Integrating machine learning and structure-based approaches for repurposing potent tyrosine protein kinase Src inhibitors to treat inflammatory disorders by Muhammad Waleed Iqbal, Muhammad Shahab, Zakir ullah, Guojun Zheng, Irfan Anjum, Gamal A. Shazly, Atrsaw Asrat Mengistie, Xinxiao Sun, Qipeng Yuan

“…Molecular Mechanics/Generalized Born Surface Area (MMGBSA) analysis validated their binding affinities by providing comparably lower binding free energies for orlistat (− 33.4743 ± 3.8908), acarbose (− 19.5455 ± 5.4702), and afatinib (− 36.4944 ± 5.4929) than the control, dasatinib (− 13.7785 ± 5.8058). …”
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EN The combined effect of heating zone length and inclination angle on start-up, transient and operational characteristics of pulsating heat pipe by К. Мане, Є.С. Алексеїк

“…The impact of inclination angle varies with the coolant used; generally, water outperforms methanol and pentane across all orientations. …”
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‘Piloting a framework for analysing the public contributions to R&D: new antibiotics in focus’ by Louise Schmidt, Ozren Sehic, Ursula Theuretzbacher, Daniel Fabian, Claudia Wild

“…We found the classification framework generally practicable and we suggest recommendations to improve its granularity and applicability.Conclusion In this paper we piloted and revised a framework that has been developed to classify types of public contributions to pharmaceutical products at different stages of development. …”
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Development and validation of soil test crop response model for beetroot (Beta vulgaris) grown in ultisols of India by Ramasamy Arulmani, Ramasamy Arulmani, Kuppayevalasu Malayappagounder Sellamuthu, Kuppayevalasu Malayappagounder Sellamuthu, Subramaniam Maragatham, Subramaniam Maragatham, Alargarsamy Senthil, Alargarsamy Senthil, Seenapuram Palaniswami Thamaraiselvi, Seenapuram Palaniswami Thamaraiselvi, Palaniappan Malathi, Palaniappan Malathi, Govindaraja Sridevi, Govindaraja Sridevi

“…The Soil analysis crop response - combined Plant Nutrition System model proved that beetroot yield can be increased by 34.74%, in relation to the generally recommended dose This inductive method could save 37, 26 and 34 kg of Nitrogen, Phosphorus and Potassium, respectively when Nitrogen, Phosphorus, Potassium fertilizers are combined with 12.5 t ha-1 FYM as per soil test and targeted yield of beetroot.…”
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Zoonotic Parasites and Their Association With Human Activities in Northern Tanzania: An Integrated Ecosystem Approach for One Health by Barakaeli Abdieli Ndossi, Eblate Ernest Mjingo, Hansol Park, Dongmin Lee, Mohammed Mebarek Bia, Heejae Yang, Sungbo Seo, Keeseon S. Eom

“…This study reveals that there was a generally low level of awareness regarding zoonotic diseases and STHs. …”
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Development of an Operational Map for the 3D Printing of Phytosterol-Enriched Oleogels: Rheological Insights and Applications in Nutraceutical Design by María Itatí De Salvo, Camila Palla, Ivana M. Cotabarren

“…While higher PS content generally led to an increase in both Tg and µ, the 10 wt% PS mixture exhibited a different behavior, showing lower Tg and µ compared to the 0 wt% and 5 wt% PS mixtures. …”
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Effect of silane coupling agent on flexural properties of fiber-reinforced geopolymer-cemented aeolian sand by Shuai Pang, Jiaze Li, Mengjie Li, Changzhi Zhao, Henghui Fan, Xiangdong Zhang

“…In the three-point bending test, the maximum crack width was reduced by 54.96 %, the farthest crack extension was shortened by 6.80 mm, and the maximum generalized crack area decreased by 42.39 %. Incorporating 1.5 % KH570 into the specimens effectively improved the physico-chemical properties of the fiber-matrix interface, promoted product formation, and strengthened the interfacial bonding ability. …”
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Assessing the Industrial Effluent Effect on Irrigation Water Quality and Farm Soil near Kombolcha Town, Ethiopia by Mohammed Jemal Awol, Amare Tiruneh Adugna, Kamaraj M

“…The concentration of most selected parameters in downstream farm soil was also decreasing along with depth except pH, CO3−2, and HCO3-. Generally, there is a significant quality difference (at P ≤ 0.05) between the upstream and downstream irrigation water quality on the parameters of Mg+2, Cl−, Pb, and Cu.…”
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Advancing global herbal medicine: Enhancing herb quality through innovative strategies explored in Hong Kong - An international hub by Hiu-Lam Ngai, Pang-Chui Shaw

“…Moreover, it was found that chemical inspection tests were generally avoided due to cost and time concerns. Conclusion: The current situation is not conducive to consumer rights and public health protection, and supply chain practices should be improved to provide high-quality herbs to the community consistently. …”
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Biochar effects on durum wheat (Triticum durum) under ambient and elevated atmospheric CO2 by Lorenzo Brilli, Franz-Werner Badeck, Lorenzo Genesio, Silvia Baronti, Fulvia Rizza, Clara Fares, Luigi Cattivelli, Franco Miglietta, Anita Maienza, Alessandro Zaldei, Federica Camin, Rosella Motzo, Piero Toscano

“…Wheat has a pivotal role in food chains and human diet, and the understanding of its productive and qualitative performance under elevated CO2 (e[CO2]) is therefore a primary research target. While e[CO2] generally boosts wheat yield and biomass, major concerns remain about the impact on qualitative traits. …”
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Plant response to the fire regime (1970–2023) in a fynbos World Heritage Site: Ecological indicators for fire management by Tineke Kraaij, Johan Baard, AnneLise Schutte-Vlok

“…Assessment of maturation rates and post-fire recruitment of proteoids at OWHS revealed juvenile periods of 5–10 years; superior recruitment success after longer fire return intervals (FRIs), warm-season fires, and larger fires; and long FRIs not generally compromising recruitment. Accordingly, we postulate (i) a minimum tolerable FRI of 14 years, particularly on the drier northern slopes where plants are slower-maturing; (ii) no need for establishing maximum tolerable FRIs; and (iii) a requirement for the predominance of warm-season fires. …”
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The Effect of Platelet and Mean Platelet Volume Levels on Standard-dose Methylprednisolone Treatment Response in Primary Immune Thrombocytopenia by Emrah KILICASLAN, Murat YILDIRIM, Selim SAYIN, Erdem CEVIK, Meltem AYLI, Muhammet Kursat KAPTAN

“…Objective: Standard-dose methylprednisolone (methyl-Pd) is generally preferred as the first-line treatment in immune thrombocytopenia (ITP) unless there is an urgent indication to increase the platelet value. …”
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Evaluation and Adjustment of Precipitable Water Vapor Products from FY-4A Using Radiosonde and GNSS Data from China by Xiangping Chen, Yifei Yang, Wen Liu, Changzeng Tang, Congcong Ling, Liangke Huang, Shaofeng Xie, Lilong Liu

“…The RMSE of FY-4A PWV generally increases with decreasing latitude, and the bias is predominantly negative, indicating an underestimation of water vapor. …”
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Similar Material Simulation Study on Protection Effect of Steeply Inclined Upper Protective Layer Mining with Varying Interlayer Distances by Zhigang Yuan, Yaohua Shao, Zhuohui Zhu

“…Protective layer mining, as a dominating regional prevention measure, is generally adopted to prevent and control gas disasters in highly gassy or outburst mines of China. …”
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Comparison of the lower genital tract microbiome composition in patients with benign gynecological disease by Yonghui Shi, Jun Li, Jinjing Xie, Tianye Yang, Qiongyan Ma, Hua Chen, Wenwei Guo

“…The richness and evenness of the microbiome were generally consistent among the HW, EP, UM, and OC groups. …”
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Research on adaptive control of self-moving temporary support based on fuzzy PID by MA Changqing, LI Feng, HUANG Yubo, MAO Junjie, LI Xuyang, WEI Xiangyu, MA Xiaoyang

“…Results indicated that the synchronization error between adjacent hydraulic cylinders was generally controlled within ±5×10−15 m, showing significant precise improvement over traditional PID control method. …”
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Discrete Element Modeling on Mechanical Behavior of Heterogeneous Rock Containing X-Shaped Fissure under Uniaxial Compression by Ming Chen, Jian Liu, Zhengyong Xie, Jianjun Liu, Xunjian Hu, Bingyang Li, Yue Cen

“…Numerical simulated results showed the following: (1) Due to the X-shaped fissures, not only the peak strength, elastic modulus, crack initiation stress, and damage stress were significantly reduced, and the reduced degree of the peak strength was obviously greater than that of the elastic modulus, but also the brittleness and energy were significantly weakened. (2) The peak strength and elastic modulus generally decreased with the increase of β and increased with the increase of α. …”
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Very low urinary marinobufagenin excretion reflects a high risk of disease progression in non-advanced CKD by Davide Bolignano, Davide Bolignano, Marta Greco, Marta Greco, Loredana Tripodi, Mario D’Agostino, Paola Cianfrone, Roberta Misiti, Roberta Misiti, Sara Pugliese, Mariateresa Zicarelli, Michela Musolino, Michela Musolino, Daniela Patrizia Foti, Daniela Patrizia Foti, Michele Andreucci, Michele Andreucci, Giuseppe Coppolino, Giuseppe Coppolino

“…Validation studies are needed to generalize these findings in larger heterogeneous cohorts.…”
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Predictors of sickness absence among employees with common mental disorders in Sweden– a longitudinal study by Anna Frantz, Anna Toropova, Iben Axén, Gunnar Bergström, Anna Finnes, Elisabeth Björk Brämberg

“…Data was analyzed using generalized estimating equations. Results The sample consisted of 197 employees. …”
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Rapid Verbal Persuasion to increase influenza vaccine uptake: protocol for a randomized hybrid type 2 effectiveness -implementation trial by Siyuan Liu, Lan Gao, Yingying Jin, Jiangyun Chen, Dadong Wu, Yiyuan Cai, Tao Wang, Sanhao Huang, Ciling Yan, Run Wang, Dong Roman Xu

“…Modified Poisson regression models and generalized linear mixed-effects models will be utilized to analyze the association between primary outcomes and interventions. …”
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