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Bioinformatics insights into mitochondrial and immune gene regulation in Alzheimer's disease
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Epigenetic and gene regulatory functions of small RNAs
Published 2023-12-01Subjects: Get full text
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CoTF-reg reveals cooperative transcription factors in oligodendrocyte gene regulation using single-cell multi-omics
Published 2025-02-01“…Abstract Oligodendrocytes are the myelinating cells within the central nervous system, but the mechanisms by which transcription factors (TFs) cooperate for gene regulation in oligodendrocytes remain unclear. We introduce coTF-reg, an analytical framework that integrates scRNA-seq and scATAC-seq data to identify cooperative TFs co-regulating the target gene (TG). …”
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Identification of a comprehensive set of transcriptional regulators involved in the long-term survivability of Escherichia coli in soil
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Deciphering the generation of heterogeneity in esophageal squamous cell carcinoma metastasis via single-cell multiomics analysis
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Multi-locus CRISPRi targeting with a single truncated guide RNA
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EpigenomeViewer: A Shiny Web Application for Visualizing Methylation Patterns Across Biological Samples
Published 2025-02-01“…DNA methylation plays a crucial role in gene regulation and is involved in the development of numerous diseases including cancer. …”
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Sex and gender differences in the molecular etiology of Parkinson’s disease: considerations for study design and data analysis
Published 2025-02-01“…In this review, we summarize known contributors to sex differences in PD etiology across the life course, with a focus on neurological development and gene regulation. Sex differences that are established at conception and heightened during adolescence and midlife may partially embed future PD risk, due to the complex interactions between gonadal hormones, gene regulation, lifestyle factors, and aging. …”
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Genetics : analysis of genes and genomes /
Published 2019Table of Contents: “…Genes, genomes and genetic analysis -- DNA structure and genetic variation -- Transmission genetics : the principle of segregation -- The chromosomal basis of inheritance -- Genetic linkage and chromosome mapping -- Human karyotypes and chromosome behavior -- The genetics of complex characters -- Genetics of the bacteria and their viruses -- Molecular organization of chromosomes and genomes -- DNA replication and sequencing -- Mutation, repair, and recombination -- Molecular biology of gene expression -- Molecular mechanisms of gene regulation -- Manipulating genes and genomes -- Genetic control of development -- The genetics of cancer -- Extranuclear inheritance -- Genetics of populations -- Human evolution.…”
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Messenger RNA in differentiating muscle cells—my experience in François Gros’ lab in the 1970s and 80s
Published 2023-12-01“…In the early 1970s, it was the beginning of research in his lab on muscle cell differentiation, as a model eukaryotic system for studying mRNAs and gene regulation. In this article, I recount our work on myogenesis and mention the other research themes in his lab and the people concerned. …”
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A universal method for the purification of C2H2 zinc finger arrays.
Published 2025-01-01“…Zinc fingers (ZFs) are compact, modular, sequence-specific polynucleotide-binding domains uniquely suited for use as DNA probes and for the targeted delivery of effector domains for purposes such as gene regulation and editing. Despite recent advances in both the design and application of ZF-containing proteins, there is still a lack of a general method for their expression and purification. …”
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MICRO RNA: A PROSPECTIVE DIAGNOSTICBIOMARKER IN ALZHEIMER’S DISEASE
Published 2024-12-01“…This research explores the mechanisms and roles of miRNAs in gene regulation related to AD and highlights their potential as therapeutic agents for neurodegenerative diseases. …”
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UV-induced reorganization of 3D genome mediates DNA damage response
Published 2025-02-01“…Through the analysis of DNA damage and excision repair maps, we uncover a correlation between genome folding, gene regulation, damage formation probability, and repair efficacy. …”
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An Autocatalytic Platform Combining a Nonlinear Hybridization Chain Reaction and DNAzyme to Detect microRNA
Published 2024-12-01“…MicroRNAs (miRNAs) are small, non-coding RNAs that play pivotal roles in gene regulation; they are increasingly recognized as vital biomarkers for various diseases, notably cancer. …”
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Axon regeneration: an issue of translation
Published 2024-12-01“…Conversely, the translation process (from mRNA to protein) provides an additional layer of gene regulation. This aspect has been overlooked in CNS regeneration. …”
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Detection by Single-Cell RNA Sequencing of Virally Mediated Skin Diseases
Published 2025-05-01“…Combining single-cell RNA-sequencing data with virome detection strategies represents a potentially powerful approach to investigate and elucidate virus-mediated gene regulation in health and disease.…”
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A hammerhead ribozyme selects mechanically stable conformations for catalysis against viral RNA
Published 2025-02-01“…Abstract Ribozymes, widely found in prokaryotes and eukaryotes, target nucleic acids and can be engineered as biotechnical tools or for gene regulation or immune therapy. Among them, hammerhead is the smallest and best characterized ribozyme. …”
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