Transcriptomic Profiling and Tumor Microenvironment Classification Reveal Unique and Dynamic Immune Biology in HIV-Associated Kaposi Sarcoma by Jihua Yang, Ayse Ece Cali Daylan, Aleksei Shevkoplias, Ekaterina Postovalova, Meng Wang, Andrey Tyshevich, Matthew Lee, Hiba Narvel, Ksenia Zornikova, Nara Shin, Nikita Kotlov, Luca Paoluzzi, Changcheng Zhu, Balazs Halmos, Xingxing Zang, Haiying Cheng

“…Furthermore, sequencing identified a shared TCR<i>β</i> chain in all patients analyzed, indicating a T-cell immune response to a common antigen. This study demonstrates unique transcriptomic features and TME subtypes in KS that differ based on HIV status. …”
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Bisphenol S exposure interrupted human embryonic stem cell derived cardiomyocytes differentiation through ER-NF-κB/ERK signaling pathway by Yongru Zhou, Lin Tian, Liang Wang, Wenjing Wu, Baofang Liang, Wei Xiong, Lishi Zhang, Xiaomeng Li, Jinyao Chen

“…However, exposure to BPS throughout the differentiation stage may disrupt the immune response and cell differentiation, which in turn interrupts heart function. …”
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Immunogenicity and safety of a live-attenuated SARS-CoV-2 vaccine candidate based on multiple attenuation mechanisms by Mie Suzuki Okutani, Shinya Okamura, Tang Gis, Hitomi Sasaki, Suni Lee, Akiho Kashiwabara, Simon Goto, Mai Matsumoto, Mayuko Yamawaki, Toshiaki Miyazaki, Tatsuya Nakagawa, Masahito Ikawa, Wataru Kamitani, Shiro Takekawa, Koichi Yamanishi, Hirotaka Ebina

“…However, some limitations remain to be resolved, such as the short-lived induced immune response and certain adverse effects. Therefore, there is an urgent need to develop new vaccines that address these issues. …”
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Depressive and Negative Symptoms in the Early and Established Stages of Schizophrenia: Integrating Structural Brain Alterations, Cognitive Performance, and Plasma Interleukin 6 Lev... by Fabiana Corsi-Zuelli, Gary Donohoe, Siân Lowri Griffiths, Cristina M. Del-Ben, Andrew J. Watson, Tom Burke, Paris A. Lalousis, Declan McKernan, Derek Morris, John Kelly, Colm McDonald, Saahithh R. Patlola, Carmine Pariante, Nicholas M. Barnes, Golam M. Khandaker, John Suckling, Bill Deakin, Rachel Upthegrove, Maria R. Dauvermann

“…Methods: We evaluated whether higher plasma interleukin 6 (IL-6) levels would be associated with more severe negative or depressive symptoms in schizophrenia and explored illness stage utilizing early (BeneMin [Benefit of Minocycline on Negative Symptoms of Psychosis: Extent and Mechanism], n = 201, 72.8% male) and established (iRELATE [Immune Response &amp; Social Cognition in Schizophrenia], n = 94, 67.3% male) schizophrenia cohorts. …”
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Recombinant XBB.1.5 boosters induce robust neutralization against KP.2- and KP.3-included JN.1 sublineages by Jingyun Yang, Xuemei He, Huashan Shi, Cai He, Hong Lei, Heng He, Li Yang, Wei Wang, Guobo Shen, Jinliang Yang, Zhiwei Zhao, Xiangrong Song, Zhenling Wang, Guangwen Lu, Jiong Li, Yuquan Wei

“…We further investigated humoral immune response of recombinant XBB vaccines against Omicron variants and estimated the neutralization resistance of JN.1 sublineages, including KP.2 and KP.3. …”
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Comparative transcriptome analysis reveals molecular mechanisms of resistance in Chinese cabbage to Plasmodiophora brassicae pathotype 11 by Yue Qiu, Yue Qiu, Yue Qiu, Jinhao Zhang, Jinhao Zhang, Chunju Deng, Chunju Deng, Jiasheng Yuan, Jiasheng Yuan, Bowen Wang, Bowen Wang, Han Meng, Han Meng, Mohamed Mohany, Liting Zeng, Liting Zeng, Lanfang Wei, Lanfang Wei, Waqar Ahmed, Guanghai Ji, Guanghai Ji

“…Although the highly resistant variety JP did not exhibit a complete immune response to pathotype 11, it demonstrated a significant resistance level against P. brassicae pathotype 11 by restricting its proliferation in the xylem vessels. …”
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Systematic evaluation of intratumoral and peripheral BCR repertoires in three cancers by Sofia V Krasik, Ekaterina A Bryushkova, George V Sharonov, Daria S Myalik, Elizaveta V Shurganova, Dmitry V Komarov, Irina A Shagina, Polina S Shpudeiko, Maria A Turchaninova, Maria T Vakhitova, Igor V Samoylenko, Dimitr T Marinov, Lev V Demidov, Vladimir E Zagaynov, Dmitriy M Chudakov, Ekaterina O Serebrovskaya

“…The current understanding of humoral immune response in cancer patients suggests that tumors may be infiltrated with diffuse B cells of extra-tumoral origin or may develop organized lymphoid structures, where somatic hypermutation and antigen-driven selection occur locally. …”
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The anti-circumsporozoite antibody response to repeated, seasonal booster doses of the malaria vaccine RTS,S/AS01E by M. Sanni Ali, Lisa Stockdale, Issaka Sagara, Issaka Zongo, Rakiswendé Serge Yerbanga, Almahamoudou Mahamar, Frédéric Nikièma, Amadou Tapily, Frédéric Sompougdou, Modibo Diarra, Duncan Bellamy, Samuel Provstgaard-Morys, Charles Zoungrana, Djibrilla Issiaka, Alassane Haro, Koualy Sanogo, Abdoul Aziz Sienou, Mahamadou Kaya, Seydou Traore, Oumar M. Dicko, Youssouf Kone, Hama Yalcouye, Ismaila Thera, Kalifa Diarra, Paul Snell, Opokua Ofori-Anyinam, Chris Ockenhouse, Cynthia Lee, Katie Ewer, Halidou Tinto, Abdoulaye Djimde, Jean-Bosco Ouedraogo, Alassane Dicko, Daniel Chandramohan, Brian Greenwood

“…However, there is little information about the immune response to repeated booster doses of RTS,S/AS01E. …”
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Non-small cell lung cancer and the tumor microenvironment: making headway from targeted therapies to advanced immunotherapy by Anna De Lucia, Lucia Mazzotti, Lucia Mazzotti, Anna Gaimari, Anna Gaimari, Matteo Zurlo, Roberta Maltoni, Claudio Cerchione, Sara Bravaccini, Angelo Delmonte, Lucio Crinò, Patricia Borges de Souza, Luigi Pasini, Fabio Nicolini, Fabrizio Bianchi, Manel Juan, Hugo Calderon, Chiara Magnoni, Chiara Magnoni, Luca Gazzola, Luca Gazzola, Paola Ulivi, Massimiliano Mazza

“…The TME sets major obstacles for CAR-T therapies, creating conditions that suppress the immune response, inducing T cell exhaustion. To enhance treatment efficacy, specific efforts associated with CAR-T cell therapy in NSCLC, should definitely focus TME-related immunosuppression and antigen escape mechanisms, by combining CAR-T cells with immune checkpoint blockades.…”
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CD21low B cells reveal a unique glycosylation pattern with hypersialylation and hyperfucosylation by Peter Tobias Felixberger, Peter Tobias Felixberger, Geoffroy Andrieux, Andrea Maul-Pavicic, Andrea Maul-Pavicic, Sigune Goldacker, Sigune Goldacker, Ina Harder, Ina Harder, Sylvia Gutenberger, Sylvia Gutenberger, Jonathan J. M. Landry, Vladimir Benes, Till Fabian Jakob, Melanie Boerries, Melanie Boerries, Lars Nitschke, Reinhard Edmund Voll, Reinhard Edmund Voll, Klaus Warnatz, Klaus Warnatz, Baerbel Keller, Baerbel Keller

“…These glycome changes appear to be driven by the prominent type I immune response in complicated CVID patients. A better understanding of how altered glycosylation influences immune cell function could lead to new therapeutic strategies.…”
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Research Progress on Stem Cell Therapies for Articular Cartilage Regeneration by Shuangpeng Jiang, Guangzhao Tian, Xu Li, Zhen Yang, Fuxin Wang, Zhuang Tian, Bo Huang, Fu Wei, Kangkang Zha, Zhiqiang Sun, Xiang Sui, Shuyun Liu, Weimin Guo, Quanyi Guo

“…However, recent evidence has shown that the stem cell secretome plays an important role in biological processes such as the immune response, inflammation regulation, and drug delivery. …”
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A phase 1b clinical trial to determine the safety, tolerability and immunogenicity of simian adenovirus and poxvirus vectored vaccines against Mycobacterium avium complex subspecie... by Jeremy Sanderson, Jeremy Aboagye, Rebecca Makinson, Katerina Rapi, Samuel Provstgaard-Morys, Lisa Stockdale, Alison Lawrie, Isabelle Lanigan, Nishat Halim, Abdel Douiri, Emily Greenlay, Rayka Malek, Emma Gray, Lindsey West, Fatima El Oulidi, Paul Ian Cross, Michael Stallibrass, Sarah C. Gilbert, Adrian V.S. Hill, Katie J. Ewer

“…A heterologous prime-boost schedule induces a T cell-mediated immune response. Further studies are required to determine the efficacy and optimal regime of the vaccines. …”
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Multi-omics uncovers immune-modulatory molecules in plasma contributing to resistance exercise-ameliorated locomotor disability after incomplete spinal cord injury by Ren Zhou, Jibao Chen, Yunhan Tang, Chuijin Wei, Ping Yu, Xinmei Ding, Li’ao Zhu, Jiajia Yao, Zengqiang Ouyang, Jing Qiao, Shumin Xiong, Liaoliao Dong, Tong Yin, Haiqing Li, Ye Feng, Lin Cheng

“…Results Plasma proteomic and PBMC transcriptomic profiling underscored the notable involvement of the complement pathways and humoral immune response in the process of restoring locomotor function following SCI in the human trial. …”
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Multiple pathways to evaluate the immunoprotective effect of Turkeys Herpesvirus recombinant vaccine expressing HA of H9N2 by Wenhao Yang, Jin Zhang, Jing Dai, Mengjiao Guo, Xiaolong Lu, Ruyi Gao, Kaituo Liu, Min Gu, Shunlin Hu, Xiufan Liu, Xiaoquan Wang, Xiaowen Liu

“…Subcutaneous injection and in-ovo injection of HVT-HA induced different levels of immune response. Compared to in-ovo injection of HVT-HA, subcutaneous injection induced significantly higher neutralizing serum antibodies. …”
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Longitudinal mitochondrial bioenergetic signatures of blood monocytes and lymphocytes improve during treatment of drug-susceptible pulmonary tuberculosis patients by Bridgette M. Cumming, Kelvin W. Addicott, Fernanda Maruri, Fernanda Maruri, Vanessa Pillay, Rukaya Asmal, Sashen Moodley, Beatriz Barreto-Durate, Beatriz Barreto-Durate, Mariana Araújo-Pereira, Mariana Araújo-Pereira, Matilda Mazibuko, Zoey Mhlane, Nikiwe Mbatha, Khadija Khan, Senamile Makhari, Farina Karim, Lauren Peetluk, Alexander S. Pym, Mahomed Yunus S. Moosa, Yuri F. van der Heijden, Yuri F. van der Heijden, Yuri F. van der Heijden, Timothy S. Sterling, Timothy S. Sterling, Bruno B. Andrade, Bruno B. Andrade, Alasdair Leslie, Alasdair Leslie, Alasdair Leslie, Adrie J. C. Steyn, Adrie J. C. Steyn, Adrie J. C. Steyn

“…Network analysis of the bioenergetic parameters of circulating immune cells with serum cytokine levels indicated a highly coordinated immune response at month 6. These findings underscore the importance of metabolic health in combating TB, supporting the need for further investigation of the bioenergetic immunometabolism associated with TB infection for novel therapeutic approaches aimed at bolstering cellular energetics to enhance immune responses and expedite recovery in TB patients.…”
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Pegilated interferon alpha 2b «Pegaltevir» chronic hepatitis C treatment (randomized clinical trial) by Marina V. Mayevskaya, Ye. N. Bessonova, P. O. Bogomolov, N. I. Geyvandova, K. V. Zhdanov, V. G. Morozov, V. D. Pasechnikov, I. Yu. Khomenko, A. V. Yagoda, V. T. Ivashkin

“…Beneficial interferon properties include: absence of mutagenic capacity for hepatitis C virus and drug interaction, stimulation of host immune response. These qualities formed the basis for development of the Russian pegilated interferon-alpha 2b (Pegaltevir®, LLC «FARMAPARK», Russia) and carrying out doublestaged randomized open clinical trial: study of safety, tolerability and pharmacokinetics of Pegaltevir® at single injection of increasing doses in various groups of healthy volunteers - the I stage; studying of efficacy and safety of Pegaltevir® in comparison to PegIntron® (Schering-Plough, USA) at CHC as a part of double antiviral therapy with ribavirin (Rebetol®, Schering-Plough, USA) - the II stage. …”
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Blood biomarker dynamics in people with relapsing multiple sclerosis treated with cladribine tablets: results of the 2-year MAGNIFY-MS study by Heinz Wiendl, Frederik Barkhof, Frederik Barkhof, Xavier Montalban, Anat Achiron, Anat Achiron, Tobias Derfuss, Andrew Chan, Suzanne Hodgkinson, Alexandre Prat, Letizia Leocani, Letizia Leocani, Letizia Leocani, Klaus Schmierer, Klaus Schmierer, Finn Sellebjerg, Finn Sellebjerg, Patrick Vermersch, Hulin Jin, Anita Chudecka, Andreas Kloetgen, Dongdong Lin, Lidia Gardner, Nicola De Stefano

“…Changes in genes and pathways associated with innate and adaptive immune response were observed after CladT treatment, along with reductions in pro-inflammatory cytokine-producing B and T cells and increases in anti-inflammatory cytokine-producing T cells. …”
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Correlations between primary tumour location, biomarkers of inflammation and lung injury, and postoperative pulmonary complications in patients underwent laparoscopic colorectomy:... by Hui-xian Li, Li Che, Yuan Li, Tai-hang Wang, Fang-di Min, Lei Xu, Meng Wang, Zhao-xu Zheng, Shi-ning Qu, Fei Wang, Wei Tang, Shi-jing Wei, Yu-lin Sun, Hui Zheng, Tao Yan

“…Additionally, assessments have been performed for plasma biomarkers of immune response dynamics and lung injury (plasma soluble advanced glycation end-product receptor [sRAGE], angiopoietin-2 [ANG-2], interleukin-1β/6 [IL-1β/IL-6]) and other parameters.ResultsAlthough the increase in postoperative lung epithelial damage, as indicated by the plasma sRAGE levels, was significant in the RSC group (DAC vs. …”
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Single-cell RNA sequencing highlights the role of distinct natural killer subsets in sporadic amyotrophic lateral sclerosis by Esther Álvarez-Sánchez, Álvaro Carbayo, Natalia Valle-Tamayo, Laia Muñoz, Joaquim Aumatell, Soraya Torres, Sara Rubio-Guerra, Jesús García-Castro, Judit Selma-González, Daniel Alcolea, Janina Turon-Sans, Alberto Lleó, Ignacio Illán-Gala, Juan Fortea, Ricard Rojas-García, Oriol Dols-Icardo

“…Our results revealed extensive gene expression alterations in NK_2 cells, pointing towards the activation of immune response (adj. p-value = 9.2 × 10− 11) and the regulation of lymphocyte proliferation (adj. p-value = 6.46 × 10− 6). …”
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Dynamic hierarchical ligand anisotropy for competing macrophage regulation in vivo by Kanghyeon Kim, Sunhong Min, Ramar Thangam, Kyong-Ryol Tag, Hyun-Jeong Lee, Jeongyun Heo, Hwapyung Jung, Thet Thet Swe, Iman Zare, Guosheng Song, Alireza Hassani Najafabadi, Junmin Lee, Hyun-Do Jung, Jong Seung Kim, Sunghoon Hur, Hyun-Cheol Song, Sung-Gyu Park, Kunyu Zhang, Pengchao Zhao, Liming Bian, Se Hoon Kim, Juyoung Yoon, Jae-Pyoung Ahn, Hong-Kyu Kim, Heemin Kang

“…Diverse connective tissues exhibit hierarchical anisotropic structures that intricately regulate homeostasis and tissue functions for dynamic immune response modulation. In this study, remotely manipulable hierarchical nanostructures are tailored to exhibit multi-scale ligand anisotropy. …”
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