Exploring the therapeutic effect of human recombinant IL11 on lesioned OA human osteochondral explants by Margo Tuerlings, Evelyn Houtman, Elisa J.H. Muusers, Janneke Simon, Maurice W. de Haan, Ilja Boone, Yolande F.M. Ramos, Rachid Mahdad, Ingrid Meulenbelt

“…Upon treatment of ex vivo OA articular cartilage with hrIL11, we overall observed unbeneficial effects on chondrocyte phenotype, as illustrated by upregulation of MMP13, EPAS1, RUNX2, and POSTN. …”
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The role of Akkermansia muciniphila in maintaining health: a bibliometric study by Fangfang Gao, Canyu Cheng, Canyu Cheng, Runwei Li, Zongcun Chen, Zongcun Chen, Ke Tang, Guankui Du, Guankui Du, Guankui Du

“…Thirty-nine high-frequency keywords were grouped into five clusters, illustrating Akkermansia muciniphila’s associations with metabolic diseases, chronic kidney disease, the gut-brain axis, intestinal inflammation, and Bacteroidetes-Firmicutes shifts.ConclusionGiven Akkermansia muciniphila’s anti-inflammatory and gut-barrier-strengthening properties, it holds promise as a therapeutic for obesity, metabolic disorders, and inflammatory conditions. …”
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The Role of Motivation to Promote Personal and Social Responsibility Through PE and Sport: A Comparative Exploratory Investigation of Prospective PE Teachers and Sports Leaders in... by Istvan Soos, Ian Whyte, Diana Szekeres, Karoly Ozsvath, Attila Szabo, Jonathan Ling, Jose Francisco Jiménez-Parra, Alfonso Valero-Valenzuela

“…Background: Increasingly, young people are exposed to or exhibit socially toxic negative behaviours illustrating a need to influence behaviour positively by developing personal and social responsibility. …”
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Case report of the first use of a hydrogel rectal spacer for prostate cancer reirradiation via LDR brachytherapy: applications and technical notes by Amina Lazrek, Sebastiano Finocchi Ghersi, Adeline Petre, Sarah Houabes, Anne-Agathe Serre, Frederic Gassa, Magali Sandt, Cecile Laude, Camille Roukoz, Salvatore Cozzi

“…The patient remains asymptomatic with no urinary or gastrointestinal complications 6 months after the salvage treatment.DiscussionThis case illustrates the complexities in managing recurrent prostate cancer and the evolving role of reirradiation strategies. …”
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Predicting the effects of introducing an emergency transport system in low-income and middle-income countries: a spatial-epidemiological modelling study by Justine Davies, Dmitri Nepogodiev, Stephen Tabiri, Richard Lilford, Srinivasa Vittal Katikireddi, Samuel I Watson, Katie Scandrett

“…We apply the model to the illustrative case study of providing emergency transport for postpartum haemorrhage in Northern Ghana.Results The model predicts that the effects of an ambulance service are likely to be ephemeral, varying according to local circumstances such as population density and road networks. …”
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Concentrations, composition profiles, and in vitro–in silico-based mixture risk assessment of bisphenol A and its analogs in plant-based foods by Chun-Hui Chiu, Shih-Han Sun, Yun-Jia Yao, Yi Chuang, Yu-Tsung Lee, Yi-Jun Lin

“…This study advances the understanding of the dietary risks associated with BP mixtures and illustrates the potential of in vitro–in silico approaches for assessing human health risks from environmental contaminants.…”
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The JADES Transient Survey: Discovery and Classification of Supernovae in the JADES Deep Field by Christa DeCoursey, Eiichi Egami, Justin D. R. Pierel, Fengwu Sun, Armin Rest, David A. Coulter, Michael Engesser, Matthew R. Siebert, Kevin N. Hainline, Benjamin D. Johnson, Andrew J. Bunker, Phillip A. Cargile, Stephane Charlot, Wenlei Chen, Mirko Curti, Shea DeFour-Remy, Daniel J. Eisenstein, Ori D. Fox, Suvi Gezari, Sebastian Gomez, Jacob Jencson, Bhavin A. Joshi, Sanvi Khairnar, Jianwei Lyu, Roberto Maiolino, Takashi J. Moriya, Robert M. Quimby, George H. Rieke, Marcia J. Rieke, Brant Robertson, Melissa Shahbandeh, Louis-Gregory Strolger, Sandro Tacchella, Qinan Wang, Christina C. Williams, Christopher N. A. Willmer, Chris Willott, Yossef Zenati

“…We also found that two z ∼ 16 galaxy candidates from the first imaging epoch were actually transients that faded in the second epoch, illustrating the possibility that moderate/high-redshift SNe could mimic high-redshift dropout galaxies.…”
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Incidence and Mechanisms of Coronary Perforations during Rotational Atherectomy in Modern Practice by Yen-Hsiang Wang, Wei-Jhong Chen, Yu-Wei Chen, Chih-Hung Lai, Chieh-Shou Su, Wei-Chun Chang, Chi-Yen Wang, Kae-Woei Liang, Tsun-Jui Liu, Wen-Lieng Lee

“…The mechanisms for certain CPs were unique and illustrated in diagrams. Conclusion. CPs due to RA occur in certain percentage of patients. …”
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Beyond COVID-19, the case for collecting, analysing and using sex-disaggregated data and gendered data to inform outbreak response: a scoping review by Simone E Carter, Shirin Heidari, Leah Zilversmit Pao, Marie-Amelie Degail, Marie Meudec, McKinzie Gales, Emelie Love Yonally Phillips, Christine Dubray, Clara Rodriguez Ribas Elizalde, M Ruby Siddiqui

“…Evidence that is available illustrates that sex and gender disparities in outbreaks vary by disease, setting and population, and these differences play significant roles in shaping outbreak dynamics. …”
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The intestinal microbial community and function of Riptortus pedestris at different developmental stages and its effects on development by Yanbin Wang, Rong Li, Chunjing Wang, Ting Sun, Hongjuan Zhang, Fang Zhao, Jiehui Liu, Yuqiong Hao, Xiansheng Xie

“…Excitingly, Burkholderia bacteria eliminated by antibiotic treatment were unable to molt normally, and their lifespan was shortened in nymphs, indicating that the gut microbiota had a significant effect on nymph development.ConclusionIn summary, our results, for the first time, systematically illustrate the abundance and function across the gut microbiota from the different developmental stages of R. pedestris and demonstrate that the genera Burkholderia are crucial during the development of R. pedestris. …”
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Impact of dietary Spirulina on performance, antioxidant status, carcass traits and pathological alteration in broilers exposed to ochratoxin A stress by Ayman S. Salah, Mahmoud S. El-Tarabany, Marwa Mostafa, Rania Samir Zaki, Mahmoud M. Azzam, Omnia I. El Euony, Mahmoud Alagawany, Antonia Lestingi, Ahmed A. Elolimy, Mahmoud Madkour, Ahmed Fotouh

“…The duration of this study was six weeks, during which the experimental groups were organized as follows: G1 consumed a basal diet (control), G2 consumed a basal diet treated with OTA at a level of 1 mg/kg of diet, G3 consumed a basal diet treated with Spirulina platensis at a level of 1 g/kg of diet, G4 consumed a basal diet treated with OTA at a level of 1 mg/kg of diet and Spirulina platensis at a level of 1 g/kg diet.Results and discussionThe results illustrated that OTA-contaminated feed resulted in a significant elevation in total cholesterol, triglyceride, low- and very low density lipoprotein, and malondialdehyde, along with a significant reduction in antioxidant status and immunological response. …”
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Clinical calculator based on clinicopathological characteristics predicts local recurrence and overall survival following radical resection of stage II-III colorectal cancer by Fei Huang, Ran Wei, Shiwen Mei, Tixian Xiao, Wei Zhao, Zhaoxu Zheng, Qian Liu

“…Our clinical risk calculator provided good discrimination, with AUC values of local recurrence-free survival (LRFS) (0.764) and overall survival (OS) (0.815) in the training cohort and LRFS (0.740) and OS (0.730) in the test cohort. Calibration plots illustrated excellent agreement between the clinical risk calculator predictions and actual observations for 3- and 5-year LRFS and OS. …”
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Use of implementation logic models in the Quadruple Aim QUERI: conceptualization and evolution by Russell E. Glasgow, Marina S. McCreight, Brianne Morgan, Heidi Sjoberg, Anne Hale, Lexus Ujano-De Motta, Lauren McKown, Rachael Kenney, Heather Gilmartin, Christine D. Jones, Joseph Frank, Borsika A. Rabin, Catherine Battaglia

“…This evolution and reasons for changes are summarized and illustrated with the resulting logic models, both for the overall Quadruple Aim QUERI and the three specific projects. …”
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Telemedicine in home enteral nutrition: a structured survey exploring acceptability, preferences and experiences among patients by Ya Ma, Xuemei Li, Qian You, Wen Hu, Zhiyong Rao, Yanru Deng, Yiyao Zhang, Lei Shi

“…For interview subjects, distance and expense from home to hospital for HENST patients were more than those for face-to-face clinic visit patients, illustrating that HENST can save time and expenses. The patient satisfaction rate for HENST was 98.7%, and viewpoints of HENST improve the visit experience have been deemed by majority HENST patients (81.8%). …”
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Seropositivity to tick-borne pathogens in nature management workers in the Netherlands by B.J.A. Hoeve-Bakker, G. Çelik, O.E. van den Berg, C.C. van den Wijngaard, A. Hofhuis, J.H.J. Reimerink, S.F.T. Thijsen, K. Kerkhof

“…For A. phagocytophilum-seropositivity, increasing age and working in North Holland province were significant risk factors.This study illustrates the exposure to TBPs in the Netherlands, emphasizing the need for ongoing vigilance and international collaborations to better understand and address the growing threat of TBPs in regions with demonstrated environmental TBP circulation.…”
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Ethanol Extracts of Solanum lyratum Thunb Regulate Ovarian Cancer Cell Proliferation, Apoptosis, and Epithelial-to-Mesenchymal Transition (EMT) via the ROS-Mediated p53 Pathway by Chen Zhang, Zheming Li, Jie Wang, Xuelu Jiang, Mengting Xia, Jianfen Wang, Shenyi Lu, Shouye Li, Hanmei Wang

“…In summary, this study illustrated the anticancer effects of SLT on ovarian cancer cells, suggesting that SLT may have the potential to provide basic evidence for the discovery of antiovarian cancer agents.…”
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Prediction and Analysis of metabolic mechanism for regional water system from the perspective of quantity-quality collaborative control——A case study of Zhejiang Province, China... by Siqi Li, Yang Zhang, Tianqi Liu, Jinbo Zhang, Huaicheng Guo, Xiao Pu, Lu Lu, Changbo Qin

“…The regional water metabolism development trends are illustrated, water quantity-quality pollutants (COD, NH3-N) metabolism mechanisms are analyzed, and key industrial sectors for future scenario water system management are identified. …”
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Transcriptome Sequencing Reveals Regulatory Mechanisms of Taxol Synthesis in Taxus wallichiana var. Mairei by Tao Wang, Yiming Chen, Weibing Zhuang, Fengjiao Zhang, Xiaochun Shu, Zhong Wang, Qing Yang

“…To our knowledge, this is the first study to illustrate the regulatory mechanisms of taxol synthesis in a new cultivar of T. mairei with a high taxol content in its needles. …”
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Formation of the Figge Maar Seafloor Crater During the 1964 B1 Blowout in the German North Sea by Jens Karstens, Jens Schneider von Deimling, Christian Berndt, Christoph Böttner, Michel Kühn, Benedict T. I. Reinardy, Axel Ehrhardt, Jonas Gros, Bettina Schramm, Dirk Klaeschen, Judith Elger, Matthias Haeckel, Mark Schmidt, Sven Heinrich, Philipp Müller, Frithjof Bense

“…The formation of Figge Maar illustrates hazards related to the formation of secondary fluid pathways, which can bypass safety measures at the wellhead and are thus difficult to control.…”
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The Secondary Component of the Extremely Low Mass Ratio Massive Binary HD 165246 Revealed by GHOST by C. N. Rodriguez, T. Ansin, G. A. Ferrero, O. G. Benvenuto, R. Gamen, N. I. Morrell, J. I. Arias, R. E. Higa, C. Putkuri, C. Johnston, K. Chiboucas, E. Deibert, C. R. Hayes, J.-E. Heo, M. Jeong, V. Kalari, E. Martioli, V. M. Placco, K. A. Venn, S. Xu, R. Diaz, M. Gomez-Jimenez, R. Ruiz-Carmona, C. Simpson, A. W. McConnachie, J. Pazder, G. Burley, T. A. M. Berg, J. G. Robertson, K. Labrie, J. Thomas-Osip

“…Moreover, the secondary star is identified as a pre-main-sequence object, progressing toward the zero-age main sequence. This paper illustrates the power of high-resolution spectrographs such as GHOST in finding much lower mass, previously unseen stellar components of binary star systems.…”
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