An Assessment of the Intestinal Lumen as a Site for Intervention in Reducing Body Burdens of Organochlorine Compounds by Ronald J. Jandacek, Stephen J. Genuis

“…Once in the body, stored OCs can mobilize from adipose tissue storage sites and, along with circulating OCs, are delivered into the small intestine via hepatic processing and biliary transport. Retained OCs are also transported into both the large and small intestinal lumen via non-biliary mechanisms involving both secretion and desquamation from enterocytes. …”
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Peroxisome Proliferator Activated Receptors and Lipoprotein Metabolism by Sander Kersten

“…Activation of PPARα in mice and humans markedly reduces hepatic triglyceride production and promotes plasma triglyceride clearance, leading to a clinically significant reduction in plasma triglyceride levels. …”
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Biochemical and Clinical Features of Insulinoma in a Patient with Turner Syndrome by Darius A. Schneider, M. Zare, F. Behnia, M. Matesan, T. Tylee

“…MR and multiphase CT showed a solid 2.5 cm pancreatic tail mass with absent uptake in the 111In-pentetreotide (Octreoscan) scan. Subsequent hepatic vein blood sampling after intra-arterial calcium stimulation showed sharp increase in insulin and modest increase in proinsulin levels. …”
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Challenging Case of Ectopic ACTH Secretion from Prostate Adenocarcinoma by Wanling Zeng, Joan Khoo

“…He was started on ketoconazole, which was switched to IV octreotide in view of liver dysfunction from hepatic metastases. He eventually succumbed to the disease after 3 months of his diagnosis. …”
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Expert Opinion on Fixed Dose Combination of Dapagliflozin Plus Sitagliptin for Unmet Cardiovascular Benefits in Type 2 Diabetes Mellitus by Soumitra Ray, J Ezhilan, Rajiv Karnik, Ashish Prasad, Rajashree Dhar

“…Guidelines recommend clinicians to consider CV/HF risk, renal/hepatic risk, and other comorbidities while choosing an antidiabetic regimen. …”
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Ultrasonography of the Kidneys in Healthy and Diseased Camels (Camelus dromedarius) by Mohamed Tharwat

“…Examples of diseases evaluated by ultrasonography are paratuberculosis, trypanosomiasis, pneumonia, pleurisy, gastrointestinal neoplasms, chronic peritonitis, splenic abscessation, and hepatic disorders. Of the renal disorders assessed by ultrasonography are nephrolithiasis, hydronephrosis, pyelonephritis, renal abscessation, and renal neoplasms. …”
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Targeted In Situ Gene Correction of Dysfunctional APOE Alleles to Produce Atheroprotective Plasma ApoE3 Protein by Ioannis Papaioannou, J. Paul Simons, James S. Owen

“…This technology is applicable ex vivo, for example to target haematopoietic or induced pluripotent stem cells, and also for in vivo hepatic gene targeting. It is to be hoped that such emerging technology will eventually translate to patient therapy to reduce CVD risk.…”
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A Case of Segmental Arterial Mediolysis Presenting as Mucosal Gastric Hematoma by Shunsuke Sakuraba, Hajime Orita, Shuhei Ueda, Satoshi Tokuda, Tomoaki Ito, Tomoyuki Kushida, Mutsumi Sakurada, Hiroshi Maekawa, Ryo Wada, Koichi Sato

“…After that surgery, aneurysm of common hepatic artery ruptured and coil embolization was performed. …”
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Suppression Effects of Betaine-Enriched Spinach on Hyperhomocysteinemia Induced by Guanidinoacetic Acid and Choline Deficiency in Rats by Yi-Qun Liu, Zheng Jia, Feng Han, Takahiro Inakuma, Tatsuya Miyashita, Kimio Sugiyama, Li-Cui Sun, Xue-Song Xiang, Zhen-Wu Huang

“…Supplementation with betaine or spinach partially prevented the effects of GAA on hepatic concentrations of methionine metabolites. …”
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Association of Serum Adiponectin, Leptin, and Resistin Concentrations with the Severity of Liver Dysfunction and the Disease Complications in Alcoholic Liver Disease by Beata Kasztelan-Szczerbinska, Agata Surdacka, Maria Slomka, Jacek Rolinski, Krzysztof Celinski, Agata Smolen, Mariusz Szczerbinski

“…High serum Acrp30 level revealed an independent association with advanced liver dysfunction, as well as the development of ALD complications, that is, ascites and hepatic encephalopathy. Conclusion. Gender-related differences in serum leptin concentrations may influence the ALD course, different in females compared with males. …”
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Effect of yellow rice wine on anti-aging ability in aged mice induced by d-galactose by Rong Liu, Zukang Fu, Fengjie Zhang, Qingzhong Mao, Chunguang Luan, Xinglin Han, Jie Xue, Deliang Wang, Si Qin, Feike Hao

“…Furthermore, a forced swim test showed that moderate intake of YRW (8 mL/kg BW) significantly decreased the duration of immobility, reduced the blood content of urea nitrogen and lactic acid, and increased hepatic glycogen storage. Besides, results from the Morris water maze test suggested that YRW significantly reversed cognitive impairment and also alleviated neuroapoptosis in the experimental mice by regulating the gene expressions of Bax/Bcl-2 and caspase-3. …”
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Targeting Fibrosis: From Molecular Mechanisms to Advanced Therapies by Xingpeng Di, Ya Li, Jingwen Wei, Tianyue Li, Banghua Liao

“…In this review, the organ‐specific molecular mechanisms of fibrosis is systematically summarized, including cardiac fibrosis, hepatic fibrosis, renal fibrosis, and pulmonary fibrosis. …”
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The enriched gut commensal Faeciroseburia intestinalis contributes to the anti-metabolic disorders effects of the Ganoderma meroterpene derivative by Shanshan Qiao, Kai Wang, Chang Liu, Nan Zhou, Li Bao, Jun Wang, Shuangjiang Liu, Hongwei Liu

“…Oral administration with F. intestinalis further demonstrated its benefits on regulating hyperglycemia and hyperlipidemia, on decreasing plasma lipopolysaccharide (LPS) and inflammation, and on improving hepatic injuries. Treatment with F. intestinalis effectively enhanced the level of gut butyrate, which subsequently ameliorated the intestinal barrier function and activated epithelial PPAR-γ signaling pathway to regulate microbiome homeostasis in gut. …”
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Effects of pesticide dichlorvos on liver injury in rats and related toxicity mechanisms by Pengcheng Zhang, Zixian Zhou, Jiaqi Yao, Yuhong Jiang, Hang Lei, Zhijun Xie, Juan Li, Xianlin Zhao, Lv Zhu, Meihua Wan, Ling Liu, Wenfu Tang

“…Furthermore, targeting IRGM overexpression through hepatic portal vein injection of adeno-associated virus mitigated DDVP-induced liver injury. …”
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Metachronous Rectum Metastases from Gastric Adenocarcinoma: A Case Report by Deniz Tural, Fatih Selçukbiricik, Abdülkadir Erçalışkan, Berin İnanç, Feray Günver, Evin Büyükünal

“…Introduction. Hepatic metastases of gastric adenocarcinomas are frequently observed due to the drainage into portal vein. …”
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Alpha-Fetoprotein and Novel Tumor Biomarkers as Predictors of Hepatocellular Carcinoma Recurrence after Surgery: A Brilliant Star Raises Again by Quirino Lai, Fabio Melandro, Rafael S. Pinheiro, Andrea Donfrancesco, Bashir A. Fadel, Giovanni B. Levi Sandri, Massimo Rossi, Pasquale B. Berloco, Fabrizio M. Frattaroli

“…All these markers have been largely used as predictors in patients treated with hepatic resection or locoregional therapies, mainly in Eastern countries. …”
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Molecular mechanisms in liver repair and regeneration: from physiology to therapeutics by Xiao Ma, Tengda Huang, Xiangzheng Chen, Qian Li, Mingheng Liao, Li Fu, Jiwei Huang, Kefei Yuan, Zhen Wang, Yong Zeng

“…Abstract Liver repair and regeneration are crucial physiological responses to hepatic injury and are orchestrated through intricate cellular and molecular networks. …”
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Experimental Evaluation of the Pathogenicity of Different Strains of Schistosoma mansoni by Antônio Aurélio Euzébio, Nádia Regina Borim Zuim, Arício Xavier Linhares, Luiz Augusto Magalhães, Eliana Maria Zanotti-Magalhães

“…The parameters analyzed were as follows: number of S. mansoni eggs in mice feces; number of granulomas per tissue area in liver, spleen, lungs, pancreas, and ascending colon; measurements of hepatic and intestinal granulomas; number of adult worms; and measurements of trematode eggs. …”
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Association Between Sociodemographic Variables, Healthy Habits, and Stress with Risk Scales for Liver Disease Associated with Metabolic Dysfunction by Ángel Arturo López-González, Emilio Martínez-Almoyna Rifá, Hernán Paublini Oliveira, Cristina Martorell Sánchez, Pedro Juan Tárraga López, José Ignacio Ramírez-Manent

“…Materials and Methods: A descriptive, cross-sectional study was conducted on 16,708 Spanish workers to assess how sociodemographic variables (age, gender, and socioeconomic status), healthy habits (smoking, Mediterranean diet adherence, and physical activity), and stress correlate with values from three MAFLD risk scales: fatty liver index (FLI), hepatic steatosis index (HSI), and lipid accumulation product (LAP). …”
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Effect of Continuous Feeding of Ayu-Narezushi on Lipid Metabolism in a Mouse Model of Metabolic Syndrome by Takeshi Nishida, Koichi Tsuneyama, Yasuhiko Tago, Koji Nomura, Makoto Fujimoto, Takahiko Nakajima, Akira Noguchi, Takashi Minamisaka, Hideki Hatta, Johji Imura

“…Serum triglyceride and cholesterol levels were significantly lower in the Ayu-narezushi group than in the control group at 24 weeks of age. Furthermore, hepatic mRNA levels of carnitine-palmitoyl transferase 1 and acyl-CoA oxidase, which related to fatty acid oxidation, were significantly increased in the ayu-narezushi group than in the control group at 24 weeks of age. …”
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