Improving drug repositioning with negative data labeling using large language models by Milan Picard, Mickael Leclercq, Antoine Bodein, Marie Pier Scott-Boyer, Olivier Perin, Arnaud Droit

“…Supervised machine learning is commonly used to score drug candidates but is hindered by the lack of reliable negative data—drugs that fail due to inefficacy or toxicity— which is difficult to access, lowering their prediction accuracy and generalization. Positive-Unlabeled (PU) learning has been used to overcome this issue by either randomly sampling unlabeled drugs or identifying probable negatives but still suffers from misclassification or oversimplified decision boundaries. …”
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The effect of R&D capitalization on revenue-expense matching: Focusing on the bio-pharmaceutical industries in South Korea by Dongjoon Choi, Inkyung Yoon, Hansol Lee

“…The results indicate that R&D capitalization generally weakens revenue-expense matching in these industries. …”
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Oral health status, behavior and impact profile among naval personnel in the Malaysian naval armed forces by Nik Madihah Nik Azis, Raja Noreihan Raja Abdullah, Mohamad Nur Adzmi Mohamad Ayub, Badiah Baharin

“…Additionally, oral health behaviours were generally inadequate, with 12% of participants reporting infrequent brushing and 68.2% indicating limited use of interdental aids. …”
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Opioid consumption frequency and its associations with potential life problems during opioid agonist treatment in individuals with prescription-type opioid use disorder: explorator... by Anne Bouthillier, Gabriel Bastien, Christina McAnulty, Hamzah Bakouni, Bernard Le Foll, M. Eugenia Socias, Didier Jutras-Aswad

“…A repeated-measures generalized linear mixed model (GLMM) was used to evaluate the influence of OUF on potential life problems. …”
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Parameters of the Component Composition of the Body and Their Relationship with the Development of Ascites in Liver Cirrhosis by Yu. O. Zharikov, M. S. Zharkova, A. N. Gadjiakhmedova, A. M. Aliyeva, V. N. Nikolenko, V. T. Ivashkin

“…Patients with a lower percentage of body fat mass had a more severe ascites severity and vice versa, and the proportion of fat mass was generally higher in women than in men (r = –0.290; p = 0.002). …”
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An intelligent lithology identification method for sandstone and mudstone strata and its applications: A case study of the Jurassic strata in the Lunnan area, Xinjiang, China by Ming CAI, Qingwen ZHOU, Cong YANG, Feng CHEN, Dong WU, Wang LIN, Chengguang ZHANG, Yuanjun ZHANG, Yuxin MIAO

“…However, traditional identification methods generally utilize the interactive relationships between only 2‒3 logging parameters, suffering from low utilization rates of logging information and low identification accuracy for strata with small differences in logging responses. …”
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Small intestinal bacterial overgrowth syndrome and systemic inflammation in pathogenesis of hemodynamic changes at liver cirrhosis by R. V. Maslennikov, A. A. Driga, K. V. Ivashkin, M. S. Zharkova, M. V. Mayevskaya, Ch. S. Pavlov, M. G. Arslanyan, N. B. Musina, Ye. N. Berezina, V. T. Ivashkin

“…Original study included 50 LC patients and 15 generally healthy controls. Lactulose hydrogen breath test, serum level of C-reactive protein and cardiac ultrasound with simultaneous blood pressure (BP) and heart rate measurement, estimation of basic hemodynamic scores: mean blood pressure (MBP), cardiac output (CO), total peripheral vascular resistance (TPVR) were investigated in all patients. …”
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GEOINFORMATION TECHNOLOGIES IN THE TRAINING OF FUTURE MINING ENGINEERS by Vladimir S. Morkun, Serhiy O. Semerikov, Svitlana M. Hryshchenko

“…The program of experimental research to test the effectiveness of methods of using Geoinformation technologies in the formation of environmental competence was implemented in three stages: analytical and stating, design and search and forming and generalizing. The discrepancies identified at the analytical and stating stage of the pedagogical experiment required the development of a new competence system with separate components of environmental competence. …”
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Gastrointestinal symptoms and bowel habits in 53 046 healthy Danish blood donors: a nationwide cross-sectional study by Christian Erikstrup, Ole Birger Pedersen, Henrik Hjalgrim, Erik Sørensen, Jens Frederik Dahlerup, Klaus Rostgaard, Mikkel Steen Petersen, Sisse Rye Ostrowski, Susan Mikkelsen, Khoa Manh Dinh, Thorsten Brodersen, Janna Nissen, Anne Karmisholt Grosen, Jens Kjærgaard Boldsen, Simon Mark Dahl Baunwall, Mie Topholm Bruun, Bitten Aagaard, Christina Mikkelsen, Christian Lodberg Hvas

“…Half of the participants (50%) had a regular defaecation pattern (defined as generally the same stool consistency and stool frequency) consisting of Bristol Stool Form Scale 4 stools 1–3 times per day. …”
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Exploring avocado consumption and health: a scoping review and evidence map by Stephen A. Fleming, Tristen L. Paul, Rachel A. F. Fleming, Alison K. Ventura, Megan A. McCrory, Corrie M. Whisner, Paul A. Spagnuolo, Louise Dye, Jana Kraft, Jana Kraft, Nikki A. Ford

“…Studies were largely conducted in the United States or Latin America and generally included adults, with overweight/obesity, frequently with elevated lipid concentrations. …”
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Single-shot super-resolved fringe projection profilometry (SSSR-FPP): 100,000 frames-per-second 3D imaging with deep learning by Bowen Wang, Wenwu Chen, Jiaming Qian, Shijie Feng, Qian Chen, Chao Zuo

“…However, the imaging speed of current FPP methods is generally capped at several kHz, which is limited by the projector-camera hardware and the number of fringe patterns required for phase retrieval and unwrapping. …”
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Diurnal and Daily Variations of PM2.5 and its Multiple-Wavelet Coherence with Meteorological Variables in Indonesia by Nani Cholianawati, Tiin Sinatra, Ginaldi Ari Nugroho, Didin Agustian Permadi, Asri Indrawati, Halimurrahman, Meta Kallista, Moch Syarif Romadhon, Ilma Fauziah Ma’ruf, Dipo Yudhatama, Tesalonika Angela Putri Madethen, Asif Awaludin

“…A bimodal pattern with two peaks appears in Padang, Manado, Palu, and Pangkalpinang, while in Jakarta, Surabaya, and Pontianak, the diurnals have a unimodal pattern with one peak at night until morning. All cities generally present higher diurnal PM2.5 concentrations in the dry season than in the wet season. …”
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The concentration of selected organophosphorus pesticides associated with PM10 in agricultural ambient air in Iran: Health risk assessment using Monte Carlo simulation by Asma Tabanasl, Amin Mohammadpour, Aboozar Soltani, Mohammad Hoseini, Mohammadali Baghapour

“…Although no significant overall difference was observed in organophosphate pesticide levels in PM10 between urban and suburban areas, suburban regions generally exhibited higher concentrations, with the exceptions of Parathion and Butachlor. …”
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Changes in Tropospheric Nitrogen Dioxide Vertical Column Densities over Japan and Korea during the COVID-19 Using Pandora and MAX-DOAS by Yongjoo Choi, Yugo Kanaya, Hisahiro Takashima, Kihong Park, Haebum Lee, Jihyo Chong, Jae Hwan Kim, Jin-Soo Park

“…The differences in correlations might be caused by the different social distancing policies in Korea (voluntary) and Japan (mandatory). By applying generalized boosted models to exclude meteorological and seasonal effects associated with NO2 TropVCD variations, we revealed that the decreasing trend from 2019 to 2020 was much steeper than that from 2015 to 2020 (a factor of two), and a significant change was identified in January 2020, when the first cases of COVID-19 were observed in both Korea and Japan. …”
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Clinically meaningful improvements after gene therapy for aromatic L-amino acid decarboxylase deficiency (AADCd) in the Peabody Developmental Motor Scale, Second Edition (PDMS-2) a... by Wuh-Liang Hwu, Hui-Min Lee, John Devin Peipert, Rongrong Zhang, Christian Werner, J. Rafael Sierra, Thomas O’Connell, Jonathan J. Woolley, Marjorie Crowell, Antonia Wang, Ioannis Tomazos

“…Results An MSD of 40 points for Total PDMS-2 score was selected for analysis as it yielded specificity > 0.95 using the ROC approach, and generally aligned with the mean-difference approach. …”
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Anxiety, Anger and Depression Amongst Low-Income Earners in Southwestern Uganda During the COVID-19 Total Lockdown by Archibong, Victor, Usman, Ibe Michael, Keneth Iceland, Kasozi, Osamudiamwen, Eric Aigbogun Jr., Josiah, Ifie, Monima, Ann Lemuel, Ssebuufu, Robinson, Chekwech, Gaudencia, Terkimbi, Swase Dominic, Owoisinke, Okon, Mbiydzenyuy, Ngala Elvis, Adeoye, Azeez, Aruwa, oshua Ojodale, Afodun, Adam Moyosore, Odoma, Saidi, Ssempijja, Fred, Ayikobua, Emmanuel Tiyo, Ayuba, John Tabakwot, Nankya, Viola, Onongha, Comfort, Sussan, Henry, Matama, Kevin, Yusuf, Helen, Nalugo, Halima, MacLeod, Ewan, Welburn, Susan Christina

“…Two hundred and fifty-three (n = 253) male and female low-income earners between the ages of 18 and 60 years of age were recruited to the study. Modified generalized anxiety disorder (GAD-7), Spielberger’s State-Trait Anger Expression Inventory-2 (STAXI-2), and Beck Depression Inventory (BDI) tools as appropriate were used to assess anxiety, anger, and depression respectively among our respondents. …”
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Impact of the Timing of Enzyme Replacement Therapy Initiation and Cognitive Impairment Status on Outcomes for Patients with Mucopolysaccharidosis II (MPS II) in the United States:... by Karen S. Yee, David Alexanderian, Yidie Feng, Xiaowei Ren, Bernd Schweikert, Olulade Ayodele

“…Evaluation of developmental and behavioral signs and symptoms in the full study population showed that communication delay (70.0% of patients), cognitive delay (62.1%), behavioral problems (52.9%), and toileting delay (50.0%) were particularly common; earliest documented signs and symptoms were motor delay (median [range] age at first documentation: 4.2 [0.9-18.7] years) and behavioral problems (4.4 [0.6-13.7] years). Patients with CI generally experienced greater symptom burden and higher HRU than those without CI, with the most notable differences documented for communication and toileting delays. …”
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An automated adaptive trading system for enhanced performance of emerging market portfolios by Cristiana Tudor, Robert Sova

“…The system incorporates an Autoregressive Moving Average-Generalized AutoRegressive Conditional Heteroskedasticity model that offers an interpretability advantage over machine-learning methods. …”
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The Impact of Baseline Risk Factors on the Incidence of Febrile Neutropenia in Breast Cancer Patients Receiving Chemotherapy with Pegfilgrastim Prophylaxis: A Real-World Data Analy... by Edward Li, Bridgette Kanz Schroader, David Campbell, Kim Campbell, Weijia Wang

“…Logistic regression and generalized estimating equations models were used to compare outcomes among patients with and without patient-specific risk factors and among those receiving regimens categorized as high-, intermediate-, or other-risk for FN (low-risk or undefinable by clinical practice guidelines). …”
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Progress in the Management of Retinal Detachment Associated With Morning Glory Syndrome by Wu S, Wang W, Liu L, Wang W, Jiang K, Peng C, Sun H, Zhang J

“…Surgical interventions are generally employed to manage complications, especially retinal detachments, with procedures such as vitrectomy, paraoptic disc laser photocoagulation, and the use of silicone oil or gas tamponade, though success rates can vary widely. …”
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