DNA Methyltransferase Inhibition Promotes Th1 Polarization in Human CD4+CD25high FOXP3+ Regulatory T Cells but Does Not Affect Their Suppressive Capacity by Sija Landman, Marjan Cruijsen, Paulo C. M. Urbano, Gerwin Huls, Piet E. J. van Erp, Esther van Rijssen, Irma Joosten, Hans J. P. M. Koenen

“…In vivo studies in patients with hematological malignancies that were treated with 5-azacytidine (Vidaza) supported the in vitro findings. …”
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A Rare Case of Renal Recovery in a Young Patient with Multiple Myeloma by Hasan J. Salameh, Adeel Ahmad, Tina Kochar

“…Multiple myeloma (MM) is an uncommon hematologic malignancy accounting for 1% of all malignancies. …”
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A non-conditioned bone marrow transplantation mouse model to study clonal hematopoiesis and myeloid malignancies by Sofia Bentivegna, Marwa Almosailleakh, Lin-Pierre Zhao, Mikkel Bruhn Schuster, Sébastien Benquet, Alexander Balhuizen, Helga Fibiger Munch-Petersen, Lene Dissing Sjö, Mads Hald Andersen, Nicolas Dulphy, Bo Porse, Kirsten Grønbæk

“…Abstract Clonal hematopoiesis of indeterminate potential (CHIP) is a condition where blood or bone marrow cells carry mutations associated with hematological malignancies. Individuals with CHIP have an increased risk of developing hematological malignancies, atherosclerotic cardiovascular disease, and all-cause mortality. …”
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Prognostic Factors on the Graft-versus-Host Disease-Free and Relapse-Free Survival after Adult Allogeneic Hematopoietic Stem Cell Transplantation by Yao-Chung Liu, Sheng-Hsuan Chien, Nai-Wen Fan, Ming-Hung Hu, Jyh-Pyng Gau, Chia-Jen Liu, Yuan-Bin Yu, Liang-Tsai Hsiao, Tzeon-Jye Chiou, Cheng-Hwai Tzeng, Po-Min Chen, Jin-Hwang Liu

“…For 2-year GRFS, EBMT risk score > 2 (p<0.001), being male (p=0.028), and hematologic malignancy (p=0.010) were significant for poor outcome. …”
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Homoharringtonine: mechanisms, clinical applications and research progress by Wen Wang, Lan He, Lan He, Ting Lin, Ting Lin, Ting Lin, Fulan Xiang, Yibin Wu, Fangliang Zhou, Fangliang Zhou, Fangliang Zhou, Yingchun He, Yingchun He, Yingchun He

“…In clinical trials, Homoharringtonine has demonstrated promising efficacy in the treatment of hematological malignancies, particularly in various types such as acute myeloid leukemia and chronic myeloid leukemia. …”
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Chronic Eosinophilic Leukemia—Not Otherwise Specified (NOS) in the Background of a Large Cell Lymphoma by Wilson I. Gonsalves, Rong He, Animesh Pardanani, Vinay Gupta, Jacob P. Smeltzer, Curtis A. Hanson, Thomas E. Witzig

“…Clonal eosinophilic disorders are rare among hematological malignancies. Most eosinophilia tends to be due to secondary causes such as infections, hypersensitivity conditions, drug reactions, and connective tissue disorders. …”
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The Evolution of Prognostic Factors in Multiple Myeloma by Amr Hanbali, Mona Hassanein, Walid Rasheed, Mahmoud Aljurf, Fahad Alsharif

“…Multiple myeloma (MM) is a heterogeneous hematologic malignancy involving the proliferation of plasma cells derived by different genetic events contributing to the development, progression, and prognosis of this disease. …”
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Subacute Disseminated Intravascular Coagulation in a Patient with Liver Metastases of a Renal Cell Carcinoma by L. C. van der Wekken, R. J. L. F. Loffeld

“…Its acute form is associated with severe bacterial infections and hematological malignancies. It has a fulminant presentation with prolonged bleeding times and diffuse thrombosis. …”
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Advances in engineered T cell immunotherapy for autoimmune and other non-oncological diseases by Qiaolin Huang, Xiaojian Zhu, Yicheng Zhang

“…Abstract Adoptive immunotherapy using engineered T cells expressing chimeric antigen receptors has shown remarkable success in treating patients with hematological malignancies. However, realizing broader therapeutic applications of engineered T cells in other diseases requires further exploration in clinical investigations. …”
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Case report: a rare case of hereditary colorectal cancer and brain tumor with café au lait spots in a child: constitutional mismatch repair deficiency (CMMRD) syndrome by Zubair Khurshid, Mishraz Shaikh, Tarek Talaat Harb Elkadi

“…Hereditary cancers due to mismatch repair deficiency cause colorectal, brain, hematological malignancies, and other tumors in early childhood. …”
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Biparatopic binding of ISB 1442 to CD38 in trans enables increased cell antibody density and increased avidity by Jeremy Loyau, Thierry Monney, Marco Montefiori, Fedir Bokhovchuk, Jeremy Streuli, Matthew Blackburn, Arnaud Goepfert, Lydia N. Caro, Samitabh Chakraborti, Stefania De Angelis, Camille Grandclément, Stanislas Blein, M. Lamine Mbow, Ankita Srivastava, Mario Perro, Stefano Sammicheli, Eugene A. Zhukovsky, Michael Dyson, Cyrille Dreyfus

“…ISB 1442 is a bispecific biparatopic antibody in clinical development to treat hematological malignancies. It consists of two adjacent anti-CD38 arms targeting non-overlapping epitopes that preferentially drive binding to tumor cells and a low-affinity anti-CD47 arm to enable avidity-induced blocking of proximal CD47 receptors. …”
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Iatrogenic T-Cell Lymphoma with Associated Hemophagocytic Lymphohistiocyotsis in a Patient with Long-Standing Rheumatoid Arthritis by X. A. Andrade, H. E. Fuentes, D. M. Oramas, H. Mann, P. Kovarik

“…Patients with rheumatoid arthritis are at increased risk of hematological malignancies, especially when exposed to immunosuppressive therapy. …”
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Advances in the Application of New Ultrasound Technology for the Diagnosis and Treatment of Lymphoma by Bao Rui, Chen Lu, Luo Yukun, Zhang Mingbo

“…Lymphoma is a common hematological malignancy with markedly increasing incidence. …”
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Oral Squamous Cell Carcinoma in a Patient with Fanconi Anemia by Milla Huuhka, Aaro Turunen

“…Fanconi anemia (FA) is a rare autosomal recessive genetic disorder characterized by different types of malformations, skin lesions, bone marrow failure, and increased risk for both hematological malignancies and solid tumors, especially head and neck squamous cell carcinomas (HNSCC). …”
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A Rare Case of Suppurative Aspergillosis of the Thyroid by Nikhil Dinaker Thada, Sampath Chandra Prasad, Bhasker Alva, Monika Pokharel, Kishore Chandra Prasad

“…Fungal infections of the thyroid usually occur in immunocompromised patients with hematological malignancies, recipients of bone marrow and solid organ allografts on immunosuppression, and patients with AIDS. …”
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Management of Metachronous Bilateral Testis Cancer in a Patient with Pre-B Cell ALL by Kelly T. Harris, Shakil A. Shaikh, Mark W. Ball, Mohamad E. Allaf, Phillip M. Pierorazio

“…We discuss the management of bilateral testis masses in a young patient with a hematologic malignancy as well as the role of immunosuppressive chemotherapy in developing a second cancer. …”
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Targeting Cancer Stem Cells and Their Niche: Current Therapeutic Implications and Challenges in Pancreatic Cancer by Jiangang Zhao, Jiahui Li, Hans A. Schlößer, Felix Popp, Marie Christine Popp, Hakan Alakus, Karl-Walter Jauch, Christiane J. Bruns, Yue Zhao

“…Cancer stem cells (CSCs) have been identified as a subpopulation of stem-like cancer cells with the ability of self-renewal and differentiation in hematological malignancies and solid tumors. Pancreatic cancer is one of the most lethal cancers worldwide. …”
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Single-Domain Antibody-Based TCR-Like CAR-T: A Potential Cancer Therapy by Lichen Zhu, Xiaomei Yang, Dani Zhong, Shenxia Xie, Wei Shi, Yangzi Li, Xiaoqiong Hou, HuaYao, Huihui Zhou, Minlong Zhao, Ziqiang Ding, Xinyue Zhao, Fengzhen Mo, Shihua Yin, Aiqun Liu, Xiaoling Lu

“…With the exception of the commercialized CD19 CAR-T for hematological malignancies and other CAR-T therapies aiming mostly at extracellular antigens achieving great success, the rareness and scarcity of TCR-like CAR-T therapies might be due to their current status and limitations. …”
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Receipt of specialized palliative care and health care utilization at the end of life in hematological cancer patients – the Stockholm experience by Lena von Bahr, Peter Strang, Torbjörn Schultz, Per Fürst

“…Background: The treatments of hematological malignancies tend to be intense, and compared with solid tumors, less is known about the health care consumption during end of life (EOL). …”
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Pulmonary Mucormycosis: A Case Report of a Rare Infection with Potential Diagnostic Problems by Salwa O. Mekki, Amal A. Hassan, Afnan Falemban, Nashwa Alkotani, Salem M. Alsharif, Ahmed Haron, Basim Felemban, Mohammad S. Iqbal, Aisha Tabassum

“…It is seen in patients with hematological malignancies, diabetes mellitus, and immunocompromised states. …”
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