Global progress, challenges and strategies in eliminating public threat of viral hepatitis by Sihui Zhang, Fuqiang Cui

“…Finally, use complete and measurable data to monitor progress. Graphical Abstract…”
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Exploring the mechanism of Schisandra rubriflora in the treatment of polycystic ovary syndrome based on network pharmacology and molecular docking by Zhengyan Dou, Qingxian Li, Jing Zhang, Xin Zhang

“…Schisandrin, a main component of S. rubriflora, may be a candidate for the treatment of PCOS. Graphical Abstract…”
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Kaempferol enhances ER-mitochondria coupling and protects motor neurons from mitochondrial dysfunction and ER stress in C9ORF72-ALS by Federica Pilotto, Paulien Hermine Smeele, Olivier Scheidegger, Rim Diab, Martina Schobesberger, Julieth Andrea Sierra-Delgado, Smita Saxena

“…Thus, kaempferol holds great promise for treating neurodegenerative diseases where both mitochondrial and ER dysfunction are causally linked to the pathophysiology. Graphical abstract…”
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A Comparative Spatiotemporal Analysis for Long-Term Trends of Hydrometeorological Variables in Maritsa River Basin by Mehmet Seren Korkmaz, Kevser Merkür Başkesen, Ertuğrul Sunan

“…Trend increases were visualized using the graphical method ITA. Significant increasing trends in both monthly and annual precipitation and evapotranspiration reveal changes in the hydrological cycle of the basin. …”
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In vitro sperm generation from immature mouse testicular tissue using plasma rich in growth factors by Seyyed Amir Moradian, Mansoureh Movahedin

“…The results highlight PRGF’s potential to improve culture media for in vitro sperm production, suggesting promising avenues for future human research. Graphical Abstract…”
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Pretreatment with serine protease inhibitors impairs Leishmania amazonensis survival on macrophages by Patrícia de Almeida Machado, Pollyanna Stephanie Gomes, Elaine Soares Coimbra, Herbert Leonel de Matos Guedes

“…Conclusions This work highlights the importance of serine proteases in L. amazonensis as a possible target for new therapeutic alternatives in Leishmania spp. Graphical Abstract…”
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Management of sudden sensorineural hearing loss among primary care physicians in Canada: a survey study by Benjamin Ng, Matthew G. Crowson, Vincent Lin

“…Further research is needed to understand why some family physicians do not prescribe corticosteroids for treatment of SSNHL, which may then identify any gaps in knowledge or inform improvements in clinical protocol. Graphical abstract…”
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Ag-Ag2O nanocomposite biosynthesis by mixed bacterial cultivation and effect of the ph on size and optical properties of the nanocomposite by Morad G. S. S. Al-Asbahi, Bashir A. Al-Ofiri, Fuad A. A. Saad, Adnan Alnehia, Muhammad Hadi

“…Future research may focus on integrating these biologically synthesized nanoparticles into advanced materials and coatings to improve their performance. Graphical Abstract…”
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Design of a new class of broad-spectrum therapeutics targeted to drug-resistant bacteria by Amrutha Surendran, Agnes Turnbull, Allen Flockhart, Fern Findlay-Greene, Martyna Nowosielska, Donald Morrison, David J. Mincher, Samantha Donnellan

“…The anthraquinone-TPP conjugates (4) and (5) were active in vitro against Mycobacterium smegmatis (graphical abstract) and were equipotent as determined by their MIC values; in contrast to MRSA, the less hydrophobic (4) had 2-fold greater bactericidal potency than (5) as measured by their MBC values. …”
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NAT10 promotes ovarian cancer cell migration, invasion, and stemness via N4-acetylcytidine modification of CAPRIN1 by Yang Song, Min Cheng

“…These findings suggest that NAT10 may be a promising therapy target for OC. Graphical abstract…”
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Linearity of natural versus laboratory-imparted remanence demagnetization diagram and reliability of relative paleointensity estimation by Toshitsugu Yamazaki, Jiaxi Li

“…In sediments with changing proportion of magnetofossils, normalization with IRM may work better than ARM. Graphical Abstract…”
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Total thyroidectomy versus hemithyroidectomy with intraoperative radiofrequency ablation for unilateral thyroid cancer with contralateral nodules: A propensity score matching study by Qianqian Yuan, Lewei Zheng, Jinxuan Hou, Rui Zhou, Gaoran Xu, Chengxin Li, Gaosong Wu

“…Conclusions Hemithyroidectomy for unilateral PTC and intraoperative RFA for contralateral nodules were acceptable and effective treatment approaches and did not increase the risk of complications. Graphical Abstract…”
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Factors Hindering the Proper Management of Academic Libraries in Kabale Municipality: A Case Study of the Uganda Martyrs University Kabale Campus Library. by Oliva, Arineitwe

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Engineered CAF-cancer cell hybrid membrane biomimetic dual-targeted integrated platform for multi-dimensional treatment of ovarian cancer by Yuwei Yao, Jiarui Zhang, Kexin Huang, Yingying Peng, Shuangshuang Cheng, Shuangge Liu, Ting Zhou, Jinhua Chen, Haojia Li, Yingchao Zhao, Hongbo Wang

“…Therefore, these TME-regulating nanoparticles, combining specificity, efficiency, and effectiveness, provide new insights into ovarian cancer treatment. Graphical Abstract…”
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Contrast quality control for segmentation task based on deep learning models—Application to stroke lesion in CT imaging by Juliette Moreau, Juliette Moreau, Laura Mechtouff, Laura Mechtouff, David Rousseau, Omer Faruk Eker, Omer Faruk Eker, Yves Berthezene, Yves Berthezene, Tae-Hee Cho, Tae-Hee Cho, Carole Frindel, Carole Frindel

“…The critical contrast is found-thanks to the following three methods: Performance, graphical, and clustering analysis. Defining this threshold improves dataset design and accelerates training by excluding low-contrast images.ResultsApplication of this method to brain lesion segmentation in CT imaging highlights a Fisher's ratio threshold value of 0.05, and training validation of a new model without these images confirms this with similar results with only 60% of the training data, resulting in an almost 30% reduction in initial training time. …”
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Feruloyl-amides as natural antimicrobials for crop and food protection by Denise Dozio, Sharmila Ghosh, Daniele Alessandro Consolini, Josè Luis Ermini Starna, Loris Pinto, Federico Baruzzi, Martina Letizia Contente, Andrea Pinto, Paolo Cortesi, Salvatore Princiotto, Andrea Kunova, Sabrina Dallavalle

“…Together with the observed in vitro antibacterial activity against foodborne bacterial pathogens, we conclude that PAs are promising candidates for future developments in the agri-food sector. Graphical Abstract…”
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Advanced mandibular reconstruction with fibular free flap and alloplastic TMJ prosthesis with digital planning by Justin M. Pyne, Clayton M. Davis, Ryan Kelm, Claudine Bussolaro, Walter Dobrovolsky, Hadi Seikaly

“…Based on our findings, patients can obtain an acceptable QOL and good function following simultaneous reconstruction with FFF employing SDS and an alloplastic TMJ prosthesis. Graphical Abstract…”
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Does the transfer of knowledge from the pioneer generation to the second‐generation speed‐up the learning curve of robot‐assisted partial nephrectomies? TRANSFER trial (UroCCR n°83... by Louis Vignot, Zine‐Eddine Khene, Adil Mellouki, Arnoult Morrone, Jean‐Christophe Bernhard, Karim Bensalah, Daniel Chevallier, Nicolas Doumerc, Morgan Roupret, Francois‐Xavier Nouhaud, Cédric Lebacle, Jean‐Alexandre Long, Pierre Pillot, Xavier Tillou, Brannwel Tibi, Matthieu Durand, Younes Ahallal, Imad Bentellis

“…The learning speed for WIT was explored graphically by polynomial regression after cubic splines. …”
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Overcoming hypoxia-induced breast cancer drug resistance: a novel strategy using hollow gold-platinum bimetallic nanoshells by Lian-Ying Zhang, Xiao-Tong Chen, Rong-Tian Li, Wei Meng, Guo-Qin Huang, Yong-Jian Chen, Feng-Jun Ge, Qun Zhang, Yu-Jun Quan, Cai-Tao Zhang, Yi-Fei Liu, Ming Chen, Jin-Xiang Chen

“…This study presents a novel strategy to tackle tumor proliferation and enhance tumor response to chemotherapy, offering hope for reversing in drug resistance in cancerous lesions. Graphical Abstract…”
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DNA methylation of ACADS promotes immunogenic cell death in hepatocellular carcinoma by Ze Qian, Yifan Jiang, Yacong Wang, Yu Li, Lin Zhang, Xiaofeng Xu, Diyu Chen

“…We also discovered a correlation between ACADS and ICD, suggesting that ACADS is an essential target for immunotherapy in HCC. Graphical Abstract…”
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