THERAPEUTIC GENE EDITING FOR HEMOGLOBINOPATHIES by Ugo Testa, Giuseppe Leone, Maria Domenica Cappellini

Subjects: “…Gene editing; gene therapy; Hemoglobinopathies; Thalassemia; Sickle Cell Anemia.…”
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Prevalence and mortality trends of hemoglobinopathies in Italy: a nationwide study by Barbara Gianesin, Frédéric B. Piel, Khaled M. Musallam, Susanna Barella, Maddalena Casale, Elena Cassinerio, Rosario Di Maggio, Antonia Gigante, Maria Rita Gamberini, Giovanna Graziadei, Roberto Lisi, Filomena Longo, Aurelio Maggio, Raffaella Origa, Annamaria Pasanisi, Silverio Perrotta, Antonio Giulio Piga, Valeria Maria Pinto, Rosamaria Rosso, Giacomo Robello, Giovanna Russo, Marco Zecca, Lucia De Franceschi, Gian Luca Forni, Italian Hemoglobinopathies National Survey Group

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Hemoglobin Sunshine Seth: A Case Report of Low-Oxygen-Affinity Hemoglobinopathy by Leah S. Heidenreich, Jennifer L. Oliveira, Peter J. Holmberg, Vilmarie Rodriguez

“…Therefore, it is important to consider alternative, albeit rare, diagnoses, including hemoglobinopathies with abnormal oxygen binding properties. …”
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Detection of Hemoglobinopathies in Cuban Pregnant Women from the Program: Sickle Cell Anemias in Cuba by Yadira Valdés Fraser, Tatiana Acosta Sánchez, Jacqueline Pérez Rodríguez, Beatriz Suárez Besil, Sandra Bárbara Correa Jiménez

“…<strong>Foundation:</strong> prenatal detection of hemoglobinopathies in Cuba is performed on all pregnant women in Pri-mary Health Care, through hemoglobin electrophoresis to identify high-risk couples. …”
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Red blood cell indices in different hemoglobinopathies: A cross-sectional study in Eastern India by Ayandip Nandi, Manas Talukdar, Saikat Bhattacharya, Susruta Sen, Supratik Biswas, Kuntal Roy

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A 2-decade survival from a double hemolytic disease: A case of paroxysmal nocturnal hemoglobinuria with hemoglobinopathy by Aria Namiq Chaqmachi, Brwa Ali Hussein

“…Although by different processes, hemoglobinopathies, such as thalassemia, can manifest with hemolytic anemia. …”
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Misdiagnosis: Acute Chest Syndrome That Evolved into Acute Respiratory Distress Syndrome in a Patient without a Documented History of Hemoglobinopathy by Christoph Sossou, Ogechukwu Chika-Nwosuh, Christopher Nnaoma, Jose Bustillo, Asad Chohan, Etinosasere Okundaye, Pratik Patel

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Prevalence of hemoglobinopathies using high-performance liquid chromatography as diagnostic tool in anemic patients of tertiary care center of Western India by Virender Singh, Amit Kumar Biswas, Ajay Kumar Baranwal, Bhushan Asthana, Tejpal Dahiya

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Prevalence and spectrum of haemoglobinopathies in females of reproductive age group- A first tertiary care center experience in Punjab, North India by Vikram Narang, Anshul Jain, Sumit Grover, Ankita Soni, Monika Narang, Ashima Taneja

Subjects: “…hemoglobinopathies…”
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Enhanced fetal hemoglobin production via dual-beneficial mutation editing of the HBG promoter in hematopoietic stem and progenitor cells for β-hemoglobinopathies by Prathibha Babu Chandraprabha, Manoj Kumar K. Azhagiri, Vigneshwaran Venkatesan, Wendy Magis, Kirti Prasad, Sevanthy Suresh, Aswin Anand Pai, Srujan Marepally, Alok Srivastava, Kumarasamypet Murugesan Mohankumar, David I. K. Martin, Saravanabhavan Thangavel

Subjects: “…β-hemoglobinopathies…”
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Comprehensive review of angioid streaks by Sindhuja Kandasamy, Nawazish Shaikh, Abhidnya Surve, Somya Kumari, Amber A. Bhayana, Pradeep Kumar, Rohan Chawla, Vinod Kumar

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Subnational mapping of anaemia and aetiologic factors in the West and Central African region by Kaleab Baye, Bayuh Asmamaw Hailu, Simeon Nanama, John Ntambi, Arnaud Laillou

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SICKLE CELL TRAIT, CLINICAL MANIFESTATIONS AND OUTCOMES: A CROSS-SECTIONAL STUDY by Diego A Vargas-Hernández, Adriana Catalina Uscategui-Ruiz, Andrés Jesus Prada-Rueda, Consuelo Romero-Sánchez

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Delays in Blood Work and Disease Burden: A Cross-Sectional Analysis of Unmet Blood Work Need and Seven Key Health Conditions Across 21 Countries by Eunice Chung, Louisa Ewald, Nicholas J. Kassembaum, Nicholas J. Kassembaum, Taylor Noyes, Emmanuela Gakidou, Emmanuela Gakidou, Ali H. Mokdad, Ali H. Mokdad

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Autoimmune Complications after Hematopoietic Stem Cell Transplantation in Children with Nonmalignant Disorders by Abdalla Khalil, Irena Zaidman, Reuven Bergman, Ronit Elhasid, Myriam Weyl Ben-Arush

“…Between 2000 and 2012, 92 patients (47 males, 45 females) were treated with HSCT in our hospital, 51 with congenital hemoglobinopathies, 19 with primary immunodeficiency disease, 10 with metabolic disorders, five with Fanconi anemia, three with aplastic anemia, and four with familial hemophagocytic lymphohistiocytosis. …”
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Indirect determination of hemoglobin A2 reference intervals in Pakistani infants using data mining by Muhammad Shariq Shaikh, Sibtain Ahmed, Saba Farrukh, Shahnawaz Bayunus

“…Abstract Background Reference intervals (RIs) are crucial for distinguishing healthy from sick individuals and vary across age groups. Hemoglobinopathies are common in Pakistan, making the quantification of hemoglobin variants essential for screening. …”
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Red blood cell alloimmunization among transfusion-dependent thalassemia major patients in Northeastern Iran by Leila Mobasheri, Tayyebeh Chahkandi, Amir Talebpour, Gholamreza Anani Sarab

“…BACKGROUND: Thalassemia is one of the most common congenital hemoglobinopathies globally. Regular red blood cell (RBC) transfusion is of paramount importance in the treatment of thalassemia patients. …”
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Adaptive Genetic Traits in Human Populations: Evolutionary Responses to Malaria by Arun Ghosh, Aparna Ajith S, Abhijith Pradeep

“…Notable adaptations include hemoglobinopathies (sickle cell trait, thalassemias, hemoglobin C), enzyme disorders (G6PD deficiency, pyruvate kinase deficiency), and membrane protein variations (Duffy antigen negativity, hereditary ovalocytosis). …”
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Distinctive Acellular Lipid Emboli in Hemoglobin SC Disease following Bone Marrow Infarction with Parvovirus Infection by Danielle M. Graff, Erin Owen, Robert Bendon, Salvatore Bertolone, Ashok Raj

“…The brain lesion both grossly and microscopically presented a distinct pathology of acellular fat emboli that led to the correct diagnosis of this increasingly recognized association of sickle hemoglobinopathies with fat embolism syndrome (FES). A clinical diagnosis of FES is difficult to confirm in many patients with sickle hemoglobinopathy presenting with pain crisis because of concurrent illness. …”
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The Neonatal Screening for Sickle Cell Disease, Thalassemia, and G6PD Deficiency in Central India by Rakesh K. Jha, Meghali Kaple, Ranjit S. Ambad, Archana Dhok, Ashsish Anjankar

“…Materials and Methods: A total of 382 newborns were screened using high-performance liquid chromatography (HPLC) for hemoglobinopathies and a colorimetric method for G6PD deficiency. …”
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