Fosab, but not fosaa, plays important role in learning and memory in fish—insights from zebrafish gene knockout study by Qiuling Wang, Qiuling Wang, Qiuling Wang, Lixin Zhang, Lixin Zhang, Lixin Zhang, Chenyuan Zhu, Chenyuan Zhu, Chenyuan Zhu, Ke Lu, Ke Lu, Ke Lu, Jiaqi Wu, Jiaqi Wu, Jiaqi Wu, Xu-Fang Liang, Xu-Fang Liang, Xu-Fang Liang

“…For the first time, we illustrated the role of fosaa and fosab in learning and memory via c-fos knockout in fish, which can provide new insights into environmental adaptation.…”
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MiR-128-3p mediates MRP2 internalization in estrogen-induced cholestasis through targeting PDZK1 by Yue Zu, Qianyan Gao, Yisheng He, Qiao Deng, Guodong Li, Xiping Li, Tianze Shang, Xinwei Cheng, Chenglong Zhu, Jianqiao Wang, Dong Liu, Chengliang Zhang

“…Overall, our findings illustrate that miR-128-3p inhibits PDZK1 expression, thereby inhibiting the membrane localization of MRP2 in EIC. …”
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Case studies in adaptation: centring equity in global health education during the COVID-19 pandemic and beyond by Anna Pancheshnikov, C Nicholas Cuneo, Wilfredo R Matias, Rebeca Cázares-Adame, Abner Gamaliel Santos López, Ryan M Paxton, Chi Chiung Grace Chen

“…We present four case studies illustrating this promising movement towards a more sustainable, ethical and equitable model of global health education practice.Case 1: trainees from the Massachusetts General Hospital Center for Global Health partnered with the Board of Health of Holyoke, a majority Latinx city with high poverty levels, to respond to the COVID-19 pandemic through research and intervention. …”
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Constitutive expression of Cas9 and rapamycin-inducible Cre recombinase facilitates conditional genome editing in Plasmodium berghei by Samhita Das, Tanaya Unhale, Carine Marinach, Belsy del Carmen Valeriano Alegria, Camille Roux, Hélène Madry, Badreddine Mohand Oumoussa, Rogerio Amino, Shiroh Iwanaga, Sylvie Briquet, Olivier Silvie

“…Owing to the dual integration of CRISPR/Cas9 and DiCre, these new lines allow unparalleled levels of gene modification and conditional regulation simultaneously. To illustrate the versatility of this new tool, we conditionally knocked out the essential gene encoding the claudin-like apicomplexan micronemal protein (CLAMP) in P. berghei and confirmed the role of CLAMP during invasion of erythrocytes.…”
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Two-warehouse deterministic inventory model of expiry date known deteriorating items with just-in-time purchases for slotted backlogs by R. Thilagavathi, J. Viswanath, Miroslav Mahdal, Jayavelu Udaya Prakash, Sachin Salunkhe, Sachin Salunkhe

“…The finite number of JIT purchases is employed to satisfy the backlogged slotted demands that occur before the last slot.Results and DiscussionWe optimize the total cost of the replenishment cycle, RW utility, and total items purchased. The model is illustrated with an appropriate numerical example, and extensive sensitivity analysis is conducted on the system’s performance.…”
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Modulation of the Microstructure and Enhancement of the Photocatalytic Performance of g-C3N4 by Thermal Exfoliation by Xinshan Zhao, Junwei Yu, Tingyu Meng, Yuanyuan Luo, Yanzhen Fu, Zhao Li, Lin Tian, Limei Sun, Jing Li

“…The analysis conducted using XRD, FT-IR, XPS, SEM, and elements mapping tests, illustrated an increase in nitrogen-vacancy and oxygen content on the surface of the CN photocatalyst, resulting in a porous and sparse structure, changes in crystal size, and improved visible light absorption performance. …”
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Sustained release of miR-21 carried by mesenchymal stem cell-derived exosomes from GelMA microspheres inhibits ovarian granulosa cell apoptosis in premature ovarian insufficiency by Xiaofei Zhang, Linzi Ma, Xiaotong Liu, Xingyu Zhou, Ao Wang, Yunhui Lai, Jun Zhang, Ying Li, Shiling Chen

“…Conclusion: Our findings illustrate that activating miR-21 through Agomir21-Exo could improve the function of ovarian granulosa cells. …”
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Fuzzy Random Characterization of Pore Structure in Frozen Sandstone: Applying Improved Niche Genetic Algorithm by Yao Ya-feng, Lin Jian, Ge Jian, Peng Shi-long, Yin Jian-chao, Ouyang Li-na

“…Finally, based on the T2 spectrum test of frozen sandstone, the fuzzy random characterization of frozen sandstone pore distribution is carried out by using this transformation method. The results illustrate that the conversion coefficient obtained through the improved algorithm indirectly considers the different surface relaxation rates of different pore sizes and effectively reduces the diffusion coupling effects, and the pore characteristics achieved are more applicable in engineering practices than previous methods.…”
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Inhibiting ATP6V0D2 Aggravates Liver Ischemia-Reperfusion Injury by Promoting NLRP3 Activation via Impairing Autophagic Flux Independent of Notch1/Hes1 by Ziyi Wang, Hao Wang, Xuejiao Chen, Sheng Han, Yulin Zhu, Hanhua Wang, Feng Cheng, Liyong Pu

“…Knocking down ATP6V0D2 impaired the formation of autophagolysosome and aggravated liver IR injury through nonspecific V-ATPase activation independent of V-ATPase-Notchl-Hesl signal axis. In general, we illustrated that the expression of ATP6V0D2 in liver macrophages was upregulated after liver IR, and by gradually promoting the formation of autophagolysosomes to increase autophagy flux to limit the activation of liver inflammation, this regulation is independent of the Notch1-Hes1 signal axis.…”
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Molecular mechanisms of cis-oxygen bridge neonicotinoids to Apis mellifera Linnaeus chemosensory protein: Surface plasmon resonance, multiple spectroscopy techniques, and molecular... by Xiangshuai Li, Shiyu Li, Yang Liu, Li Cui, Daibin Yang, Shuning Chen, Xusheng Shao, Huizhu Yuan, Xiaojing Yan

“…Molecular docking and dynamics simulations further illustrated the stability of these interactions within the active site of the protein. …”
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A Case of Undiagnosed HIV Infection in a 57-Year-Old Woman with Multiple Myeloma: Consequences on Chemotherapy Efficiency and Safety by I. Poizot-Martin, S. Brégigeon, C. Tamalet, R. Bouabdallah, O. Zaegel-Faucher, V. Obry-Roguet, A. Ivanova, C.E. Cano, C. Solas

“…Conclusion. Our case illustrates the drawback that ignored HIV infection is still causing to cancer patients receiving chemotherapy and highlights the importance of early HIV testing in oncology. …”
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The Treatment Effect of Plantago Major on Lung Cancer Based on the Computed Tomography and Pathological Findings: A Case Report Study by Saade Abdalkareem Jasim, Bashar Mudhaffar Abdullah, Patricio Yánez-Moretta, Wesam R. Kadhum, Yasser Fakri Mustafa, Enas R. Alwaily, Munther Abosoda, Ali Alsalamy, Sada Ghalib Al-Musawi, Alaa A. Omran

“…In addition, the laboratory examinations illustrate that ESR and CRP levels reduced remarkably (from 97 mm/h to 24 mm/h for ESR; from 36.8 mg/L to 1.2 mg/L for CRP) after the treatment. …”
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Green Analytical Method for Simultaneous Determination of Glucosamine and Calcium in Dietary Supplements by Capillary Electrophoresis with Capacitively Coupled Contactless Conducti... by Yen Nhi Do, Thi Lan Phuong Kieu, Thi Huyen My Dang, Quang Huy Nguyen, Thu Hien Dang, Cao Son Tran, Anh Phuong Vu, Thi Trang Do, Thi Ngan Nguyen, Son Luong Dinh, Thi Minh Thu Nguyen, Thi Ngoc Mai Pham, Anh Quoc Hoang, Bach Pham, Thi Anh Huong Nguyen

“…After optimization, the CE conditions for selective determination of glucosamine and Ca2+ were obtained, including a 10 mM tris (hydroxymethyl) aminomethane/acetic acid (Tris/Ace) buffer of pH 5.0 as the background electrolyte; separation voltage of 20 kV; and hydrodynamic injection (siphoning) at 25 cm height for 30 s. The method illustrated good linearity over the concentration range of 5.00 to 200 mg/L of for glucosamine (R2 = 0.9994) and 1.00 to 100 mg/L for Ca2+ (R2 = 0.9994). …”
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A Heterogeneously Integrated 256-Element 5G Phased Array: Design, Assembly, Test by Bodhisatwa Sadhu, Arun Paidimarri, Atom O. Watanabe, Duixian Liu, Xiaoxiong Gu, Christian W. Baks, Yujiro Tojo, Yoshiharu Fujisaku, Isabel De Sousa, Yo Yamaguichi, Ning Guan, Alberto Valdes-Garcia

“…The paper discusses the several challenges and system trade-offs for 5G mmWave phased arrays and illustrates the advantages of heterogeneous integration at the antenna-in-package level. …”
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Crop protection by RNA interference: a review of recent approaches, current state of developments and use as of 2013 by Kirsten Germing, Cecilia Andrea Díaz Navarrete, Andreas Schiermeyer, Udo Hommen, Luise Zühl, Sebastian Eilebrecht, Elke Eilebrecht

“…A horizon scan was conducted with a specific emphasis to identify and illustrate the current state of RNAi developments and applications in crop protection as well as their biomanufacturing readiness levels. …”
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Process variables in mixture experimental design applied to wood plastic composites by Javier Cruz-Salgado, Sergio Alonso-Romero, Edgar Augusto Ruelas-Santoyo, José Alfredo Jiménez-García, Israel Miguel-Andrés, Roxana Zaricell Bautista-López

“…The absence of high multicollinearity, as indicated by variance inflation factor (VIF) values below 5, further supports the model's stability and interpretability. Contour plots illustrate the effect of varying mixture proportions on the response, such as tensile strength, showing a positive impact of both particle size and mixing time. …”
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K-nearest neighbor algorithm for imputing missing longitudinal prenatal alcohol data by Ayesha Sania, Ayesha Sania, Nicolò Pini, Nicolò Pini, Morgan E. Nelson, Michael M. Myers, Michael M. Myers, Lauren C. Shuffrey, Maristella Lucchini, Maristella Lucchini, Amy J. Elliott, Amy J. Elliott, Hein J. Odendaal, William P. Fifer, William P. Fifer

“…AimsThe objective of this study is to illustrate the application of a machine learning algorithm, K Nearest Neighbor (k-NN) to impute missing alcohol data in a prospective study among pregnant women.MethodsWe used data from the Safe Passage study (n = 11,083). …”
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Effect of Modulating Spin-Coating Rate of TiO2 Precursor for Mesoporous Layer on J-V Hysteresis of Solar Cells with Polar CH3NH3PbI3 Perovskite Thin Film by Qi Li, Xiaoping Zou, Yuanyuan Li, Yaxian Pei, Shuangxiong Zeng, Dongdong Guo

“…Firstly, the AFM images illustrate that the polarization behaviors exist and the deformation scale is large at the corresponding position when the DC bias voltage increases. …”
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Alternative splicing for tuneable expression of protein subunits at desired ratios by Christel Aebischer-Gumy, Pierre Moretti, Timothee Brunstein Laplace, Jana Frank, Ysaline Grand, Farid Mosbaoui, Emilie Hily, Anna Galea, Megane Peltret, Carole Estoppey, Daniel Ayoub, Roberto Giovannini, Martin Bertschinger

“…This specific design enables the modulation of the splice ratio by adjusting the strength of the splice acceptor. To illustrate this approach, we developed constructs expressing varying ratios of GFP and dsRED and extended their application to multimeric proteins such as monoclonal antibodies, achieving industrially relevant expression levels (>1 g/L) in a 14-day fed-batch process. …”
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Exome sequencing of UK birth cohorts [version 2; peer review: 2 approved, 1 approved with reservations] by Petr Danecek, Amy Hough, John Wright, Karen Ho, Nicholas J. Timpson, Sarah J. Lindsay, Davide Bonfanti, Daniel S. Malawsky, Rafaq Azad, Deborah Plowman, Sara Widaa, Gemma Shireby, Emla Fitzsimons, David Bann, Matthew E. Hurles, Hilary C. Martin, Susan M. Ring, Dan Mason, Michael A. Quail, Wei Huang, Vivek Iyer, Mahmoud Koko, Iaroslav Popov, Laurie Fabian, Gennadii Zakharov, Ruth Y. Eberhardt, Emma E. Wade, Qin Qin Huang

“…We then present some preliminary analyses to illustrate the quality of the datasets and probe potential sources of bias. …”
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