First Case Report of a Late Onset Knee Periprosthetic Joint Infection Caused by Lactococcus garvieae by V.-I. Neagoe, S. Zytoun, H.-J. Neuhaus

“…The association between Lactococcus spp. and human infectious diseases is described as being mainly associated with lumbar osteomyelitis, hepatic abscess, and infective endocarditis. In the literature of orthopedic post-prosthetic infections, L. garvieae was associated with a case of hip prosthetic infection in a fishmonger woman. …”
Get full text

Anti-diabetic effect of aloin via JNK-IRS1/PI3K pathways and regulation of gut microbiota by Ruting Zhong, Lanbin Chen, Yuanyuan Liu, Shouxia Xie, Sumei Li, Bin Liu, Chao Zhao

“…Histopathological analysis of the liver indicated hepatic protection by aloin. Additionally, aloin treatment inhibited the protein expression of c-Jun N-terminal kinases and activated that of IRS1/PI3K/Akt in the liver. …”
Get full text

Biological properties of Moringa oleifera: A systematic review of the last decade [version 2; peer review: 2 approved, 1 approved with reservations] by Andrea Catalina Gómez, Javier Andrés Soto, C. A. Zuniga-Gonzalez, Karen Shirley Molina, Andrea Natalia Barreto, Maryeli Vásquez

“…Results Moringa oleifera extracts showed antioxidant, hypoglycemic, antihypertensive and cytoprotective properties at neuronal, hepatic, renal and cardiac levels. Besides, cytotoxic effects, apoptotic and antiploriferative activity against several cancer cell lines has been demonstrated. …”
Get full text

Case report: Rare observation of thyroid-like cholangiocarcinoma by Ekaterina Bondarenko, Dmitriy Kalinin, Liliya Urusova, Dariya Pastukhova, Rustam Salimkhanov, Natalia Mokrysheva

“…This clinical case underscores the importance of recognizing novel subtypes of cholangiocarcinoma and exercising vigilance in the management of patients with presumed benign hepatic lesions.…”
Get full text

The protective effect and crucial biological pathways analysis of Trametes lactinea mycelium polysaccharides on acute alcoholic liver injury in mice based on transcriptomics and me... by Jinbin Hao, Liyun Ye, Guoliang Meng, Yanjiao Song, Junsheng Fu, Xiaoping Wu

“…TLMPS protected the liver against alcohol-induced injury, as evidenced by the reduced alcohol-induced elevation of the liver index, serum biochemical indices, and maintenance of hepatic morphology. Potential mechanisms were analyzed using transcriptome and metabolome analyses. …”
Get full text

HMGB1 and Extracellular Histones Significantly Contribute to Systemic Inflammation and Multiple Organ Failure in Acute Liver Failure by Runkuan Yang, Xiaoping Zou, Jyrki Tenhunen, Tor Inge Tønnessen

“…ALF occurs when the extent of hepatocyte death exceeds the hepatic regenerative capacity. ALF has a high mortality that is associated with multiple organ failure (MOF) and sepsis; however, the underlying mechanisms are still not clear. …”
Get full text

Vaccination with Enzymatically Cleaved GPI-Anchored Proteins from Schistosoma mansoni Induces Protection against Challenge Infection by Vicente P. Martins, Carina S. Pinheiro, Barbara C. P. Figueiredo, Natan R. G. Assis, Suellen B. Morais, Marcelo V. Caliari, Vasco Azevedo, William Castro-Borges, R. Alan Wilson, Sergio C. Oliveira

“…The protection engendered by this vaccination protocol was confirmed by 42% reduction in worm burden, 45% reduction in eggs per gram of hepatic tissue, 29% reduction in the number of granulomas per area, and 53% reduction in the granuloma fibrosis. …”
Get full text

Alda-1 Ameliorates Liver Ischemia-Reperfusion Injury by Activating Aldehyde Dehydrogenase 2 and Enhancing Autophagy in Mice by Meng Li, Min Xu, Jichang Li, Lili Chen, Dongwei Xu, Ying Tong, Jianjun Zhang, Hailong Wu, Xiaoni Kong, Qiang Xia

“…Mice were pretreated with Alda-1 and subjected to a 90 min hepatic 70% ischemia model, and liver tissues or serum samples were collected at indicated time points after reperfusion. …”
Get full text

Hepatocytic Differentiation Potential of Human Fetal Liver Mesenchymal Stem Cells: In Vitro and In Vivo Evaluation by Hoda El-Kehdy, Guillaume Pourcher, Wenwei Zhang, Zahia Hamidouche, Sylvie Goulinet-Mainot, Etienne Sokal, Pierre Charbord, Mustapha Najimi, Anne Dubart-Kupperschmitt

“…Following transplantation, naive and differentiated FL-MSC were engrafted into the hepatic parenchyma of newborn immunodeficient mice and differentiated in situ. …”
Get full text

Reduced Serum Butyrylcholinesterase Activity Indicates Severe Systemic Inflammation in Critically Ill Patients by Aleksandar R. Zivkovic, Karsten Schmidt, Annette Sigl, Sebastian O. Decker, Thorsten Brenner, Stefan Hofer

“…Furthermore, BChE activity showed an inverse correlation with the severity of the disease. Although hepatic function has previously been found essential for BChE production, we show here that the reduced BChE activity associated with systemic inflammation occurs independently of and is thus not caused by any deficit in liver function in these patients. …”
Get full text

Porcine transient receptor potential channel 1 promotes adipogenesis and lipid deposition by Yu Fu, Xin Hao, Jingru Nie, Peng Shang, Xinxing Dong, Bo Zhang, Dawei Yan, Hao Zhang

“…In vivo, transgenic mice expressing porcine TRPC1 exhibited aggravated high-fat diet–induced obesity, hepatic steatosis, and insulin resistance. Moreover, TRPC1 may facilitate adipogenesis via activating phosphatidylinositol 3 kinase/AKT and β-catenin signaling pathways. …”
Get full text

Protective Effect of Adipose-Derived Mesenchymal Stem Cell Secretome against Hepatocyte Apoptosis Induced by Liver Ischemia-Reperfusion with Partial Hepatectomy Injury by Zhihui Jiao, Yajun Ma, Yue Wang, Tao Liu, Qianzhen Zhang, Xiaoning Liu, Chenxi Piao, Boyang Liu, Hongbin Wang

“…Hepatocyte apoptosis plays a significant role in the pathological process of hepatic IRI. Adipose-derived stem cells (ADSCs) are known to repair and regenerate damaged tissues by producing bioactive factors, including cytokines, exosomes, and extracellular matrix components, which collectively form the secretome of these cells. …”
Get full text

Nanosuspension Innovations: Expanding Horizons in Drug Delivery Techniques by Shery Jacob, Fathima Sheik Kather, Sai H. S. Boddu, Mahesh Attimarad, Anroop B. Nair

“…Rapid advances in the field of NS could resolve issues related to permeability-limited absorption and hepatic first-pass metabolism, offering promise for medications based on proteins and peptides. …”
Get full text

Challenges in Diagnosing Intrahepatic Cholangiolithiasis in a 39-Year-Old Patient by A. K. Guseva, O. N. Sergeyeva, T. P. Nekrasova, O. T. Imaraliev, A. V. Okhlobystin, Y. N. Shirokova, A. S. Ostrovskaya, M. S. Zharkova, A. S. Cherenda, V. T. Ivashkin

“…The presented clinical case demonstrates the difficulties in assessing pathogenesis, choosing diagnostic and therapeutic approaches in patients with severe intrahepatic lithiasis that may mimic hepatic neoplasm. Combination of non-invasive and endoscopic methods, such as magnetic resonance imaging, magnetic resonance cholangiopancreatography, endoscopic retrograde cholangiopancreatography, and cholangioscopy, appears to be the most effective both diagnostically and therapeutically.…”
Get full text

Estrogen-dependent activation of TRX2 reverses oxidative stress and metabolic dysfunction associated with steatotic disease by Alfredo Smiriglia, Nicla Lorito, Marina Bacci, Angela Subbiani, Francesca Bonechi, Giuseppina Comito, Marta Anna Kowalik, Andrea Perra, Andrea Morandi

“…Abstract Metabolic dysfunction-associated steatotic liver disease (MASLD) encompasses a spectrum of hepatic disorders, ranging from simple steatosis to steatohepatitis, with the most severe outcomes including cirrhosis, liver failure, and hepatocellular carcinoma. …”
Get full text

Synthesis and antiplasmodial evaluation of novel mefloquine-based fumardiamides by Beus Maja, Fontinha Diana, Held Jana, Rajić Zrinka, Prudêncio Miguel, Zorc Branka

“…Title compounds showed marked, dose dependent activity in vitro against hepatic stages of Plasmodium berghei. IC50 values of the most active compounds 5, 7 and 9 bearing 3-fluoro, 3-chloro and 3-trifluoromethyl substituents were 3.04–4.16 µmol L−1, respectively. …”
Get full text

Serum Cytokine Profile by ELISA in Patients with Echinococcal Cysts of the Liver: A Stage-Specific Approach to Assess Their Biological Activity by Luca Piccoli, Valeria Meroni, Francesca Genco, Francesca Tamarozzi, Carmine Tinelli, Carlo Filice, Enrico Brunetti

“…To investigate the usefulness of serum cytokine dosage in the clinical management of cystic echinococcosis (CE), we analyzed serum levels of Th1 and Th2 cytokines in patients with hepatic CE in different cyst stages, CE1-2 (active), CE3a-3b (transitional), and CE4-5 (inactive). …”
Get full text

Lethal End of Spectrum of Clots-Thrombotic Storm by Muhammad Asim Rana, Ahmed F. Mady, Abdullah Ali Lashari, Rehab Eltreafi, Nicola Fischer-Orr, Kamal Naser

“…A single thrombotic event can set off a number of thromboembolic events, often including unusual locations like hepatic, portal, or renal veins, skin (purpura fulminans), adrenal glands, and cerebral sinus venous thrombosis. …”
Get full text

Biological properties of Moringa oleifera: A systematic review of the last decade [version 1; peer review: 2 approved, 1 approved with reservations] by Andrea Catalina Gómez, Javier Andrés Soto, C. A. Zuniga-Gonzalez, Karen Shirley Molina, Andrea Natalia Barreto, Maryeli Vásquez

“…Results Moringa oleifera extracts showed antioxidant, hypoglycemic, antihypertensive and cytoprotective properties at neuronal, hepatic, renal and cardiac levels. Besides, cytotoxic effects, apoptotic and antiploriferative activity against several cancer cell lines has been demonstrated. …”
Get full text

Wickerhamomyces anomalous: A Rare Cause of Fungemia Causing Febrile Neutropenia in Acute Lymphoblastic Leukemia by Vibha Mehta, Aroop Mohanty, Suneeta Meena, J. S. Rahul, Nath Uttam Kumar, Debranjani Chattopadhyay, Anamika Bakliwal, Ranjana Choudhary, Pratima Gupta

Get full text