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9661
Patient-derived follicular lymphoma spheroids recapitulate lymph node signaling and immune profile uncovering galectin-9 as a novel immunotherapeutic target
Published 2024-05-01“…Abstract Follicular lymphoma (FL), the most common indolent non-Hodgkin lymphoma, constitutes a paradigm of immune tumor microenvironment (TME) contribution to disease onset, progression, and heterogenous clinical outcome. Here we present the first FL-Patient Derived Lymphoma Spheroid (FL-PDLS), including fundamental immune actors and features of TME in FL lymph nodes (LNs). …”
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9662
Renal function and clinical outcomes in survivors of out-of-hospital cardiac arrest
Published 2025-03-01“…Background: Comprehensive studies about renal-function changes in the context of out-of-hospital cardiac arrest (OHCA) have been lacking. Therefore, we investigated the impact of renal function on clinical outcomes among patients with OHCA. …”
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9663
Biogenic silver nanoparticles produced by Trichoderma reesei inhibit SARS-CoV-2 infection, reduce lung viral load and ameliorate acute pulmonary inflammation
Published 2025-01-01“…The COVID-19 pandemic, caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), posed a significant global health challenge and still demands efforts to develop new therapies. In this study, we investigated the potential of biogenic silver nanoparticles (AgNPs) synthesized by the fungus Trichoderma reesei to combat SARS-CoV-2 infection. …”
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9664
Diagnosis, screening, and follow-up of patients with familial interstitial lung disease: Results from an international survey
Published 2025-02-01“…International standards for genetic testing in ILD have not yet been established. We aimed to examine current real-world strategies employed by pulmonologists working with familial ILD. …”
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9665
Bisphenol S exposure interrupted human embryonic stem cell derived cardiomyocytes differentiation through ER-NF-κB/ERK signaling pathway
Published 2025-01-01“…To explore the effect of BPS on cardiomyocyte differentiation and its mechanism, our study established the human embryonic stem cell-cardiomyocyte differentiation model (hESC-CM), which was divided into early period of differentiation (DP1:1–8d), anaphase period of differentiation (DP2:9–16d) and whole stage of differentiation (DP3:1–16d) exposed to human-related levels of BPS. We found that the survival rate of cardiomyocytes was more sensitive to BPS at the early stage of differentiation than at the anaphase stage of differentiation, and exposure to higher than 30 µg/mL BPS throughout the differentiation period decreased the expression of cTnT. …”
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9666
Tumor mutational burden and survival on immune checkpoint inhibition in >8000 patients across 24 cancer types
Published 2025-02-01“…Using a large real-world dataset with validated survival endpoint data, we evaluated clinical validity of TMB measurement by the test in over 8000 patients across 24 cancer types who received single-agent immune checkpoint inhibitor (ICI).Methods Patients with advanced-stage cancers from 24 cancer types treated with single-agent anti-PD(L)1 therapy in standard-of-care settings were included. …”
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9667
Effect of different 1-methylcyclopropene formulations and dosing on the ripening profile of Tommy Atkins mango fruits
Published 2025-02-01“…Overall, the findings of this study suggest that 2.0ppm of the ‘powder’ formulation and 4.0ppm of the ‘Inbox Sachet’ formulation of SmartFresh™ would offer optimal effects at 24hrs and 12hrs exposure respectively. We, therefore, wish to recommend these two formulations at the reported levels for commercial application in the Tommy Atkins' mango variety to prolong postharvest shelf life and maintain desirable quality attributes.…”
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9668
Protocol of the TransformUs SecondaryTeachers’ perceptions of the program reach, effectiveness,adoption, implementation and maintenance schools program: a type II hybrid implementa...
Published 2025-02-01“…Qualitative data will be thematically analysed.We will assess effectiveness outcomes in 10 Victorian secondary schools using a pragmatic 1:1 waitlist control design. …”
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9669
What is the near-natural catchment? An application of hydrological signatures assessment
Published 2025-02-01“…To determine whether a catchment can be considered near-natural, we derive several key hydrological signatures that characterize catchment behavior among numerous hydrological signatures. …”
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9670
Preservation of cfRNA in cytological supernatants for cfDNA & cfRNA double detection in non‐small cell lung cancer patients
Published 2024-09-01“…Methods A protective solution (PS) was applied for preserving cfRNA in cytological supernatant (CS), and the quality of protected cfRNA was assessed by cycle threshold (CT) values from reverse transcription quantitative polymerase chain reaction (RT‐qPCR). Furthermore, we collected an additional set of malignant cytological and matched tumor samples from 84 NSCLC patients, cfDNA & cfRNA extraction and double detection for driver gene mutations was validated using the multi‐gene mutations detection by RT‐qPCR. …”
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9671
Compensatory synaptotagmin-11 expression conceals parkinson’s disease-like phenotypes in parkin knockout mice
Published 2025-02-01“…However, the mechanism underlying this discrepancy remains elusive. Here, we provide compelling evidence that the compensatory expression of synaptotagmin-11 (Syt11) plays a key role in concealing PD-associated phenotypes in parkin knockout (KO) mouse models. …”
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9672
Multidisciplinary care in pediatric severe asthma: A comparative outcomes analysis
Published 2025-05-01“…Objective: Our aim was to compare asthma outcomes between SACs and SDCs clinics and examine longitudinal health outcomes for patients with severe asthma who were followed in SACs. Methods: We conducted a retrospective cohort study comparing pediatric asthma outcomes among patients with severe asthma between 2018 and 2022 who were treated at the multidisciplinary Arkansas Children's SAC with those of patients with severe asthma treated at SDCs. …”
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9673
Duodenal Organoids From Metabolic Dysfunction-Associated Steatohepatitis Patients Exhibit Absorptive and Barrier Alterations
Published 2025-01-01“…Recent research has emphasized the importance of the gut-liver axis in its pathogenesis, an aspect less explored in human studies. Here, we investigated whether the duodenal epithelium of MASH patients could exhibit intrinsic dysfunctions. …”
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9674
Efficacy and safety of Janus kinase inhibitors in the treatment of psoriasis and psoriatic arthritis: An analysis of evidence from 2014 to 2022
Published 2025-02-01“…Adverse events (AEs) were classified according to eight systems of the human body. Results: We included 16 relevant RCTs involving 4,936 patients with psoriasis, with interventions performed using different doses of JAK inhibitors. …”
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9675
Prognostic Modeling for Bone Sarcomas Based on a Large Prospective Cohort From a Tertiary Care Cancer Center in India
Published 2025-02-01“…PURPOSEOutcomes of adolescents and young adults (AYA) with bone sarcomas including osteosarcoma (OGS) and Ewing sarcoma (ES) are affected by various factors including inadvertent previous treatment and poor compliance. We aimed to develop a risk-scoring system derived and validated at a tertiary care cancer center in India.METHODSAll AYA OGS and ES cases treated at our institute with OGS-12 and Ewing’s family of tumors-2001 (EFT-2001) protocols from 2011 to 2021 and 2013 to 2018, respectively, were prospectively analyzed. …”
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9676
An assessment of breast cancer HER2, ER, and PR expressions based on mammography using deep learning with convolutional neural networks
Published 2025-02-01“…Area under receiver operating characteristic curve (AUC), accuracy (ACC), and F1-score were calculated to assess the ability of the model to predict each receptor. For comparison we also developed original ResNet-18 without attention module and VGG-19 with and without attention module. …”
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9677
Ground-based Reconnaissance Observations of 21 Exoplanet Atmospheres with the Exoplanet Transmission Spectroscopy Imager
Published 2025-01-01“…This work also describes the various statistical tests performed on the data to evaluate the efficacy of the CMI method and the ETSI instrument in combination. We find that none of the eight comparisons of exoplanet atmospheres measured with ETSI and other observatories (including the Hubble Space Telescope) provide evidence that the spectra are statistically dissimilar. …”
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9678
Large range sizes link fast life histories with high species richness across wet tropical tree floras
Published 2025-02-01“…For Amazonian genera, we also explore whether traits are related to species richness via variation among genera in mean species-level range size. …”
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9679
Same data, different analysts: variation in effect sizes due to analytical decisions in ecology and evolutionary biology
Published 2025-02-01“…However, there were also several striking outliers in the Eucalyptus dataset, with effects far from zero. For both datasets, we found substantial variation in the variable selection and random effects structures among analyses, as well as in the ratings of the analytical methods by peer reviewers, but we found no strong relationship between any of these and deviation from the meta-analytic mean. …”
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9680
Exometabolomic exploration of culturable airborne microorganisms from an urban atmosphere
Published 2025-02-01“…However, the metabolic activities of cultivable atmospheric microorganisms in settled habitats remain less understood. Here, we cultured typical bacterial and fungal species isolated from the urban atmosphere using tryptic soy broth (TSB) and Sabouraud dextrose broth (SDB), respectively, and investigated their exometabolites to elucidate their potential roles in biogeochemical cycles. …”
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