Accuracy of Intraoperative Transesophageal Echocardiographic Doppler Parameters in Assessing the Right Ventricular Diastolic Function After Repair of Tetralogy of Fallot in Pediatr... by Nagarjuna Panidapu, Saravana Babu, Baiju S. Dharan, Barsha Sen, Thomas Koshy

“…The ASE-described parameters (late diastolic forward flow in the main pulmonary artery, right atrial dilatation, inferior vena cava dilatation, and hepatic venous flow reversal) were acquired to diagnose the RVDD. …”
Get full text

Exploring the Most Promising Stem Cell Therapy in Liver Failure: A Systematic Review by Jeanne AdiwinataPawitan

“…Fresh or cryopreserved, and autologous or allogeneic MSCs were equally beneficial; and giving too many cells via intraportal or the hepatic artery might be counterproductive.…”
Get full text

Review of Laboraotory and Clinical Studies of Olestra, a Nonabsorbable Lipid by Carolyn M Bergholz, Ronald J Jandacek, Alan BR Thomson

“…Although serum retinol levels are not reduced, additional research is focusing on effects of olestra on hepatic stores of vitamin A to assess the appropriateness of supplementation. …”
Get full text

Quality of Life in Wilson’s Disease: A Systematic Literature Review by Chakrapani Balijepalli, Kevin Yan, Lakshmi Gullapalli, Stephane Barakat, Helene Chevrou-Severac, Eric Druyts

“…Overall, the pattern in QOL from most studies demonstrated a worse QOL in WD patients compared with the general population, a deterioration in QOL for patients presenting with neurologic symptoms, and more frequent psychiatric symptoms compared with the ones with hepatic symptoms. **Discussion:** Although our understanding of the underlying pathophysiology of WD has advanced, and novel therapeutics are on the horizon, our understanding of how WD affects overall QOL remains limited. …”
Get full text

Impact of interferon-free regimens in patients with chronic HCV and successfully ablated HCC by Amr Maged Mahmoud Rasheed, Maissa E. L. Raziky, Mohammad El Sayed, Mai Mehrez, Gamal Esmat

“…Patients and methods This trial was carried out on 90 Egyptian persons with chronic HCV infection who were eligible for treatment with oral antiviral agents (DAAs) with hepatic focal lesion(s). Patients were referred to from both the outpatient clinic and hepatocellular carcinoma clinic at the National Hepatology and Tropical Medicine Research Institute (NHTMRI), and the trial was conducted in the period between October 2017 and May 2021. …”
Get full text

High interindividual variability of indoxyl sulfate production identified by an oral tryptophan challenge test by Ting-Yun Lin, Wei-Kai Wu, Szu-Chun Hung

“…IS is converted from indole, a metabolite of dietary tryptophan through the action of gut microbial tryptophanase, by two hepatic enzymes: CYP2E1 and SULT1A1. We hypothesized that the effect of tryptophan intake on IS production might differ from person to person. …”
Get full text

Hepatorenal Syndrome: Outcome of Response to Therapy and Predictors of Survival by Jan Heidemann, Christoph Bartels, Christoph Berssenbrügge, Hartmut Schmidt, Tobias Meister

“…Patient characteristics and clinical parameters (Child stage, ascites, hepatic encephalopathy, HRS type I/II, and initial MELD score) were retrieved. …”
Get full text

Can improving sleeping hours enhance the depression and anxiety of young males with chronic musculoskeletal pain? by Huipeng Zhou, Zhishi Yang, Ling Tang, Yongrun Sun, Yutao Tu, Yeye Sha, Zhiwei Wang, Yanpu Jia

Get full text

Isolated Superior Mesenteric Vein Tumor Thrombus in a Patient with Gastric Cancer by Barış Özcan, Metin Çevener, Ayşegül Kargı, Mustafa Özdoğan, Alihan Gürkan

“…The patient received adjuvant chemotherapy, and he is at his 22nd-month follow-up with extensive hepatic metastases and intra-abdominal disease. It should be kept in mind that gastric cancer may lead to portal vein tumor thrombus or that it may rarely be associated with an isolated SMV tumor thrombus, both of which are associated with poor prognosis.…”
Get full text

Macrophage MST1 protects against schistosomiasis-induced liver fibrosis by promoting the PPARγ-CD36 pathway and suppressing NF-κB signaling. by Jianyang Li, Xinyuan Cai, Yan Yang, Yulin Mao, Lin Ding, Qian Xue, Xunhao Hu, Yan Huang, Cong Sui, Yuxia Zhang

“…Schistosomiasis is characterized by egg-induced hepatic granulomas and subsequent fibrosis. Monocyte-derived macrophages play critical and plastic roles in the progression and regression of liver fibrosis, adopting different polarization phenotypes. …”
Get full text

Prognostic Factors Affecting Long-Term Survival after Resection for Noncolorectal, Nonneuroendocrine, and Nonsarcoma Liver Metastases by Fabio Uggeri, Enrico Pinotti, Marta Sandini, Luca Nespoli, Luca Gianotti, Fabrizio Romano

“…To evaluate feasibility and long-term outcome after hepatic resection for noncolorectal, nonneuroendocrine, and nonsarcoma (NCNNNS) liver metastases in a single center. …”
Get full text

Effects of ultra-processed foods on the liver: insights from gut microbiome and metabolomics studies in rats by Liping Shi, Zhuoyuan Li, Xiaojun Ma, Junru Wang, Yueping Wu, Yongbin Zhu, Yanrong Wang, Yue Yang, Minxiu Luo, Jiangping Li, Xian Sun, Xian Sun, Shulan He, Shulan He

“…Furthermore, the consumption of UPF led to a metabolomic disorder characterized by disruptions in the sphingolipid signaling pathway, sulfur relay system, and arachidonic acid metabolism.ConclusionIn conclusion, the findings of this study indicate that the consumption of UPF influences the development of simple hepatic steatosis, potentially through alterations in gut microbiota and metabolomics.…”
Get full text

Lung-Derived Mediators Induce Cytokine Production in Downstream Organs via an NF-κB-Dependent Mechanism by E. K. Patterson, L. J. Yao, N. Ramic, J. F. Lewis, G. Cepinskas, L. McCaig, R. A. W. Veldhuizen, C. M. Yamashita

“…Additionally, liver tissue obtained from mice subjected to 2 hours of in vivo MV demonstrated significant increases in hepatic gene transcription of IL-6, CXCL-1, and CXCL-2 compared to nonventilated controls. …”
Get full text

Catastrophic Brain Aspergillosis after Liver Transplantation by Mohammadmahdi Abbasi, Shirin Shams Ardakani, Nasir Fakhar, Hamid Eshaghi, Hosein Alimadadi, Toktam Faghihi, Behdad Gharib, Meisam Sharifzadeh, Masoomeh Safaei

“…The patient was an 8-year-old boy, with a case of Wilson disease, who underwent liver transplantation due to acute fulminant hepatic failure. Four days after the surgery, he was affected by fever, agitation, loss of consciousness, hemiparesis, and focal seizure. …”
Get full text

Standardization of Tragopogon graminifolius DC. Extract Based on Phenolic Compounds and Antioxidant Activity by Mohammad Hosein Farzaei, Mahnaz Khanavi, Ghazaleh Moghaddam, Farzaneh Dolatshahi, Roja Rahimi, Mohammad Reza Shams-Ardekani, Gholamreza Amin, Mannan Hajimahmoodi

“…(TG), Compositae family, is traditionally used for the treatment of various diseases like gastrointestinal and hepatic disorders. The aim of the present study is to standardize extracts from TG used for preparation of different dosage forms in traditional Iranian medicine (TIM) based on phenolic compounds. …”
Get full text

Liraglutide Attenuates Nonalcoholic Fatty Liver Disease through Adjusting Lipid Metabolism via SHP1/AMPK Signaling Pathway by Peng Yu, Xi Xu, Jing Zhang, Xuan Xia, Fen Xu, Jianping Weng, Xiaoyang Lai, Yunfeng Shen

“…LR administration significantly lowered the serum lipid profile and lipid disposition in vitro and in vivo because of the altered expression of enzymes on hepatic gluconeogenesis and lipid metabolism. Moreover, LR significantly decreased Src homology region 2 domain-containing phosphatase-1 (SHP1) and then increased the expression of phosphorylated-AMP-activated protein kinase (p-AMPK). …”
Get full text

Surveillance of HCC Patients after Liver RFA: Role of MRI with Hepatospecific Contrast versus Three-Phase CT Scan—Experience of High Volume Oncologic Institute by Vincenza Granata, Mario Petrillo, Roberta Fusco, Sergio Venanzio Setola, Elisabetta de Lutio di Castelguidone, Orlando Catalano, Mauro Piccirillo, Vittorio Albino, Francesco Izzo, Antonella Petrillo

“…Thirty-four consecutive HCC patients (42 hepatic nodules) were treated with percutaneous RFA and underwent MR and CT scans. …”
Get full text

Chimonanthus nitens Oliv. leaves flavonoids alleviate hyperuricemia by regulating uric acid metabolism and intestinal homeostasis in mice by Wenya Meng, Lingli Chen, Kehui Ouyang, Suyun Lin, Yang Zhang, Jing He, Wenjun Wang

“…The results showed that CLF lowered the serum levels of uric acid (UA), creatinine and blood urea nitrogen, downregulated hepatic mRNA expressions of xanthine oxidase (XO), phosphate ribose pyrophosphate synthetase (PRPS) and adenosine deaminase (ADA) in hyperuricemia mice. …”
Get full text

Single‐cell sequencing reveals the features of adaptive immune responses in the liver of a mouse model of dengue fever by Yizhen Yuan, Qian Chen, Zhe Li, Fangzhou Cai, Dan Li, Wei Wang

“…Abstract Background Dengue fever, an acute insect‐borne infectious disease caused by the dengue virus (DENV), poses a great challenge to global public health. Hepatic involvement is the most common complication of severe dengue and is closely related to the occurrence and development of disease. …”
Get full text

X-Linked Lymphoproliferative Syndrome and Common Variable Immunodeficiency May Not Be Differentiated by SH2D1A and XIAP/BIRC4 Genes Sequence Analysis by Nesrin Gulez, Guzide Aksu, Afig Berdeli, Neslihan Karaca, Sema Tanrıverdi, Necil Kutukculer, Elif Azarsiz

“…A six-year-old male patient was admitted with the complaints of persistent general lymphadenopathy, for two years had fever, bilateral cervical multiple microlymphadenopathy, hepatic/splenic enlargement with laboratory findings as decreased serum immunoglobulins, negative EBV VCA IgM (viral capsid antigen) and anti-EBV EA (antibody to early D antigen), positive EBV VCA IgG (viral capsid antigen) and EBV EBNA (antibody to nuclear antigen). …”
Get full text