Methods of massive parallel reporter assays for investigation of enhancers by S. E. Romanov, D. A. Kalashnikova, P. P. Laktionov

“…These approaches have contributed substantially to the understanding of the fundamental principles of gene regulation.…”
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Exploring the protective role of caffeine against Taraxacum-Induced ribotoxic stress mediated through autophagy and mitochondrial depolarization by Chien-Jung Lin, Shu-Ting Liu, Zih-Syuan Wu, Shih-Ming Huang, Teng-Wei Chen

“…By providing detailed information on Taraxacum-induced rRNA cleavage and N-truncated histone H3’s mechanisms of gene regulation, we hope to understand their respective cellular death and survival stresses.…”
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FishPi: a bioinformatic prediction tool to link piRNA and transposable elements by Alice M. Godden, Benjamin Rix, Simone Immler

“…A tool to link piRNAs with complementary TE targets will improve our understanding of the role of piRNAs in genome maintenance and gene regulation. Existing tools such as TEsmall can process sRNA-seq datasets to produce differentially expressed piRNAs, and piRScan developed for nematodes can link piRNAs and TEs but it requires knowledge about the target region of interest and works backwards. …”
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miR-134-3p Regulates Cell Proliferation and Apoptosis by Targeting INHBA via Inhibiting the TGF-β/PI3K/AKT Pathway in Sheep Granulosa Cells by Xinai Huang, Yongjin Bao, Fan Yang, Xiaodan Li, Feng Wang, Chunxiang Zhang

“…Although miRNAs are essential for post-transcriptional gene regulation, it is not yet known how they affect the expression of <i>INHBA</i> during follicle development. …”
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Recent trends in nanocomposite packaging films utilising waste generated biopolymers: Industrial symbiosis and its implication in sustainability by Zeba Tabassum, Anand Mohan, Narsimha Mamidi, Ajit Khosla, Anil Kumar, Pratima R. Solanki, Tabarak Malik, Madhuri Girdhar

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Protein interference for regulation of gene expression in plants by A. O. Vyacheslavova, I. A. Abdeeva, E. S. Piruzian, S. A. Bruskin

“…Transcription factors (TFs) play a central role in the gene regulation associated with a plant's development and its response to the environmental factors. …”
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Emerging roles of circular RNAs on the regulation of production traits in chicken by Guishuang You, Hong Long, Xiaoxu Shen, Huadong Yin, Shibin Zhang

“…This performance is determined by various production traits that are primarily influenced by multiple factors, including epigenetics—a critical aspect of gene regulation. Circular RNAs (circRNAs), a unique class of non-coding RNAs, have emerged as key epigenetic regulators. …”
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The interaction of Adipose Derived Stem Cells and Breast Cancer by Natasha Cunningham, Ava O'Meara, Cathy L. Brougham

“…MicroRNAs have been linked to gene regulation essential in oncogenic, and tumour suppression as well as cell signalling pathways in BC. …”
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Brain-derived tau oligomer polymorphs: distinct aggregations, stability profiles, and biological activities by Filippa Lo Cascio, Suhyeorn Park, Urmi Sengupta, Nicha Puangmalai, Nemil Bhatt, Nikita Shchankin, Cynthia Jerez, Naomi Moreno, Alice Bittar, Rhea Xavier, Yingxin Zhao, Cankun Wang, Hongjun Fu, Qin Ma, Mauro Montalbano, Rakez Kayed

“…Our results indicate that the aBDTOs possess different structural and morphological features that impact neuronal function, gene regulation, and ultimately disease progression. The distinct tau oligomeric polymorphs may thus contribute to the development of clinical phenotypes and shape the progression of diseases. …”
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Modification of Gene Expression Involved in Alkaloid Production in Opium Poppy by VIGS Combined With Pretreatment of Macerozyme Enzyme by Deniz Ece Özcan, Deniz Köm, Ozan Doğan, Semiha Erişen, Selma Onarici

“…These findings underscore the complex interplay of gene regulation in the morphine biosynthesis pathway. …”
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Promoter engineering with programmable upstream activating sequences in Aspergillus Niger cell factory by Xiaomei Zheng, Yuting Guo, Meiling Chen, Yudan Lu, Yimou Du, Yu Lei, Ping Zheng, Jibin Sun

“…It also underscores the potential of promoter engineering for gene regulation in strain improvement of fungal cell factories.…”
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Revealing systematic changes in the transcriptome during the transition from exponential growth to stationary phase by Hyun Gyu Lim, Ye Gao, Kevin Rychel, Cameron Lamoureux, Xuwen A. Lou, Bernhard O. Palsson

“…The insights gained from this work advance our knowledge of bacterial physiology, gene regulation, and metabolic adaptation.…”
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Preparation, characterisation, and in vitro cancer‐suppression function of RNA nanoparticles carrying miR‐301b‐3p Inhibitor by Junjie Zhao, Niu Niu, Fan Yang, Haitao Liu, Weibo Qi

“…Conclusion Based on RNA self‐assembling, the authors researched the effect of miRNA on DDP sensitivity in LUAD regarding gene regulation. 3WJ‐apt‐miR paves the way for clinical tumour therapy.…”
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Discovery of novel PRMT1 inhibitors: a combined approach using AI classification model and traditional virtual screening by Jungan Zhang, Yixin Ren, Yixin Ren, Yun Teng, Han Wu, Jingsu Xue, Lulu Chen, Xiaoyue Song, Yan Li, Ying Zhou, Zongran Pang, Zongran Pang, Hao Wang, Hao Wang, Hao Wang

“…Protein arginine methyltransferases (PRMTs) play crucial roles in gene regulation, signal transduction, mRNA splicing, DNA repair, cell differentiation, and embryonic development. …”
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Transcriptomic signatures of severe acute mountain sickness during rapid ascent to 4,300 m by Ruoting Yang, Aarti Gautam, Rasha Hammamieh, Robert C. Roach, Beth A. Beidleman

“…This study aimed to investigate differential gene regulation and biological pathways to diagnose AMS from high-altitude (HA; 4,300 m) blood samples and predict AMS-susceptible (AMS+) and AMS-resistant (AMS─) individuals from sea-level (SL; 50 m) blood samples.MethodsTwo independent cohorts were used to ensure the robustness of the findings. …”
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Nuclear mRNA export by Chen Suli, Jiang Qingyi, Fan Jing, Cheng Hong

“…This coordination is essential, as recent studies have revealed that mRNA export factors not only assist in transport but also influence upstream processing steps, adding a layer of complexity to gene regulation. Furthermore, the export process competes with RNA processing and degradation pathways, maintaining a delicate balance vital for accurate gene expression. …”
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Crucial Genes in Aortic Dissection Identified by Weighted Gene Coexpression Network Analysis by Hongliang Zhang, Tingting Chen, Yunyan Zhang, Jiangbo Lin, Wenjun Zhao, Yangyang Shi, Huichong Lau, Yang Zhang, Minjun Yang, Cheng Xu, Lijiang Tang, Baohui Xu, Jianjun Jiang, Xiaofeng Chen

“…Specifically, gene expression profiling helps illustrate the potential mechanism of aortic dissection in terms of gene regulation and its modification by risk factors. …”
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Phosphodiesterase 10A Is a Mediator of Osteogenic Differentiation and Mechanotransduction in Bone Marrow-Derived Mesenchymal Stromal Cells by Sigrid Müller-Deubert, Carolin Ege, Melanie Krug, Jutta Meißner-Weigl, Maximilian Rudert, Oliver Bischof, Franz Jakob, Regina Ebert

“…Mechanotransduction leads to the formation of second messengers such as cAMP, cGMP, or Ca2+ influx resulting in the activation of transcription factors mediating gene regulation. The second messengers cAMP and cGMP are degraded by phosphodiesterase isoenzymes (PDE), but the role of these enzymes during osteogenic differentiation or mechanotransduction remains unclear. …”
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Next generation sequencing uncovers multiple miRNAs associated molecular targets in gallbladder cancer patients by Rahul Saxena, Baskar Chakrapani, M. P. Sarath Krishnan, Amit Gupta, Sweety Gupta, Jayanta Das, Subash C. Gupta, Anissa A. Mirza, Shalinee Rao, Bela Goyal

“…Next-generation sequencing has improved our understanding of molecular pathways in cancer, sparking interest in microRNA-based gene regulation. The aim of the study is to identify dysregulated miRNAs in GBC and investigate their potential as therapeutic tools for effective and targeted treatment strategies. …”
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DeepRetention: A Deep Learning Approach for Intron Retention Detection by Zhenpeng Wu, Jiantao Zheng, Jiashu Liu, Cuixiang Lin, Hong-Dong Li

“…As the least understood mode of alternative splicing, Intron Retention (IR) is emerging as an interesting area and has attracted more and more attention in the field of gene regulation and disease studies. Existing methods detect IR exclusively based on one or a few predefined metrics describing local or summarized characteristics of retained introns. …”
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