Exploiting the Achilles’ Heel of Viral RNA Processing to Develop Novel Antivirals by Ali Zahedi Amiri, Choudhary Ahmed, Subha Dahal, Filomena Grosso, Haomin Leng, Peter Stoilov, Maria Mangos, Johanne Toutant, Lulzim Shkreta, Liliana Attisano, Benoit Chabot, Martha Brown, Mario Huesca, Alan Cochrane

“…Previously, the small molecule 5342191 was identified as a potent inhibitor of HIV-1 replication by altering viral RNA accumulation at doses that minimally affect host gene expression. In this report, we document 5342191 as a potent inhibitor of adenovirus, coronavirus, and influenza replication. …”
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Roles of the <i>Sec2p</i> Gene in the Growth and Pathogenicity Regulation of <i>Aspergillus fumigatus</i> by Yuhuan Liu, Shumi Shang, Cong Liu, Yichen Liu, Keyang Xu, Dan He, Li Wang

“…Furthermore, this gene positively regulated the autophagy pathway and enhanced CWI pathway gene expression to respond to rapamycin-induced autophagy. …”
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Genome-wide characterization and expression analysis of the ADF gene family in response to salt and drought stress in alfalfa (Medicago sativa) by Mengmeng Shi, Yike Wang, Peng Lv, Yujie Gong, Qi Sha, Xinyan Zhao, Wen Zhou, Lingtao Meng, Zegang Han, Lingxiao Zhang, Lingxiao Zhang, Yongwang Sun, Yongwang Sun

“…The promoter region of these genes was found to contain multiple cis-acting elements related to hormone responses, defence, and stress, indicating that they may respond to a variety of developmental and environmental stimuli. Gene expression profiles analyzed by RT-qPCR experiments demonstrated that MsADF genes exhibited distinct expression patterns among different organs. …”
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Newly identified single-nucleotide polymorphism associated with the transition from nonalcoholic fatty liver disease to liver fibrosis: results from a nested case-control study in... by Yitong Ling, Yu Xuan Yang, Yan Chun Chen, Jing Hao Wang, Dong Ge Feng, Shi Jian Xiang, Xiaoyu Zhang, Jun Lyu, Sha Sha Li

“…Our procedures included cultivating these cells, employing SAMM50-rs2073080 plasmid techniques to enhance the expression of recently discovered SNPs, and conducting biochemical assays. To quantify gene expression, we used real-time PCR with fluorescence detection.Results The study analyzed data from 5467 participants (1094 cases and 4373 controls). …”
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A panel of cancer testis antigens in squamous cell carcinoma of the lung, head and neck, and esophagus: implication for biomarkers and therapeutic targets by Lin Li, Xin Zhang, Jiayao Yan, Jingyi Guo, Fangcen Liu, Xiao Wei, Qin Liu, Kongcheng Wang, Baorui Liu

“…The prognostic impact of CTAs gene expression was evaluated using the Kaplan–Meier Plotter website. …”
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Identification and validation of prognostic biomarkers in ccRCC: immune-stromal score and survival prediction by Fang Lyu, Yuxin Zhong, Qingliu He, Wen Xiao, Xiaoping Zhang

“…Prognostic biomarkers were subsequently identified through univariate, LASSO, and multivariate Cox regression analyses, culminating in the development of a risk score model. Gene expression was confirmed in ccRCC cell lines (786-O, Caki-1) and tumor tissues. …”
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Rapid and Specific Detection of Escherichia coli O157:H7 in Ground Beef Using Immunomagnetic Separation Combined with Loop-Mediated Isothermal Amplification by Qin Yu, Puthiyakunnon Santhosh, Zhang Yiduo, Wu Xianbo, Boddu Swapna, Luo Binde, Fan Hongying

“…Then, EHEC O157:H7 was identified by LAMP assay for amplifying and detecting the rfbE gene, which is highly conserved in all EHEC O157:H7 strains and exhibits strain-specifi c gene expression. The LAMP method results analyzed with real time turbidity measurements showed a high specificity and sensitivity, with a positive detection rate of amplifi cation of EHEC O157:H7 DNA diluted to a minimum equivalent concentration of 1.8 × 101 CFU/mL, which was 10 times more sensitive than the conventional PCR assay. …”
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Sex-specific effects of prenatal bisphenol A exposure on transcriptome-interactome profiles of autism candidate genes in neural stem cells from offspring hippocampus by Kasidit Kasitipradit, Surangrat Thongkorn, Songphon Kanlayaprasit, Thanit Saeliw, Pattanachat Lertpeerapan, Pawinee Panjabud, Depicha Jindatip, Valerie W. Hu, Takako Kikkawa, Noriko Osumi, Tewarit Sarachana

“…Our results revealed that prenatal BPA exposure induced sex-specific alterations in NSC gene expression, with ASD-related genes such as Atp1a3, Nefl, and Grin1 being particularly dysregulated in male offspring. …”
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Age-related changes in DNA methylation in a sample of elderly Brazilians by Hayley Welsh, Caio M. P. F. Batalha, Weili Li, Nadja C. Souza-Pinto, Yeda A. O. Duarte, Michel S. Naslavsky, Esteban J. Parra

“…Abstract Background Age-related changes in DNA methylation (DNAm) play a critical role in regulating gene expression. However, most epigenome-wide association studies have predominantly focused on individuals of European descent. …”
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A rare intersection: squamous cell carcinoma of the tonsil and the anti-TIF1 syndrome masquerade by Manush Sondhi, Megan Lear, Saleha Dar, Madiha Tariq

“…Mechanisms connecting TIF1 dermatomyositis and cancer involve gene expression dysregulation and chronic inflammation. …”
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Morphological, Physiological, and Molecular Responses to Heat Stress in Brassicaceae by Iram Batool, Ahsan Ayyaz, Tongjun Qin, Xiaofen Wu, Weiqi Chen, Fakhir Hannan, Zafar Ullah Zafar, Muhammad Shahbaz Naeem, Muhammad Ahsan Farooq, Weijun Zhou

“…While such studies are limited in <i>B. napus</i>, contrasting trends in gene expression have been observed across different species and cultivars, suggesting these genes play a complex role in heat stress tolerance. …”
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T-Cell Subpopulations and Differentiation Bias in Diabetic and Non-Diabetic Patients with Chronic Kidney Disease by Ana Cecilia Granda Alacote, Gabriela Goyoneche Linares, María Gracia Castañeda Torrico, Daysi Zulema Diaz-Obregón, Michael Bryant Castro Núñez, Alexis Germán Murillo Carrasco, Cesar Liendo Liendo, Katherine Susan Rufasto Goche, Víctor Arrunátegui Correa, Joel de León Delgado

“…Objective: The aim of this study was to determine whether T2D influences the profile of memory T lymphocytes, regulatory T cells (Tregs), and the gene expression of transcription factors such as <i>T-bet (Tbx21)</i>, <i>GATA3</i>, <i>RORyT (RORC)</i>, and <i>FOXP3</i> in CKD patients. …”
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miR-210 in Exosomes Derived from Macrophages under High Glucose Promotes Mouse Diabetic Obesity Pathogenesis by Suppressing NDUFA4 Expression by Feng Tian, Ping Tang, Zhilian Sun, Ruifen Zhang, Danhua Zhu, Junying He, Jixing Liao, Qinghua Wan, Jie Shen

“…Conclusion. miR-210 derived from adipose tissue macrophages promotes mouse obese diabetes pathogenesis by regulating glucose uptake and mitochondrial CIV activity through targeting NDUFA4 gene expression.…”
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The expression profile of genes associated with behavior, stress, and adult neurogenesis along the hippocampal dorsoventral axis in tame and aggressive foxes by Yu. V. Alexandrovich, E. V. Antonov, S. G. Shikhevich, A. V. Kharlamova, L. V. Meister, Y. V. Makovka, D. V. Shepeleva, R. G. Gulevich, Yu. E. Herbeck

“…Twelve genes tested demonstrate significant gene expression differences between the dorsal and ventral hippocampi. …”
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A Pilot Study Investigating the Expression Levels of Pluripotency-Associated Genes in Rectal Swab Samples for Colorectal Polyp and Cancer Diagnosis and Prognosis by Ryan Wai-Yan Sin, Dominic Chi-Chung Foo, Deepak Narayanan Iyer, May Sau-Yee Fan, Xue Li, Oswens Siu-Hung Lo, Wai-Lun Law, Lui Ng

“…Change in gene expression is inevitable in cancer development. With more studies demonstrating the contributions of cancer stem cells (CSCs) in colorectal cancer (CRC) development, this study is aimed at investigating whether rectal swab specimen serves as a tool for detection of dysregulation of CSC or stem cell (SC) markers and at evaluating its potential as a new promising screening method for high-risk patients. …”
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Revisiting ABC Transporters and Their Clinical Significance in Glioblastoma by Brandon Wee Siang Phon, Shalini Sundramurthi Chelliah, Dina El-Rabie Osman, Saatheeyavaane Bhuvanendran, Ammu Kutty Radhakrishnan, Muhamad Noor Alfarizal Kamarudin

“…Using the datasets in The Cancer Genome Atlas and Gene Expression Omnibus, we found upregulated ABC transporters that either negatively impacted survival in univariate analyses (ABCA1, ABCA13, ABCB9, ABCD4) or were independent negative prognosis factors for patients with GBM (ABCA13, ABCB9). …”
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Downregulated mRNA Expression of ZNF385B Is an Independent Predictor of Breast Cancer by Ning Yan, Cong Liu, Fang Tian, Ling Wang, Yimin Wang, Zhaoying Yang, Yan Jiao, Miao He

“…Furthermore, the effects of ZNF385B on BC patients’ survival were evaluated by the Kaplan-Meier and Cox regression. Data from the Gene Expression Omnibus (GEO) database were employed to validate the results of TCGA. …”
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Enhancing Food Security via selecting Superior Camelina (Camelina sativa L.) parents: a positive approach incorporating pheno-morphological traits, fatty acids composition, and Toc... by Amin Ebrahimi, Hamzeh Minaei Chenar, Sajad Rashidi-Monfared, Danial Kahrizi

“…Conversely, in the realm of biochemical traits, lines 35, 66, 47, 30, 65, 135, 83, 27, 4, 77, 62, 81, and 93 stood out for their elevated potential. The gene expression analysis related to the tocopherol biosynthesis pathway revealed distinct expression patterns. …”
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Comprehensive analysis of the circRNA expression profile and circRNA-miRNA-mRNA network in pelvic organ prolapse by Qian Wang, Zuoxi He, Lisha Ding, Yuqing Liu, Xiaoli Zhang, Tao Wang, Xiaoyu Niu

“…Circular RNAs (circRNAs) are covalently closed, endogenous biomolecules, which are thought to play an important role on skeletal muscle development by regulating gene expression. In this study, five pairs of peripheral blood samples from control and POP groups were used for circRNA sequencing analysis to obtain differential expression profiles. …”
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Mechanism of <italic>Hedyotis Diffusa</italic> in Treatment of Osteosarcoma based on Network Pharmacology and Molecular Docking by Qin LIU, Xinwei DUAN, Xihai LI

“…Objective:To explore the mechanism of intervention of Hedyotis diffusa on osteosarcoma by network pharmacology and molecular docking.Methods:The active components and related targets of Hedyotis diffusa were predicted through the Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform(TCMSP), while, osteosarcoma-related genes were obtained through Gene Expression Omnibus database. The osteosarcoma-related genes and the target genes of the components of Hedyotis diffusa were intersected to obtain the common target genes of Hedyotis diffusa to interfere with osteosarcoma. …”
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