Impact Assessment of Energy Transition Policy on Air Quality over a Typical District of the Pearl River Delta Region, China by Weidong Chen, Haixian Li, Yun Zhu, Jicheng Jang, Che-Jen Lin, Pen-Chi Chiang, Shuxiao Wang, Jia Xing, Tingting Fang, Jie Li, Qingshan Yang, Kaiming Zheng

“…Using Shunde District as a case study, we developed the emission inventories of CO2 and air pollutants, projected the trend of CO2 emissions, and estimated the air quality under three energy transition scenarios using the Long-range Energy Alternatives Planning (LEAP) model and the Weather Research and Forecasting-Community Multiscale Air Quality Modeling (WRF-CMAQ) system. …”
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Predictive Validity of Hospital-Associated Complications of Older People Identified Using Diagnosis Procedure Combination Data From an Acute Care Hospital in Japan: Observational S... by Seigo Mitsutake, Tatsuro Ishizaki, Shohei Yano, Takumi Hirata, Kae Ito, Ko Furuta, Yoshitomo Shimazaki, Hideki Ito, Alison Mudge, Kenji Toba

“…MethodsThis retrospective cohort study acquired DPC data (routinely collected administrative data) from a general acute care hospital in Tokyo, Japan. We included data from index hospitalizations for patients aged ≥65 years hospitalized for ≥3 days and discharged between July 2016 and March 2021. …”
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Rationale and design for Healthy Hearts in Manufacturing (HHM): A pragmatic single-arm hybrid effectiveness-implementation study for hypertension management and tobacco cessation by Hanzi Jiang, Yao Tian, Jennifer Bannon, Amy E. Krefman, Lawrence C. An, Dustin D. French, Claude R. Maechling, Jane Holl, Richard Chagnon, Theresa L. Walunas, Christopher Burch, Anthony Musci, Darce Latsis, Dawn Carey, Megan McHugh

“…The approach is inspired by the stepped-wedge cluster-randomized trial to assess intervention effectiveness. We will conduct interviews to identify facilitators and barriers to implementation and budget impact analysis to estimate the financial impact of the HMM interventions and the potential healthcare savings to companies and Medicare. …”
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Dissolved Mn(III) is a key redox intermediate in sediments of a seasonally euxinic coastal basin by R. Klomp, R. Klomp, O. M. Żygadłowska, M. S. M. Jetten, V. E. Oldham, N. A. G. M. van Helmond, N. A. G. M. van Helmond, C. P. Slomp, C. P. Slomp, W. K. Lenstra, W. K. Lenstra

“…The role of organically complexed dissolved Mn(III) (dMn(III)-L) as an electron acceptor and donor in marine environments is still incompletely understood. Here, we use geochemical depth profiles of solutes and solids for the sediment and overlying waters and a reactive transport model to reconstruct the seasonality in sedimentary dMn(III)-L dynamics and benthic Mn release in a eutrophic, seasonally euxinic coastal basin (Lake Grevelingen, the Netherlands). …”
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Transcription factor RUNX1 regulates coagulation factor XIII-A (F13A1): decreased platelet-megakaryocyte F13A1 expression and clot contraction in RUNX1 haplodeficiency by Fabiola Del Carpio-Cano, Natthapol Songdej, Liying Guan, Guangfen Mao, Lawrence E. Goldfinger, Jeremy G.T. Wurtzel, Kiwon Lee, Michele P. Lambert, Mortimer Poncz, A. Koneti Rao

“…Objectives: To understand RUNX1 regulation of F13A1 expression in platelets/megakaryocytes and the mechanisms and consequences of decreased F13A1 in RHD. Methods: We performed studies in platelets, human erythroleukemia (HEL) cells, and human CD34+ cell-derived megakaryocytes including on clot contraction in cells following small inhibitor RNA knockdown (KD) of RUNX1 or F13A1. …”
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Vitamin D deficiency and intracranial aneurysms: Systematic Review by Lívio Pereira de Macêdo, Glaudir Donato, Maria Eduarda d’Almeida Lins Regis, Isabela Fernandes de Melo Pereira, Gustavo Rodrigues Paulo, Kamilla Azevedo Bringel, Gabriel Carvalho Andrade Gadelha, Fábio Antônio Serra de Lima Júnior, Yally Dayanne Oliveira Ferreira, Renata de Castro Tavares, Arlindo Ugulino Netto, Kauê Franke, Pierre Vansant Oliveira Eugênio, Auricélio Batista Cezar-Junior, Igor Vilela Faquini, Eduardo Vieira de Carvalho Júnior, Nivaldo Sena de Almeida, Francisco Alfredo Bandeira e Farias, Marcelo Moraes Valença, Hildo Rocha Cirne Azevedo-Filho

“…From the results obtained, we can identify a higher incidence of hypovitaminosis D in patients with IA. …”
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The oncolytic adenovirus TILT-123 with pembrolizumab in platinum resistant or refractory ovarian cancer: the phase 1a PROTA trial by Matthew Stephen Block, James Hugo Armstrong Clubb, Johanna Mäenpää, Santeri Pakola, Dafne Carolina Alves Quixabeira, Tatiana Kudling, Elise Jirovec, Lyna Haybout, Mirte van der Heijden, Sanae Zahraoui, Susanna Grönberg-Vähä-Koskela, Sini Raatikainen, Victor Arias, Saru Basnet, Nea Ojala, Teijo Pellinen, Annabrita Hemmes, Katja Välimäki, Annukka Pasanen, Tuomo Alanko, Daniel Adamo, Susan Ramadan, Jorma Sormunen, Juha Kononen, Julia Wanda Cohen, Michael Jon Chisamore, John Goldfinch, Suvi Sorsa, Riikka Havunen, Claudia Kistler, Aino Kalervo, Víctor Cervera-Carrascon, João Manuel dos Santos, Akseli Hemminki

“…Originally developed to improve efficacy of T-cell therapies such as immune checkpoint inhibitors and adoptive cell transfer, TILT-123 (Ad5/3-E2F-D24-hTNFα-IRES-hIL-2) is a serotype chimeric oncolytic adenovirus encoding tumor necrosis factor alpha and interleukin-2. Here we report results from phase 1a of PROTA, a single-arm, multicentre dose escalation trial with TILT-123 and pembrolizumab in female patients with platinum resistant or refractory ovarian cancer (NCT05271318). …”
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Sources, Compositions, and Health Risks of PM2.5-bound PAHs at the Rural Area along with the “Coal to Gas” Law by Zhiyong Li, Ziyuan Yue, Wenjia Zhu, Wenquan Liu, Jintao Gao, Jiaqiang Zhang, Ziyi Zhan, Lan Chen, Huiying Gao, Jihong Wei

“…Existing researches about CTG impacts on components, sources, and health risks of PM2.5-bound PAHs mainly focused on metropolitan area, whereas they were lacking in rural area of north China. Here, we deployed an intensive observation in winter of 2020 at a rural site in the central area of the Beijing-Tianjin-Hebei (BTH) region. …”
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Recent Advances in Fiber-Optic Sensors for the Detection of Inorganic Acidic Gases by Lingnan Kong, Yuanke Gong, Xiaoyu Zhong, Yang Liu, Bo Wan, Quanhua Xie, Yuanyuan He, Xiaoling Peng, Haixing Chang, Dengjie Zhong, Huiling Liu, Nianbing Zhong

“…However, the sensitivity, selectivity, repeatability, and limits of detection of these sensors can be improved to achieve acceptable performance levels for practical applications. In this review, we introduce fiber-optic sensors based on structured optical fibers and fiber gratings for detecting H2S, SO2, NO2, CO2, and N2O. …”
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Phantom motor execution as a treatment for phantom limb pain: protocol of an international, double-blind, randomised controlled clinical trial by Brian E McGuire, Lina Bunketorp-Käll, Eva Lendaro, Liselotte Hermansson, Helena Burger, Corry K Van der Sluis, Monika Pilch, Katarzyna Kulbacka-Ortiz, Ingrid Rignér, Anita Stockselius, Lena Gudmundson, Cathrine Widehammar, Wendy Hill, Sybille Geers, Max Ortiz-Catalan

“…Preliminary investigations have shown that decoding motor volition using myoelectric pattern recognition, while providing real-time feedback via virtual and augmented reality (VR-AR), facilitates phantom motor execution (PME) and reduces PLP. Here we present the study protocol for an international (seven countries), multicentre (nine clinics), double-blind, randomised controlled clinical trial to assess the effectiveness of PME in alleviating PLP.Methods and analysis Sixty-seven subjects suffering from PLP in upper or lower limbs are randomly assigned to PME or phantom motor imagery (PMI) interventions. …”
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In the coevolution of cotton and pathogenic fungi, resistant cotton varieties lead to an escalation in the virulence of Verticillium dahliae by Yalin Zhang, Lifang Cui, Ruibing Liu, Zili Feng, Hongjie Feng, Jinglong Zhou, Lihong Zhao, Feng Wei, Heqin Zhu

“…To better understand the mechanisms of this phenomenon, we applied the host selective pressures of resistant and susceptible cotton varieties on V. dahliae strain Vd076 within an artificial cotton Verticillium wilt nursery and greenhouse. …”
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Placental Vascular Malperfusion in Pregnancies With Congenital Heart Disease by Nour Rahnama, MD, Arthur Colson, MD, PhD, Pamela Baldin, MD, PhD, Agnès Pasquet, MD, PhD, Damien Gruson, MD, PhD, David Vancraeynest, MD, PhD, Christophe Beauloye, MD, PhD, Frédéric Debiève, MD, PhD, Sophie Pierard, MD, PhD

“…Methods: In this prospective single-center study, we enrolled pregnant women with CHD who were followed from March 2021 to June 2023, along with a control group matched for age, parity, and body mass index. …”
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Evidence adaptation and tailored implementation of family bereavement support in specialised palliative care: A multi-method study by Myrta Kohler, Qëndresa Thaqi, Silke Kuske, Torsten Schwalbach, Marco Riguzzi, Rahel Naef

“…To close this know-do gap, we undertook an implementation science research project. …”
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Comprehensive coronary CT angiography in people living with HIV: a systematic review and meta-analysis by Binh T Nguyen, Edward Hulten, Venkatesh L Murthy, Tarin Phillips, Gregory M Blake, Jonathan A Aun, Lisa M Conte, Ritika Gadodia, Aakash Tuli, Sara L Robinson, Travis E Harrell

“…This systematic review and meta-analysis summarise and estimate pooled effect sizes for observational studies among PLWH using comprehensive coronary CT angiography (CTA).Design Preferred Reporting Items for Systematic Review and Meta-analysis reporting guidelines were used.Data sources PubMed, Embase, Web of Science, CINAHL, Cochrane Clinical Trials and EBM were searched from inception to 23 February 2024.Eligibility criteria We included studies evaluating coronary atherosclerosis in adult PLWH with controls and CTA results for plaque prevalence, extent, severity and high-degree stenosis.Data extraction and synthesis Two independent reviewers used standardised methods to screen for relevance by title, abstract and full-text review. …”
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The Multifaceted Roles of Myrrha in the Treatment of Breast Cancer: Potential Therapeutic Targets and Promises by Anwar Shams MD, MSc, PhD, Abdullah Ahmed Alzahrani, Taghreed A Ayash MSc, PhD, Shadi Tamur MD, FRCPC, FAAP, Majed AL-Mourgi MD, FRCS, FCCP, FACS

“…Nonetheless, myrrh’s precise rudimentary mechanisms of action in regulating genes involved in breast cancer evolution and progression remain elusive. Purpose: Herein, we use a network pharmacology platform to identify the potential genes targeted by myrrh-active molecules in breast cancer. …”
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Assessment of six insulin resistance surrogate indexes for predicting stroke incidence in Chinese middle-aged and elderly populations with abnormal glucose metabolism: a nationwide... by Luqing Jiang, Tengxiao Zhu, Wenjing Song, Ying Zhai, Yu Tang, Fengxia Ruan, Zichen Xu, Lei Li, Xia Fu, Daoqin Liu, Aidong Chen, Qiwen Wu

“…Results After adjusting for potential confounders, we observed that each standard deviation (SD) increase in eGDR was associated with a reduced risk of stroke, with an adjusted odds ratio (OR) of 0.746 [95% confidence interval (CI): 0.661–0.842]. …”
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Auxin signaling related to H+-ATPase synthesis and antioxidant enzyme activities regulates fluoranthene uptake by ryegrass roots by Yuanzhou Xu, Yunyun Li, Xinyue Zhang, Zhuoliang Xiao, Jiaguo Jiao, Huijuan Zhang, Huixin Li, Feng Hu, Li Xu

“…However, the molecular mechanisms underlying these behaviors remain unclear. To address this, we exposed ryegrass to different Flu concentrations (0, 5, and 20 mg/L) and conducted a combined transcriptomic and physiological analysis of the root system to elucidate the specific mechanisms of Flu uptake. …”
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A lightweight wheat ear counting model in UAV images based on improved YOLOv8 by Ruofan Li, Xiaohua Sun, Kun Yang, Zhenxue He, Zhenxue He, Xinxin Wang, Xinxin Wang, Chao Wang, Chao Wang, Bin Wang, Fushun Wang, Fushun Wang, Hongquan Liu, Hongquan Liu

“…To address the challenges of missed detections, false detections, and diminished detection accuracy arising from the dense distribution, small size, and high overlap of wheat ears in Unmanned Aerial Vehicle (UAV) imagery, we propose a lightweight model, PSDS-YOLOv8 (P2-SPD-DySample-SCAM-YOLOv8), on the basis of the improved YOLOv8 framework, for the accurate detection of wheat ears in UAV images. …”
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Phase II clinical trial assessing the addition of hyperthermia to salvage concurrent chemoradiotherapy for unresectable recurrent head and neck cancer in previously irradiated pati... by Kai-Lin Yang, Mau-Shin Chi, Chung-Yu Hao, Hui-Ling Ko, Yi-Ying Huang, Ren-Hong Wu, Hung-Chih Lai, Ying-Chu Lin, Sheng-Po Hao, Kwan-Hwa Chi

“…Abstract Background This single-arm phase II trial aimed to assess the effectiveness and safety of incorporating hyperthermia into salvage concurrent chemoradiotherapy (CCRT) for previously irradiated unresectable recurrent head and neck cancer. Methods We enrolled patients with non-metastatic recurrent head and neck cancer who had previously undergone radiotherapy (RT) and were unfit for salvage surgery. …”
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Analisis Kesiapan Penerapan Process Mining pada Sistem Manajemen Pembelajaran Universitas Telkom by Angelina Prima Kurniati, Gede Agung Ary Wisudiawan

“…This paper is written following the main stages on the Process Mining Project Methodology (PM2). We explore a case study of the learning process of a course in a semester, based on an event log extracted from the LMS. …”
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