Análisis crítico del programa curso propio Terapéutica Razonada para la carrera de Medicina en Cuba by Adriel Torres Saldaña, Pedro Miguel Milián Vázquez, Norlie Mendoza Mendoza, Rogeynier Romero López, Lidia Vázquez Montero, María del Carmen Romero Sánchez

“…<br /><strong>Resultados:</strong> se identifican las fortalezas y debilidades en torno a la justificación, pertinencia social, aspectos generales que lo caracterizan, nexos con el currículo formal, secuencia lógica en el currículo, organización de los temas, equilibrio entre las horas teóricas, prácticas y de trabajo independiente, análisis de los componentes no personales, orientaciones metodológicas, así como el análisis de la bibliografía. …”
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Clinicopathological and Prognostic Characteristics of Malaysian Triple Negative Breast Cancer Patients Undergoing TAC Chemotherapy Regimen by Ahmad Aizat Abdul Aziz, Md Salzihan Md Salleh, Ravindran Ankathil

“…Triple negative breast cancer (TNBC) is associated with aggressive tumour phenotype and early tumour relapse following diagnosis. Generally, clinicopathological features such as tumour size, patient’s age at diagnosis, tumour histology subtypes, grade and stage, involvement of lymph nodes, and menopausal status are commonly used for predicting disease progression, prospects of recurrence, and treatment response. …”
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Factores biológicos y sociales relacionados con la salud de la mujer durante el climaterio by Elodia María Rivas Alpízar, Caridad Hernández Gutiérrez, Gisela Zerquera Trujillo, Belkis Mercedes Vicente Sánchez, José Antonio Muñoz Cocina

“…Mediante entrevista domiciliaria se les llenó un formulario que permitió conocer datos generales, clínicos y de ayuda médica.  <strong><br />Resultados:</strong> el 56,3 % de las mujeres experimentaron un síndrome climatérico leve, los síntomas circulatorios (77,2 %) y psicológicos (60 %) fueron los más referidos. …”
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Efficacy and Safety of CART Cell Therapy in Aggressive B‐Cell Lymphomas Involving the Gastrointestinal Tract by Lixia Ma, Yimeng Dou, Rui Liu, Teng Xu, Fan Yang, Peihao Zheng, Shaomei Feng, Yuelu Guo, Hui Shi, Fei Xue, Biping Deng, Xiaoyan Ke, Kai Hu

“…The gastrointestinal hemorrhage group exhibited markedly lower ORR and inferior OS compared to the non‐hemorrhage group. Conclusion Generally, the CART cell therapy is valid in relapsed/refractory B‐cell lymphoma with gastrointestinal involvement, but gastrointestinal bleeding is a unique risk factor that requires special attention, particularly in patients with high gastrointestinal tumor burden, as it is associated with poor efficacy and survival.…”
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Myxedema Psychosis: Neuropsychiatric Manifestations and Rhabdomyolysis Unmasking Hypothyroidism by Sundus Sardar, Mhd-Baraa Habib, Aseel Sukik, Bashar Tanous, Sara Mohamed, Raad Tahtouh, Abdelrahman Hamad, Mouhand F. H. Mohamed

“…Hypothyroidism is a prevalent endocrine disorder, often presenting with a spectrum of symptoms reflecting a hypothyroid state. It is also generally linked to causing mood swings, psychomotor slowing, and fatigue; however, in rare instances, it may lead to or induce acute psychosis, a condition referred to as myxedema psychosis (MP). …”
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Predictors of Noncompliance to Antihypertensive Therapy among Hypertensive Patients Ghana: Application of Health Belief Model by Yaa Obirikorang, Christian Obirikorang, Emmanuel Acheampong, Enoch Odame Anto, Daniel Gyamfi, Selorm Philip Segbefia, Michael Opoku Boateng, Dari Pascal Dapilla, Peter Kojo Brenya, Bright Amankwaa, Evans Asamoah Adu, Emmanuel Nsenbah Batu, Adjei Gyimah Akwasi, Beatrice Amoah

“…Noncompliance to AHT was considerably high and HBM is generally reliable in assessing treatment noncompliance in the Ghanaian hypertensive patients. …”
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The extremely halotolerant black yeast Hortaea werneckii - a model for intraspecific hybridization in clonal fungi by Polona Zalar, Jerneja Zupančič, Cene Gostinčar, Janja Zajc, G. Sybren de Hoog, Filomena De Leo, Armando Azua-Bustos, Nina Gunde-Cimerman

“…Analysis of whole-genome sequences of selected H. werneckii strains generally confirmed the phylogenetic distances estimated on the basis of ribosomal genes, but also showed substantial reticulation within the phylogenetic history of the strains. …”
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First-in-human phase 1 study of the arginase inhibitor INCB001158 alone or combined with pembrolizumab in patients with advanced or metastatic solid tumours by Michael Smith, Aung Naing, Todd Bauer, Kyriakos P Papadopoulos, Osama Rahma, Elena Garralda, Glenn J Hanna, Michael J Pishvaian, Xuejun Chen, Sven Gogov, Omar Saavedra, Howard Kallender, LuLu Cheng, Emil Kuriakose

“…Arginase 1 expression in the tumour microenvironment did not correlate with response.Conclusions INCB001158 was generally well tolerated. Response rates did not exceed background for given tumour types despite demonstrable pharmacodynamic activity. …”
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Leveraging two-dimensional pre-trained vision transformers for three-dimensional model generation via masked autoencoders by Muhammad Sajid, Kaleem Razzaq Malik, Ateeq Ur Rehman, Tauqeer Safdar Malik, Masoud Alajmi, Ali Haider Khan, Amir Haider, Seada Hussen

“…Numerous tests demonstrate how effectively our method works with pre-trained models and how well it generalizes to a range of downstream tasks. In particular, our pre-trained model achieved 93.63% accuracy for linear SVM on ScanObjectNN and 91.31% accuracy on ModelNet40. …”
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Fabrication and Compression Properties of Reinforced Epoxy Syntactic Foam With Basalt Fiber by Shuai Cao, Tao Jiang, Shanshan Shi, Xiaofan Gui, Ying Wang, Bo Tang, Lixue Xiang, Xuming Dai, Donghai Lin, Ning Zhong, Wenge Li, Jinhong Yu, Xinfeng Wu

“…Deep-sea equipment is generally made of lightweight and pressure-resistant materials in order to meet the requirements of the actual work. …”
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A New X-Ray and Radio Burst Activity from the Magnetar SGR 1935+2154 by Noor S. Rehan, Alaa I. Ibrahim

“…The mean spectral parameters (Γ _CPL ∼ 0.82, E _p _ CPL ∼ 26 keV and kT _BBs ∼ 5.10 keV, kT _BBh ∼ 8.96 keV) are generally comparable to the previous activities but with a softer Γ _CPL and larger R _BBh than in 2020 April. …”
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Interaction between 24 h Urinary Free Cortisol and Obesity in Hypertension-Mediated Organ Damage in Patients with Untreated Hypertension by Gao-Zhen Cao, Jia-Yi Huang, Qing-Shan Lin, Cong Chen, Min Wu, Run Wang, Ming-Yen Ng, Kai-Hang Yiu, Jian-Cheng Xiu

“…Multivariate logistic regression was conducted to evaluate the associations of HMOD indicators with 24 h UFC and obesity. Generalized linear models were used to test for the interaction effects of obesity in the associations between log 24 h UFC levels and HMOD indicators. …”
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Effect of colchicine on physiological and biochemical properties of <i>Rhodococcus qingshengii</i> by Yu. A. Markova, L. A. Belovezhets, V. N. Nurminsky, I. S. Kapustina, N. V. Ozolina, V. V. Gurina, A. L. Rakevich, A. V. Sidorov

“…The microviscosity of the membrane of individual cells was distributed from the lowest to the highest values of the generalized laurdan f luorescence polarization index (GP), which indicates a variety of adaptive responses to this alkaloid. …”
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Study on the Key Influential Factors on Water Huff-n-Puff in Ultralow-Permeability Reservoir by Xiaoyan Wang, Kun Xie, Jie Zhang, Yong Zhang, Yang Zhang, Wei Wang, Xi Yan, Fengxiang Zhao

“…Ultralow-permeability reservoirs are difficult to effectively develop using conventional technologies, so it generally produces using horizontal wells’ volume fracturing. …”
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Combination Blockade of the IL6R/STAT-3 Axis with TIGIT and Its Impact on the Functional Activity of NK Cells against Prostate Cancer Cells by S. González-Ochoa, M. C. Tellez-Bañuelos, A. S. Méndez-Clemente, A. Bravo-Cuellar, G. Hernández Flores, L. A. Palafox-Mariscal, J. Haramati, E. J. Pedraza-Brindis, K. Sánchez-Reyes, P. C. Ortiz-Lazareno

“…Advanced stages of the disease are usually very aggressive, and most are treated with chemotherapeutic drugs that generally cause side effects in these patients. However, additional therapeutic targets such as the IL6R/STAT-3 axis and TIGIT have been proposed, mainly due to their relevance in the development of PCa and regulation of NK cell-mediated cytotoxicity. …”
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Perceptions in 3.6 Million Web-Based Posts of Online Communities on the Use of Cancer Immunotherapy: Data Mining Using BERTopic by Xingyue Wu, Chun Sing Lam, Ka Ho Hui, Herbert Ho-fung Loong, Keary Rui Zhou, Chun-Kit Ngan, Yin Ting Cheung

“…The sentiment score of around 0.3 across the 14 topics suggested generally positive sentiments toward immunotherapy within the online communities. …”
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Metabolic Performance of Mealworms and Black Soldier Fly Larvae Reared on Food and Agricultural Waste and By-Products by Frederik Kjær Nielsen, Rasmus Juhl Hansen, Asmus Toftkær Muurmann, Simon Bahrndorff, Niels Thomas Eriksen

“…The type of feed substrates had stronger effects on the growth of mealworms than on black soldier fly larvae. Generally, BSF larvae were advantageous in terms of the highest maximal specific growth rate (0.50–0.77 day⁻¹) and feed assimilation rate (0.81–1.16 day⁻¹) and shortest development period (23–25 days) but disadvantageous in terms of metabolic maintenance cost (0.07–0.21 day⁻¹). …”
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“We’re all in the same storm, but not all of us are in the same boat”: qualitative exploration of UK response-focused civil servants experiences of working from home during COVID-1... by Charlotte E. Hall, Samantha K. Brooks, Neil Greenberg, Dale Weston

“…But, the work was demanding, particularly for those who had to rapidly, and unexpectedly, transition from office or lab work to home working. More generally, the nature of their homeworking experience depended on a range of practical (e.g., space in the home), organisational (e.g., relationships with managers) and personal factors (e.g., caring responsibilities). …”
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Gender differences in use of cigarette and non-cigarette tobacco products among adolescents aged 13–15 years in 20 African countries by Israel T. Agaku, Rose Sulentic, Adriana Dragicevic, Gibril Njie, Candace K. Jones, Satomi Odani, Tina Tsafa, Joy Gwar, Constantine I. Vardavas, Olalekan Ayo-Yusuf

“…Current use of e-cigarettes, shisha, and smokeless tobacco was generally comparable between boys and girls where data existed. …”
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The Optimum Dietary Phenylalanine Requirement of Hybrid Grouper (Epinephelusfuscoguttatus ♀ × Epinepheluslanceolatus ♂) Juveniles: Effects on Growth Performance, Gut Micromorpholog... by Pinxian Yang, Haijiao Wang, Lei Ma, Haoran Yin, Zhanying Zhu, Cong Liu, Wei Huang, Zhiyu Zhou, Xiaoyi Wu, Sehrish Taj

“…In addition, fish fed Phe 10.1 had lower levels of nuclear factor erythroid 2 (Nrf2) and heat shock protein 70 (HSP70) in the head kidney, and Cu/Zn-superoxide (Cu/ZnSOD) dismutases in the midgut compared to fish fed other Phe levels. Generally, optimal Phe content in the diet of hybrid grouper was estimated to be 12.7 g/kg of dry matter (27.3 g/kg of dietary protein), and at this level, the feed utilization, gut micromorphology, and immunity of fish were also elevated.…”
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