Size effect-based improved antioxidant activity of selenium nanoparticles regulating Anti-PI3K-mTOR and Ras-MEK pathways for treating spinal cord injury to avoid hormone shock-indu... by Peixin Liu, Xiaodong Liu, Zihao Wu, Kui Shen, Zhaofeng Li, Xiaowei Li, Qifeng Wu, Leung Chan, Zhong Zhang, Yutong Wu, Liwen Liu, Tianfeng Chen, Yi Qin

“…These findings suggest that LNT-UsSeNPs are promising candidates for further development in nanomedicine for the effective treatment of SCI. Graphical abstract…”
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A ROS-responsive hydrogel encapsulated with matrix metalloproteinase-13 siRNA nanocarriers to attenuate osteoarthritis progression by Qiuyang Wang, Kai Feng, Guangsheng Wan, Wei Liao, Jing Jin, Peng Wang, Xiaolian Sun, Weijun Wang, Qing Jiang

“…This study reveals that si-Fe-HPP, with its ROS-responsive and RNAi abilities, can significantly protect chondrocytes and attenuate OA progression, providing novel insights and directions for the development of therapeutic materials for OA treatment. Graphical Abstract…”
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18F-FDG-PET/CT can be used to predict distant metastasis in hypopharyngeal squamous cell carcinoma by Shinsuke Suzuki, Satoshi Toyoma, Tomoe Abe, Tentaro Endo, Teppei Kouga, Yohei Kaswasaki, Takechiyo Yamada

“…Conclusions SUVmax determined via pretreatment FDG-PET/CT is useful for predicting distant metastasis, distant metastasis-free survival, and overall survival in patients with HPSCC. Graphical Abstract…”
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The SIRT5-JIP4 interaction promotes osteoclastogenesis by modulating RANKL-induced signaling transduction by Kecheng Zhu, Chunxiang Sheng, Linlin Zhang, Yuying Yang, Xiaojing Chen, Tao Jiang, Jiaxi Song, Deng Zhang, Xiao Wang, Hongyan Zhao, Lihao Sun, Libin Zhou, Bei Tao, Jianmin Liu

“…Taken together, the results of this study reveal that the SIRT5-JIP4 axis is a novel positive regulator that finely regulates RANKL-induced osteoclast differentiation and suggest that targeting this axis is a therapeutic strategy for preventing osteoporotic bone loss. Graphical Abstract…”
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Exposure of Apis mellifera (Hymenoptera: Apidae) colonies to imidacloprid impairs larval development, promotes oxidative stress in pupae, and induces changes in the midgut of adult... by Daiani Rodrigues Moreira, Tuan Henrique Smielevski de Souza, Douglas Galhardo, Cinthia Leão Figueira, Samara Calvi Baulli, Breno Gabriel da Silva, Francieli das Chagas, José Washington Santos Oliveira, Jean Samel Rocha, Angélica de Souza Khatlab, Eliane Gasparino, Vagner de Alencar Arnaut de Toledo, Adriana Aparecida Sinópolis Gigliolli, Maria Claudia Colla Ruvolo-Takasusuki

“…Oxidative stress, which was detected at different stages of bee development, may induce lipid, protein, and DNA oxidation, leading to cell death. Graphical Abstract…”
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RBD-displaying OMV nanovaccine boosts immunity against SARS-CoV-2 by Rang Feng, Ruo-Yi Xue, Chang Liu, Guo-Cheng Li, Yan Deng, Zhe Jin, Jing-Yi Liu, Shan-Shan Zhang, Hao Cheng, Man-Ying Guo, Quan-Ming Zou, Hai-Bo Li

“…Conclusions This vaccine platform offers an alternative strategy for developing recombinant subunit vaccines against SARS-CoV-2, potentially enhancing immune responses and improving vaccine efficacy. Graphical abstract…”
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Effect of low salicylate diet on clinical and inflammatory markers in patients with aspirin exacerbated respiratory disease – a randomized crossover trial by Leigh J. Sowerby, Krupal B. Patel, Crystal Schmerk, Brian W. Rotenberg, Taciano Rocha, Doron D. Sommer

“…Trial registration NCT01778465 ( www.clinicaltrials.gov ) Graphical abstract…”
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Exploring a high-level programming model for the NWP domain using ECMWF microphysics schemes by S. Ubbiali, C. Kühnlein, C. Schär, L. Schlemmer, T. C. Schulthess, T. C. Schulthess, M. Staneker, H. Wernli

“…We benchmark all prototype codes on three European supercomputers characterized by diverse graphics processing unit (GPU) and central processing unit (CPU) hardware, node designs, software stacks, and compiler suites. …”
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Magnetohydrodynamic Peristaltic Propulsion of Casson Nanofluids With Slip Effects Over Heterogeneous Rough Channel by Hanumesh Vaidya, Fateh Mebarek‐Oudina, Rakesh Kumar, C. Rajashekhar, Kerehalli Vinayaka Prasad, Sangeeta Kalal, Kottakkaran Sooppy Nisar

“…The study primarily examines the velocity, temperature, and concentration profiles graphically for various pertinent physiological parameters. …”
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CCL21-CCR7 blockade prevents neuroinflammation and degeneration in Parkinson’s disease models by Felipe Saceanu Leser, Flavio de Souza Júnyor, Iohanna Bianca Pagnoncelli, Anna Beatriz Delgado, Isabelle Medeiros, Ana Clara Campanelli Nóbrega, Brenda da Silva Andrade, Maiara Nascimento de Lima, Nícolas Emanoel da Silva, Laurent Jacob, Kevin Boyé, Luiz Henrique Medeiros Geraldo, Alessandra Mendonça Teles de Souza, Tatiana Maron-Gutierrez, Hugo Castro-Faria-Neto, Cristian Follmer, Carolina Braga, Gilda Angela Neves, Anne Eichmann, Luciana Ferreira Romão, Flavia Regina Souza Lima

“…Altogether, our data indicate that navarixin blocks CCL21/CCR7-mediated neuron-microglia communication and could be used as a therapeutic strategy against PD. Graphical Abstract…”
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Cancer patients’ sense of coherence – psycho-oncological consultations and therapeutic alliance as salutogenic factors by Natalia Cecon-Stabel, Ibrahim Demirer, Holger Pfaff, Antje Dresen

“…Survey data were matched to care documentation data, which contain consultation dates and sociodemo-graphics. Four stepwise regression analyses were conducted with overall SoC and its subscales of meaningfulness, compre-hensibility and manageability at T2 as outcome variables. …”
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Network analysis of the association between social anxiety and problematic smartphone use in college students by Wanying Xing, Xianyang Wang, Tingwei Feng, Jiaxin Xie, Chang Liu, Xiuchao Wang, Hui Wang, Lei Ren, Lei Ren, Xufeng Liu

“…A regularized Gaussian graphical model was used to estimate the relationships between these symptoms. …”
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Do wolframin, P-glycoprotein, and GRP78/BiP cooperate to alter the response of L1210 cells to endoplasmic reticulum stress or drug sensitivity? by Simona Kurekova, Lucia Pavlikova, Mario Seres, Viera Bohacova, Jana Spaldova, Albert Breier, Zdena Sulova

“…Immunoprecipitation experiments revealed the formation of complexes between wolframin and ERS related proteins (PERK, ATF6 and GRP78/BiP), the amount of which varied depending on the presence of the above ER stressors. Graphical Abstract…”
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Physicochemical and antioxidant properties of Citrus macroptera peel pectin extracted by different methods and its impact on nutritional quality of strawberry jam during long-term... by Robin Sarkar, Mukta Roy, Mahabub Alam, Animesh Sarkar, Abdullah A. Alarfaj, Sulaiman Ali Alharbi, Mohammad Javed Ansari

“…Notably, pectin extracted using MAE-600 W, MAE-450 W, and UAE was most effective in maintaining both the quality and nutritional value of the strawberry jam, yielding particularly promising results. Graphical Abstract…”
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Injection laryngoplasty during transoral laser microsurgery for early glottic cancer: a randomized controlled trial by Ayham Al Afif, Matthew H. Rigby, Colin MacKay, Timothy F. Brown, Timothy J. Phillips, Usman Khan, Jonathan R. B. Trites, Martin Corsten, S. Mark Taylor

“…We saw no significant impact for intra-operative HA injection laryngoplasty on subjective or objective voice outcomes following surgery for early glottic cancers. Graphical abstract…”
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Determining the cultural safety of chronic disease interventions for Aboriginal and Torres Strait Islander Australians: a scoping review by Hannah Woodall, Hannah Woodall, Hannah Woodall, Sarah Larkins, Janani Pinidiyapathirage, Janani Pinidiyapathirage, Raelene Ward, Rebecca Evans

“…In the analysed studies, elements contributing to cultural safety included practitioner behaviour (n = 15), knowledge (n = 6), skills (n = 1) and attitudes (n = 4), partnership with community (n = 4) and culturally safe services (n = 5), and graphics and artwork (n = 6). The inconsistent terminology and lack of definitions made comparison of studies challenging.ConclusionThis review underscores the importance of adopting the Australian Health Practitioner Regulation Agency (AHPRA) definition of cultural safety to standardise terminology and explore the many elements of cultural safety. …”
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Dysregulation of transposable elements and PIWI-interacting RNAs in myelodysplastic neoplasms by Zdenek Krejcik, David Kundrat, Jiri Klema, Andrea Hrustincova, Iva Trsova, Monika Belickova, Jaroslav Cermak, Anna Jonasova, Jiri Dostal, Michaela Dostalova Merkerova

“…Conclusions Our findings demonstrate the parallel dysregulation of TEs and piRNAs in HR-MDS patients, highlighting their potential role in MDS progression and indicating that the PIWIL2 level is a promising molecular marker for prognosis. Graphical Abstract…”
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In vitro high-throughput screening of the antimicrobial activity of different compounds against Xylella fastidiosa subsp. pauca by Carmine Del Grosso, Luca Grandi, Tommaso Lombardi, Giusy D’Attoma, Nicolas Schmitt, Vito Rocco De Michele, Maria Saponari

“…The methodologies described proved to be useful for profiling the antimicrobial activity of a large panel of compounds and the data collected provide evidence of their in vitro effectiveness. Graphical Abstract…”
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Improving 10-year cardiovascular risk prediction in patients with type 2 diabetes with metabolomics by Ruijie Xie, Teresa Seum, Sha Sha, Kira Trares, Bernd Holleczek, Hermann Brenner, Ben Schöttker

“…Given the latest cost reduction and standardization efforts, NMR metabolomics has the potential for translation into the clinical routine. Graphical abstract…”
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Comparative analysis of real-world data on the efficacy and safety of and adherence to ICS/LABA combinations in asthma management by Hee Sun Park, Jungkuk Lee, Hasung Kim, Seong-Dae Woo

“…These results provide valuable insights for clinicians in selecting appropriate and individually tailored inhaler therapies in real-world settings. Graphical abstract…”
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