UV-C and Nanomaterial-Based Approaches for Sulfite-Free Wine Preservation: Effects on Polyphenol Profile and Microbiological Quality by Kamila Pachnowska, Jolanta Kochel-Karakulska, Adrian Augustyniak, Valentina Obradović, Ireneusz Ochmian, Sabina Lachowicz-Wiśniewska, Ireneusz Kapusta, Klaudia Maślana, Ewa Mijowska, Krzysztof Cendrowski

“…These results open up discussion on the possible use of the proposed hurdle technology in winemaking to control the polyphenol composition and alcohol reduction.…”
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Challenges in the Diagnosis and Management of Growth Hormone Deficiency in India by Mathew John, Ekaterina Koledova, Kanakatte Mylariah Prasanna Kumar, Harshal Chaudhari

“…The diagnosis and treatment of GHD are hurdled with various challenges, restricting the availability of growth hormone (GH) therapy to only a very limited segment of the children in India. …”
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Impact of E-Learning, Perception and Attitude among Students and Faculty following the COVID-19 Pandemic by Syed Hamza Zia, Ghina Rizwan, Afifa Ehsan, Zarnab Rizwan, Rabia Masood, Naila Umer

“…Many efforts such as social distancing was made to cut down the spread of the virus in its early days and restrictions were followed by numerous countries worldwide which resulted in serious hurdles in all sectors of our daily lives such as education, financial and social activities. …”
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Brown Bear, Brown Bear, What Can You See? Exploring the Tension Between Strategic Choices and Claimants’ Voices in Environmental Litigation in the EU by Reilly Anne Dempsey Willis

“…There are many legal hurdles to bringing environmental claims and it is possible that the voice of the environment and those most adversely affected by its degradation is lost in the strategic legal decision-making. …”
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Volatile Organic Metabolites as Potential Biomarkers for Genitourinary Cancers: Review of the Applications and Detection Methods by Kiana L. Holbrook, Wen-Yee Lee

“…However, developing robust VOC detection methods remains a hurdle. This review outlines the current landscape of major genitourinary cancers (kidney, prostate, bladder, and testicular), including epidemiology, risk factors, and current diagnostic tools. …”
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Functional Properties of Human Stem Cell-Derived Neurons in Health and Disease by Jason P. Weick

“…While significant advances have been made, critical hurdles must be overcome in order for this technology to support progression toward clinical applications.…”
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Advancements in training and deployment strategies for AI-based intrusion detection systems in IoT: a systematic literature review by S. Kumar Reddy Mallidi, Rajeswara Rao Ramisetty

“…The study concludes by synthesizing the major challenges facing current IDS implementations in IoT and suggesting future research directions aimed at overcoming these hurdles. This review highlights the technological advancements in IDS and sets the stage for future enhancements in IoT security, emphasizing the integration of innovative training and deployment strategies.…”
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Correlation Analysis of Sprint Performance and Reaction Time Based on Double Logarithm Model by Jing Zhang, Xin-Yu Lin, Su Zhang

“…This study examines the reaction time and the results of the male and female sprinters participating in the World Athletics Championships from 2011 to 2019 in the 100 m, 200 m, 100 m, and 110 m hurdles. The researchers used least squares estimation, multivariate analysis of variance, and other methods and theories to construct a double logarithmic model and a multivariate analysis of a variance model. …”
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Convergence of nanotechnology and artificial intelligence in the fight against liver cancer: a comprehensive review by Manjusha Bhange, Darshan Telange

“…However, data privacy, regulatory hurdles, and the need for large-scale clinical validation remain. …”
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Reducing Nitrogen Waste: Factors Influencing Neem‐Coated Urea Adoption in Bhutan by Toritseju Begho, Tashi Dorji, Sonam Dendup

“…Analysing data from 235 farmers using a double hurdle regression model, the paper identified several positive drivers of NCU adoption, including multiple plots, larger farm size, organic fertiliser use, recent agricultural training, and seeking advice on fertiliser decisions. …”
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An UAV-assisted VANET architecture for intelligent transportation system in smart cities by Ali Raza, Syed Hashim Raza Bukhari, Farhan Aadil, Zeshan Iqbal

“…The severity of these challenges become even more intensified when deployed in urban areas. To overcome these hurdles, integrating micro unmanned aerial vehicles with vehicular ad hoc network provides a viable solution. …”
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Missed, but Momentous: A Comprehensive Review of Neglected Tropical Skin Diseases in Southern India and their Global Impact by Ramesha M Bhat, N Swathi

“…This systematic review aims to probe into the intricate facets of NTDs in South India, delving into each dermatological NTD in detail, spotlighting their essence, prevalence, socio-economic reverberations, hurdles, and the necessity for collective action. …”
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The effect of smart contracts (blockchain technology) on Jordan’s land registry and survey department for sustainable development by AbdelKarim Fawwaz AlBataineh

“…Despite these promising results, the study acknowledges critical challenges such as the need for technical expertise, regulatory frameworks, and initial investment hurdles. Addressing these challenges is crucial for balanced implementation and sustained engagement with the technology. …”
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Current Status of Comprehensive Chromosome Screening for Elective Single-Embryo Transfer by Ming-Yih Wu, Kuang-Han Chao, Chin-Der Chen, Li-Jung Chang, Shee-Uan Chen, Yu-Shih Yang

“…However, unsatisfactory results in IVF may result from plenty of factors, in which aneuploidy associated with advanced maternal age is a major hurdle. Throughout the past few years, we have got a big leap in advancement of the genetic screening of embryos on aneuploidy, translocation, or mutations. …”
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Direct Reprogramming of Mouse Fibroblasts to Neural Stem Cells by Small Molecules by Yan-Chuang Han, Yoon Lim, Michael D. Duffieldl, Hua Li, Jia Liu, Nimshitha Pavathuparambil Abdul Manaph, Miao Yang, Damien J. Keating, Xin-Fu Zhou

“…Although it is possible to generate neural stem cells (NSC) from somatic cells by reprogramming technologies with transcription factors, clinical utilization of patient-specific NSC for the treatment of human diseases remains elusive. The risk hurdles are associated with viral transduction vectors induced mutagenesis, tumor formation from undifferentiated stem cells, and transcription factors-induced genomic instability. …”
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Developing glycoproteomics reveals the role of posttranslational glycosylation in the physiological and pathological processes of male reproduction by Qingyuan Cheng, Mengqi Luo, Zihe Xu, Fuping Li, Yong Zhang

“…However, our grasp on glycosylation within male reproductive processes remains limited, largely due to the technical hurdles. Recent advancements have seen the mapping of the glycoproteome of human semen, utilizing cutting‐edge glycoproteomic technologies. …”
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Transposon mediated functional genomic screening for BRAF inhibitor resistance reveals convergent Hippo and MAPK pathway activation events by Li Chen, Iulian Pruteanu-Malinici, Anahita Dastur, Xunqin Yin, Dennie Frederick, Ruslan I. Sadreyev, Cyril H. Benes

“…Abstract Genotype-informed anticancer therapies such as BRAF inhibitors can show remarkable clinical efficacy in BRAF-mutant melanoma; however, drug resistance poses a major hurdle to successful cancer treatment. Many resistance events to targeted therapies have been identified, suggesting a complex path to improve therapeutics. …”
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Integrating malaria vaccine and CRISPR/Cas9 gene drive: a comprehensive strategy for accelerated malaria eradication by Israel Charles Abraham, John Ehi Aboje, Bonaventure Michael Ukoaka, Kehinde Tom-Ayegunle, Maryam Amjad, Anas Abdulkader, Chinonyelum Emmanuel Agbo, Oluwatosin Ayokunle Akinruli, Taiwo Rebecca Akisanmi, Emmanuel Oyedeji Oyetola, Gbolahan Olatunji, Emmanuel Kokori, Nicholas Aderinto

“…Challenges such as regulatory hurdles, community acceptance, ecological impacts, and sustainable funding are examined, alongside strategies for implementation within existing malaria control programmes. …”
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A Process Model for the Implementation of Blockchain-Based Systems by Muhammad Nasim Bahar, Michal Ries, Kristian Kostal

“…This study tackles these hurdles by introducing a process model for the implementation of a blockchain-based system (PM-IBS), a comprehensive framework that guides organizations through the complexities of the adoption of blockchain systems. …”
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Fibroblasts in rheumatoid arthritis: novel roles in joint inflammation and beyond by Elpida Neofotistou-Themeli, Elpida Neofotistou-Themeli, Panagiota Goutakoli, Panagiota Goutakoli, Theodoros Chanis, Theodoros Chanis, Maria Semitekolou, Maria Semitekolou, Eirini Sevdali, Eirini Sevdali, Prodromos Sidiropoulos, Prodromos Sidiropoulos

“…Although our knowledge of ILD has progressed, significant gaps in both basic and clinical science remain, posing hurdles to efficient diagnosis, prediction of disease course and its effective treatment. …”
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