High-Grade Cervical Intraepithelial Neoplasia: Impact of Colposcopic Lesion Area on Systemic Immune Responses by Mantoani PTS, Micheli DC, Jammal MP, Vieira JH, Michelin MA, Ferreira CGX, Silva HN, Murta EFC, Nomelini RS

“…Getúlio Guaritá, s/n, Bairro Abadia, Uberaba, MG, 38025-440, Brazil, Tel +55 34 3318 5326, Fax +55 34 3318 5342, Email rosekeila@terra.com.brBackground: The progression of high-grade cervical intraepithelial neoplasia (CIN) and cervical cancer is accompanied by a reduction in the immune response. The objectives of the study were to determine whether colposcopic lesion area is associated with serum levels of cytokines IL (interleukin) − 1, IL-6, IL-8, IL-10, IL-12 and TNF-α in precursor lesions of cervical cancer.Methods: The study population comprised patients with high-grade squamous intraepithelial lesion who had undergone colposcopy, cervical biopsy, and measurements of serum cytokines by ELISA (Enzyme-Linked Immunosorbent Assay). …”
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Exploring Immune Responses through Dynamic Modeling of Cell-Immune Interactions in Viral Infection and Vaccination by Kwang Su Kim, Il Hyo Jung, Jong Hyuk Byun

“…This study examines the dynamics of viral infections and immune responses, with a particular focus on the roles of antibodies and CD8+ T cells induced by vaccination. …”
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Enhancement of non-specific immune response, resistance and growth of (Litopenaeus vannamei) by oral administration of nucleotide by Henky Manoppo, . Sukenda, Daniel Djokosetiyanto, Mochamad Fatuchri Sukadi, Enang Harris

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mTORC1-Activated Monocytes Increase Tregs and Inhibit the Immune Response to Bacterial Infections by Lijun Fang, Huaijun Tu, Wei Guo, Shixuan Wang, Ting Xue, Fei Yang, Xiaoyan Zhang, Yazhi Yang, Qian Wan, Zhexin Shi, Xulong Zhan, Jian Li

“…The TSC1/2 heterodimer, a key upstream regulator of the mTOR, can inhibit the activation of mTOR, which plays a critical role in immune responses after bacterial infections. Monocytes are an innate immune cell type that have been shown to be involved in bacteremia. …”
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Immune responses in rodent whole eye transplantation: elucidation and preliminary investigations into rejection diagnosis and monitoring by Bing Li, Yong Wang, Charles R. Owens, Touka Banaee, Charleen T. Chu, Kayvon Jabbari, Anna D. Lee, Neil J. Khatter, Alan G. Palestine, An-Jey A. Su, Christene A. Huang, Kia M. Washington

“…This study delves into the timeline and nature of immune responses in a rodent model of WET without immunosuppression, aiming to elucidate a detailed picture of the immune landscape post-transplantation and establish innovative diagnostic and monitoring methods.MethodsWe employed a multi-faceted approach to analyze immune responses post-WET, including assessments of gross changes in corneal transparency, thickness, and skin condition. …”
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RIF1 integrates DNA repair and transcriptional requirements during the establishment of humoral immune responses by Eleni Kabrani, Ali Rahjouei, Maria Berruezo-Llacuna, Svenja Ebeling, Tannishtha Saha, Robert Altwasser, Veronica Delgado-Benito, Rushad Pavri, Michela Di Virgilio

“…Abstract The establishment of protective immune responses relies on the ability of terminally differentiated B cells to secrete a broad variety of antigen-specific antibodies with different effector functions. …”
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Ficolins and the Recognition of Pathogenic Microorganisms: An Overview of the Innate Immune Response and Contribution of Single Nucleotide Polymorphisms by Stefan Bidula, Darren W. Sexton, Silke Schelenz

“…Ficolins are innate pattern recognition receptors (PRR) and play integral roles within the innate immune response to numerous pathogens throughout the circulation, as well as within organs. …”
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The Role of Th17 Cells and IL-17 in Th2 Immune Responses of Allergic Conjunctivitis by Xiang-Tian Meng, Yun-Yue Shi, Hong Zhang, Hong-Yan Zhou

“…This paper will focus on how T-helper 17 cells and interleukin-17 are activated in the Th2 immune response of allergic conjunctivitis and how they promote the Th2 immune response of AC.…”
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Systematic review of innate immune responses against Mycobacterium tuberculosis complex infection in animal models by Luisa Maria Nieto Ramirez, Carolina Mehaffy, Karen Marie Dobos

“…Deciphering the role of innate immune responses during MTBC infection is crucial for understanding disease progression or protection. …”
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Neutrophilic Inflammation in the Immune Responses of Chronic Obstructive Pulmonary Disease: Lessons from Animal Models by Gang Huang, Xu-Chen Xu, Jie-Sen Zhou, Zhou-Yang Li, Hai-Pin Chen, Yong Wang, Wen Li, Hua-Hao Shen, Zhi-Hua Chen

“…This review aims to summarize the current animal models of COPD, focusing on their advantages and disadvantages on immune responses and neutrophilic inflammation. Also, we propose a potential new animal model of COPD, which may mimic the most characteristics of human COPD pathogenesis, including persistent moderate-to-high levels of neutrophilic inflammation.…”
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Immune Response to “Self” Lens in Xenopus laevisEnucleated during Larval Life by Takeshi Enomoto, Shin Tochinai

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Study of pathogenesis and immune response at experimental infection of broiler chicks with avian metapneumovirus subtype В by M. A. Volkova, P. S. Yaroslavtseva, V. Yu. Sosi Pato Rova, T. L. Eroshina, I. A. Chvala

“…Using real-time RT-PCR avian metapneumovirus genome was detected in the upper part of the respiratory tract, infraorbital sinuses and Harderian gland within 2-12 days post infection. The immune response was characterized by formation of humoral and local antibodies in 7-21 days post infection. …”
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Depletion of Neutrophils Exacerbates the Early Inflammatory Immune Response in Lungs of Mice Infected with Paracoccidioides brasiliensis by Paula Andrea Pino-Tamayo, Juan David Puerta-Arias, Damaris Lopera, Martha Eugenia Urán-Jiménez, Ángel González

“…These results indicate that neutrophils are essential for protection as well as being important for regulating the early inflammatory immune response in experimental pulmonary paracoccidioidomycosis.…”
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The role of HSPA14 in breast cancer: implications for tumorigenesis, immune response modulation, and personalized therapies by Ruipeng Zhao, Xiaocun Zhu, Wan Wei, Linlin Zhen

“…The expression of HSPA14 may also indicate drug sensitivity.Conclusion Our study elucidates the involvement of HSPA14 in tumorigenesis, particularly in modulating the immune response, shaping the immune microenvironment, and contributing to drug resistance, which are pivotal for the development of personalized breast cancer therapies.…”
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Growth and immune response of Litopenaeus vannamei fed on β-(1, 3) glucan and poly-β hydroxybutyrate by , Sarmin, Muhammad Agus Suprayudi, Dedi Jusadi, Julie Ekasari

“…ABSTRACT   This research was aimed to examine the growth performance and non-specific immune response of Pacific white shrimp (Litopenaeus vannamei) fed on the diet supplemented with β-(1,3) glucan (BG) and poly-β-hydroxybutyrate (PHB) as feed additives. …”
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TRPV1 Antagonism by Capsazepine Modulates Innate Immune Response in Mice Infected with Plasmodium berghei ANKA by Elizabeth S. Fernandes, Carolina X. L. Brito, Simone A. Teixeira, Renato Barboza, Aramys S. dos Reis, Ana Paula S. Azevedo-Santos, Marcelo Muscará, Soraia K. P. Costa, Claudio R. F. Marinho, Susan D. Brain, Marcos A. G. Grisotto

“…Thousands of people suffer from severe malaria every year. The innate immune response plays a determinant role in host’s defence to malaria. …”
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Toll-Like Receptors and Cytokines as Surrogate Biomarkers for Evaluating Vaginal Immune Response following Microbicide Administration by Sadhana M. Gupta, Clara C. Aranha, Madhu C. Mohanty, K. V. R. Reddy

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Evaluation of the Ability of Miltefosine Associated with Topical GM-CSF in Modulating the Immune Response of Patients with Cutaneous Leishmaniasis by Fábio Peixoto, Maurício T. Nascimento, Rúbia Costa, Juliana Silva, Gaby Renard, Luiz Henrique Guimarães, Gerson Penna, Manoel Barral-Netto, Lucas P. Carvalho, Paulo R. L. Machado, Edgar M. Carvalho

“…In addition to the ability of miltefosine to kill Leishmania, the changes in the immune response caused by miltefosine and GM-CSF may increase the cure rate of CL patients using these drugs.…”
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Role of Toll-Like Receptor 2 in Regulation of T-Helper Immune Response in Chronic Obstructive Pulmonary Disease by Karolina A. Sidletskaya, Tatyana I. Vitkina, Yulia K. Denisenko, Elena E. Mineeva

“…According to modern views, the differences in the clinical course of chronic obstructive pulmonary disease (COPD) are associated with certain types of T-helper (Th) immune response. Recent data have shown that toll-like receptor 2 (TLR2) is involved in the development of Th immune response. …”
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Mannan-decorated STING-activating vaccine carrier for spatial coordinative stimulating antigen-specific immune responses by Liping Liu, Jiayu Zhao, Zichao Huang, Yudi Xu, Hongyu Chen, Ruirui Qiao, Wantong Song, Zhaohui Tang, Thomas P. Davis, Xuesi Chen

“…However, current nanocarriers are restricted by difficulties in the systematic spatial coordinative transport of antigens, which greatly hampers the immune response efficacy of nanovaccines. Herein, we designed a mannan-decorated stimulator of the interferon genes (STING)-activating vaccine carrier for spatial coordinative stimulation of antigen-specific immune responses and elicitation of robust antitumor immunity. …”
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