbitz, MD, Auro Viswabandya, MD, Rajat Kumar, MD, Fotios V. Michelis, MD, Jonas Mattsson, MD, PhD

“…This study aimed to assess the impact of granulocyte colony-stimulating factor (G-CSF) administration posttransplantation on neutrophil and platelet engraftment, incidence of bloodstream infections (BSIs), graft-versus-host disease, engraftment syndrome (ES), and survival metrics including overall survival, nonrelapse mortality, and graft-versus-host disease–free/relapse-free survival. …”
Get full text

Comparative Structural and Biophysical Investigation of <i>Lycosa erythrognatha</i> Toxin I (LyeTx I) and Its Analog LyeTx I-b by Amanda Neves de Souza, Gabriele de Azevedo Cardoso, Lúcio Otávio Nunes, Christopher Aisenbrey, Evgeniy Salnikov, Kelton Rodrigues de Souza, Ahmad Saad, Maria Elena de Lima, Jarbas Magalhães Resende, Burkhard Bechinger, Rodrigo Moreira Verly

“…<b>Conclusions</b>: Our findings provide insights into the structural and functional modifications that enhance the antimicrobial and therapeutic potential of LyeTx I-b, offering valuable guidance for the design of novel peptides targeting resistant bacterial infections and cancer.…”
Get full text

Studying formation of <I>Pseudomonas aeruginosa</I> biofilms grown under different cultivation conditions by T. E. Mironova, V. S. Сherepushkina, V. N. Afonyushkin, N. V. Davydova, V. Yu. Koptev, A. S. Dimova

“…The topic is of great importance due to high incidence of P. aeruginosa-caused infections and P. aeruginosa resistance associated with its ability to form biofilms. …”
Get full text

Sickle Cell Anemia Patients Display an Intricate Cellular and Serum Biomarker Network Highlighted by TCD4+CD69+ Lymphocytes, IL-17/MIP-1β, IL-12/VEGF, and IL-10/IP-10 Axis by Nadja Pinto Garcia, Alexander Leonardo S. Júnior, Geyse Adriana S. Soares, Thainá Cristina C. Costa, Alicia Patrine C. dos Santos, Allyson Guimarães Costa, Andréa Monteiro Tarragô, Rejane Nina Martins, Flávia do Carmo Leão Pontes, Emerson Garcia de Almeida, Erich Vinícius de Paula, Olindo Assis Martins-Filho, Adriana Malheiro

“…Sickle cell anemia (SCA) is associated with a chronic proinflammatory state characterized by elevated leukocyte count, mortality from severe recurrent infections, and subsequent vasoocclusive complications with leukocyte adhesion to the endothelium and increased plasma levels of inflammatory cytokines. …”
Get full text

Pneumonia among Under-Five Children in Northwest Ethiopia: Prevalence and Predictors—A Community-Based Cross-Sectional Study by Zewudu Andualem, Tsegaye Adane, Abiye Tigabu, Walelign Worku Yallew, Sintayehu Daba Wami, Henok Dagne, Jember Azanaw, Gebisa Guyasa, Zelalem Nigussie Azene, Mastewal Endalew

“…Background. Acute respiratory infections in particular pneumonia constitutes the leading cause of morbidity and mortality among children under five years of age throughout the world. …”
Get full text