aPD-L1-facilitated theranostic and tumor microenvironment remodeling of pancreatic cancer via docetaxel-loaded phase-transformation nanoparticles triggered by low-intensity pulsed... by Yi Tang, Qingling Shen, Peng Lin, Zhixin Chen, Denghui Fan, Minling Zhuo, Yajiao Gan, Yixi Su, Qingfu Qian, Liwu Lin, Ensheng Xue, Zhikui Chen

“…In conclusion, aPD-L1-modified liquid‒vapor phase-transformation nanoparticles loaded with docetaxel (DTX) and PFP were successfully combined with ultrasound for the molecular diagnosis and targeted treatment of PDAC. aPDL1-DTX/PFP@Lipid could reshape the PDAC TME, offering a new approach for ultrasound-mediated diagnosis and treatment with promising clinical applications. Graphical Abstract…”
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Epidermal stem cell derived exosomes-induced dedifferentiation of myofibroblasts inhibits scarring via the miR-203a-3p/PIK3CA axis by Shixin Zhao, Haoran Kong, Dahu Qi, Yushuang Qiao, Yu Li, Zhiming Cao, Hanwen Wang, Xuefeng He, Hengdeng Liu, Hao Yang, Suyue Gao, Tao Liu, Julin Xie

“…In vivo studies confirmed that EpiSC-EVs attenuate excessive scarring through the miR-203a-3p/PIK3CA axis, suggesting EpiSC-EVs as a promising therapeutic approach for HS. Graphical abstract…”
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Bidirectional approach of Punica granatum natural compounds: reduction in lung cancer and SARS-CoV-2 propagation by Md. Abul Barkat, Afreen Fatima, Bushra Riaz, Mohd. Zaheen Hassan, Tanveer Ahamad, Abdulkareem A. Alanezi, Harshita Barkat, Afaf F. Almuqati, Yahya I. Asiri, Sahabjada Siddiqui

“…The PGP phytoconstituents are suggested to be dual agents for lung cancer and SARS-CoV-2 pathogenesis. Graphical Abstract…”
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Increased TSPO alleviates neuropathic pain by preventing pyroptosis via the AMPK-PGC-1α pathway by Baolong Li, Kaiming Yu, Xiongyao Zhou, Jialu Sun, Le Qi, Weiye Li, Tuo Yang, Weizhen Li, Ningning Wang, Xiaosong Gu, Shusen Cui, Rangjuan Cao

“…In summary, this study enhances our understanding of the molecular interplay between TSPO, mitochondrial health, and neuropathic pain, highlighting TSPO as a potential therapeutic target for pain management. Graphical Abstract…”
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Duration of exposure to night work and cardiovascular risk factors: results from 52,234 workers of the CONSTANCES study by Eve Bourgkard, Stéphanie Boini, Michel Grzebyk, Mathieu Dziurla, Jean Ferrières, Marcel Goldberg, Céline Ribet, Yolande Esquirol

“…These results support the need for early and appropriate monitoring of cardiovascular risk factors among current and former night workers. Graphical Abstract…”
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A national study of choanal atresia in tertiary care centers in Canada – part I: clinical presentation by Josee Paradis, Agnieszka Dzioba, Hamdy El-Hakim, Paul Hong, Frederick K. Kozak, Lily H. P. Nguyen, Demitri Perera, Evan Jon Propst, Jennifer M. Siu, Monika Wojtera, Murad Husein, National Choanal Atresia Study Working Group

“…Further investigation into hereditary linkages to CA development is warranted. Graphical abstract…”
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Identification of compounds against atherosclerosis induced by ox-LDL based on cell extraction/UPLC–MS/MS from mulberry twigs and their mechanistic analysis by Zhihui Jin, Wei Xiang, Xiaowen Shi, Fenglin Jiang, Yanan Jia, Yuansong Zhang, Lingshu Zeng, Xianzhi Huang, Li Xu

“…These compounds hold potential in treating atherosclerosis and related oxidative stress diseases. Graphical Abstract…”
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The relationships between mental health and social media addiction, and between academic burnout and social media addiction among Chinese college students: A network analysis by Tingwei Feng, Buyao Wang, Mingdi Mi, Lei Ren, Lin Wu, Hui Wang, Xufeng Liu, Xiuchao Wang

“…Network analysis was performed using R to model the relationships between study variables, employing Gaussian Graphical Models and the least absolute shrinkage and selection operator technique for robust network estimation. …”
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Easy, fast and reproducible Stochastic Cellular Automata with chouca by Génin, Alexandre, Dupont, Guillaume, Valencia, Daniel, Zucconi, Mauro, Ávila-Thieme, M. Isidora, Navarrete, Sergio A., Wieters, Evie A.

“…Exact and mean-field simulations can be run, and both numerical and graphical results can be easily exported. Besides providing better reproducibility and accessibility, a fast engine for SCA unlocks novel, computationally intensive statistical approaches, such as simulation-based inference of ecological interactions from field data, which represents by itself an important avenue for research. …”
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Impact of diabetes remission or progression on the incidence of cardiovascular disease in Japan: historical cohort study using a nationwide claims database by Chihiro Shimayama, Kazuya Fujihara, Laymon Khin, Hiroki Takizawa, Chika Horikawa, Takaaki Sato, Masaru Kitazawa, Yasuhiro Matsubayashi, Takaho Yamada, Hirohito Sone

“…Conclusions In a real-world setting without intensive intervention, diabetes remission decreased the risk of CVD by approximately 30% regardless of changes in BMI, suggesting that diabetes remission can prevent CVD without weight loss in routine care and emphasizing the importance of achieving remission. Graphical Abstract…”
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Upskilling or deskilling? Measurable role of an AI-supported training for radiology residents: a lesson from the pandemic by Mattia Savardi, Alberto Signoroni, Sergio Benini, Filippo Vaccher, Matteo Alberti, Pietro Ciolli, Nunzia Di Meo, Teresa Falcone, Marco Ramanzin, Barbara Romano, Federica Sozzi, Davide Farina

“…This approach is advisable for evaluating AI tools in radiology training. Graphical Abstract…”
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Enhanced penetration and biofilm eradication by sophorolipid micelles encapsulating Honokiol: a comprehensive solution for biofilm-associated lung infections by Shiyu Lin, Xiaojuan Li, Wei Zhang, Gang Shu, Tim Tolker-Nielsen, Haohuan Li, Funeng Xu, Juchun Lin, Guangneng Peng, Li Zhang, Hualin Fu

“…Conclusions HK-SL Ms offers a novel strategy for the clinical treatment of biofilm-associated infections by dispersing and removing S. aureus biofilms and preventing new infections. Graphical Abstract…”
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A new scheme for boosting in situ Fenton-like reaction in plant pathogenic tissues for selective structural degradation of capsid proteins by Jun Ma, Ming Chen, Yujie Wang, Jiaying Li, Jian Tang, Shengjun Wu, Chi He, J. Paul Chen

“…Our findings provide a new, efficient, and environmentally friendly approach for plant virus control. Graphical Abstract…”
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The association between TyG index and cardiovascular mortality is modified by antidiabetic or lipid-lowering agent: a prospective cohort study by Changchang Fang, Nanqin Peng, Jiang Cheng, Xiyu Zhang, Wenli Gu, Zicheng Zhu, Xiaoping Yin, Zhiwei Yan, Jing Zhang, Peng Yu, Xiao Liu

“…These findings suggest that future studies on the TyG index and its relationship with CVD and mortality should account for the modifying effects of these agents. Graphical abstract…”
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Pathologically altered articular cartilage attracts intense chondrocyte invasion into the extracellular matrix: in vitro pilot study by Victoria A. Shestakova, Ilya D. Klabukov, Ilya V. Kolobaev, Longfeng Rao, Dmitry A. Atiakshin, Michael A. Ignatyuk, Mikhail E. Krasheninnikov, Bagavdin G. Ahmedov, Sergey A. Ivanov, Peter V. Shegay, Andrey D. Kaprin, Denis S. Baranovskii

“…Conclusions Our preliminary results showed that human nasal chondrocytes are capable of infiltrating the pathologically altered extracellular matrix of articular cartilage damaged by arthritis, thereby promoting its repair to a physiologically relevant state. Graphical Abstract…”
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Selective arm-usage of pre-miR-1307 dysregulates angiogenesis and affects breast cancer aggressiveness by Oyku Ece Sumer, Korbinian Schelzig, Janine Jung, Xiaoya Li, Janina Moros, Luisa Schwarzmüller, Ezgi Sen, Sabine Karolus, Angelika Wörner, Verônica Rodrigues de Melo Costa, Nishanth Belugali Nataraj, Efstathios-Iason Vlachavas, Clarissa Gerhäuser, Karin Müller-Decker, Dominic Helm, Yosef Yarden, Birgitta Elisabeth Michels, Cindy Körner

“…The underlying mechanisms might inspire new therapeutic strategies aimed at shifting the balance towards tumor-suppressive miRNA species. Graphical Abstract…”
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Surgical margins of the oral cavity: is 5 mm really necessary? by James Fowler, Yael Campanile, Andrew Warner, Francisco Laxague, Naif Fnais, Kevin Fung, Adrian Mendez, Danielle MacNeil, John Yoo, David Palma, Anthony Nichols

“…These findings require validation through multi-institutional collaborative efforts. Graphical abstract…”
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Ceria nanoparticles ameliorate renal fibrosis by modulating the balance between oxidative phosphorylation and aerobic glycolysis by Mengling Wang, Feng Zeng, Fengling Ning, Yinhang Wang, Shilin Zhou, Jiaqi He, Cong Li, Cong Wang, Xiaolin Sun, Dongliang Zhang, Jisheng Xiao, Ping Hu, Svetlana Reilly, Hong Xin, Xudong Xu, Xuemei Zhang

“…This may provide another therapeutic option for renal fibrosis. Graphical Abstract…”
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Combination of rapamycin and adipose-derived mesenchymal stromal cells enhances therapeutic potential for osteoarthritis by Damien Veret, Gautier Tejedor, Esther Perez, Alison Chomette, Maylis Farno, Rosanna Ferreira-Lopez, Louis Dagneaux, Yves-Marie Pers, Christian Jorgsensen, Claire Gondeau, Jean-Marc Brondello

“…Conclusions Our findings suggest that the rapamycin and AD-MSC combination enhances the therapeutic efficacy of these cells in senescence-driven degenerative diseases such as OA, notably by improving their anti-fibrotic and anti-inflammatory properties. Graphical abstract…”
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Structural characterization and immunomodulatory activity of polysaccharides from the flowers of Imperata cylindrica Beauv.var. major (Nees) C.E.Hubb by Honglin He, Haijun Huang, Yunheng Yang, Yi Liu, Ailing Liang, Yao Lei, Chenghuai Tang, Ling Yao, Zhiwei Chen

“…Conclusions These findings provide useful evidence that support the development and potential clinical application of polysaccharides derived from the flowers of Imperata cylindrica. Graphical Abstract…”
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