Comment on “Unlocking the therapeutic potential of microalgal astaxanthin a super antioxidant in oral cancer and associated ailments” by Antonyraj Matharasi Perianaika Anahas, Dhanraj Ganapathy

“…In order to enhance the therapeutic uses of C-PC in oral cancer, further studies may investigate genetically modified microalgae. Validating these therapeutic effects and advancing cyanobacterial pigment-based drugs into clinical applications demand further studies.…”
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Caspase-10 Is the Key Initiator Caspase Involved in Tributyltin-Mediated Apoptosis in Human Immune Cells by Harald F. Krug

“…When compared to Fas-ligand control stimulation, the same sequence of events occurs: membrane blebbing, phosphatidylserine externalisation, the activation of the “death-inducing signalling complex,” and the following sequence of cleavage processes. In genetically modified caspase-8-deficient Jurkat cells, the apoptotic effects are only slightly reduced, whereas, in FADD-negative Jurkat cells, the TBT effect is significantly diminished. …”
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Liver Xenotransplantation: A Path to Clinical Reality by Serkan Sucu, Serkan Sucu, Yucel Yankol, Luis A. Fernandez, Burcin Ekser

“…Early efforts using non-human primates and genetically modified pigs faced significant challenges such as thrombocytopenia and graft rejection. …”
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Gene function revealed at the moment of stochastic gene silencing by Shreyan Gupta, James J. Cai

“…Analysis of real data demonstrates that scSGS can reveal regulatory relationships up- and downstream of target genes, circumventing the survivorship bias that often affects gene knockout and perturbation studies. scSGS thus offers an efficient approach for gene function prediction, with significant potential to reduce the use of genetically modified animals in gene function research.…”
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Recombinant venom proteins in insect seminal fluid reduce female lifespan by Samuel J. Beach, Maciej Maselko

“…Numerous genetic biocontrol approaches, which involve the release of genetically modified organisms to control pest populations, are in various stages of development to provide highly targeted pest control. …”
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The Ongoing Challenge of Hematopoietic Stem Cell-Based Gene Therapy for β-Thalassemia by Ekati Drakopoulou, Eleni Papanikolaou, Nicholas P. Anagnou

“…Furthermore, as human HSCs have intrinsic barriers to HIV-1 infection, attention is drawn towards their ex vivo manipulation, aiming to achieve higher yield of genetically modified HSCs. This paper presents the current status of gene therapy for β-thalassemia, its success and limitations, and the novel promising strategies available involving the therapeutic role of HSCs.…”
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Trait and plasticity evolution under competition and mutualism in evolving pairwise yeast communities. by ShengPei Wang, Renuka Agarwal, Kari A Segraves, David M Althoff

“…We experimentally tested how competition and mutualism affected trait and plasticity evolution of pairwise communities of genetically modified brewer's yeast. We quantified evolutionary changes in growth rate, resource use efficiency (RUE), and their plasticity in strains evolving alone, with a competitor, and with a mutualist. …”
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Densely vascularized thick 3D tissue shows enhanced protein secretion constructed with intermittent positive pressure by Misako Katsuura, Jun Homma, Yuhei Higashi, Hidekazu Sekine, Tatsuya Shimizu

“…Furthermore, in vivo experiments showed that IPP-cultured cell sheets enhanced the secretion of Gaussian luciferase by genetically modified mesenchymal stem cells. These findings highlight the IPP method as a technique that simultaneously enables the thickening of planar tissues and the construction of vascular networks. …”
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Diversity and bioindicators of natural enemies in organic paddy fields implementing habitat modification by Setyadin Yuris, Leksono Amin Setyo, Tarno Hagus

“…Organic systems are a viable alternative characterized by organic fertilizers and biopesticides, avoiding genetically modified microorganisms and promoting biodiversity. …”
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Europejska Konwencja Bioetyczna w ochronie (bio)bezpieczeństwa człowieka w obszarze biomedycyny: wymiar jednostkowy i społeczny by Mariusz Ciszek

“…It was noticed that biosafety was related to three basic dimensions of threats to human safety connected with biotechnological products. They are genetically modified organisms (GMO), the use of biological weapons, and the development of biomedical disciplines. …”
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Advancing nuclear transfer cloning in zebrafish (Danio rerio) into a translational pathway using interdisciplinary tools. by Sarah Bodenstein, William Poulos, Fermin Jimenez, Michael Stout, Yue Liu, Zoltan M Varga, Jose Cibelli, Terrence R Tiersch

“…The Zebrafish International Resource Center (ZIRC) is an NIH-funded national stock center and germplasm repository that maintains and distributes genetically modified and wild-type zebrafish (Danio rerio) lines to the biomedical research community. …”
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Addressing the limitations of the regulatory landscape in South Africa regarding advanced cell and gene therapies and related sectors involving human cells, tissues and organs by I M Viljoen, M S Pepper

“…However, South Africa (SA)’s regulatory frameworks for medicines, human biological materials and genetically modified organisms have not kept pace with scientific and technological developments, leaving regulatory gaps. …”
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Selective Herbicides for Cultivation of Eucalyptus urograndis Clones by Patrick J. Minogue, Anna Osiecka

“…Five herbicides, flumioxazin, imazamox, imazapic, oxyfluorfen, and sulfometuron methyl, were evaluated for selective weed control in the establishment of genetically modified frost tolerant Eucalyptus urograndis clones. …”
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The role of oxidative stress, glucocorticoid receptor and ARMC5 in lipid metabolism by Yosuke Okuno, Atsunori Fukuhara, Iichiro Shimomura

“…We previously found novel roles of adipocyte oxidative stress in diet-induced obesity, adipocyte glucocorticoid receptor in Cushing syndrome, and ARMC5 in adrenocortical cells. Using genetically modified mice in which oxidative stress was eliminated or augmented specifically in adipose tissues, we have been able to elucidate that obesity-induced oxidative stress inhibited healthy adipose expansion and ameliorated insulin sensitivity. …”
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A Cell Model for Conditional Profiling of Androgen-Receptor-Interacting Proteins by K. A. Mooslehner, J. D. Davies, I. A. Hughes

“…For this purpose, male genital development relevant mouse cell lines were genetically modified to express a tagged version of wild-type AR, allowing copurification of multiprotein complexes under native conditions followed by mass spectrometry. …”
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The Role of NK Cells in Pig-to-Human Xenotransplantation by Gisella Puga Yung, Mårten K. J. Schneider, Jörg D. Seebach

“…The potential of cell-based strategies including tolerogenic dendritic cells (DC) and regulatory T cells (Treg) and the latest progress using transgenic pigs genetically modified to reduce xenogeneic NK cell responses are discussed. …”
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Generation of a genetically double-attenuated Plasmodium berghei parasite that fully arrests growth during late liver stage development. by Melanie Schmid, Raphael Beyeler, Reto Caldelari, Ruth Rehmann, Volker Heussler, Magali Roques

“…One approach to combat this disease involves vaccinating individuals with whole sporozoites that have been genetically modified to arrest their development at a specific stage in the liver by targeted gene deletion, resulting in a genetically attenuated parasite (GAP). …”
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Analysis of Fractional Order Mathematical Model of Hematopoietic Stem Cell Gene-Based Therapy by Mohammad Imam Utoyo, Windarto, Aminatus Sa’adah

“…This therapy protects target cells from infections or specifying technic and immune responses to face virus by using genetically modified HSCs. A mathematical model approach could be used to predict the dynamics of HSC gene-based therapy of viral infections. …”
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Machine learning methods for predicting essential metabolic genes from Plasmodium falciparum genome-scale metabolic network. by Itunuoluwa Isewon, Stephen Binaansim, Faith Adegoke, Jerry Emmanuel, Jelili Oyelade

“…Detecting these genes in disease-causing organisms is critical for various biological studies, including understanding microbe metabolism, engineering genetically modified microorganisms, and identifying targets for treatment. …”
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Impact of tillage and no-tillage cultivation on the occurrence of entomopathogenic fungi in soil with integrated plant protection by Roman Kierzek, Danuta Sosnowska, Agata Pruciak-Nowak

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